Experiments were performed to reveal some of the computational properties of the human motor memory system. We show that as humans practice reaching movements while interacting with a novel mechanical environment, they learn an internal model of the inverse dynamics of that environment. The representation of the internal model in memory is such that there is interference when there is an attempt to learn a new inverse dynamics map immediately after an anticorrelated mapping was learned. We suggest that this interference is an indication that the same computational elements used to encode the first inverse dynamics map are being used to learn the second mapping. We predict that this leads to a forgetting of the initially learned skill. 1 Introduction In tasks where we use our hands to interact with a tool, our motor system develops a model of the dynamics of that tool and uses this model to control the coupled dynamics of our arm and the tool (Shadmehr and Mussa-Ivaldi 1994). In physical systems theory, the tool is a mechanical analogue of an admittance, mapping a force as input onto a change in state as output (Hogan 1985).

We describe an analog VLSI implementation of the ARTI algorithm (Carpenter, 1987).

Almost all models of orientation and direction selectivity in visual cortex are based on feedforward connection schemes, where geniculate input provides all excitation to both pyramidal and inhibitory neurons. The latter neurons then suppress the response of the former for non-optimal stimuli. However, anatomical studies show that up to 90 % of the excitatory synaptic input onto any cortical cell is provided by other cortical cells. The massive excitatory feedback nature of cortical circuits is embedded in the canonical microcircuit of Douglas &. Martin (1991). We here investigate analytically and through biologically realistic simulations the functioning of a detailed model of this circuitry, operating in a hysteretic mode. In the model, weak geniculate input is dramatically amplified by intracortical excitation, while inhibition has a dual role: (i) to prevent the early geniculate-induced excitation in the null direction and (ii) to restrain excitation and ensure that the neurons fire only when the stimulus is in their receptive-field.

This paper presents results from the first use of neural networks for the real-time feedback control of high temperature plasmas in a tokamak fusion experiment. The tokamak is currently the principal experimental device for research into the magnetic confinement approach to controlled fusion. In the tokamak, hydrogen plasmas, at temperatures of up to 100 Million K, are confined by strong magnetic fields. Accurate control of the position and shape of the plasma boundary requires real-time feedback control of the magnetic field structure on a timescale of a few tens of microseconds. Software simulations have demonstrated that a neural network approach can give significantly better performance than the linear technique currently used on most tokamak experiments. The practical application of the neural network approach requires high-speed hardware, for which a fully parallel implementation of the multilayer perceptron, using a hybrid of digital and analogue technology, has been developed.

Semi-Markov Decision Problems are continuous time generalizations of discrete time Markov Decision Problems. A number of reinforcement learning algorithms have been developed recently for the solution of Markov Decision Problems, based on the ideas of asynchronous dynamic programming and stochastic approximation. Among these are TD(,x), Q-Iearning, and Real-time Dynamic Programming. After reviewing semi-Markov Decision Problems and Bellman's optimality equation in that context, we propose algorithms similar to those named above, adapted to the solution of semi-Markov Decision Problems. We demonstrate these algorithms by applying them to the problem of determining the optimal control for a simple queueing system. We conclude with a discussion of circumstances under which these algorithms may be usefully applied.

More than ten of the most prominent models for the structure and for the activity dependent formation of orientation and ocular dominance columns in the striate cort( x have been evaluated. We implemented those models on parallel machines, we extensively explored parameter space, and we quantitatively compared model predictions with experimental data which were recorded optically from macaque striate cortex. In our contribution we present a summary of our results to date. Briefly, we find that (i) despite apparent differences, many models are based on similar principles and, consequently, make similar predictions, (ii) certain "pattern models" as well as the developmental "correlation-based learning" models disagree with the experimental data, and (iii) of the models we have investigated, "competitive Hebbian" models and the recent model of Swindale provide the best match with experimental data. 1 Models and Data The models for the formation and structure of orientation and ocular dominance columns which we have investigated are summarized in table 1. Models fall into two categories: "Pattern models" whose aim is to achieve a concise description of the observed patterns and "developmental models" which are focussed on the pro- 94

The TNM staging system has been used since the early 1960's to predict breast cancer patient outcome. In an attempt to increase prognostic accuracy, many putative prognostic factors have been identified. Because the TNM stage model can not accommodate these new factors, the proliferation of factors in breast cancer has lead to clinical confusion. What is required is a new computerized prognostic system that can test putative prognostic factors and integrate the predictive factors with the TNM variables in order to increase prognostic accuracy. Using the area under the curve of the receiver operating characteristic, we compare the accuracy of the following predictive models in terms of five year breast cancer-specific survival: pTNM staging system, principal component analysis, classification and regression trees, logistic regression, cascade correlation neural network, conjugate gradient descent neural, probabilistic neural network, and backpropagation neural network. Several statistical models are significantly more ac- 1064 Harry B. Burke, David B. Rosen, Philip H. Goodman

The localization and orientation to various novel or interesting events in the environment is a critical sensorimotor ability in all animals, predator or prey. In mammals, the superior colliculus (SC) plays a major role in this behavior, the deeper layers exhibiting topographically mapped responses to visual, auditory, and somatosensory stimuli. Sensory information arriving from different modalities should then be represented in the same coordinate frame. Auditory cues, in particular, are thought to be computed in head-based coordinates which must then be transformed to retinal coordinates. In this paper, an analog VLSI implementation for auditory localization in the azimuthal plane is described which extends the architecture proposed for the barn owl to a primate eye movement system where further transformation is required. This transformation is intended to model the projection in primates from auditory cortical areas to the deeper layers of the primate superior colliculus. This system is interfaced with an analog VLSI-based saccadic eye movement system also being constructed in our laboratory.

This paper presents results from the first use of neural networks for the real-time feedback control of high temperature plasmas in a tokamak fusion experiment. The tokamak is currently the principal experimental device for research into the magnetic confinement approach to controlled fusion. In the tokamak, hydrogen plasmas, at temperatures of up to 100 Million K, are confined by strong magnetic fields. Accurate control of the position and shape of the plasma boundary requires real-time feedback control of the magnetic field structure on a timescale of a few tens of microseconds. Software simulations have demonstrated that a neural network approach can give significantly better performance than the linear technique currently used on most tokamak experiments. The practical application of the neural network approach requires high-speed hardware, for which a fully parallel implementation of the multilayer perceptron, using a hybrid of digital and analogue technology, has been developed.

Songbirds learn to imitate a tutor song through auditory and motor learning. We have developed a theoretical framework for song learning that accounts for response properties of neurons that have been observed in many of the nuclei that are involved in song learning. Specifically, we suggest that the anteriorforebrain pathway, which is not needed for song production in the adult but is essential for song acquisition, provides synaptic perturbations and adaptive evaluations for syllable vocalization learning. A computer model based on reinforcement learning was constructed that could replicate a real zebra finch song with 90% accuracy based on a spectrographic measure. The second generation of the birdsong model replicated the tutor song with 96% accuracy.