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Comparative Gene Prediction using Conditional Random Fields

Neural Information Processing Systems

Computational gene prediction using generative models has reached a plateau, with several groups converging to a generalized hidden Markov model (GHMM) incorporating phylogenetic models of nucleotide sequence evolution. Further improvements in gene calling accuracy are likely to come through new methods that incorporate additional data, both comparative and species specific. Conditional Random Fields (CRFs), which directly model the conditional probability P (y x) of a vector of hidden states conditioned on a set of observations, provide a unified framework for combining probabilistic and non-probabilistic information and have been shown to outperform HMMs on sequence labeling tasks in natural language processing. We describe the use of CRFs for comparative gene prediction. We implement a model that encapsulates both a phylogenetic-GHMM (our baseline comparative model) and additional non-probabilistic features. We tested our model on the genome sequence of the fungal human pathogen Cryptococcus neoformans.


Online Clustering of Moving Hyperplanes

Neural Information Processing Systems

We propose a recursive algorithm for clustering trajectories lying in multiple moving hyperplanes. Starting from a given or random initial condition, we use normalized gradient descent to update the coefficients of a time varying polynomial whose degree is the number of hyperplanes and whose derivatives at a trajectory give an estimate of the vector normal to the hyperplane containing that trajectory. As time proceeds, the estimates of the hyperplane normals are shown to track their true values in a stable fashion. The segmentation of the trajectories is then obtained by clustering their associated normal vectors. The final result is a simple recursive algorithm for segmenting a variable number of moving hyperplanes. We test our algorithm on the segmentation of dynamic scenes containing rigid motions and dynamic textures, e.g., a bird floating on water. Our method not only segments the bird motion from the surrounding water motion, but also determines patterns of motion in the scene (e.g., periodic motion) directly from the temporal evolution of the estimated polynomial coefficients. Our experiments also show that our method can deal with appearing and disappearing motions in the scene.


A Complexity-Distortion Approach to Joint Pattern Alignment

Neural Information Processing Systems

Image Congealing (IC) is a nonparametric method for the joint alignment of a collection of images affected by systematic and unwanted deformations. The method attempts to undo the deformations by minimizing a measure of complexity of the image ensemble, such as the averaged per-pixel entropy. This enables alignment without an explicit model of the aligned dataset as required by other methods (e.g.


Generalized Maximum Margin Clustering and Unsupervised Kernel Learning

Neural Information Processing Systems

Maximum margin clustering was proposed lately and has shown promising performance in recent studies [1, 2]. It extends the theory of support vector machine to unsupervised learning. Despite its good performance, there are three major problems with maximum margin clustering that question its efficiency for real-world applications. First, it is computationally expensive and difficult to scale to large-scale datasets because the number of parameters in maximum margin clustering is quadratic in the number of examples. Second, it requires data preprocessing to ensure that any clustering boundary will pass through the origins, which makes it unsuitable for clustering unbalanced dataset. Third, it is sensitive to the choice of kernel functions, and requires external procedure to determine the appropriate values for the parameters of kernel functions. In this paper, we propose "generalized maximum margin clustering" framework that addresses the above three problems simultaneously.


Large-Scale Sparsified Manifold Regularization

Neural Information Processing Systems

Semi-supervised learning is more powerful than supervised learning by using both labeled and unlabeled data. In particular, the manifold regularization framework, together with kernel methods, leads to the Laplacian SVM (LapSVM) that has demonstrated state-of-the-art performance. However, the LapSVM solution typically involves kernel expansions of all the labeled and unlabeled examples, and is slow on testing. Moreover, existing semi-supervised learning methods, including the LapSVM, can only handle a small number of unlabeled examples. In this paper, we integrate manifold regularization with the core vector machine, which has been used for large-scale supervised and unsupervised learning. By using a sparsified manifold regularizer and formulating as a center-constrained minimum enclosing ball problem, the proposed method produces sparse solutions with low time and space complexities. Experimental results show that it is much faster than the LapSVM, and can handle a million unlabeled examples on a standard PC; while the LapSVM can only handle several thousand patterns.


Learning Motion Style Synthesis from Perceptual Observations

Neural Information Processing Systems

This paper presents an algorithm for synthesis of human motion in specified styles. We use a theory of movement observation (Laban Movement Analysis) to describe movement styles as points in a multidimensional perceptual space. We cast the task of learning to synthesize desired movement styles as a regression problem: sequences generated via space-time interpolation of motion capture data are used to learn a nonlinear mapping between animation parameters and movement styles in perceptual space. We demonstrate that the learned model can apply a variety of motion styles to prerecorded motion sequences and it can extrapolate styles not originally included in the training data.


Large Margin Component Analysis

Neural Information Processing Systems

Metric learning has been shown to significantly improve the accuracy of k-nearest neighbor (kNN) classification. In problems involving thousands of features, distance learning algorithms cannot be used due to overfitting and high computational complexity. In such cases, previous work has relied on a two-step solution: first apply dimensionality reduction methods to the data, and then learn a metric in the resulting low-dimensional subspace. In this paper we show that better classification performance can be achieved by unifying the objectives of dimensionality reduction and metric learning. We propose a method that solves for the low-dimensional projection of the inputs, which minimizes a metric objective aimed at separating points in different classes by a large margin. This projection is defined by a significantly smaller number of parameters than metrics learned in input space, and thus our optimization reduces the risks of overfitting. Theory and results are presented for both a linear as well as a kernelized version of the algorithm. Overall, we achieve classification rates similar, and in several cases superior, to those of support vector machines.


Logistic Regression for Single Trial EEG Classification

Neural Information Processing Systems

We propose a novel framework for the classification of single trial ElectroEncephaloGraphy (EEG), based on regularized logistic regression. Framed in this robust statistical framework no prior feature extraction or outlier removal is required.


Linearly-solvable Markov decision problems

Neural Information Processing Systems

We introduce a class of MPDs which greatly simplify Reinforcement Learning. They have discrete state spaces and continuous control spaces. The controls have the effect of rescaling the transition probabilities of an underlying Markov chain. A control cost penalizing KL divergence between controlled and uncontrolled transition probabilities makes the minimization problem convex, and allows analytical computation of the optimal controls given the optimal value function. An exponential transformation of the optimal value function makes the minimized Bellman equation linear.