The regulAS software package is a bioinformatics tool designed to support computational biology researchers in investigating regulatory mechanisms of splicing alterations through integrative analysis of large-scale RNA-Seq data from cancer and healthy human donors, characterized by TCGA and GTEx projects. This technical report provides a comprehensive overview of regulAS, focusing on its core functionality, basic modules, experiment configuration, further extensibility and customisation. The core functionality of regulAS enables the automation of computational experiments, efficient results storage and processing, and streamlined workflow management. Integrated basic modules extend regulAS with features such as RNA-Seq data retrieval from the public multi-omics UCSC Xena data repository, predictive modeling and feature ranking capabilities using the scikit-learn package, and flexible reporting generation for analysing gene expression profiles and relevant modulations of alternative splicing aberrations across tissues and cancer types. Experiment configuration is handled through YAML files with the Hydra and OmegaConf libraries, offering a user-friendly approach. Additionally, regulAS allows for the development and integration of custom modules to handle specialized tasks. In conclusion, regulAS provides an automated solution for alternative splicing and cancer biology studies, enhancing efficiency, reproducibility, and customization of experimental design, while the extensibility of the pipeline enables researchers to further tailor the software package to their specific needs. Source code is available under the MIT license at https://github.com/slipnitskaya/regulAS.

The Electron-Ion Collider (EIC), a state-of-the-art facility for studying the strong force, is expected to begin commissioning its first experiments in 2028. This is an opportune time for artificial intelligence (AI) to be included from the start at this facility and in all phases that lead up to the experiments. The second annual workshop organized by the AI4EIC working group, which recently took place, centered on exploring all current and prospective application areas of AI for the EIC. This workshop is not only beneficial for the EIC, but also provides valuable insights for the newly established ePIC collaboration at EIC. This paper summarizes the different activities and R&D projects covered across the sessions of the workshop and provides an overview of the goals, approaches and strategies regarding AI/ML in the EIC community, as well as cutting-edge techniques currently studied in other experiments.

Stellar ages are critical building blocks of evolutionary models, but challenging to measure for low mass main sequence stars. An unexplored solution in this regime is the application of probabilistic machine learning methods to gyrochronology, a stellar dating technique that is uniquely well suited for these stars. While accurate analytical gyrochronological models have proven challenging to develop, here we apply conditional normalizing flows to photometric data from open star clusters, and demonstrate that a data-driven approach can constrain gyrochronological ages with a precision comparable to other standard techniques. We evaluate the flow results in the context of a Bayesian framework, and show that our inferred ages recover literature values well. This work demonstrates the potential of a probabilistic data-driven solution to widen the applicability of gyrochronological stellar dating.

Robotic Exploration has evolved rapidly in the past two decades as new and more complex techniques have been created to explore unknown regions efficiently. Exciting advancements in exploration, autonomous navigation, and sensor technology have created opportunities for robots to be utilized in new environments and for new objectives ranging from mapping of abandon mines and deep oceans to the efficient creation of indoor models for navigation and search. In this paper we present and discuss a number of examples in research literature of these recent advancements, specifically focusing on robotic exploration algorithms for unmanned vehicles.

Zusammenfassung The more AI-assisted decisions affect people's lives, the more important the fairness of such decisions becomes. In this chapter, we provide an introduction to research on fairness in machine learning. We explain the main fairness definitions and strategies for achieving fairness using concrete examples and place fairness research in the European context. Our contribution is aimed at an interdisciplinary audience and therefore avoids mathematical formulation but emphasizes visualizations and examples. Machine Bias - There's software used across the country to predict future criminals.

One of the main risks accompanying the use of artificial intelligence in decision making is that the algorithms that are used are biased, and as a result can lead to unfair outcomes (Pessach and Shmueli, 2020). In particular, artificial intelligence is prone to (unintentionally) indirectly discriminate against certain groups. Machine learning systems (a type of AI) are fitted to data and find patterns in that data in order to predict a target variable. In doing so, they often use correlations present in the data (e.g. between ethnicity and zip codes, as with segregated neighbourhoods the zip code is a good predictor for ethnicity) to select on a problematic property (ethnicity) not directly but through the use of information on an unproblematic property (zip codes). This means that often these systems do not have direct access to variables that would be unfair to select on, but they still produce outputs that would lead to unfair treatment of certain groups. Put more precisely, indirect discrimination is the situation where a group A (e.g.

Biomedical datasets are often modeled as knowledge graphs (KGs) because they capture the multi-relational, heterogeneous, and dynamic natures of biomedical systems. KG completion (KGC), can, therefore, help researchers make predictions to inform tasks like drug repositioning. While previous approaches for KGC were either rule-based or embedding-based, hybrid approaches based on neurosymbolic artificial intelligence are becoming more popular. Many of these methods possess unique characteristics which make them even better suited toward biomedical challenges. Here, we survey such approaches with an emphasis on their utilities and prospective benefits for biomedicine.

For the most popular x-vector-based approaches to speaker anonymisation, the bulk of the anonymisation can stem from vocoding rather than from the core anonymisation function which is used to substitute an original speaker x-vector with that of a fictitious pseudo-speaker. This phenomenon can impede the design of better anonymisation systems since there is a lack of fine-grained control over the x-vector space. The work reported in this paper explores the origin of so-called vocoder drift and shows that it is due to the mismatch between the substituted x-vector and the original representations of the linguistic content, intonation and prosody. Also reported is an original approach to vocoder drift compensation. While anonymisation performance degrades as expected, compensation reduces vocoder drift substantially, offers improved control over the x-vector space and lays a foundation for the design of better anonymisation functions in the future.

The recent release of very large language models such as PaLM and GPT-4 has made an unprecedented impact in the popular media and public consciousness, giving rise to a mixture of excitement and fear as to their capabilities and potential uses, and shining a light on natural language processing research which had not previously received so much attention. The developments offer great promise for education technology, and in this paper we look specifically at the potential for incorporating large language models in AI-driven language teaching and assessment systems. We consider several research areas - content creation and calibration, assessment and feedback - and also discuss the risks and ethical considerations surrounding generative AI in education technology for language learners. Overall we find that larger language models offer improvements over previous models in text generation, opening up routes toward content generation which had not previously been plausible. For text generation they must be prompted carefully and their outputs may need to be reshaped before they are ready for use. For automated grading and grammatical error correction, tasks whose progress is checked on well-known benchmarks, early investigations indicate that large language models on their own do not improve on state-of-the-art results according to standard evaluation metrics. For grading it appears that linguistic features established in the literature should still be used for best performance, and for error correction it may be that the models can offer alternative feedback styles which are not measured sensitively with existing methods. In all cases, there is work to be done to experiment with the inclusion of large language models in education technology for language learners, in order to properly understand and report on their capacities and limitations, and to ensure that foreseeable risks such as misinformation and harmful bias are mitigated.

Traffic sign recognition is an essential component of perception in autonomous vehicles, which is currently performed almost exclusively with deep neural networks (DNNs). However, DNNs are known to be vulnerable to adversarial attacks. Several previous works have demonstrated the feasibility of adversarial attacks on traffic sign recognition models. Traffic signs are particularly promising for adversarial attack research due to the ease of performing real-world attacks using printed signs or stickers. In this work, we survey existing works performing either digital or real-world attacks on traffic sign detection and classification models. We provide an overview of the latest advancements and highlight the existing research areas that require further investigation.