In this review, we explore the potential applications of Artificial General Intelligence (AGI) models in healthcare, focusing on foundational Large Language Models (LLMs), Large Vision Models, and Large Multimodal Models. We emphasize the importance of integrating clinical expertise, domain knowledge, and multimodal capabilities into AGI models. In addition, we lay out key roadmaps that guide the development and deployment of healthcare AGI models. Throughout the review, we provide critical perspectives on the potential challenges and pitfalls associated with deploying large-scale AGI models in the medical field. This comprehensive review aims to offer insights into the future implications of AGI in medical imaging, healthcare and beyond.

Transformer has achieved remarkable success in language, image, and speech processing. Recently, various efficient attention architectures have been proposed to improve transformer's efficiency while largely preserving its efficacy, especially in modeling long sequences. A widely-used benchmark to test these efficient methods' capability on long-range modeling is Long Range Arena (LRA). However, LRA only focuses on the standard bidirectional (or noncausal) self attention, and completely ignores cross attentions and unidirectional (or causal) attentions, which are equally important to downstream applications. In this paper, we propose Comprehensive Attention Benchmark (CAB) under a fine-grained attention taxonomy with four distinguishable attention patterns, namely, noncausal self, causal self, noncausal cross, and causal cross attentions. CAB collects seven real-world tasks from different research areas to evaluate efficient attentions under the four attention patterns. Among these tasks, CAB validates efficient attentions in eight backbone networks to show their generalization across neural architectures. We conduct exhaustive experiments to benchmark the performances of nine widely-used efficient attention architectures designed with different philosophies on CAB. Extensive experimental results also shed light on the fundamental problems of efficient attentions, such as efficiency length against vanilla attention, performance consistency across attention patterns, the benefit of attention mechanisms, and interpolation/extrapolation on long-context language modeling.

Inclinometer probes are devices that can be used to measure deformations within earthwork slopes. This paper demonstrates a novel application of Bayesian techniques to real-world inclinometer data, providing both anomaly detection and forecasting. Specifically, this paper details an analysis of data collected from inclinometer data across the entire UK rail network. Practitioners have effectively two goals when processing monitoring data. The first is to identify any anomalous or dangerous movements, and the second is to predict potential future adverse scenarios by forecasting. In this paper we apply Uncertainty Quantification (UQ) techniques by implementing a Bayesian approach to anomaly detection and forecasting for inclinometer data. Subsequently, both costs and risks may be minimised by quantifying and evaluating the appropriate uncertainties. This framework may then act as an enabler for enhanced decision making and risk analysis. We show that inclinometer data can be described by a latent autocorrelated Markov process derived from measurements. This can be used as the transition model of a non-linear Bayesian filter. This allows for the prediction of system states. This learnt latent model also allows for the detection of anomalies: observations that are far from their expected value may be considered to have `high surprisal', that is they have a high information content relative to the model encoding represented by the learnt latent model. We successfully apply the forecasting and anomaly detection techniques to a large real-world data set in a computationally efficient manner. Although this paper studies inclinometers in particular, the techniques are broadly applicable to all areas of engineering UQ and Structural Health Monitoring (SHM).

Metamaterials are artificial materials designed to exhibit effective material parameters that go beyond those found in nature. Composed of unit cells with rich designability that are assembled into multiscale systems, they hold great promise for realizing next-generation devices with exceptional, often exotic, functionalities. However, the vast design space and intricate structure-property relationships pose significant challenges in their design. A compelling paradigm that could bring the full potential of metamaterials to fruition is emerging: data-driven design. In this review, we provide a holistic overview of this rapidly evolving field, emphasizing the general methodology instead of specific domains and deployment contexts. We organize existing research into data-driven modules, encompassing data acquisition, machine learning-based unit cell design, and data-driven multiscale optimization. We further categorize the approaches within each module based on shared principles, analyze and compare strengths and applicability, explore connections between different modules, and identify open research questions and opportunities.

Counterspeech offers direct rebuttals to hateful speech by challenging perpetrators of hate and showing support to targets of abuse. It provides a promising alternative to more contentious measures, such as content moderation and deplatforming, by contributing a greater amount of positive online speech rather than attempting to mitigate harmful content through removal. Advances in the development of large language models mean that the process of producing counterspeech could be made more efficient by automating its generation, which would enable large-scale online campaigns. However, we currently lack a systematic understanding of several important factors relating to the efficacy of counterspeech for hate mitigation, such as which types of counterspeech are most effective, what are the optimal conditions for implementation, and which specific effects of hate it can best ameliorate. This paper aims to fill this gap by systematically reviewing counterspeech research in the social sciences and comparing methodologies and findings with computer science efforts in automatic counterspeech generation. By taking this multi-disciplinary view, we identify promising future directions in both fields.

Recent generative approaches for multi-hop question answering (QA) utilize the fusion-in-decoder method~\cite{izacard-grave-2021-leveraging} to generate a single sequence output which includes both a final answer and a reasoning path taken to arrive at that answer, such as passage titles and key facts from those passages. While such models can lead to better interpretability and high quantitative scores, they often have difficulty accurately identifying the passages corresponding to key entities in the context, resulting in incorrect passage hops and a lack of faithfulness in the reasoning path. To address this, we propose a single-sequence prediction method over a local reasoning graph (\model)\footnote{Code/Models will be released at \url{https://github.com/gowtham1997/SeqGraph}} that integrates a graph structure connecting key entities in each context passage to relevant subsequent passages for each question. We use a graph neural network to encode this graph structure and fuse the resulting representations into the entity representations of the model. Our experiments show significant improvements in answer exact-match/F1 scores and faithfulness of grounding in the reasoning path on the HotpotQA dataset and achieve state-of-the-art numbers on the Musique dataset with only up to a 4\% increase in model parameters.

Natural Language Feedback (NLF) is an increasingly popular avenue to align Large Language Models (LLMs) to human preferences. Despite the richness and diversity of the information it can convey, NLF is often hand-designed and arbitrary. In a different world, research in pedagogy has long established several effective feedback models. In this opinion piece, we compile ideas from pedagogy to introduce FELT, a feedback framework for LLMs that outlines the various characteristics of the feedback space, and a feedback content taxonomy based on these variables. Our taxonomy offers both a general mapping of the feedback space, as well as pedagogy-established discrete categories, allowing us to empirically demonstrate the impact of different feedback types on revised generations. In addition to streamlining existing NLF designs, FELT also brings out new, unexplored directions for research in NLF. We make our taxonomy available to the community, providing guides and examples for mapping our categorizations to future resources.

For its robust predictive power (compared to pure physics-based models) and sample-efficient training (compared to pure deep learning models), physics-informed deep learning (PIDL), a paradigm hybridizing physics-based models and deep neural networks (DNN), has been booming in science and engineering fields. One key challenge of applying PIDL to various domains and problems lies in the design of a computational graph that integrates physics and DNNs. In other words, how physics are encoded into DNNs and how the physics and data components are represented. In this paper, we provide a variety of architecture designs of PIDL computational graphs and how these structures are customized to traffic state estimation (TSE), a central problem in transportation engineering. When observation data, problem type, and goal vary, we demonstrate potential architectures of PIDL computational graphs and compare these variants using the same real-world dataset.

In contrast, transformers employ a "Scaled Dot-Product Attention" mechanism that is parallelizable. This unique attention mechanism allows for large-scale pretraining. Additionally, self-supervised pretraining paradigm such as masked language modeling onlarge unlabeled datasets enabled transformers to be trained without costly annotations. Transformer model, although originally designed for the NLP [3] domain, Transformers have witnessed adaptations in various domains such as computer vision [5, 6], remote sensing [7], time series [8], speech processing [9] and multimodal learning [10]. Consequently, modality specific surveys emerged, focusing on medical imaging [11-13] and biomedical language models [14] in the medical domain. This paper aims to provide comprehensive overview of Transformer models utilized across multiple modalities of data to address healthcare objectives. We discuss pre-training strategies to manage the lack of robust and annotated healthcare datasets. The rest of the paper is organized as follows: Section 2 discusses the strategy to search for relevant citations; Section 3 describes the architecture of the original transformer; Section 4 describes the two primary Transformer variants: the Bidirectional Encoder Representations from Transformers (BERT) and the Vision Transformer (ViT). Section 5 describes advancements in large language models (LLM), and section 6 through 12 provides a review of Transformers in healthcare.

Black-box zero-th order optimization is a central primitive for applications in fields as diverse as finance, physics, and engineering. In a common formulation of this problem, a designer sequentially attempts candidate solutions, receiving noisy feedback on the value of each attempt from the system. In this paper, we study scenarios in which feedback is also provided on the safety of the attempted solution, and the optimizer is constrained to limit the number of unsafe solutions that are tried throughout the optimization process. Focusing on methods based on Bayesian optimization (BO), prior art has introduced an optimization scheme -- referred to as SAFEOPT -- that is guaranteed not to select any unsafe solution with a controllable probability over feedback noise as long as strict assumptions on the safety constraint function are met. In this paper, a novel BO-based approach is introduced that satisfies safety requirements irrespective of properties of the constraint function. This strong theoretical guarantee is obtained at the cost of allowing for an arbitrary, controllable but non-zero, rate of violation of the safety constraint. The proposed method, referred to as SAFE-BOCP, builds on online conformal prediction (CP) and is specialized to the cases in which feedback on the safety constraint is either noiseless or noisy. Experimental results on synthetic and real-world data validate the advantages and flexibility of the proposed SAFE-BOCP.