Nonlinear dimensionality reduction embeddings computed from datasets do not provide a mechanism to compute the inverse map. In this paper, we address the problem of computing a stable inverse map to such a general bi-Lipschitz map. Our approach relies on radial basis functions (RBFs) to interpolate the inverse map everywhere on the low-dimensional image of the forward map. We demonstrate that the scale-free cubic RBF kernel performs better than the Gaussian kernel: it does not suffer from ill-conditioning, and does not require the choice of a scale. The proposed construction is shown to be similar to the Nystr\"om extension of the eigenvectors of the symmetric normalized graph Laplacian matrix. Based on this observation, we provide a new interpretation of the Nystr\"om extension with suggestions for improvement.

Scalability of statistical estimators is of increasing importance in modern applications and dimension reduction is often used to extract relevant information from data. A variety of popular dimension reduction approaches can be framed as symmetric generalized eigendecomposition problems. In this paper we outline how taking into account the low rank structure assumption implicit in these dimension reduction approaches provides both computational and statistical advantages. We adapt recent randomized low-rank approximation algorithms to provide efficient solutions to three dimension reduction methods: Principal Component Analysis (PCA), Sliced Inverse Regression (SIR), and Localized Sliced Inverse Regression (LSIR). A key observation in this paper is that randomization serves a dual role, improving both computational and statistical performance. This point is highlighted in our experiments on real and simulated data.

Many algorithms have been proposed for fitting network models with communities, but most of them do not scale well to large networks, and often fail on sparse networks. Here we propose a new fast pseudo-likelihood method for fitting the stochastic block model for networks, as well as a variant that allows for an arbitrary degree distribution by conditioning on degrees. We show that the algorithms perform well under a range of settings, including on very sparse networks, and illustrate on the example of a network of political blogs. We also propose spectral clustering with perturbations, a method of independent interest, which works well on sparse networks where regular spectral clustering fails, and use it to provide an initial value for pseudo-likelihood. We prove that pseudo-likelihood provides consistent estimates of the communities under a mild condition on the starting value, for the case of a block model with two communities.

Fundamentally, the HMM is a mixture model whose mixing distribution is a finite state Markov chain (Rabiner, 1989; Capp e et al., 2005). Whilst the Markov assumptions rarely correspond to the true physical generative process, it often adequately captures first-order properties that make it a useful approximating model for sequence data in many instances whilst remaining tractable even for very large datasets. As a consequence, HMM-based algorithms can give highly competitive performance in many applications. Central to the tractability of HMMs is the availability of recursive algorithms that allow fundamental quantities to be computed efficiently (Baum and Petrie, 1966; Viterbi, 1967). These include the Viterbi algorithm which computes the most probable hidden state sequence and the forward-backward algorithm which computes the marginal probability of a given state at a point in the sequence. Computation for the HMM has been well-summarized in the comprehensive and widely read tutorial by Rabiner (1989) with a Bayesian treatment given more recently by Scott (2002). It is a testament to the completeness of these recursive methods that there have been few generic additions to the HMM toolbox since these were first described in the 1960s. However, as HMM approaches continue to be applied in increasingly diverse scientific domains and ever larger data sets, there is interest in expanding the generic toolbox available for HMM inference to encompass unmet needs. The motivation for our work is to develop mechanisms to allow theexploration of the posterior sequence space.

Multi-armed bandit problems are receiving a great deal of attention because they adequately formalize the exploration-exploitation trade-offs arising in several industrially relevant applications, such as online advertisement and, more generally, recommendation systems. In many cases, however, these applications have a strong social component, whose integration in the bandit algorithm could lead to a dramatic performance increase. For instance, we may want to serve content to a group of users by taking advantage of an underlying network of social relationships among them. In this paper, we introduce novel algorithmic approaches to the solution of such networked bandit problems. More specifically, we design and analyze a global strategy which allocates a bandit algorithm to each network node (user) and allows it to "share" signals (contexts and payoffs) with the neghboring nodes. We then derive two more scalable variants of this strategy based on different ways of clustering the graph nodes. We experimentally compare the algorithm and its variants to state-of-the-art methods for contextual bandits that do not use the relational information. Our experiments, carried out on synthetic and real-world datasets, show a marked increase in prediction performance obtained by exploiting the network structure.

We propose a new stochastic dual coordinate ascent technique that can be applied to a wide range of regularized learning problems. Our method is based on Alternating Direction Multiplier Method (ADMM) to deal with complex regularization functions such as structured regularizations. Although the original ADMM is a batch method, the proposed method offers a stochastic update rule where each iteration requires only one or few sample observations. Moreover, our method can naturally afford mini-batch update and it gives speed up of convergence. We show that, under mild assumptions, our method converges exponentially. The numerical experiments show that our method actually performs efficiently.

We consider stochastic multi-armed bandit problems with complex actions over a set of basic arms, where the decision maker plays a complex action rather than a basic arm in each round. The reward of the complex action is some function of the basic arms' rewards, and the feedback observed may not necessarily be the reward per-arm. For instance, when the complex actions are subsets of the arms, we may only observe the maximum reward over the chosen subset. Thus, feedback across complex actions may be coupled due to the nature of the reward function. We prove a frequentist regret bound for Thompson sampling in a very general setting involving parameter, action and observation spaces and a likelihood function over them. The bound holds for discretely-supported priors over the parameter space and without additional structural properties such as closed-form posteriors, conjugate prior structure or independence across arms. The regret bound scales logarithmically with time but, more importantly, with an improved constant that non-trivially captures the coupling across complex actions due to the structure of the rewards. As applications, we derive improved regret bounds for classes of complex bandit problems involving selecting subsets of arms, including the first nontrivial regret bounds for nonlinear MAX reward feedback from subsets.

Adaptive networks are suitable for decentralized inference tasks, e.g., to monitor complex natural phenomena. Recent research works have intensively studied distributed optimization problems in the case where the nodes have to estimate a single optimum parameter vector collaboratively. However, there are many important applications that are multitask-oriented in the sense that there are multiple optimum parameter vectors to be inferred simultaneously, in a collaborative manner, over the area covered by the network. In this paper, we employ diffusion strategies to develop distributed algorithms that address multitask problems by minimizing an appropriate mean-square error criterion with $\ell_2$-regularization. The stability and convergence of the algorithm in the mean and in the mean-square sense is analyzed. Simulations are conducted to verify the theoretical findings, and to illustrate how the distributed strategy can be used in several useful applications related to spectral sensing, target localization, and hyperspectral data unmixing.

We propose a family of multivariate Gaussian process models for correlated outputs, based on assuming that the likelihood function takes the generic form of the multivariate exponential family distribution (EFD). We denote this model as a multivariate generalized Gaussian process model, and derive Taylor and Laplace algorithms for approximate inference on the generic model. By instantiating the EFD with specific parameter functions, we obtain two novel GP models (and corresponding inference algorithms) for correlated outputs: 1) a Von-Mises GP for angle regression; and 2) a Dirichlet GP for regressing on the multinomial simplex.

High-throughput sequencing allows the detection and quantification of frequencies of somatic single nucleotide variants (SNV) in heterogeneous tumor cell populations. In some cases, the evolutionary history and population frequency of the subclonal lineages of tumor cells present in the sample can be reconstructed from these SNV frequency measurements. However, automated methods to do this reconstruction are not available and the conditions under which reconstruction is possible have not been described. We describe the conditions under which the evolutionary history can be uniquely reconstructed from SNV frequencies from single or multiple samples from the tumor population and we introduce a new statistical model, PhyloSub, that infers the phylogeny and genotype of the major subclonal lineages represented in the population of cancer cells. It uses a Bayesian nonparametric prior over trees that groups SNVs into major subclonal lineages and automatically estimates the number of lineages and their ancestry. We sample from the joint posterior distribution over trees to identify evolutionary histories and cell population frequencies that have the highest probability of generating the observed SNV frequency data. When multiple phylogenies are consistent with a given set of SNV frequencies, PhyloSub represents the uncertainty in the tumor phylogeny using a partial order plot. Experiments on a simulated dataset and two real datasets comprising tumor samples from acute myeloid leukemia and chronic lymphocytic leukemia patients demonstrate that PhyloSub can infer both linear (or chain) and branching lineages and its inferences are in good agreement with ground truth, where it is available.