In December 2020 we announced the launch of our focus series AI for Good: UN sustainable development goals (SDGs). Each month we pick a different sustainable development goal (SDG) and highlight work in that area. Following a terrific response to our first focus on "good health and well-being", we bring you the first of our monthly summary articles where we provide a brief overview of the topic and some highlights from the series. With the COVID-19 pandemic dominating our lives at the moment, research relating to the disease has rightly received considerable coverage in our focus series. In partnership with CLAIRE's COVID-19 taskforce initiative we have brought you articles covering the formation of the taskforce, and about some of the research from the participants.

The family of methods collectively known as classifier chains has become a popular approach to multi-label learning problems. This approach involves chaining together off-the-shelf binary classifiers in a directed structure, such that individual label predictions become features for other classifiers. Such methods have proved flexible and effective and have obtained state-of-the-art empirical performance across many datasets and multi-label evaluation metrics. This performance led to further studies of the underlying mechanism and efficacy, and investigation into how it could be improved. In the recent decade, numerous studies have explored the theoretical underpinnings of classifier chains, and many improvements have been made to the training and inference procedures, such that this method remains among the best options for multi-label learning. Given this past and ongoing interest, which covers a broad range of applications and research themes, the goal of this work is to provide a review of classifier chains, a survey of the techniques and extensions provided in the literature, as well as perspectives for this approach in the domain of multi-label classification in the future. We conclude positively, with a number of recommendations for researchers and practitioners, as well as outlining key issues for future research.

Time series data is a collection of chronological observations which is generated by several domains such as medical and financial fields. Over the years, different tasks such as classification, forecasting, and clustering have been proposed to analyze this type of data. Time series data has been also used to study the effect of interventions over time. Moreover, in many fields of science, learning the causal structure of dynamic systems and time series data is considered an interesting task which plays an important role in scientific discoveries. Estimating the effect of an intervention and identifying the causal relations from the data can be performed via causal inference. Existing surveys on time series discuss traditional tasks such as classification and forecasting or explain the details of the approaches proposed to solve a specific task. In this paper, we focus on two causal inference tasks, i.e., treatment effect estimation and causal discovery for time series data, and provide a comprehensive review of the approaches in each task. Furthermore, we curate a list of commonly used evaluation metrics and datasets for each task and provide in-depth insight. These metrics and datasets can serve as benchmarks for research in the field.

Insider threat is one of the most pernicious threat vectors to information and communication technologies (ICT)across the world due to the elevated level of trust and access that an insider is afforded. This type of threat can stem from both malicious users with a motive as well as negligent users who inadvertently reveal details about trade secrets, company information, or even access information to malignant players. In this paper, we propose a novel approach that uses system logs to detect insider behavior using a special recurrent neural network (RNN) model. Ground truth is established using DANTE and used as the baseline for identifying anomalous behavior. For this, system logs are modeled as a natural language sequence and patterns are extracted from these sequences. We create workflows of sequences of actions that follow a natural language logic and control flow. These flows are assigned various categories of behaviors - malignant or benign. Any deviation from these sequences indicates the presence of a threat. We further classify threats into one of the five categories provided in the CERT insider threat dataset. Through experimental evaluation, we show that the proposed model can achieve 99% prediction accuracy.

This graduate textbook on machine learning tells a story of how patterns in data support predictions and consequential actions. Starting with the foundations of decision making, we cover representation, optimization, and generalization as the constituents of supervised learning. A chapter on datasets as benchmarks examines their histories and scientific bases. Self-contained introductions to causality, the practice of causal inference, sequential decision making, and reinforcement learning equip the reader with concepts and tools to reason about actions and their consequences. Throughout, the text discusses historical context and societal impact. We invite readers from all backgrounds; some experience with probability, calculus, and linear algebra suffices.

Domain-aware machine learning (ML) models have been increasingly adopted for accelerating small molecule therapeutic design in the recent years. These models have been enabled by significant advancement in state-of-the-art artificial intelligence (AI) and computing infrastructures. Several ML architectures are pre-dominantly and independently used either for predicting the properties of small molecules, or for generating lead therapeutic candidates. Synergetically using these individual components along with robust representation and data generation techniques autonomously in closed loops holds enormous promise for accelerated drug design which is a time consuming and expensive task otherwise. In this perspective, we present the most recent breakthrough achieved by each of the components, and how such autonomous AI and ML workflow can be realized to radically accelerate the hit identification and lead optimization. Taken together, this could significantly shorten the timeline for end-to-end antiviral discovery and optimization times to weeks upon the arrival of a novel zoonotic transmission event. Our perspective serves as a guide for researchers to practice autonomous molecular design in therapeutic discovery.

Explainable Artificial Intelligence (XAI) has re-emerged in response to the development of modern AI and ML systems. These systems are complex and sometimes biased, but they nevertheless make decisions that impact our lives. XAI systems are frequently algorithm-focused; starting and ending with an algorithm that implements a basic untested idea about explainability. These systems are often not tested to determine whether the algorithm helps users accomplish any goals, and so their explainability remains unproven. We propose an alternative: to start with human-focused principles for the design, testing, and implementation of XAI systems, and implement algorithms to serve that purpose. In this paper, we review some of the basic concepts that have been used for user-centered XAI systems over the past 40 years of research. Based on these, we describe the "Self-Explanation Scorecard", which can help developers understand how they can empower users by enabling self-explanation. Finally, we present a set of empirically-grounded, user-centered design principles that may guide developers to create successful explainable systems.

The increased adoption of Artificial Intelligence (AI) presents an opportunity to solve many socio-economic and environmental challenges; however, this cannot happen without securing AI-enabled technologies. In recent years, most AI models are vulnerable to advanced and sophisticated hacking techniques. This challenge has motivated concerted research efforts into adversarial AI, with the aim of developing robust machine and deep learning models that are resilient to different types of adversarial scenarios. In this paper, we present a holistic cyber security review that demonstrates adversarial attacks against AI applications, including aspects such as adversarial knowledge and capabilities, as well as existing methods for generating adversarial examples and existing cyber defence models. We explain mathematical AI models, especially new variants of reinforcement and federated learning, to demonstrate how attack vectors would exploit vulnerabilities of AI models. We also propose a systematic framework for demonstrating attack techniques against AI applications and reviewed several cyber defences that would protect AI applications against those attacks. We also highlight the importance of understanding the adversarial goals and their capabilities, especially the recent attacks against industry applications, to develop adaptive defences that assess to secure AI applications. Finally, we describe the main challenges and future research directions in the domain of security and privacy of AI technologies.

Nature-inspired algorithms are commonly used for solving the various optimization problems. In past few decades, various researchers have proposed a large number of nature-inspired algorithms. Some of these algorithms have proved to be very efficient as compared to other classical optimization methods. A young researcher attempting to undertake or solve a problem using nature-inspired algorithms is bogged down by a plethora of proposals that exist today. Not every algorithm is suited for all kinds of problem. Some score over others. In this paper, an attempt has been made to summarize various leading research proposals that shall pave way for any new entrant to easily understand the journey so far. Here, we classify the nature-inspired algorithms as natural evolution based, swarm intelligence based, biological based, science based and others. In this survey, widely acknowledged nature-inspired algorithms namely- ACO, ABC, EAM, FA, FPA, GA, GSA, JAYA, PSO, SFLA, TLBO and WCA, have been studied. The purpose of this review is to present an exhaustive analysis of various nature-inspired algorithms based on its source of inspiration, basic operators, control parameters, features, variants and area of application where these algorithms have been successfully applied. It shall also assist in identifying and short listing the methodologies that are best suited for the problem.

Cyber-defense systems are being developed to automatically ingest Cyber Threat Intelligence (CTI) that contains semi-structured data and/or text to populate knowledge graphs. A potential risk is that fake CTI can be generated and spread through Open-Source Intelligence (OSINT) communities or on the Web to effect a data poisoning attack on these systems. Adversaries can use fake CTI examples as training input to subvert cyber defense systems, forcing the model to learn incorrect inputs to serve their malicious needs. In this paper, we automatically generate fake CTI text descriptions using transformers. We show that given an initial prompt sentence, a public language model like GPT-2 with fine-tuning, can generate plausible CTI text with the ability of corrupting cyber-defense systems. We utilize the generated fake CTI text to perform a data poisoning attack on a Cybersecurity Knowledge Graph (CKG) and a cybersecurity corpus. The poisoning attack introduced adverse impacts such as returning incorrect reasoning outputs, representation poisoning, and corruption of other dependent AI-based cyber defense systems. We evaluate with traditional approaches and conduct a human evaluation study with cybersecurity professionals and threat hunters. Based on the study, professional threat hunters were equally likely to consider our fake generated CTI as true.