The use of high-fidelity computational simulations promises to enable high-throughput hypothesis testing and optimisation of cancer therapies. However, increasing realism comes at the cost of increasing computational requirements. This article explores the use of surrogate-assisted evolutionary algorithms to optimise the targeted delivery of a therapeutic compound to cancerous tumour cells with the multicellular simulator, PhysiCell. The use of both Gaussian process models and multi-layer perceptron neural network surrogate models are investigated. We find that evolutionary algorithms are able to effectively explore the parameter space of biophysical properties within the agent-based simulations, minimising the resulting number of cancerous cells after a period of simulated treatment. Both model-assisted algorithms are found to outperform a standard evolutionary algorithm, demonstrating their ability to perform a more effective search within the very small evaluation budget. This represents the first use of efficient evolutionary algorithms within a high-throughput multicellular computing approach to find therapeutic design optima that maximise tumour regression.

This paper proposes a novel landscape smoothing method for the symmetric Traveling Salesman Problem (TSP). We first define the homotopic convex (HC) transformation of a TSP as a convex combination of a well-constructed simple TSP and the original TSP. We observe that controlled by the coefficient of the convex combination, (i) the landscape of the HC transformed TSP is smoothed in terms that its number of local optima is reduced compared to the original TSP; (ii) the fitness distance correlation of the HC transformed TSP is increased. We then propose an iterative algorithmic framework in which the proposed HC transformation is combined with a heuristic TSP solver. It works as an escaping scheme from local optima for improving the global search ability of the combined heuristic. A case study with the 3-Opt local search as the heuristic solver shows that the resultant algorithm significantly outperforms iterated local search and two other smoothing-based TSP heuristic solvers on most of commonly-used test instances.

In this work we focus on fine-tuning a pre-trained BERT model and applying it to patent classification. When applied to large datasets of over two millions patents, our approach outperforms the state of the art by an approach using CNN with word embeddings. In addition, we focus on patent claims without other parts in patent documents. Our contributions include: (1) a new state-of-the-art method based on pre-trained BERT model and fine-tuning for patent classification, (2) a large dataset USPTO-3M at the CPC subclass level with SQL statements that can be used by future researchers, (3) showing that patent claims alone are sufficient for classification task, in contrast to conventional wisdom.

Increasing urban concentration raises operational challenges that can benefit from integrated monitoring and decision support. Such complex systems need to leverage the full stack of analytical methods, from state estimation using multi-sensor fusion for situational awareness, to prediction and computation of optimal responses. The FASTER platform that we describe in this work, deployed at nation scale and handling 1.5 billion public transport trips a year, offers such a full stack of techniques for this large-scale, real-time problem. FASTER provides fine-grained situational awareness and real-time decision support with the objective of improving the public transport commuter experience. The methods employed range from statistical machine learning to agent-based simulation and mixed-integer optimization. In this work we present an overview of the challenges and methods involved, with details of the commuter movement prediction module, as well as a discussion of open problems.

The ability to estimate task difficulty is critical for many real-world decisions such as setting appropriate goals for ourselves or appreciating others' accomplishments. Here we give a computational account of how humans judge the difficulty of a range of physical construction tasks (e.g., moving 10 loose blocks from their initial configuration to their target configuration, such as a vertical tower) by quantifying two key factors that influence construction difficulty: physical effort and physical risk. Physical effort captures the minimal work needed to transport all objects to their final positions, and is computed using a hybrid task-and-motion planner. Physical risk corresponds to stability of the structure, and is computed using noisy physics simulations to capture the costs for precision (e.g., attention, coordination, fine motor movements) required for success. We show that the full effort-risk model captures human estimates of difficulty and construction time better than either component alone.

We propose moment-based variational inference as a flexible framework for approximate smoothing of latent Markov jump processes. The main ingredient of our approach is to partition the set of all transitions of the latent process into classes. This allows to express the Kullback-Leibler divergence between the approximate and the exact posterior process in terms of a set of moment functions that arise naturally from the chosen partition. To illustrate possible choices of the partition, we consider special classes of jump processes that frequently occur in applications. We then extend the results to parameter inference and demonstrate the method on several examples.

In the context of Industry 4.0, data management is a key point for decision aid approaches. Large amounts of manufacturing digital data are collected on the shop floor. Their analysis can then require a large amount of computing power. The Big Data issue can be solved by aggregation, generating smart and meaningful data. This paper presents a new knowledge-based multi-level aggregation strategy to support decision making. Manufacturing knowledge is used at each level to design the monitoring criteria or aggregation operators. The proposed approach has been implemented as a demonstrator and successfully applied to a real machining database from the aeronautic industry. Decision Making; Machining; Knowledge based system

We describe a method to infer dense depth from camera motion and sparse depth as estimated using a visual-inertial odometry system. Unlike other scenarios using point clouds from lidar or structured light sensors, we have few hundreds to few thousand points, insufficient to inform the topology of the scene. Our method first constructs a piecewise planar scaffolding of the scene, and then uses it to infer dense depth using the image along with the sparse points. We use a predictive cross-modal criterion, akin to `self-supervision,' measuring photometric consistency across time, forward-backward pose consistency, and geometric compatibility with the sparse point cloud. We also launch the first visual-inertial + depth dataset, which we hope will foster additional exploration into combining the complementary strengths of visual and inertial sensors. To compare our method to prior work, we adopt the unsupervised KITTI depth completion benchmark, and show state-of-the-art performance on it.

We propose a novel procedure which adds "content-addressability" to any given unconditional implicit model e.g., a generative adversarial network (GAN). The procedure allows users to control the generative process by specifying a set (arbitrary size) of desired examples based on which similar samples are generated from the model. The proposed approach, based on kernel mean matching, is applicable to any generative models which transform latent vectors to samples, and does not require retraining of the model. Experiments on various high-dimensional image generation problems (CelebA-HQ, LSUN bedroom, bridge, tower) show that our approach is able to generate images which are consistent with the input set, while retaining the image quality of the original model. To our knowledge, this is the first work that attempts to construct, at test time, a content-addressable generative model from a trained marginal model.

This paper develops a new deep neural network optimized equalization framework for massive multiple input multiple output orthogonal frequency division multiplexing (MIMO-OFDM) systems that employ low-resolution analog-to-digital converters (ADCs) at the base station (BS). The use of low-resolution ADCs could largely reduce hardware complexity and circuit power consumption, however, makes the channel station information almost blind to the BS, hence causing difficulty in solving the equalization problem. In this paper, we consider a supervised learning architecture, where the goal is to learn a representative function that can predict the targets (constellation points) from the inputs (outputs of the low-resolution ADCs) based on the labeled training data (pilot signals). Specially, our main contributions are two-fold: 1) First, we design a new activation function, whose outputs are close to the constellation points when the parameters are finally optimized, to help us fully exploit the stochastic gradient descent method for the discrete optimization problem. 2) Second, an unsupervised loss is designed and then added to the optimization objective, aiming to enhance the representation ability (so-called generalization). The experimental results reveal that the proposed equalizer is robust to different channel taps (i.e., Gaussian, and Poisson), significantly outperforms the linearized MMSE equalizer, and shows potential for pilot saving.