Psychophysical experiments have demonstrated that the brain integrates information from multiple sensory cues in a near Bayesian optimal manner. The present study proposes a novel mechanism to achieve this. We consider two reciprocally connected networks, mimicking the integration of heading direction information between the dorsal medial superior temporal (MSTd) and the ventral intraparietal (VIP) areas. Each network serves as a local estimator and receives an independent cue, either the visual or the vestibular, as direct input for the external stimulus. We find that positive reciprocal interactions can improve the decoding accuracy of each individual network as if it implements Bayesian inference from two cues. Our model successfully explains the experimental finding that both MSTd and VIP achieve Bayesian multisensory integration, though each of them only receives a single cue as direct external input. Our result suggests that the brain may implement optimal information integration distributively at each local estimator through the reciprocal connections between cortical regions.

In text analysis documents are represented as disorganized bags of words, models of count features are typically based on mixing a small number of topics \cite{lda,sam}. Recently, it has been observed that for many text corpora documents evolve into one another in a smooth way, with some features dropping and new ones being introduced. The counting grid \cite{cgUai} models this spatial metaphor literally: it is multidimensional grid of word distributions learned in such a way that a document's own distribution of features can be modeled as the sum of the histograms found in a window into the grid. The major drawback of this method is that it is essentially a mixture and all the content much be generated by a single contiguous area on the grid. This may be problematic especially for lower dimensional grids. In this paper, we overcome to this issue with the \emph{Componential Counting Grid} which brings the componential nature of topic models to the basic counting grid. We also introduce a generative kernel based on the document's grid usage and a visualization strategy useful for understanding large text corpora. We evaluate our approach on document classification and multimodal retrieval obtaining state of the art results on standard benchmarks.

Multi-step-ahead time series prediction is one of the most challenging research topics in the field of time series modeling and prediction, and is continually under research. Recently, the multiple-input several multiple-outputs (MISMO) modeling strategy has been proposed as a promising alternative for multi-step-ahead time series prediction, exhibiting advantages compared with the two currently dominating strategies, the iterated and the direct strategies. Built on the established MISMO strategy, this study proposes a particle swarm optimization (PSO)-based MISMO modeling strategy, which is capable of determining the number of sub-models in a self-adaptive mode, with varying prediction horizons. Rather than deriving crisp divides with equal-size s prediction horizons from the established MISMO, the proposed PSO-MISMO strategy, implemented with neural networks, employs a heuristic to create flexible divides with varying sizes of prediction horizons and to generate corresponding sub-models, providing considerable flexibility in model construction, which has been validated with simulated and real datasets.

In distributed ML applications, shared parameters are usually replicated among computing nodes to minimize network overhead. Therefore, proper consistency model must be carefully chosen to ensure algorithm's correctness and provide high throughput. Existing consistency models used in general-purpose databases and modern distributed ML systems are either too loose to guarantee correctness of the ML algorithms or too strict and thus fail to fully exploit the computing power of the underlying distributed system. Many ML algorithms fall into the category of \emph{iterative convergent algorithms} which start from a randomly chosen initial point and converge to optima by repeating iteratively a set of procedures. We've found that many such algorithms are to a bounded amount of inconsistency and still converge correctly. This property allows distributed ML to relax strict consistency models to improve system performance while theoretically guarantees algorithmic correctness. In this paper, we present several relaxed consistency models for asynchronous parallel computation and theoretically prove their algorithmic correctness. The proposed consistency models are implemented in a distributed parameter server and evaluated in the context of a popular ML application: topic modeling.

Consider observing an undirected network that is `noisy' in the sense that there are Type I and Type II errors in the observation of edges. Such errors can arise, for example, in the context of inferring gene regulatory networks in genomics or functional connectivity networks in neuroscience. Given a single observed network then, to what extent are summary statistics for that network representative of their analogues for the true underlying network? Can we infer such statistics more accurately by taking into account the noise in the observed network edges? In this paper, we answer both of these questions. In particular, we develop a spectral-based methodology using the adjacency matrix to `denoise' the observed network data and produce more accurate inference of the summary statistics of the true network. We characterize performance of our methodology through bounds on appropriate notions of risk in the $L^2$ sense, and conclude by illustrating the practical impact of this work on synthetic and real-world data.

Gaussian processes are rich distributions over functions, which provide a Bayesian nonparametric approach to smoothing and interpolation. We introduce simple closed form kernels that can be used with Gaussian processes to discover patterns and enable extrapolation. These kernels are derived by modelling a spectral density -- the Fourier transform of a kernel -- with a Gaussian mixture. The proposed kernels support a broad class of stationary covariances, but Gaussian process inference remains simple and analytic. We demonstrate the proposed kernels by discovering patterns and performing long range extrapolation on synthetic examples, as well as atmospheric CO2 trends and airline passenger data. We also show that we can reconstruct standard covariances within our framework.

This paper proposes the formalization and implementation of a novel class of constraints aimed at modeling problems related to placement of multi-body systems in the 3-dimensional space. Each multi-body is a system composed of body elements, connected by joint relationships and constrained by geometric properties. The emphasis of this investigation is the use of multi-body systems to model native conformations of protein structures---where each body represents an entity of the protein (e.g., an amino acid, a small peptide) and the geometric constraints are related to the spatial properties of the composing atoms. The paper explores the use of the proposed class of constraints to support a variety of different structural analysis of proteins, such as loop modeling and structure prediction. The declarative nature of a constraint-based encoding provides elaboration tolerance and the ability to make use of any additional knowledge in the analysis studies. The filtering capabilities of the proposed constraints also allow to control the number of representative solutions that are withdrawn from the conformational space of the protein, by means of criteria driven by uniform distribution sampling principles. In this scenario it is possible to select the desired degree of precision and/or number of solutions. The filtering component automatically excludes configurations that violate the spatial and geometric properties of the composing multi-body system. The paper illustrates the implementation of a constraint solver based on the multi-body perspective and its empirical evaluation on protein structure analysis problems.

Multi-task learning has shown to significantly enhance the performance of multiple related learning tasks in a variety of situations. We present the fused logistic regression, a sparse multi-task learning approach for binary classification. Specifically, we introduce sparsity inducing penalties over parameter differences of related logistic regression models to encode similarity across related tasks. The resulting joint learning task is cast into a form that lends itself to be efficiently optimized with a recursive variant of the alternating direction method of multipliers. We show results on synthetic data and describe the regime of settings where our multi-task approach achieves significant improvements over the single task learning approach and discuss the implications on applying the fused logistic regression in different real world settings.

Training large machine learning (ML) models with many variables or parameters can take a long time if one employs sequential procedures even with stochastic updates. A natural solution is to turn to distributed computing on a cluster; however, naive, unstructured parallelization of ML algorithms does not usually lead to a proportional speedup and can even result in divergence, because dependencies between model elements can attenuate the computational gains from parallelization and compromise correctness of inference. Recent efforts toward this issue have benefited from exploiting the static, a priori block structures residing in ML algorithms. In this paper, we take this path further by exploring the dynamic block structures and workloads therein present during ML program execution, which offers new opportunities for improving convergence, correctness, and load balancing in distributed ML. We propose and showcase a general-purpose scheduler, STRADS, for coordinating distributed updates in ML algorithms, which harnesses the aforementioned opportunities in a 1 systematic way. We provide theoretical guarantees for our scheduler, and demonstrate its efficacy versus static block structures on Lasso and Matrix Factorization. 1. INTRODUCTION Sensory techniques and digital storage media have improved at a breakneck pace, leading to massive collections of data. The resultant so-called Big Data problems have been a common focus in recent enthusiasms toward scalable machine learning, and numerous algorithmic and system solutions have been proposed to alleviate the time-bottleneck due to Big Data by exploring various heuristic or principled strategies for data parallelism [3, 18, 20, 28].

Problems in machine learning (ML) can involve noisy input data, and ML classification methods have reached limiting accuracies when based on standard ML data sets consisting of feature vectors and their classes. Greater accuracy will require incorporation of prior structural information on data into learning. We study methods to regularize feature vectors (unsupervised regularization methods), analogous to supervised regularization for estimating functions in ML. We study regularization (denoising) of ML feature vectors using Tikhonov and other regularization methods for functions on ${\bf R}^n$. A feature vector ${\bf x}=(x_1,\ldots,x_n)=\{x_q\}_{q=1}^n$ is viewed as a function of its index $q$, and smoothed using prior information on its structure. This can involve a penalty functional on feature vectors analogous to those in statistical learning, or use of proximity (e.g. graph) structure on the set of indices. Such feature vector regularization inherits a property from function denoising on ${\bf R}^n$, in that accuracy is non-monotonic in the denoising (regularization) parameter $\alpha$. Under some assumptions about the noise level and the data structure, we show that the best reconstruction accuracy also occurs at a finite positive $\alpha$ in index spaces with graph structures. We adapt two standard function denoising methods used on ${\bf R}^n$, local averaging and kernel regression. In general the index space can be any discrete set with a notion of proximity, e.g. a metric space, a subset of ${\bf R}^n$, or a graph/network, with feature vectors as functions with some notion of continuity. We show this improves feature vector recovery, and thus the subsequent classification or regression done on them. We give an example in gene expression analysis for cancer classification with the genome as an index space and network structure based protein-protein interactions.