The ill-posed nature of the MEG/EEG source localization problem requires the incorporation of prior assumptions when choosing an appropriate solution out of an infinite set of candidates. Bayesian methods are useful in this capacity because they allow these assumptions to be explicitly quantified. Recently, a number of empirical Bayesian approaches have been proposed that attempt a form of model selection by using the data to guide the search for an appropriate prior. While seemingly quite different in many respects, we apply a unifying framework based on automatic relevance determination (ARD) that elucidates various attributes of these methods and suggests directions for improvement. We also derive theoretical properties of this methodology related to convergence, local minima, and localization bias and explore connections with established algorithms.

The neurons of the neocortex communicate by asynchronous events called action potentials (or'spikes'). However, for simplicity of simulation, most models of processing by cortical neural networks have assumed that the activations of their neurons can be approximated by event rates rather than taking account of individual spikes. The obstacle to exploring the more detailed spike processing of these networks has been reduced considerably in recent years by the development of hybrid analog-digital Very-Large Scale Integrated (hVLSI) neural networks composed of spiking neurons that are able to operate in real-time. In this paper we describe such a hVLSI neural network that performs an interesting task of selective attentional processing that was previously described for a simulated'pointer-map' rate model by Hahnloser and colleagues. We found that most of the computational features of their rate model can be reproduced in the spiking implementation; but, that spike-based processing requires a modification of the original network architecture in order to memorize a previously attended target.

We present a new statistical framework called hidden Markov Dirichlet process (HMDP) to jointly model the genetic recombinations among possibly infinite number of founders and the coalescence-with-mutation events in the resulting genealogies. The HMDP posits that a haplotype of genetic markers is generated by a sequence of recombination events that select an ancestor for each locus from an unbounded set of founders according to a 1st-order Markov transition process. Conjoining this process with a mutation model, our method accommodates both between-lineage recombination and within-lineage sequence variations, and leads to a compact and natural interpretation of the population structure and inheritance process underlying haplotype data. We have developed an efficient sampling algorithm for HMDP based on a two-level nested Pólya urn scheme. On both simulated and real SNP haplotype data, our method performs competitively or significantly better than extant methods in uncovering the recombination hotspots along chromosomal loci; and in addition it also infers the ancestral genetic patterns and offers a highly accurate map of ancestral compositions of modern populations.

Correlation between instances is often modelled via a kernel function using input attributes of the instances. Relational knowledge can further reveal additional pairwise correlations between variables of interest. In this paper, we develop a class of models which incorporates both reciprocal relational information and input attributes using Gaussian process techniques. This approach provides a novel nonparametric Bayesian framework with a data-dependent covariance function for supervised learning tasks. We also apply this framework to semi-supervised learning. Experimental results on several real world data sets verify the usefulness of this algorithm.

Discriminative learning methods for classification perform well when training and test data are drawn from the same distribution. In many situations, though, we have labeled training data for a source domain, and we wish to learn a classifier which performs well on a target domain with a different distribution. Under what conditions can we adapt a classifier trained on the source domain for use in the target domain? Intuitively, a good feature representation is a crucial factor in the success of domain adaptation. We formalize this intuition theoretically with a generalization bound for domain adaption. Our theory illustrates the tradeoffs inherent in designing a representation for domain adaptation and gives a new justification for a recently proposed model. It also points toward a promising new model for domain adaptation: one which explicitly minimizes the difference between the source and target domains, while at the same time maximizing the margin of the training set.

One of the intuitions underlying many graph-based methods for clustering and semi-supervised learning, is that class or cluster boundaries pass through areas of low probability density. In this paper we provide some formal analysis of that notion for a probability distribution. We introduce a notion of weighted boundary volume, which measures the length of the class/cluster boundary weighted by the density of the underlying probability distribution. We show that sizes of the cuts of certain commonly used data adjacency graphs converge to this continuous weighted volume of the boundary.

If language users are rational, they might choose to structure their utterances so as to optimize communicative properties. In particular, information-theoretic and psycholinguistic considerations suggest that this may include maximizing the uniformity of information density in an utterance. We investigate this possibility in the context of syntactic reduction, where the speaker has the option of either marking a higher-order unit (a phrase) with an extra word, or leaving it unmarked. We demonstrate that speakers are more likely to reduce less information-dense phrases. In a second step, we combine a stochastic model of structured utterance production with a logistic-regression model of syntactic reduction to study which types of cues speakers employ when estimating the predictability of upcoming elements. We demonstrate that the trend toward predictability-sensitive syntactic reduction (Jaeger, 2006) is robust in the face of a wide variety of control variables, and present evidence that speakers use both surface and structural cues for predictability estimation.

In large-scale applications, the data are often highly sparse. CRS combines sketching and sampling in that it converts sketches of the data into conditional random samples online in the estimation stage, with the sample size determined retrospectively.

A reliable motion estimation algorithm must function under a wide range of conditions. One regime, which we consider here, is the case of moving objects with contours but no visible texture. Tracking distinctive features such as corners can disambiguate the motion of contours, but spurious features such as T-junctions can be badly misleading. It is difficult to determine the reliability of motion from local measurements, since a full rank covariance matrix can result from both real and spurious features. We propose a novel approach that avoids these points altogether, and derives global motion estimates by utilizing information from three levels of contour analysis: edgelets, boundary fragments and contours.

By adopting Gaussian process priors a fully Bayesian solution to the problem of integrating possibly heterogeneous data sets within a classification setting is presented. Approximate inference schemes employing Variational & Expectation Propagation based methods are developed and rigorously assessed. We demonstrate our approach to integrating multiple data sets on a large scale protein fold prediction problem where we infer the optimal combinations of covariance functions and achieve state-of-the-art performance without resorting to any ad hoc parameter tuning and classifier combination.