Background and Purpose: Biopsy is the main determinants of glioma clinical management, but require invasive sampling that fail to detect relevant features because of tumor heterogeneity. The purpose of this study was to evaluate the accuracy of a voxel-wise, multiparametric MRI radiomic method to predict features and develop a minimally invasive method to objectively assess neoplasms. Methods: Multiparametric MRI were registered to T1-weighted gadolinium contrast-enhanced data using a 12 degree-of-freedom affine model. The retrospectively collected MRI data included T1-weighted, T1-weighted gadolinium contrast-enhanced, T2-weighted, fluid attenuated inversion recovery, and multi-b-value diffusion-weighted acquired at 1.5T or 3.0T. Clinical experts provided voxel-wise annotations for five disease states on a subset of patients to establish a training feature vector of 611,930 observations. Then, a k-nearest-neighbor (k-NN) classifier was trained using a 25% hold-out design. The trained k-NN model was applied to 13,018,171 observations from seventeen histologically confirmed glioma patients. Linear regression tested overall survival (OS) relationship to predicted disease compositions (PDC) and diagnostic age (alpha = 0.05). Canonical discriminant analysis tested if PDC and diagnostic age could differentiate clinical, genetic, and microscopic factors (alpha = 0.05). Results: The model predicted voxel annotation class with a Dice similarity coefficient of 94.34% +/- 2.98. Linear combinations of PDCs and diagnostic age predicted OS (p = 0.008), grade (p = 0.014), and endothelia proliferation (p = 0.003); but fell short predicting gene mutations for TP53BP1 and IDH1. Conclusions: This voxel-wise, multi-parametric MRI radiomic strategy holds potential as a non-invasive decision-making aid for clinicians managing patients with glioma.

A central challenge in multi-agent reinforcement learning is the induction of coordination between agents of a team. In this work, we investigate how to promote inter-agent coordination and discuss two possible avenues based respectively on inter-agent modelling and guided synchronized sub-policies. We test each approach in four challenging continuous control tasks with sparse rewards and compare them against three variants of MADDPG, a state-of-the-art multi-agent reinforcement learning algorithm. To ensure a fair comparison, we rely on a thorough hyper-parameter selection and training methodology that allows a fixed hyper-parameter search budget for each algorithm and environment. We consequently assess both the hyper-parameter sensitivity, sample-efficiency and asymptotic performance of each learning method. Our experiments show that our proposed algorithms are more robust to the hyper-parameter choice and reliably lead to strong results.

Recently, the field of adversarial machine learning has been garnering attention by showing that state-of-the-art deep neural networks are vulnerable to adverserial examples, stemming from small perturbations being added to the input image. Adversarial examples are generated by a malicious adversary by obtaining access to the model parameters, such as gradient information, to alter the input or by attacking a substitute model and transferring those malicious examples over to attack the victim model. Specifically, one of these attack algorithms, Robust Physical Perturbations ($RP_2$), generates adverserial images of stop signs with black and white stickers to achieve high targeted misclassification rates against standard-architecture traffic sign classifiers. In this paper, we propose BlurNet, a defense against the $RP_2$ attack. First, we motivate the defense with a frequency analysis of the first layer feature maps of the network on the LISA dataset by demonstrating high frequency noise is introduced into the input image by the $RP_2$ algorithm. To alleviate the high frequency, we introduce a depthwise convolution layer of standard blur kernels after the first layer. Finally, we present a regularization scheme to incorporate this low-pass filtering behavior into the training regime of the network.

The DANE algorithm is an approximate Newton method popularly used for communication-efficient distributed machine learning. Reasons for the interest in DANE include scalability and versatility. Convergence of DANE, however, can be tricky; its appealing convergence rate is only rigorous for quadratic objective, and for more general convex functions the known results are no stronger than those of the classic first-order methods. To remedy these drawbacks, we propose in this paper some new alternatives of DANE which are more suitable for analysis. We first introduce a simple variant of DANE equipped with backtracking line search, for which global asymptotic convergence and sharper local non-asymptotic convergence rate guarantees can be proved for both quadratic and non-quadratic strongly convex functions. Then we propose a heavy-ball method to accelerate the convergence of DANE, showing that nearly tight local rate of convergence can be established for strongly convex functions, and with proper modification of algorithm the same result applies globally to linear prediction models. Numerical evidence is provided to confirm the theoretical and practical advantages of our methods.

Bayesian Network Based Label Correlation Analysis For Multi-label Classifier Chain Ran Wang 1,2, Suhe Ye 1,2, Ke Li 3 and Sam Kwong 4 1 College of Mathematics and Statistics, Shenzhen University, Shenzhen 518060, China. 2 Shenzhen Key Laboratory of Advanced Machine Learning and Applications, Shenzhen University, Shenzhen 518060, China. Abstract: Classifier chain (CC) is a multi-label learning approach that constructs a sequence of binary classifiers according to a label order. Each classifier in the sequence is responsible for predicting the relevance of one label. When training the classifier for a label, proceeding labels will be taken as extended features. If the extended features are highly correlated to the label, the performance will be improved, otherwise, the performance will not be influenced or even degraded. How to discover label correlation and determine the label order is critical for CC approach. This paper employs Bayesian network (BN) to model the label correlations and proposes a new BN-based CC method (BNCC). First, conditional entropy is used to describe the dependency relations among labels. Then, a BN is built up by taking nodes as labels and weights of edges as their dependency relations. A new scoring function is proposed to evaluate a BN structure, and a heuristic algorithm is introduced to optimize the BN. At last, by applying topological sorting on the nodes of the optimized BN, the label order for constructing CC model is derived. Experimental comparisons demonstrate the feasibility and effectiveness of the proposed method.

A new and an enriched JPEG algorithm is provided for identifying redundancies in a sequence of irregular noisy data points which also accommodates a reference-free criterion function. Our main contribution is by formulating analytically (instead of approximating) the inverse of the transpose of JPEGwavelet transform without involving matrices which are computationally cumbersome. The algorithm is suitable for the widely-spread situations where the original data distribution is unobservable such as in cases where there is deficient representation of the entire population in the training data (in machine learning) and thus the covariate shift assumption is violated. The proposed estimator corrects for both biases, the one generated by endogenous truncation and the one generated by endogenous covariates. Results from utilizing 2,000,000 different distribution functions verify the applicability and high accuracy of our procedure to cases in which the disturbances are neither jointly nor marginally normally distributed.

Graph clustering is a basic technique in machine learning, and has widespread applications in different domains. While spectral techniques have been successfully applied for clustering undirected graphs, the performance of spectral clustering algorithms for directed graphs (digraphs) is not in general satisfactory: these algorithms usually require symmetrising the matrix representing a digraph, and typical objective functions for undirected graph clustering do not capture cluster-structures in which the information given by the direction of the edges is crucial. To overcome these downsides, we propose a spectral clustering algorithm based on a complex-valued matrix representation of digraphs. We analyse its theoretical performance on a Stochastic Block Model for digraphs in which the cluster-structure is given not only by variations in edge densities, but also by the direction of the edges. The significance of our work is highlighted on a data set pertaining to internal migration in the United States: while previous spectral clustering algorithms for digraphs can only reveal that people are more likely to move between counties that are geographically close, our approach is able to cluster together counties with a similar socio-economical profile even when they are geographically distant, and illustrates how people tend to move from rural to more urbanised areas.

Architectures for sparse hierarchical representation learning have recently been proposed for graph-structured data, but so far assume the absence of edge features in the graph. We close this gap and propose a method to pool graphs with edge features, inspired by the hierarchical nature of chemistry. In particular, we introduce two types of pooling layers compatible with an edge-feature graph-convolutional architecture and investigate their performance for molecules relevant to drug discovery on a set of two classification and two regression benchmark datasets of MoleculeNet. We find that our models significantly outperform previous benchmarks on three of the datasets and reach state-of-the-art results on the fourth benchmark, with pooling improving performance for three out of four tasks, keeping performance stable on the fourth task, and generally speeding up the training process.

When applying principal component analysis (PCA) for dimension reduction, the most varying projections are usually used in order to retain most of the information. For the purpose of anomaly and change detection, however, the least varying projections are often the most important ones. In this article, we present a novel method that automatically tailors the choice of projections to monitor for sparse changes in the mean and/or covariance matrix of high-dimensional data. A subset of the least varying projections is almost always selected based on a criteria of the projection's sensitivity to changes. Our focus is on online/sequential change detection, where the aim is to detect changes as quickly as possible, while controlling false alarms at a specified level. A combination of tailored PCA and a generalized log-likelihood monitoring procedure displays high efficiency in detecting even very sparse changes in the mean, variance and correlation. We demonstrate on real data that tailored PCA monitoring is efficient for sparse change detection also when the data streams are highly auto-correlated and non-normal. Notably, error control is achieved without a large validation set, which is needed in most existing methods.

An algorithm used to extract HMM parameters is revisited. Most parts of the extraction process are taken from implemented Hidden Markov Toolkit (HTK) program under name HInit. The algorithm itself shows a few variations compared to another domain of implementations. The HMM model is introduced briefly based on the theory of Discrete Time Markov Chain. We schematically outline the Viterbi method implemented in HTK. Iterative definition of the method which is ready to be implemented in computer programs is reviewed. We also illustrate the method calculation precisely using manual calculation and extensive graphical illustration. The distribution of observation probability used is simply independent Gaussians r.v.s. The purpose of the content is not to justify the performance or accuracy of the method applied in a specific area. This writing merely to describe how the algorithm is performed. The whole content should enlighten the audience the insight of the Viterbi Extraction method used by HTK.