This paper addresses the issue of numerical computation in machine learning domains based on similarity metrics, such as kernel methods, spectral techniques and Gaussian processes. It presents a general solution strategy based on Krylov subspace iteration and fast N-body learning methods. The experiments show significant gains in computation and storage on datasets arising in image segmentation, object detection and dimensionality reduction. The paper also presents theoretical bounds on the stability of these methods.

Experimental data indicate that norepinephrine is critically involved in aspects of vigilance and attention. Previously, we considered the function of this neuromodulatory system on a time scale of minutes and longer, and suggested that it signals global uncertainty arising from gross changes in environmental contingencies. However, norepinephrine is also known to be activated phasically by familiar stimuli in welllearned tasks. Here, we extend our uncertainty-based treatment of norepinephrine to this phasic mode, proposing that it is involved in the detection and reaction to state uncertainty within a task. This role of norepinephrine can be understood through the metaphor of neural interrupts.

We characterize the sample complexity of active learning problems in terms of a parameter which takes into account the distribution over the input space, the specific target hypothesis, and the desired accuracy.

Neurons can have rapidly changing spike train statistics dictated by the underlying network excitability or behavioural state of an animal. To estimate the time course of such state dynamics from single-or multiple neuron recordings, we have developed an algorithm that maximizes the likelihood of observed spike trains by optimizing the state lifetimes and the state-conditional interspike-interval (ISI) distributions. Our nonparametric algorithm is free of time-binning and spike-counting problems and has the computational complexity of a Mixed-state Markov Model operating on a state sequence of length equal to the total number of recorded spikes. As an example, we fit a two-state model to paired recordings of premotor neurons in the sleeping songbird. We find that the two state-conditional ISI functions are highly similar to the ones measured during waking and singing, respectively.

We initiate the study of learning from multiple sources of limited data, each of which may be corrupted at a different rate. We develop a complete theory of which data sources should be used for two fundamental problems: estimating the bias of a coin, and learning a classifier in the presence of label noise. In both cases, efficient algorithms are provided for computing the optimal subset of data.

A dynamic texture is a video model that treats a video as a sample from a spatiotemporal stochastic process, specifically a linear dynamical system. One problem associated with the dynamic texture is that it cannot model video where there are multiple regions of distinct motion. In this work, we introduce the layered dynamic texture model, which addresses this problem. We also introduce a variant of the model, and present the EM algorithm for learning each of the models. Finally, we demonstrate the efficacy of the proposed model for the tasks of segmentation and synthesis of video.

We prove the strongest known bound for the risk of hypotheses selected from the ensemble generated by running a learning algorithm incrementally on the training data. Our result is based on proof techniques that are remarkably different from the standard risk analysis based on uniform convergence arguments.

Gradient flow representation of the traveling wave signals acquired over a miniature (1cm diameter) array of four microphones yields linearly mixed instantaneous observations of the time-differentiated sources, separated and localized by independent component analysis (ICA). The gradient flow and ICA processors each measure 3mm 3mm in 0.5 µm CMOS, and consume 54 µW and 180 µW power, respectively, from a 3 V supply at 16 ks/s sampling rate. Experiments demonstrate perceptually clear (12dB) separation and precise localization of two speech sources presented through speakers positioned at 1.5m from the array on a conference room table. Analysis of the multipath residuals shows that they are spectrally diffuse, and void of the direct path.

This paper presents a rigorous statistical analysis characterizing regimes in which active learning significantly outperforms classical passive learning. Active learning algorithms are able to make queries or select sample locations in an online fashion, depending on the results of the previous queries. In some regimes, this extra flexibility leads to significantly faster rates of error decay than those possible in classical passive learning settings. The nature of these regimes is explored by studying fundamental performance limits of active and passive learning in two illustrative nonparametric function classes. In addition to examining the theoretical potential of active learning, this paper describes a practical algorithm capable of exploiting the extra flexibility of the active setting and provably improving upon the classical passive techniques. Our active learning theory and methods show promise in a number of applications, including field estimation using wireless sensor networks and fault line detection.

We present a new kernel method for extracting semantic relations between entities in natural language text, based on a generalization of subsequence kernels. This kernel uses three types of subsequence patterns that are typically employed in natural language to assert relationships between two entities. Experiments on extracting protein interactions from biomedical corpora and top-level relations from newspaper corpora demonstrate the advantages of this approach.