Former FDA Commissioner Dr. Scott Gottlieb stressed the need for modernizing the clinical trials process in a speech to the Bipartisan Policy Center in January of this year.1 He is quoted as saying, "digital technologies are one of our most promising tools for making healthcare more efficient." Improving efficiency in clinical trial development is only one potential enhancement that can result from the use of machine learning. Machine learning and artificial intelligence (AI) are often used interchangeably, but that assumption is incorrect. Machine learning is the subset of AI that is related to the development of algorithms that can make accurate predictions of future outcomes via pattern recognition and rules-based logic. Such use of logic and algorithms can improve patient selection, provide predictive long-term outcomes, and reduce the time and cost in the execution of clinical trials.

Despite the recent advancement in the social robotic field, important limitations restrain its progress and delay the application of robots in everyday scenarios. In the present paper, we propose to develop computational models inspired by our knowledge of human infants' social adaptive abilities. We believe this may provide solutions at an architectural level to overcome the limits of current systems. Specifically, we present the functional advantages that adaptive Theory of Mind (ToM) systems would support in robotics (i.e., mentalizing for belief understanding, proactivity and preparation, active perception and learning) and contextualize them in practical applications. We review current computational models mainly based on the simulation and teleological theories, and robotic implementations to identify the limitations of ToM functions in current robotic architectures and suggest a possible future developmental pathway. Finally, we propose future studies to create innovative computational models integrating the properties of the simulation and teleological approaches for an improved adaptive ToM ability in robots with the aim of enhancing human-robot interactions and permitting the application of robots in unexplored environments, such as disasters and construction sites. To achieve this goal, we suggest directing future research towards the modern cross-talk between the fields of robotics and developmental psychology.

In recent years, there has been a surge of interests in interpretable graph reasoning methods. However, these models often suffer from limited performance when working on sparse and incomplete graphs, due to the lack of evidential paths that can reach target entities. Here we study open knowledge graph reasoning---a task that aims to reason for missing facts over a graph augmented by a background text corpus. A key challenge of the task is to filter out "irrelevant" facts extracted from corpus, in order to maintain an effective search space during path inference. We propose a novel reinforcement learning framework to train two collaborative agents jointly, i.e., a multi-hop graph reasoner and a fact extractor. The fact extraction agent generates fact triples from corpora to enrich the graph on the fly; while the reasoning agent provides feedback to the fact extractor and guides it towards promoting facts that are helpful for the interpretable reasoning. Experiments on two public datasets demonstrate the effectiveness of the proposed approach. Source code and datasets used in this paper can be downloaded at https://github.com/shanzhenren/CPL

The goal is to detect the OOD cases with limited in-domain (ID) training data, since we observe that training data is often insufficient in machine learning applications. In this work, we propose an OOD-resistant Prototypical Network to tackle this zero-shot OOD detection and few-shot ID classification task. Evaluation on real-world datasets show that the proposed solution outperforms state-of-the-art methods in zero-shot OOD detection task, while maintaining a competitive performance on ID classification task. 1 Introduction Text classification tasks in real-world applications often consists of 2 components-In-Doman (ID) classification and Out-of-Domain (OOD) detection components (Liao et al., 2018; Kim and Kim, 2018; Shu et al., 2017; Shamekhi et al., 2018). ID classification refers to classifying a user's input with a label that exists in the training data, and OOD detection refers to designate a special OOD tag to the input when it does not belong to any of the labels in the ID training dataset (Dai et al., 2007). Recent state-of-the-art deep learning (DL) approaches for OOD detection and ID classification task often require massive amounts of ID or OOD labeled data (Kim and Kim, 2018).

Cancer is a complex disease, the understanding and treatment of which are being aided through increases in the volume of collected data and in the scale of deployed computing power. Consequently, there is a growing need for the development of data-driven and, in particular, deep learning methods for various tasks such as cancer diagnosis, detection, prognosis, and prediction. Despite recent successes, however, designing high-performing deep learning models for nonimage and nontext cancer data is a time-consuming, trial-and-error, manual task that requires both cancer domain and deep learning expertise. To that end, we develop a reinforcement-learning-based neural architecture search to automate deep-learning-based predictive model development for a class of representative cancer data. We develop custom building blocks that allow domain experts to incorporate the cancer-data-specific characteristics. We show that our approach discovers deep neural network architectures that have significantly fewer trainable parameters, shorter training time, and accuracy similar to or higher than those of manually designed architectures. We study and demonstrate the scalability of our approach on up to 1,024 Intel Knights Landing nodes of the Theta supercomputer at the Argonne Leadership Computing Facility.

Accurately predicting patients' risk of 30-day hospital readmission would enable hospitals to efficiently allocate resource-intensive interventions. We develop a new method, Categorical Co-Frequency Analysis (CoFA), for clustering diagnosis codes from the International Classification of Diseases (ICD) according to the similarity in relationships between covariates and readmission risk. CoFA measures the similarity between diagnoses by the frequency with which two diagnoses are split in the same direction versus split apart in random forests to predict readmission risk. Applying CoFA to de-identified data from Berkshire Medical Center, we identified three groups of diagnoses that vary in readmission risk. To evaluate CoFA, we compared readmission risk models using ICD majors and CoFA groups to a baseline model without diagnosis variables. We found substituting ICD majors for the CoFA-identified clusters simplified the model without compromising the accuracy of predictions. Fitting separate models for each ICD major and CoFA group did not improve predictions, suggesting that readmission risk may be more homogeneous that heterogeneous across diagnosis groups.

Crohn's disease, one of two inflammatory bowel diseases (IBD), affects 200,000 people in the UK alone, or roughly one in every 500. We explore the feasibility of deep learning algorithms for identification of terminal ileal Crohn's disease in Magnetic Resonance Enterography images on a small dataset. We show that they provide comparable performance to the current clinical standard, the MaRIA score, while requiring only a fraction of the preparation and inference time. Moreover, bowels are subject to high variation between individuals due to the complex and free-moving anatomy. Thus we also explore the effect of difficulty of the classification at hand on performance. Finally, we employ soft attention mechanisms to amplify salient local features and add interpretability.

Various strategies for active learning have been proposed in the machine learning literature. In uncertainty sampling, which is among the most popular approaches, the active learner sequentially queries the label of those instances for which its current prediction is maximally uncertain. The predictions as well as the measures used to quantify the degree of uncertainty, such as entropy, are almost exclusively of a probabilistic nature. In this paper, we advocate a distinction between two different types of uncertainty, referred to as epistemic and aleatoric, in the context of active learning. Roughly speaking, these notions capture the reducible and the irreducible part of the total uncertainty in a prediction, respectively. We conjecture that, in uncertainty sampling, the usefulness of an instance is better reflected by its epistemic than by its aleatoric uncertainty. This leads us to suggest the principle of "epistemic uncertainty sampling", which we instantiate by means of a concrete approach for measuring epistemic and aleatoric uncertainty. In experimental studies, epistemic uncertainty sampling does indeed show promising performance.

The large volume of text in electronic healthcare records often remains underused due to a lack of methodologies to extract interpretable content. Here we present an unsupervised framework for the analysis of free text that combines text-embedding with paragraph vectors and graph-theoretical multiscale community detection. We analyse text from a corpus of patient incident reports from the National Health Service in England to find content-based clusters of reports in an unsupervised manner and at different levels of resolution. Our unsupervised method extracts groups with high intrinsic textual consistency and compares well against categories hand-coded by healthcare personnel. We also show how to use our content-driven clusters to improve the supervised prediction of the degree of harm of the incident based on the text of the report. Finally, we discuss future directions to monitor reports over time, and to detect emerging trends outside pre-existing categories.

In this work, we focus on the task of Automatic Question Generation (AQG) where given a passage and an answer the task is to generate the corresponding question. It is desired that the generated question should be (i) grammatically correct (ii) answerable from the passage and (iii) specific to the given answer. An analysis of existing AQG models shows that they produce questions which do not adhere to one or more of {the above-mentioned qualities}. In particular, the generated questions look like an incomplete draft of the desired question with a clear scope for refinement. {To alleviate this shortcoming}, we propose a method which tries to mimic the human process of generating questions by first creating an initial draft and then refining it. More specifically, we propose Refine Network (RefNet) which contains two decoders. The second decoder uses a dual attention network which pays attention to both (i) the original passage and (ii) the question (initial draft) generated by the first decoder. In effect, it refines the question generated by the first decoder, thereby making it more correct and complete. We evaluate RefNet on three datasets, \textit{viz.}, SQuAD, HOTPOT-QA, and DROP, and show that it outperforms existing state-of-the-art methods by 7-16\% on all of these datasets. Lastly, we show that we can improve the quality of the second decoder on specific metrics, such as, fluency and answerability by explicitly rewarding revisions that improve on the corresponding metric during training. The code has been made publicly available \footnote{https://github.com/PrekshaNema25/RefNet-QG}