In these types of synapses, the short-term dynamics of the synaptic efficacies are governed by the relative timing of the pre-and post-synaptic spikes, while on long time scales the efficacies tend asymptotically to either a potentiated state or to a depressed one. We fabricated a prototype VLSI chip containing a network of integrate and fire neurons interconnected via bistable STDP synapses. Test results from this chip demonstrate the synapse's STDP learning properties, and its long-term bistable characteristics.

An essential step in understanding the function of sensory nervous systems is to characterize as accurately as possible the stimulus-response function (SRF) of the neurons that relay and process sensory information. One increasingly common experimental approach is to present a rapidly varying complex stimulus to the animal while recording the responses of one or more neurons, and then to directly estimate a functional transformation of the input that accounts for the neuronal firing. The estimation techniques usually employed, such as Wiener filtering or other correlation-based estimation of the Wiener or Volterra kernels, are equivalent to maximum likelihood estimation in a Gaussian-output-noise regression model. We explore the use of Bayesian evidence-optimization techniques to condition these estimates. We show that by learning hyperparameters that control the smoothness and sparsity of the transfer function it is possible to improve dramatically the quality of SRF estimates, as measured by their success in predicting responses to novel input.

Given a set of hidden variables with an a-priori Markov structure, we derive an online algorithm which approximately updates the posterior as pairwise measurements between the hidden variables become available. The update is performed using Assumed Density Filtering: to incorporate each pairwise measurement, we compute the optimal Markov structure which represents the true posterior and use it as a prior for incorporating the next measurement. We demonstrate the resulting algorithm by calculating globally consistent trajectories of a robot as it navigates along a 2D trajectory. To update a trajectory of length t, the update takes O(t). When all conditional distributions are linear-Gaussian, the algorithm can be thought of as a Kalman Filter which simplifies the state covariance matrix after incorporating each measurement.

This paper presents two new formulations of multiple-instance learning as a maximum margin problem. The proposed extensions of the Support Vector Machine (SVM) learning approach lead to mixed integer quadratic programs that can be solved heuristically. Our generalization of SVMs makes a state-of-the-art classification technique, including nonlinear classification via kernels, available to an area that up to now has been largely dominated by special purpose methods. We present experimental results on a pharmaceutical data set and on applications in automated image indexing and document categorization.

Recently proposed algorithms for nonlinear dimensionality reduction fall broadly into two categories which have different advantages and disadvantages: global (Isomap [1]), and local (Locally Linear Embedding [2], Laplacian Eigenmaps [3]). We present two variants of Isomap which combine the advantages of the global approach with what have previously been exclusive advantages of local methods: computational sparsity and the ability to invert conformal maps.

The goal of low-level vision is to estimate an underlying scene, given an observed image. Real-world scenes (eg, albedos or shapes) can be very complex, conventionally requiring high dimensional representations which are hard to estimate and store. We propose a low-dimensional representation, called a scene recipe, that relies on the image itself to describe the complex scene configurations. Shape recipes are an example: these are the regression coefficients that predict the bandpassed shape from image data. We describe the benefits of this representation, and show two uses illustrating their properties: (1) we improve stereo shape estimates by learning shape recipes at low resolution and applying them at full resolution; (2) Shape recipes implicitly contain information about lighting and materials and we use them for material segmentation.

We derive multiplicative updates for solving the nonnegative quadratic programming problem in support vector machines (SVMs). The updates have a simple closed form, and we prove that they converge monotonically to the solution of the maximum margin hyperplane. The updates optimize the traditionally proposed objective function for SVMs. They do not involve any heuristics such as choosing a learning rate or deciding which variables to update at each iteration. They can be used to adjust all the quadratic programming variables in parallel with a guarantee of improvement at each iteration. We analyze the asymptotic convergence of the updates and show that the coefficients of nonsupport vectors decay geometrically to zero at a rate that depends on their margins.

We present the bump mixture model, a statistical model for analog data where the probabilistic semantics, inference, and learning rules derive from low-level transistor behavior. The bump mixture model relies on translinear circuits to perform probabilistic inference, and floating-gate devices to perform adaptation. This system is low power, asynchronous, and fully parallel, and supports various on-chip learning algorithms. In addition, the mixture model can perform several tasks such as probability estimation, vector quantization, classification, and clustering. We tested a fabricated system on clustering, quantization, and classification of handwritten digits and show performance comparable to the EM algorithm on mixtures of Gaussians.

Recently, interest is growing to develop an effective communication interface connecting the human brain to a computer, the'Brain-Computer Interface' (BCI). One motivation of BCI research is to provide a new communication channel substituting normal motor output in patients with severe neuromuscular disabilities. In the last decade, various neurophysiological cortical processes, such as slow potential shifts, movement related potentials (MRPs) or event-related desynchronization (ERD) of spontaneous EEG rhythms, were shown to be suitable for BCI, and, consequently, different independent approaches of extracting BCI-relevant EEGfeatures for single-trial analysis are under investigation. Here, we present and systematically compare several concepts for combining such EEGfeatures to improve the single-trial classification. Feature combinations are evaluated on movement imagination experiments with 3 subjects where EEGfeatures are based on either MRPs or ERD, or both. Those combination methods that incorporate the assumption that the single EEGfeatures are physiologically mutually independent outperform the plain method of'adding' evidence where the single-feature vectors are simply concatenated. These results strengthen the hypothesis that MRP and ERD reflect at least partially independent aspects of cortical processes and open a new perspective to boost BCI effectiveness.

We report a system that classifies and can learn to classify patterns of visual motion online. The complete system is described by the dynamics of its physical network architectures. The combination of the following properties makes the system novel: Firstly, the front-end of the system consists of an aVLSI optical flow chip that collectively computes 2-D global visual motion in real-time [1]. Secondly, the complexity of the classification task is significantly reduced by mapping the continuous motion trajectories to sequences of'motion events'. And thirdly, all the network structures are simple and with the exception of the optical flow chip based on a Winner-Take-All (WTA) architecture. We demonstrate the application of the proposed generic system for a contactless man-machine interface that allows to write letters by visual motion. Regarding the low complexity of the system, its robustness and the already existing front-end, a complete aVLSI system-on-chip implementation is realistic, allowing various applications in mobile electronic devices.