Acetylcholine (ACh) has been implicated in a wide variety of tasks involving attentional processes and plasticity. Following extensive animal studies, it has previously been suggested that ACh reports on uncertainty and controls hippocampal, cortical and cortico-amygdalar plasticity. We extend this view and consider its effects on cortical representational inference, arguing that ACh controls the balance between bottom-up inference, influenced by input stimuli, and top-down inference, influenced by contextual information. We illustrate our proposal using a hierarchical hidden Markov model.

Multisensory response enhancement (MRE) is the augmentation of the response of a neuron to sensory input of one modality by simultaneous input from another modality. The maximum likelihood (ML) model presented here modifies the Bayesian model for MRE (Anastasio et al.) by incorporating a decision strategy to maximize the number of correct decisions. Thus the ML model can also deal with the important tasks of stimulus discrimination and identification in the presence of incongruent visual and auditory cues. It accounts for the inverse effectiveness observed in neurophysiological recording data, and it predicts a functional relation between uni-and bimodal levels of discriminability that is testable both in neurophysiological and behavioral experiments.

The way groups of auditory neurons interact to code acoustic information is investigated using an information theoretic approach. We develop measures of redundancy among groups of neurons, and apply them to the study of collaborative coding efficiency in two processing stations in the auditory pathway: the inferior colliculus (IC) and the primary auditory cortex (AI). Under two schemes for the coding of the acoustic content, acoustic segments coding and stimulus identity coding, we show differences both in information content and group redundancies between IC and AI neurons. These results provide for the first time a direct evidence for redundancy reduction along the ascending auditory pathway, as has been hypothesized for theoretical considerations [Barlow 1959,2001]. The redundancy effects under the single-spikes coding scheme are significant only for groups larger than ten cells, and cannot be revealed with the redundancy measures that use only pairs of cells. The results suggest that the auditory system transforms low level representations that contain redundancies due to the statistical structure of natural stimuli, into a representation in which cortical neurons extract rare and independent component of complex acoustic signals, that are useful for auditory scene analysis.

The model can predict the response ofindividual cells and populations to parametric manipulations of both geometric (e.g.

Driven by the progress in the field of single-trial analysis of EEG, there is a growing interest in brain computer interfaces (BCIs), i.e., systems that enable human subjects to control a computer only by means of their brain signals. In a pseudo-online simulation our BCI detects upcoming finger movements in a natural keyboard typing condition and predicts their laterality. This can be done on average 100-230 ms before the respective key is actually pressed, i.e., long before the onset of EMG. Our approach is appealing for its short response time and high classification accuracy ( 96%) in a binary decision where no human training is involved. We compare discriminative classifiers like Support Vector Machines (SVMs) and different variants of Fisher Discriminant that possess favorable regularization properties for dealing with high noise cases (inter-trial variablity).

Such model could also provide a basis for simulation of anatomically realistic virtual neurons [1]. The model should accurately distinguish among different neuronal classes: a morphological difference between classes would be captured by a difference in model parameters and reproduced in generated virtual neurons. In addition, the model should be self-consistent: there should be no statistical difference in model parameters measured from real neurons of a given class and from virtual neurons of the same class. The assumption that a simple statistical model of this sort exists relies on the similarity of average environmental and homeostatic conditions encountered by individual neurons during development and on the limited amount of genetic information that underlies differentiation of neuronal classes. Previous research in computational neuroanatomy has mainly focused on the topology and internal geometry of dendrites (i.e., the properties described in "dendrograms") [2,3].

In this paper we explore two quantitative approaches to the modelling of counterfactual reasoning - a linear and a noisy-OR model - based on information contained in conceptual dependency networks. Empirical data is acquired in a study and the fit of the models compared to it. We conclude by considering the appropriateness of nonparametric approaches to counterfactual reasoning, and examining the prospects for other parametric approaches in the future.

Animal data on delayed-reward conditioning experiments shows a striking property - the data for different time intervals collapses into a single curve when the data is scaled by the time interval. This is called the scalar property of interval timing. Here a simple model of a neural clock is presented and shown to give rise to the scalar property. The model is an accumulator consisting of noisy, linear spiking neurons. It is analytically tractable and contains only three parameters.

If the promise of computational modeling is to be fully realized in higherlevel cognitive domains such as language processing, principled methods must be developed to construct the semantic representations used in such models. In this paper, we propose the use of an established formalism from mathematical psychology, additive clustering, as a means of automatically constructing binary representations for objects using only pairwise similarity data. However, existing methods for the unsupervised learning of additive clustering models do not scale well to large problems. We present a new algorithm for additive clustering, based on a novel heuristic technique for combinatorial optimization. The algorithm is simpler than previous formulations and makes fewer independence assumptions. Extensive empirical tests on both human and synthetic data suggest that it is more effective than previous methods and that it also scales better to larger problems. By making additive clustering practical, we take a significant step toward scaling connectionist models beyond hand-coded examples.

A theory of categorization is presented in which knowledge of causal relationships between category features is represented as a Bayesian network. Referred to as causal-model theory, this theory predicts that objects are classified as category members to the extent they are likely to have been produced by a categorys causal model. On this view, people have models of the world that lead them to expect a certain distribution of features in category members (e.g., correlations between feature pairs that are directly connected by causal relationships), and consider exemplars good category members when they manifest those expectations. These expectations include sensitivity to higher-order feature interactions that emerge from the asymmetries inherent in causal relationships. Research on the topic of categorization has traditionally focused on the problem of learning new categories given observations of category members.