Game development is a complex task involving multiple disciplines and technologies. Developers and researchers alike have suggested that AI-driven game design assistants may improve developer workflow. We present a recommender system for assisting humans in game design as well as a rigorous human subjects study to validate it. The AI-driven game design assistance system suggests game mechanics to designers based on characteristics of the game being developed. We believe this method can bring creative insights and increase users' productivity. We conducted quantitative studies that showed the recommender system increases users' levels of accuracy and computational affect, and decreases their levels of workload.

MEx: Multi-modal Exercises Dataset is a multi-sensor, multi-modal dataset, implemented to benchmark Human Activity Recognition(HAR) and Multi-modal Fusion algorithms. Collection of this dataset was inspired by the need for recognising and evaluating quality of exercise performance to support patients with Musculoskeletal Disorders(MSD). We select 7 exercises regularly recommended for MSD patients by physiotherapists and collected data with four sensors a pressure mat, a depth camera and two accelerometers. The dataset contains three data modalities; numerical time-series data, video data and pressure sensor data posing interesting research challenges when reasoning for HAR and Exercise Quality Assessment. This paper presents our evaluation of the dataset on number of standard classification algorithms for the HAR task by comparing different feature representation algorithms for each sensor. These results set a reference performance for each individual sensor that expose their strengths and weaknesses for the future tasks. In addition we visualise pressure mat data to explore the potential of the sensor to capture exercise performance quality. With the recent advancement in multi-modal fusion, we also believe MEx is a suitable dataset to benchmark not only HAR algorithms, but also fusion algorithms of heterogeneous data types in multiple application domains.

With the increasing complexity of CPSs, their behavior and decisions become increasingly difficult to understand and comprehend for users and other stakeholders. Our vision is to build self-explainable systems that can, at run-time, answer questions about the system's past, current, and future behavior. As hitherto no design methodology or reference framework exists for building such systems, we propose the MAB-EX framework for building self-explainable systems that leverage requirements- and explainability models at run-time. The basic idea of MAB-EX is to first Monitor and Analyze a certain behavior of a system, then Build an explanation from explanation models and convey this EXplanation in a suitable way to a stakeholder. We also take into account that new explanations can be learned, by updating the explanation models, should new and yet un-explainable behavior be detected by the system.

Machine learning algorithms learn from data and use data from databases that are mutable; therefore, the data and the results of machine learning cannot be fully trusted. Also, the machine learning process is often difficult to automate. A unified analytical framework for trustable machine learning has been presented in the literature. It proposed building a trustable machine learning system by using blockchain technology, which can store data in a permanent and immutable way. In addition, smart contracts on blockchain are used to automate the machine learning process. In the proposed framework, a core machine learning algorithm can have three implementations: server layer implementation, streaming layer implementation, and smart contract implementation. However, there are still open questions. First, the streaming layer usually deploys on edge devices and therefore has limited memory and computing power. How can we run machine learning on the streaming layer? Second, most data that are stored on blockchain are financial transactions, for which fraud detection is often needed. However, in some applications, training data are hard to obtain. Can we build good machine learning models to do fraud detection with limited training data? These questions motivated this paper; which makes two contributions. First, it proposes training a machine learning model on the server layer and saving the model with a special binary data format. Then, the streaming layer can take this blob of binary data as input and score incoming data online. The blob of binary data is very compact and can be deployed on edge devices. Second, the paper presents a new method of synthetic data generation that can enrich the training data set. Experiments show that this synthetic data generation is very effective in applications such as fraud detection in financial data.

--Automated machine learning has gained a lot of attention recently. Building and selecting the right machine learning models is often a multi-objective optimization problem. General purpose machine learning software that simultaneously supports multiple objectives and constraints is scant, though the potential benefits are great. In this work, we present a framework called Autotune that effectively handles multiple objectives and constraints that arise in machine learning problems. Autotune is built on a suite of derivative-free optimization methods, and utilizes multilevel parallelism in a distributed computing environment for automatically training, scoring, and selecting good models. Incorporation of multiple objectives and constraints in the model exploration and selection process provides the flexibility needed to satisfy tradeoffs necessary in practical machine learning applications. Experimental results from standard multi-objective optimization benchmark problems show that Autotune is very efficient in capturing Pareto fronts. These benchmark results also show how adding constraints can guide the search to more promising regions of the solution space, ultimately producing more desirable Pareto fronts. Results from two real-world case studies demonstrate the effectiveness of the constrained multi-objective optimization capability offered by Autotune. There has been increasing interest in automated machine learning (AutoML) for improving data scientists' productivity and reducing the cost of model building. A number of general or specialized AutoML systems have been developed [1]- [7], showing impressive results in creating good models with much less manual effort. Most of these systems only support a single objective, typically accuracy or error, to assess and compare models during the automation process.

In this work we develop a distributed least squares approximation (DLSA) method, which is able to solve a large family of regression problems (e.g., linear regression, logistic regression, Cox's model) on a distributed system. By approximating the local objective function using a local quadratic form, we are able to obtain a combined estimator by taking a weighted average of local estimators. The resulting estimator is proved to be statistically as efficient as the global estimator. In the meanwhile it requires only one round of communication. We further conduct the shrinkage estimation based on the DLSA estimation by using an adaptive Lasso approach. The solution can be easily obtained by using the LARS algorithm on the master node. It is theoretically shown that the resulting estimator enjoys the oracle property and is selection consistent by using a newly designed distributed Bayesian Information Criterion (DBIC). The finite sample performance as well as the computational efficiency are further illustrated by extensive numerical study and an airline dataset. The airline dataset is 52GB in memory size. The entire methodology has been implemented by Python for a de-facto standard Spark system. By using the proposed DLSA algorithm on the Spark system, it takes 26 minutes to obtain a logistic regression estimator whereas a full likelihood algorithm takes 15 hours to reaches an inferior result.

Significant progress has been made using fMRI to characterize the brain changes that occur in ASD, a complex neuro-developmental disorder. However, due to the high dimensionality and low signal-to-noise ratio of fMRI, embedding informative and robust brain regional fMRI representations for both graph-level classification and region-level functional difference detection tasks between ASD and healthy control (HC) groups is difficult. Here, we model the whole brain fMRI as a graph, which preserves geometrical and temporal information and use a Graph Neural Network (GNN) to learn from the graph-structured fMRI data. We investigate the potential of including mutual information (MI) loss (Infomax), which is an unsupervised term encouraging large MI of each nodal representation and its corresponding graph-level summarized representation to learn a better graph embedding. Specifically, this work developed a pipeline including a GNN encoder, a classifier and a discriminator, which forces the encoded nodal representations to both benefit classification and reveal the common nodal patterns in a graph. We simultaneously optimize graph-level classification loss and Infomax. We demonstrated that Infomax graph embedding improves classification performance as a regularization term. Furthermore, we found separable nodal representations of ASD and HC groups in prefrontal cortex, cingulate cortex, visual regions, and other social, emotional and execution related brain regions. In contrast with GNN with classification loss only, the proposed pipeline can facilitate training more robust ASD classification models. Moreover, the separable nodal representations can detect the functional differences between the two groups and contribute to revealing new ASD biomarkers.

In causal inference, a variety of causal effect estimands have been studied, including the sample, uncensored, target, conditional, optimal subpopulation, and optimal weighted average treatment effects. Ad-hoc methods have been developed for each estimand based on inverse probability weighting (IPW) and on outcome regression modeling, but these may be sensitive to model misspecification, practical violations of positivity, or both. The contribution of this paper is twofold. First, we formulate the generalized average treatment effect (GATE) to unify these causal estimands as well as their IPW estimates. Second, we develop a method based on Kernel Optimal Matching (KOM) to optimally estimate GATE and to find the GATE most easily estimable by KOM, which we term the Kernel Optimal Weighted Average Treatment Effect. KOM provides uniform control on the conditional mean squared error of a weighted estimator over a class of models while simultaneously controlling for precision. We study its theoretical properties and evaluate its comparative performance in a simulation study. We illustrate the use of KOM for GATE estimation in two case studies: comparing spine surgical interventions and studying the effect of peer support on people living with HIV.

Many real-world prediction tasks have outcome (a.k.a.~target or response) variables that have characteristic heavy-tail distributions. Examples include copies of books sold, auction prices of art pieces, etc. By learning heavy-tailed distributions, ``big and rare'' instances (e.g., the best-sellers) will have accurate predictions. Most existing approaches are not dedicated to learning heavy-tailed distribution; thus, they heavily under-predict such instances. To tackle this problem, we introduce \emph{Learning to Place} (\texttt{L2P}), which exploits the pairwise relationships between instances to learn from a proportionally higher number of rare instances. \texttt{L2P} consists of two stages. In Stage 1, \texttt{L2P} learns a pairwise preference classifier: \textit{is instance A $>$ instance B?}. In Stage 2, \texttt{L2P} learns to place a new instance into an ordinal ranking of known instances. Based on its placement, the new instance is then assigned a value for its outcome variable. Experiments on real data show that \texttt{L2P} outperforms competing approaches in terms of accuracy and capability to reproduce heavy-tailed outcome distribution. In addition, \texttt{L2P} can provide an interpretable model with explainable outcomes by placing each predicted instance in context with its comparable neighbors.

Maintaining good cardiac function for as long as possible is a major concern for healthcare systems worldwide and there is much interest in learning more about the impact of different risk factors on cardiac health. The aim of this study is to analyze the impact of systolic blood pressure (SBP) on cardiac function while preserving the interpretability of the model using known clinical biomarkers in a large cohort of the UK Biobank population. We propose a novel framework that combines deep learning based estimation of interpretable clinical biomarkers from cardiac cine MR data with a variational autoencoder (VAE). The VAE architecture integrates a regression loss in the latent space, which enables the progression of cardiac health with SBP to be learnt. Results on 3,600 subjects from the UK Biobank show that the proposed model allows us to gain important insight into the deterioration of cardiac function with increasing SBP, identify key interpretable factors involved in this process, and lastly exploit the model to understand patterns of positive and adverse adaptation of cardiac function.