Reinforcement learning models have long promised to unify computational, psychological and neural accounts of appetitively conditioned behavior. However, the bulk of data on animal conditioning comes from free-operant experiments measuring how fast animals will work for reinforcement. Existing reinforcement learning (RL) models are silent about these tasks, because they lack any notion of vigor. They thus fail to address the simple observation that hungrier animals will work harder for food, as well as stranger facts such as their sometimes greater productivity even when working for irrelevant outcomes such as water. Here, we develop an RL framework for free-operant behavior, suggesting that subjects choose how vigorously to perform selected actions by optimally balancing the costs and benefits of quick responding.

In this paper, we provide a general theorem that establishes a correspondence between surrogate loss functions in classification and the family of f-divergences. Moreover, we provide constructive procedures for determining the f-divergence induced by a given surrogate loss, and conversely for finding all surrogate loss functions that realize a given f-divergence. Next we introduce the notion of universal equivalence among loss functions and corresponding f-divergences, and provide necessary and sufficient conditions for universal equivalence to hold. These ideas have applications to classification problems that also involve a component of experiment design; in particular, we leverage our results to prove consistency of a procedure for learning a classifier under decentralization requirements.

We propose a new Bayesian method for spatial cluster detection, the "Bayesian spatial scan statistic," and compare this method to the standard (frequentist) scan statistic approach. We demonstrate that the Bayesian statistic has several advantages over the frequentist approach, including increased power to detect clusters and (since randomization testing is unnecessary) much faster runtime. We evaluate the Bayesian and frequentist methods on the task of prospective disease surveillance: detecting spatial clusters of disease cases resulting from emerging disease outbreaks. We demonstrate that our Bayesian methods are successful in rapidly detecting outbreaks while keeping number of false positives low.

We present a nonlinear, simple, yet effective, feature subset selection method for regression and use it in analyzing cortical neural activity. Our algorithm involves a feature-weighted version of the k-nearest-neighbor algorithm. It is able to capture complex dependency of the target function on its input and makes use of the leave-one-out error as a natural regularization. We explain the characteristics of our algorithm on synthetic problems and use it in the context of predicting hand velocity from spikes recorded in motor cortex of a behaving monkey. By applying feature selection we are able to improve prediction quality and suggest a novel way of exploring neural data.

Survival in the natural world demands the selection of relevant visual cues to rapidly and reliably guide attention towards prey and predators in cluttered environments. We investigate whether our visual system selects cues that guide search in an optimal manner. We formally obtain the optimal cue selection strategy by maximizing the signal to noise ratio (SN R) between a search target and surrounding distractors. This optimal strategy successfully accounts for several phenomena in visual search behavior, including the effect of target-distractor discriminability, uncertainty in target's features, distractor heterogeneity, and linear separability. Furthermore, the theory generates a new prediction, which we verify through psychophysical experiments with human subjects. Our results provide direct experimental evidence that humans select visual cues so as to maximize SN R between the targets and surrounding clutter.

We show that Queyranne's algorithm for minimizing symmetric submodular functions can be used for clustering with a variety of different objective functions. Two specific criteria that we consider in this paper are the single linkage and the minimum description length criteria. The first criterion tries to maximize the minimum distance between elements of different clusters, and is inherently "discriminative". It is known that optimal clusterings into k clusters for any given k in polynomial time for this criterion can be computed. The second criterion seeks to minimize the description length of the clusters given a probabilistic generative model. We show that the optimal partitioning into 2 clusters, and approximate partitioning (guaranteed to be within a factor of 2 of the the optimal) for more clusters can be computed. To the best of our knowledge, this is the first time that a tractable algorithm for finding the optimal clustering with respect to the MDL criterion for 2 clusters has been given. Besides the optimality result for the MDL criterion, the chief contribution of this paper is to show that the same algorithm can be used to optimize a broad class of criteria, and hence can be used for many application specific criterion for which efficient algorithm are not known.

An analog focal-plane processor having a 128 128 photodiode array has been developed for directional edge filtering. It can perform 4 4-pixel kernel convolution for entire pixels only with 256 steps of simple analog processing. Newly developed cyclic line access and row-parallel processing scheme in conjunction with the "only-nearest-neighbor interconnects" architecture has enabled a very simple implementation. A proof-of-conceptchip was fabricated in a 0.35-m 2-poly 3-metal CMOS technology and the edge filtering at a rate of 200 frames/sec.

This paper presents a novel technique for analyzing electromagnetic imaging data obtained using the stimulus evoked experimental paradigm. The technique is based on a probabilistic graphical model, which describes the data in terms of underlying evoked and interference sources, and explicitly models the stimulus evoked paradigm.

This paper presents a diffusion based probabilistic interpretation of spectral clustering and dimensionality reduction algorithms that use the eigenvectors of the normalized graph Laplacian. Given the pairwise adjacency matrix of all points, we define a diffusion distance between any two data points and show that the low dimensional representation of the data by the first few eigenvectors of the corresponding Markov matrix is optimal under a certain mean squared error criterion.

Nested sampling is a new Monte Carlo method by Skilling [1] intended for general Bayesian computation. Nested sampling provides a robust alternative to annealing-based methods for computing normalizing constants. It can also generate estimates of other quantities such as posterior expectations. The key technical requirement is an ability to draw samples uniformly from the prior subject to a constraint on the likelihood. We provide a demonstration with the Potts model, an undirected graphical model.