Large language models (LLMs) have been applied to tasks in healthcare, ranging from medical exam questions to responding to patient questions. With increasing institutional partnerships between companies producing LLMs and healthcare systems, real world clinical application is coming closer to reality. As these models gain traction, it is essential for healthcare practitioners to understand what LLMs are, their development, their current and potential applications, and the associated pitfalls when utilized in medicine. This review and accompanying tutorial aim to give an overview of these topics to aid healthcare practitioners in understanding the rapidly changing landscape of LLMs as applied to medicine.

Uncovering novel drug candidates for treating complex diseases remain one of the most challenging tasks in early discovery research. To tackle this challenge, biopharma research established a standardized high content imaging protocol that tags different cellular compartments per image channel. In order to judge the experimental outcome, the scientist requires knowledge about the channel importance with respect to a certain phenotype for decoding the underlying biology. In contrast to traditional image analysis approaches, such experiments are nowadays preferably analyzed by deep learning based approaches which, however, lack crucial information about the channel importance. To overcome this limitation, we present a novel approach which utilizes multi-spectral information of high content images to interpret a certain aspect of cellular biology. To this end, we base our method on image blending concepts with alpha compositing for an arbitrary number of channels. More specifically, we introduce DCMIX, a lightweight, scaleable and end-to-end trainable mixing layer which enables interpretable predictions in high content imaging while retaining the benefits of deep learning based methods. We employ an extensive set of experiments on both MNIST and RXRX1 datasets, demonstrating that DCMIX learns the biologically relevant channel importance without scarifying prediction performance.

Since their inception in 2014, Generative Adversarial Networks (GANs) have rapidly emerged as powerful tools for generating realistic and diverse data across various domains, including computer vision and other applied areas. Consisting of a discriminative network and a generative network engaged in a Minimax game, GANs have revolutionized the field of generative modeling. In February 2018, GAN secured the leading spot on the ``Top Ten Global Breakthrough Technologies List'' issued by the Massachusetts Science and Technology Review. Over the years, numerous advancements have been proposed, leading to a rich array of GAN variants, such as conditional GAN, Wasserstein GAN, CycleGAN, and StyleGAN, among many others. This survey aims to provide a general overview of GANs, summarizing the latent architecture, validation metrics, and application areas of the most widely recognized variants. We also delve into recent theoretical developments, exploring the profound connection between the adversarial principle underlying GAN and Jensen-Shannon divergence, while discussing the optimality characteristics of the GAN framework. The efficiency of GAN variants and their model architectures will be evaluated along with training obstacles as well as training solutions. In addition, a detailed discussion will be provided, examining the integration of GANs with newly developed deep learning frameworks such as Transformers, Physics-Informed Neural Networks, Large Language models, and Diffusion models. Finally, we reveal several issues as well as future research outlines in this field.

Detecting visually similar images is a particularly useful attribute to look to when calculating product recommendations. Embedding similarity, which utilizes pre-trained computer vision models to extract high-level image features, has demonstrated remarkable efficacy in identifying images with similar compositions. However, there is a lack of methods for evaluating the embeddings generated by these models, as conventional loss and performance metrics do not adequately capture their performance in image similarity search tasks. In this paper, we evaluate the viability of the image embeddings from numerous pre-trained computer vision models using a novel approach named CorrEmbed. Our approach computes the correlation between distances in image embeddings and distances in human-generated tag vectors. We extensively evaluate numerous pre-trained Torchvision models using this metric, revealing an intuitive relationship of linear scaling between ImageNet1k accuracy scores and tag-correlation scores. Importantly, our method also identifies deviations from this pattern, providing insights into how different models capture high-level image features. By offering a robust performance evaluation of these pre-trained models, CorrEmbed serves as a valuable tool for researchers and practitioners seeking to develop effective, data-driven approaches to similar item recommendations in fashion retail.

Car-following models have made significant contributions to our understanding of longitudinal driving behavior. However, they often exhibit limited accuracy and flexibility, as they cannot fully capture the complexity inherent in car-following processes, or may falter in unseen scenarios due to their reliance on confined driving skills present in training data. It is worth noting that each car-following model possesses its own strengths and weaknesses depending on specific driving scenarios. Therefore, we propose EnsembleFollower, a hierarchical planning framework for achieving advanced human-like car-following. The EnsembleFollower framework involves a high-level Reinforcement Learning-based agent responsible for judiciously managing multiple low-level car-following models according to the current state, either by selecting an appropriate low-level model to perform an action or by allocating different weights across all low-level components. Moreover, we propose a jerk-constrained kinematic model for more convincing car-following simulations. We evaluate the proposed method based on real-world driving data from the HighD dataset. The experimental results illustrate that EnsembleFollower yields improved accuracy of human-like behavior and achieves effectiveness in combining hybrid models, demonstrating that our proposed framework can handle diverse car-following conditions by leveraging the strengths of various low-level models.

Traffic accident detection and anticipation is an obstinate road safety problem and painstaking efforts have been devoted. With the rapid growth of video data, Vision-based Traffic Accident Detection and Anticipation (named Vision-TAD and Vision-TAA) become the last one-mile problem for safe driving and surveillance safety. However, the long-tailed, unbalanced, highly dynamic, complex, and uncertain properties of traffic accidents form the Out-of-Distribution (OOD) feature for Vision-TAD and Vision-TAA. Current AI development may focus on these OOD but important problems. What has been done for Vision-TAD and Vision-TAA? What direction we should focus on in the future for this problem? A comprehensive survey is important. We present the first survey on Vision-TAD in the deep learning era and the first-ever survey for Vision-TAA. The pros and cons of each research prototype are discussed in detail during the investigation. In addition, we also provide a critical review of 31 publicly available benchmarks and related evaluation metrics. Through this survey, we want to spawn new insights and open possible trends for Vision-TAD and Vision-TAA tasks.

Pre-trained Language Models (PLMs) which are trained on large text corpus via self-supervised learning method, have yielded promising performance on various tasks in Natural Language Processing (NLP). However, though PLMs with huge parameters can effectively possess rich knowledge learned from massive training text and benefit downstream tasks at the fine-tuning stage, they still have some limitations such as poor reasoning ability due to the lack of external knowledge. Research has been dedicated to incorporating knowledge into PLMs to tackle these issues. In this paper, we present a comprehensive review of Knowledge Enhanced Pre-trained Language Models (KE-PLMs) to provide a clear insight into this thriving field. We introduce appropriate taxonomies respectively for Natural Language Understanding (NLU) and Natural Language Generation (NLG) to highlight these two main tasks of NLP. For NLU, we divide the types of knowledge into four categories: linguistic knowledge, text knowledge, knowledge graph (KG), and rule knowledge. The KE-PLMs for NLG are categorized into KG-based and retrieval-based methods. Finally, we point out some promising future directions of KE-PLMs.

Digital Twins (DT) facilitate monitoring and reasoning processes in cyber-physical systems. They have progressively gained popularity over the past years because of intense research activity and industrial advancements. Cognitive Twins is a novel concept, recently coined to refer to the involvement of Semantic Web technology in DTs. Recent studies address the relevance of ontologies and knowledge graphs in the context of DTs, in terms of knowledge representation, interoperability and automatic reasoning. However, there is no comprehensive analysis of how semantic technologies, and specifically ontologies, are utilized within DTs. This Systematic Literature Review (SLR) is based on the analysis of 82 research articles, that either propose or benefit from ontologies with respect to DT. The paper uses different analysis perspectives, including a structural analysis based on a reference DT architecture, and an application-specific analysis to specifically address the different domains, such as Manufacturing and Infrastructure. The review also identifies open issues and possible research directions on the usage of ontologies and knowledge graphs in DTs.

Autonomous robots that can perform common tasks like driving, surveillance, and chores have the biggest potential for impact due to frequency of usage, and the biggest potential for risk due to direct interaction with humans. These tasks take place in openended environments where humans socially interact and pursue their goals in complex and diverse ways. To operate in such environments, such systems must predict this behaviour, especially when the behavior is unexpected and potentially dangerous. Therefore, we summarize trends in various types of tasks, modeling methods, datasets, and social interaction modules aimed at predicting the future location of dynamic, socially interactive agents. Furthermore, we describe long-tailed learning techniques from classification and regression problems that can be applied to prediction problems. To our knowledge this is the first work that reviews social interaction modeling within prediction, and long-tailed learning techniques within regression and prediction.

As AI systems have obtained significant performance to be deployed widely in our daily live and human society, people both enjoy the benefits brought by these technologies and suffer many social issues induced by these systems. To make AI systems good enough and trustworthy, plenty of researches have been done to build guidelines for trustworthy AI systems. Machine learning is one of the most important parts for AI systems and representation learning is the fundamental technology in machine learning. How to make the representation learning trustworthy in real-world application, e.g., cross domain scenarios, is very valuable and necessary for both machine learning and AI system fields. Inspired by the concepts in trustworthy AI, we proposed the first trustworthy representation learning across domains framework which includes four concepts, i.e, robustness, privacy, fairness, and explainability, to give a comprehensive literature review on this research direction. Specifically, we first introduce the details of the proposed trustworthy framework for representation learning across domains. Second, we provide basic notions and comprehensively summarize existing methods for the trustworthy framework from four concepts. Finally, we conclude this survey with insights and discussions on future research directions.