An automated knowledge modeling algorithm for Cancer Clinical Practice Guidelines (CPGs) extracts the knowledge contained in the CPG documents and transforms it into a programmatically interactable, easy-to-update structured model with minimal human intervention. The existing automated algorithms have minimal scope and cannot handle the varying complexity of the knowledge content in the CPGs for different cancer types. This work proposes an improved automated knowledge modeling algorithm to create knowledge models from the National Comprehensive Cancer Network (NCCN) CPGs in Oncology for different cancer types. The proposed algorithm has been evaluated with NCCN CPGs for four different cancer types. We also proposed an algorithm to compare the knowledge models for different versions of a guideline to discover the specific changes introduced in the treatment protocol of a new version. We created a question-answering (Q&A) framework with the guideline knowledge models as the augmented knowledge base to study our ability to query the knowledge models. We compiled a set of 32 question-answer pairs derived from two reliable data sources for the treatment of Non-Small Cell Lung Cancer (NSCLC) to evaluate the Q&A framework. The framework was evaluated against the question-answer pairs from one data source, and it can generate the answers with 54.5% accuracy from the treatment algorithm and 81.8% accuracy from the discussion part of the NCCN NSCLC guideline knowledge model.

This paper introduces DCC Sidekick, a web-based conversational AI tool that enhances an existing LLM-powered C/C++ compiler by generating educational programming error explanations. The tool seamlessly combines code display, compile- and run-time error messages, and stack frame read-outs alongside an AI interface, leveraging compiler error context for improved explanations. We analyse usage data from a large Australian CS1 course, where 959 students engaged in 11,222 DCC Sidekick sessions, resulting in 17,982 error explanations over seven weeks. Notably, over 50% of interactions occurred outside business hours, underscoring the tool's value as an always-available resource. Our findings reveal strong adoption of AI-assisted debugging tools, demonstrating their scalability in supporting extensive CS1 courses. We provide implementation insights and recommendations for educators seeking to incorporate AI tools with appropriate pedagogical safeguards.

This paper illustrates the architecture and training of Unipa-GPT, a chatbot relying on a Large Language Model, developed for assisting students in choosing a bachelor/master degree course at the University of Palermo. Unipa-GPT relies on gpt-3.5-turbo, it was presented in the context of the European Researchers' Night (SHARPER night). In our experiments we adopted both the Retrieval Augmented Generation (RAG) approach and fine-tuning to develop the system. The whole architecture of Unipa-GPT is presented, both the RAG and the fine-tuned systems are compared, and a brief discussion on their performance is reported. Further comparison with other Large Language Models and the experimental results during the SHARPER night are illustrated.

This paper presents Words2Contact, a language-guided multi-contact placement pipeline leveraging large language models and vision language models. Our method is a key component for language-assisted teleoperation and human-robot cooperation, where human operators can instruct the robots where to place their support contacts before whole-body reaching or manipulation using natural language. Words2Contact transforms the verbal instructions of a human operator into contact placement predictions; it also deals with iterative corrections, until the human is satisfied with the contact location identified in the robot's field of view. We benchmark state-of-the-art LLMs and VLMs for size and performance in contact prediction. We demonstrate the effectiveness of the iterative correction process, showing that users, even naive, quickly learn how to instruct the system to obtain accurate locations. Finally, we validate Words2Contact in real-world experiments with the Talos humanoid robot, instructed by human operators to place support contacts on different locations and surfaces to avoid falling when reaching for distant objects.

Many application areas rely on models that can be readily simulated but lack a closed-form likelihood, or an accurate approximation under arbitrary parameter values. Existing parameter estimation approaches in this setting are generally approximate. Recent work on using neural network models to reconstruct the mapping from the data space to the parameters from a set of synthetic parameter-data pairs suffers from the curse of dimensionality, resulting in inaccurate estimation as the data size grows. We propose a dimension-reduced approach to likelihood-free estimation which combines the ideas of reconstruction map estimation with dimension-reduction approaches based on subject-specific knowledge. We examine the properties of reconstruction map estimation with and without dimension reduction and explore the trade-off between approximation error due to information loss from reducing the data dimension and approximation error. Numerical examples show that the proposed approach compares favorably with reconstruction map estimation, approximate Bayesian computation, and synthetic likelihood estimation.

Deep convolutional neural networks have made significant breakthroughs in medical image classification, under the assumption that training samples from all classes are simultaneously available. However, in real-world medical scenarios, there's a common need to continuously learn about new diseases, leading to the emerging field of class incremental learning (CIL) in the medical domain. Typically, CIL suffers from catastrophic forgetting when trained on new classes. This phenomenon is mainly caused by the imbalance between old and new classes, and it becomes even more challenging with imbalanced medical datasets. In this work, we introduce two simple yet effective plug-in methods to mitigate the adverse effects of the imbalance. First, we propose a CIL-balanced classification loss to mitigate the classifier bias toward majority classes via logit adjustment. Second, we propose a distribution margin loss that not only alleviates the inter-class overlap in embedding space but also enforces the intra-class compactness. We evaluate the effectiveness of our method with extensive experiments on three benchmark datasets (CCH5000, HAM10000, and EyePACS). The results demonstrate that our approach outperforms state-of-the-art methods.

This tutorial provides a comprehensive survey of methods for fine-tuning diffusion models to optimize downstream reward functions. While diffusion models are widely known to provide excellent generative modeling capability, practical applications in domains such as biology require generating samples that maximize some desired metric (e.g., translation efficiency in RNA, docking score in molecules, stability in protein). In these cases, the diffusion model can be optimized not only to generate realistic samples but also to explicitly maximize the measure of interest. Such methods are based on concepts from reinforcement learning (RL). We explain the application of various RL algorithms, including PPO, differentiable optimization, reward-weighted MLE, value-weighted sampling, and path consistency learning, tailored specifically for fine-tuning diffusion models. We aim to explore fundamental aspects such as the strengths and limitations of different RL-based fine-tuning algorithms across various scenarios, the benefits of RL-based fine-tuning compared to non-RL-based approaches, and the formal objectives of RL-based fine-tuning (target distributions). Additionally, we aim to examine their connections with related topics such as classifier guidance, Gflownets, flow-based diffusion models, path integral control theory, and sampling from unnormalized distributions such as MCMC. The code of this tutorial is available at https://github.com/masa-ue/RLfinetuning_Diffusion_Bioseq

Parameter-efficient tunings (PETs) have demonstrated impressive performance and promising perspectives in training large models, while they are still confronted with a common problem: the trade-off between learning new content and protecting old knowledge, leading to zero-shot generalization collapse, and cross-modal hallucination. In this paper, we reformulate Adapter, LoRA, Prefix-tuning, and Prompt-tuning from the perspective of gradient projection, and firstly propose a unified framework called Parameter Efficient Gradient Projection (PEGP). We introduce orthogonal gradient projection into different PET paradigms and theoretically demonstrate that the orthogonal condition for the gradient can effectively resist forgetting even for large-scale models. It therefore modifies the gradient towards the direction that has less impact on the old feature space, with less extra memory space and training time. We extensively evaluate our method with different backbones, including ViT and CLIP, on diverse datasets, and experiments comprehensively demonstrate its efficiency in reducing forgetting in class, online class, domain, task, and multi-modality continual settings. The project page is available at https://dmcv-ecnu-pegp.github.io/.

Comprehensive sex education (SE) is crucial in promoting sexual health and responsible behavior among students, particularly in elementary schools. Despite its significance, teaching SE can be challenging due to students' attitudes, shyness, and emotional barriers. Socially assistive robots (SARs) sometimes are perceived as more trustworthy than humans, based on research showing that they are not anticipated as judgmental. Inspired by those evidences, this study aims to assess the success of a SAR as a facilitator for SE lessons for elementary school students. This study conducted two experiments to assess the effectiveness of a SAR in facilitating SE education for elementary school students. We conducted two experiments, a) a group activity in the school classroom where the Nao robot gave a SE lecture, and we evaluated how much information the students acquired from the lecture, and b) an individual activity where the students interacted 1:1 with the robot, and we evaluated their attitudes towards the subject of SE, and if they felt comfortable to ask SE related questions to the robot. Data collected from pre- and post-questionnaires, as well as video annotations, revealed that the SAR significantly improved students' attitudes toward SE. Furthermore, students were more open to asking SE-related questions to the robot than their human teacher. The study emphasized specific SAR characteristics, such as embodiment and non-judgmental behavior, as key factors contributing to their effectiveness in supporting SE education, paving the way for innovative and effective approaches to sexual education in schools.

Combining offline and online reinforcement learning (RL) techniques is indeed crucial for achieving efficient and safe learning where data acquisition is expensive. Existing methods replay offline data directly in the online phase, resulting in a significant challenge of data distribution shift and subsequently causing inefficiency in online fine-tuning. To address this issue, we introduce an innovative approach, \textbf{E}nergy-guided \textbf{DI}ffusion \textbf{S}ampling (EDIS), which utilizes a diffusion model to extract prior knowledge from the offline dataset and employs energy functions to distill this knowledge for enhanced data generation in the online phase. The theoretical analysis demonstrates that EDIS exhibits reduced suboptimality compared to solely utilizing online data or directly reusing offline data. EDIS is a plug-in approach and can be combined with existing methods in offline-to-online RL setting. By implementing EDIS to off-the-shelf methods Cal-QL and IQL, we observe a notable 20% average improvement in empirical performance on MuJoCo, AntMaze, and Adroit environments. Code is available at \url{https://github.com/liuxhym/EDIS}.