Existing algorithms for discrete partially observable Markov decision processes can at best solve problems of a few thousand states due to two important sources of intractability: the curse of dimensionality and the policy space complexity. This paper describes a new algorithm (VDCBPI) that mitigates both sources of intractability by combining the V alue Directed Compression (VDC) technique [13] with Bounded Policy Iteration (BPI) [14]. The scalability of VDCBPI is demonstrated on synthetic network management problems with up to 33 million states. 1 Introduction Partially observable Markov decision processes (POMDPs) provide a natural and expressive framework for decision making, but their use in practice has been limited by the lack of scalable solution algorithms. T wo important sources of intractability plague discrete model-based POMDPs: high dimensionality of belief space, and the complexity of policy or value function (VF) space. Classic solution algorithms [4, 10, 7], for example, compute value functions represented by exponentially many value vectors, each of exponential size. As a result, they can only solve POMDPs with on the order of 100 states.

Alternative splicing (AS) is an important and frequent step in mammalian gene expression that allows a single gene to specify multiple products, and is crucial for the regulation of fundamental biological processes. The extent of AS regulation, and the mechanisms involved, are not well understood. We have developed a custom DNA microarray platform for surveying AS levels on a large scale. We present here a generative model for the AS Array Platform (GenASAP) and demonstrate its utility for quantifying AS levels in different mouse tissues. Learning is performed using a variational expectation maximization algorithm, and the parameters are shown to correctly capture expected AS trends. A comparison of the results obtained with a well-established but low throughput experimental method demonstrate that AS levels obtained from GenASAP are highly predictive of AS levels in mammalian tissues.

We propose the hierarchical Dirichlet process (HDP), a nonparametric Bayesian model for clustering problems involving multiple groups of data. Each group of data is modeled with a mixture, with the number of components being open-ended and inferred automatically by the model. Further, components can be shared across groups, allowing dependencies across groups to be modeled effectively as well as conferring generalization tonew groups. Such grouped clustering problems occur often in practice, e.g. in the problem of topic discovery in document corpora. We report experimental results on three text corpora showing the effective and superior performance of the HDP over previous models.

A novel linear feature selection algorithm is presented based on the global minimization of a data-dependent generalization error bound. Feature selection and scaling algorithms often lead to non-convex optimization problems,which in many previous approaches were addressed through gradient descent procedures that can only guarantee convergence to a local minimum. We propose an alternative approach, whereby the global solution of the non-convex optimization problem is derived via an equivalent optimization problem. Moreover, the convex optimization task is reduced to a conic quadratic programming problem for which efficient solversare available. Highly competitive numerical results on both artificial and real-world data sets are reported.

We describe semi-Markov conditional random fields (semi-CRFs), a conditionally trainedversion of semi-Markov chains. Intuitively, a semi-CRF on an input sequence x outputs a "segmentation" of x, in which labels are assigned to segments (i.e., subsequences) of x rather than to individual elements x

Psychologists call behavior intrinsically motivated when it is engaged in for its own sake rather than as a step toward solving a specific problem of clear practical value. But what we learn during intrinsically motivated behavior is essential for our development as competent autonomous entities ableto efficiently solve a wide range of practical problems as they arise. In this paper we present initial results from a computational study of intrinsically motivated reinforcement learning aimed at allowing artificial agentsto construct and extend hierarchies of reusable skills that are needed for competent autonomy.

We prove generalization error bounds for predicting entries in a partially observed matrix by fitting the observed entries with a low-rank matrix. In justifying the analysis approach we take to obtain the bounds, we present an example of a class of functions of finite pseudodimension such that the sums of functions from this class have unbounded pseudodimension.

GSMs pose a critical assignment problem, working out which filter responses were generated by a common multiplicative factor.

We address the problem of identifying specific instances of a class (cars) from a set of images all belonging to that class. Although we cannot build a model for any particular instance (as we may be provided with only one "training" example of it), we can use information extracted from observing othermembers of the class. We pose this task as a learning problem, in which the learner is given image pairs, labeled as matching or not, and must discover which image features are most consistent for matching instances anddiscriminative for mismatches. We explore a patch based representation, where we model the distributions of similarity measurements definedon the patches. Finally, we describe an algorithm that selects the most salient patches based on a mutual information criterion. This algorithm performs identification well for our challenging dataset of car images, after matching only a few, well chosen patches.

High retrieval precision in content-based image retrieval can be attained by adopting relevance feedback mechanisms. These mechanisms require that the user judges the quality of the results of the query by marking all the retrieved images as being either relevant or not. Then, the search engine exploits this information to adapt the search to better meet user's needs. At present, the vast majority of proposed relevance feedback mechanisms are formulated in terms of search model that has to be optimized. Such an optimization involves the modification of some search parameters so that the nearest neighbor of the query vector contains the largest number of relevant images.