We describe a computational model of the development and regeneration of specific eye-brain circuits. The model comprises a self-organizing map-forming network which uses local Hebb rules, constrained by (genetically determined) molecular markers. Various simulations of the development and regeneration of eye-brain maps in fish and frogs are described, in particular successful simulations of experiments by Schmidt-Cicerone-Easter; Meyer; and Y oon. 1 INTRODUCTION In a previous paper published in last years proceedings (Cowan & Friedman 1990) we outlined a new computational model for the development and regeneration of eye-brain maps. We indicated that such a model can simulate the results of a number of the more complicated surgical manipulations carried out on the visual pathways of goldfish and frogs. In this paper we describe in more detail some of these experiments, and our simulations of them.

The main point of this paper is that stochastic neural networks have a mathematical structure that corresponds quite closely with that of quantum field theory. Neural network Liouvillians and Lagrangians can be derived, just as can spin Hamiltonians and Lagrangians in QFf. It remains to show the efficacy of such a description.

Inspired by a visual motion detection model for the ra.bbit retina and by a computational architecture used for early audition in the barn owl, we have designed a chip that employs a correlation model to report the one-dimensional field motion of a scene in real time. Using subthreshold analog VLSI techniques, we have fabricated and successfully tested a 8000 transistor chip using a standard MOSIS process.

This paper is a summary of SPRINT project aims and results. The project focus on the use of neuro-computing techniques to tackle various problems that remain unsolved in speech recognition. First results concern the use of feedforward nets for phonetic units classification, isolated word recognition, and speaker adaptation.

Spoken input to computers, however, has yet to pass the threshold of practicality. Despite some recent successful demonstrations, current speech recognition systems typically fall far short of human capabilities of continuous speech recognition with essentially unrestricted vocabulary and speakers, under adverse acoustic environments.

Simple classical spin models well-known to physicists as the ANNNI and Heisenberg XY Models. in which long-range interactions occur in a pattern given by the Mexican Hat operator.

Inspired by the information theoretic idea of minimum description length, we add a term to the back propagation cost function that penalizes network complexity. We give the details of the procedure, called weight-elimination, describe its dynamics, and clarify the meaning of the parameters involved. From a Bayesian perspective, the complexity term can be usefully interpreted as an assumption about prior distribution of the weights. We use this procedure to predict the sunspot time series and the notoriously noisy series of currency exchange rates. 1 INTRODUCTION Learning procedures for connectionist networks are essentially statistical devices for performing inductive inference. There is a tradeoff between two goals: on the one hand, we want such devices to be as general as possible so that they are able to learn a broad range of problems.

We develop a sequential adaptation algorithm for radial basis function (RBF) neural networks of Gaussian nodes, based on the method of successive F-Projections.

A system for color correction has been designed, built, and tested successfully; the essential components are three custom chips built using subthreshold analog CMOS VLSI. The system, based on Land's Retinex theory of color constancy, produces colors similar in many respects to those produced by the visual system. Resistive grids implemented in analog VLSI perform the smoothing operation central to the algorithm at video rates. With the electronic system, the strengths and weaknesses of the algorithm are explored.

Since Kendrew & Perutz solved the first protein structures, myoglobin and hemoglobin, and explained from the discovered structures how these proteins perform their function, it has been widely recognized that protein function is intimately linked with protein structure[l]. Within the last two decades X-ray crystallographers have solved the 3-dimensional (3D) structures of a steadily increasing number of proteins in the crystalline state, and recently 2D-NMR spectroscopy has emerged as an alternative method for small proteins in solution. Today approximately three hundred 3D structures have been solved by these methods, although only about half of them can be considered as truly different, and only around a hundred of them are solved at high resolution (that is, less than 2A). The number of protein sequences known today is well over 20,000, and this number seems to be growing at least one order of magnitude faster than the number of known 3D protein structures. Obviously, it is of great importance to develop tools that can predict structural aspects of proteins on the basis of knowledge acquired from known 3D structures.