We use two co-evolving neural networks to determine new classes of protein secondary structure which are significantly more predictable from local amino sequence than the conventional secondary structure classification. Accurate prediction of the conventional secondary structure classes: alpha helix, beta strand, and coil, from primary sequence has long been an important problem in computational molecular biology. Neural networks have been a popular method to attempt to predict these conventional secondary structure classes. Accuracy has been disappointingly low. The algorithm presented here uses neural networks to similtaneously examine both sequence and structure data, and to evolve new classes of secondary structure that can be predicted from sequence with significantly higher accuracy than the conventional classes. These new classes have both similarities to, and differences with the conventional alpha helix, beta strand and coil.

Bumptrees are geometric data structures introduced by Omohundro (1991) to provide efficient access to a collection of functions on a Euclidean space of interest. We describe a modified bumptree structure that has been employed as a neural network classifier, and compare its performance on several classification tasks against that of radial basis function networks and the standard mutIi-Iayer perceptron. 1 INTRODUCTION A number of neural network studies have demonstrated the utility of the multi-layer perceptron (MLP) and shown it to be a highly effective paradigm. Studies have also shown, however, that the MLP is not without its problems, in particular it requires an extensive training time, is susceptible to local minima problems and its perfonnance is dependent upon its internal network architecture. In an attempt to improve upon the generalisation performance and computational efficiency a number of studies have been undertaken principally concerned with investigating the parametrisation of the MLP. It is well known, for example, that the generalisation performance of the MLP is affected by the number of hidden units in the network, which have to be determined empirically since theory provides no guidance.

We represent objects with n-dimensional pattern vectors and consider piecewise-linear classifiers consisting of a collection of (labeled) codebook vectors in the space of the input patterns (See Figure 1). The classification boundaries are gi ven by the voronoi tessellation of the codebook vectors. Patterns are said to belong to the class (given by the label) of the codebook vector to which they are closest.

In this paper, we show a reciprocal implementation of the "softmax" nonlinearity that is usually used to enforce local competition between neurons [Peterson, 1989]. We show that the circuit is passive and incrementally passive, and we explicitly compute its content and co-content functions. This circuit adds a new element to the library of the analog circuit designer that can be combined with reciprocal constraint boxes [Harris, 1988] and nonlinear resistive fuses [Harris, 1989] to form fast, analog VLSI optimization networks.

The distance measure and learning problem are formally described as nested objective functions. We derive an efficient algorithm by using optimization techniques that allow us to divide up the objective function into parts which may be minimized in distinct phases. The algorithm has accurately recreated 10 prototypes from a randomly generated sample database of 100 images consisting of 20 points each in 120 experiments. Finally, by incorporating permutation invariance in our distance measure, we have a technique that we may be able to apply to the clustering of graphs. Our goal is to develop measures which will enable the learning of objects with shape or structure. Acknowledgements This work has been supported by AFOSR grant F49620-92-J-0465 and ONR/DARPA grant N00014-92-J-4048.

Although there are many ways to measure efficiency, we shall be concerned with node complexity, which as its name implies, is a calculation of the required number of nodes. Node complexity is a useful measure of efficiency since the amount of resources required to implement or even simulate a recurrent neural network is typically related to the number of nodes. Node complexity can also be related to the efficiency of learning algorithms for these networks and perhaps to their generalization ability as well. We shall focus on the node complexity of recurrent neural network implementations of finite state machines (FSMs) when the nodes of the network are restricted to threshold logic units.

Scope This workshop reviewed and classified the various models which have emerged from the general concept of selective attention and context dependency, and sought to identify their commonalities. It was concluded that the motivation and mechanism of these functional models are "efficiency" and ''factoring'', respectively. The workshop focused on computational models of selective attention and context dependency within the realm of neural networks. We treated only ''functional'' models; computational models of biological neural systems, and symbolic or rule-based systems were omitted from the discussion. Presentations Thomas H. Hildebrandt presented the results of his recent survey of the literature on functional models of selective attention and context dependency.

What is the'correct' theoretical description of neuronal activity? The analysis of the dynamics of a globally connected network of spiking neurons (the Spike Response Model) shows that a description by mean firing rates is possible only if active neurons fire incoherently. If firing occurs coherently or with spatiotemporal correlations, the spike structure of the neural code becomes relevant. Alternatively, neurons can be gathered into local or distributed ensembles or'assemblies'. A description based on the mean ensemble activity is, in principle, possible but the interaction between different assemblies becomes highly nonlinear. A description with spikes should therefore be preferred.

E represents the expectation on random number K of hidden units (1:::; I\:::; n). This relationship makes it possible to characterize explicitly how a regularization term affects bias/variance of networks.

We describe the use of smoothing spline analysis of variance (SS ANOVA) in the penalized log likelihood context, for learning (estimating) the probability p of a '1' outcome, given a training set with attribute vectors and outcomes.