The structural similarity of neural networks and genetic regulatory networks todigital circuits, and hence to each other, was noted from the very beginning of their study [1, 2]. In this work, we propose a simple biochemical system whose architecture mimics that of genetic regulation andwhose components allow for in vitro implementation of arbitrary circuits.We use only two enzymes in addition to DNA and RNA molecules: RNA polymerase (RNAP) and ribonuclease (RNase). We develop a rate equation for in vitro transcriptional networks, and derive acorrespondence with general neural network rate equations [3]. As proof-of-principle demonstrations, an associative memory task and a feedforward network computation are shown by simulation. A difference between the neural network and biochemical models is also highlighted: global coupling of rate equations through enzyme saturation can lead to global feedback regulation, thus allowing a simple network without explicit mutual inhibition to perform the winner-take-all computation. Thus, the full complexity of the cell is not necessary for biochemical computation: a wide range of functional behaviors can be achieved with a small set of biochemical components.

Agents learning to act in a partially observable domain may need to overcome the problem of perceptual aliasing - i.e., different states that appear similar but require different responses. This problem is exacerbated whenthe agent's sensors are noisy, i.e., sensors may produce different observationsin the same state. We show that many well-known reinforcement learning methods designed to deal with perceptual aliasing, suchas Utile Suffix Memory, finite size history windows, eligibility traces, and memory bits, do not handle noisy sensors well. We suggest a new algorithm, Noisy Utile Suffix Memory (NUSM), based on USM, that uses a weighted classification of observed trajectories. We compare NUSM to the above methods and show it to be more robust to noise.

This paper concerns approximate nearest neighbor searching algorithms, which have become increasingly important, especially in high dimensional perceptionareas such as computer vision, with dozens of publications in recent years. Much of this enthusiasm is due to a successful new approximate nearest neighbor approach called Locality Sensitive Hashing (LSH).In this paper we ask the question: can earlier spatial data structure approaches to exact nearest neighbor, such as metric trees, be altered to provide approximate answers to proximity queries and if so, how? We introduce a new kind of metric tree that allows overlap: certain datapoints may appear in both the children of a parent. We also introduce newapproximate k-NN search algorithms on this structure. We show why these structures should be able to exploit the same randomprojection-based approximationsthat LSH enjoys, but with a simpler algorithm and perhaps with greater efficiency. We then provide a detailed empirical evaluation on five large, high dimensional datasets which show up to 31-fold accelerations over LSH. This result holds true throughout the spectrum of approximation levels.

We present an algorithm to overcome the local maxima problem in estimating theparameters of mixture models. It combines existing approaches fromboth EM and a robust fitting algorithm, RANSAC, to give a data-driven stochastic learning scheme. Minimal subsets of data points, sufficient to constrain the parameters of the model, are drawn from proposal densitiesto discover new regions of high likelihood. The proposal densities are learnt using EM and bias the sampling toward promising solutions. The algorithm is computationally efficient, as well as effective at escaping from local maxima. We compare it with alternative methods, including EM and RANSAC, on both challenging synthetic data and the computer vision problem of alpha-matting.

We consider multi-agent systems whose agents compete for resources by striving to be in the minority group. The agents adapt to the environment by reinforcement learning of the preferences of the policies they hold. Diversity of preferences of policies is introduced by adding random biases tothe initial cumulative payoffs of their policies. We explain and provide evidence that agent cooperation becomes increasingly important when diversity increases. Analyses of these mechanisms yield excellent agreement with simulations over nine decades of data.

These models have been able to account for human responses in tasks ranging from 3D shape perception t0 Visuomotor control.

Choice-based conjoint analysis builds models of consumer preferences over products with answers gathered in questionnaires. Our main goal is to bring tools from the machine learning community to solve this problem moreefficiently. Thus, we propose two algorithms to quickly and accurately estimate consumer preferences.

Gaussians grouped together into a single Gaussian [1].

In this paper, we explore the use of Random Forests (RFs) in the structured languagemodel (SLM), which uses rich syntactic information in predicting the next word based on words already seen. The goal in this work is to construct RFs by randomly growing Decision Trees (DTs) using syntacticinformation and investigate the performance of the SLM modeled by the RFs in automatic speech recognition. RFs, which were originally developed as classifiers, are a combination of decision tree classifiers. Each tree is grown based on random training data sampled independently and with the same distribution for all trees in the forest, and a random selection of possible questions at each node of the decision tree. Our approach extends the original idea of RFs to deal with the data sparseness problem encountered in language modeling. RFs have been studied in the context of n-gram language modeling and have been shown to generalize well to unseen data. We show in this paper that RFs using syntactic information can also achieve better performance in both perplexity (PPL) and word error rate (WER) in a large vocabulary speech recognition system, compared to a baseline that uses Kneser-Ney smoothing.

Complex objects can often be conveniently represented by finite sets of simpler components, such as images by sets of patches or texts by bags of words. We study the class of positive definite (p.d.) kernels for two such objects that can be expressed as a function of the merger of their respective sets of components. We prove a general integral representation ofsuch kernels and present two particular examples. One of them leads to a kernel for sets of points living in a space endowed itself with a positive definite kernel. We provide experimental results on a benchmark experiment of handwritten digits image classification which illustrate the validity of the approach.