Pocket-size ultrasound devices that cost 50 times less than the machines in hospitals (and connect to your phone). These are just some of the innovations now transforming medicine at a remarkable pace. No one can predict the future, but it can at least be glimpsed in the dozen inventions and concepts below. Like the people behind them, they stand at the vanguard of health care. Neither exhaustive nor exclusive, the list is, rather, representative of the recasting of public health and medical science likely to come in the 2020s.

Real-world datasets are often biased with respect to key demographic factors such as race and gender. Due to the latent nature of the underlying factors, detecting and mitigating bias is especially challenging for unsupervised machine learning. We present a weakly supervised algorithm for overcoming dataset bias for deep generative models. Our approach requires access to an additional small, unlabeled but unbiased dataset as the supervision signal, thus sidestepping the need for explicit labels on the underlying bias factors. Using this supplementary dataset, we detect the bias in existing datasets via a density ratio technique and learn generative models which efficiently achieve the twin goals of: 1) data efficiency by using training examples from both biased and unbiased datasets for learning, 2) unbiased data generation at test time. Empirically, we demonstrate the efficacy of our approach which reduces bias w.r.t. latent factors by 57.1% on average over baselines for comparable image generation using generative adversarial networks.

Recent years have witnessed growing interest in machine learning-based models and techniques for low-dose X-ray CT (LDCT) imaging tasks. The methods can typically be categorized into supervised learning methods and unsupervised or model-based learning methods. Supervised learning methods have recently shown success in image restoration tasks. However, they often rely on large training sets. Model-based learning methods such as dictionary or transform learning do not require large or paired training sets and often have good generalization properties, since they learn general properties of CT image sets. Recent works have shown the promising reconstruction performance of methods such as PWLS-ULTRA that rely on clustering the underlying (reconstructed) image patches into a learned union of transforms. In this paper, we propose a new Supervised-UnsuPERvised (SUPER) reconstruction framework for LDCT image reconstruction that combines the benefits of supervised learning methods and (unsupervised) transform learning-based methods such as PWLS-ULTRA that involve highly image-adaptive clustering. The SUPER model consists of several layers, each of which includes a deep network learned in a supervised manner and an unsupervised iterative method that involves image-adaptive components. The SUPER reconstruction algorithms are learned in a greedy manner from training data. The proposed SUPER learning methods dramatically outperform both the constituent supervised learning-based networks and iterative algorithms for LDCT, and use much fewer iterations in the iterative reconstruction modules.

--Federated learning (FL) has recently emerged as a new form of collaborative machine learning, where a common model can be learned while keeping all the training data on local devices. Although it is designed for enhancing the data privacy, we demonstrated in this paper a new direction in inference attacks in the context of FL, where valuable information about training data can be obtained by adversaries with very limited power . In particular, we proposed three new types of attacks to exploit this vulnerability. The first type of attack, Class Sniffing, can detect whether a certain label appears in training. The other two types of attacks can determine the quantity of each label, i.e., Quantity Inference attack determines the composition proportion of the training label owned by the selected clients in a single round, while Whole Determination attack determines that of the whole training process. We evaluated our attacks on a variety of tasks and datasets with different settings, and the corresponding results showed that our attacks work well generally. Finally, we analyzed the impact of major hyper-parameters to our attacks and discussed possible defenses. The emergence of federated learning (FL) enables multiple devices to learn a common model while keeping all the training data on their own devices. It allows for less resource consumption on the cloud and ensures the privacy at the same time. Multiple applications have benefited from FL, including mobile phones [1, 2, 3], wearable devices [4, 5], autonomous vehicles [6, 7], etc. In standard federated learning, all participants are required to train their local models. A random subset of clients will be selected each round, who will upload their gradient updates to the central server. Similar FL architectures can be found in [8, 9, 10, 11, 12, 13]. One interesting question here is about the security and privacy implication in the FL training process. Any characteristic of clients' private data needs to be protected carefully since it may reveal some important private information about the training data - e.g., the distribution of labels might show the diversity of participants. Similarly, what the training data consists of is also what attackers want to explore, i.e., can they determine the quantity proportion of different labels in the whole training dataset during the training process?

ABSTRACT Label noise is emerging as a pressing issue in sound event classification. This arises as we move towards larger datasets that are difficult to annotate manually, but it is even more severe if datasets are collected automatically from online repositories, where labels are inferred through automated heuristics applied to the audio content or metadata. While learning from noisy labels has been an active area of research in computer vision, it has received little attention in sound event classification. Most recent computer vision approaches against label noise are relatively complex, requiring complex networks or extra data resources. In this work, we evaluate simple and efficient model-agnostic approaches to handling noisy labels when training sound event classifiers, namely label smoothing regularization, mixup and noise-robust loss functions. The main advantage of these methods is that they can be easily incorporated to existing deep learning pipelines without need for network modifications or extra resources. We report results from experiments conducted with the FSDnoisy18k dataset. We show that these simple methods can be effective in mitigating the effect of label noise, providing up to 2.5% of accuracy boost when incorporated to two different CNNs, while requiring minimal intervention and computational overhead.

Variational Autoencoders (VAE) are probabilistic deep generative models underpinned by elegant theory, stable training processes, and meaningful manifold representations. However, they produce blurry images due to a lack of explicit emphasis over high-frequency textural details of the images, and the difficulty to directly model the complex joint probability distribution over the high-dimensional image space. In this work, we approach these two challenges with a novel wavelet space VAE that uses the decoder to model the images in the wavelet coefficient space. This enables the VAE to emphasize over high-frequency components within an image obtained via wavelet decomposition. Additionally, by decomposing the complex function of generating high-dimensional images into inverse wavelet transformation and generation of wavelet coefficients, the latter becomes simpler to model by the VAE. We empirically validate that deep generative models operating in the wavelet space can generate images of higher quality than the image (RGB) space counterparts. Quantitatively, on benchmark natural image datasets, we achieve consistently better FID scores than VAE based architectures and competitive FID scores with a variety of GAN models for the same architectural and experimental setup. Furthermore, the proposed wavelet-based generative model retains desirable attributes like disentangled and informative latent representation without losing the quality in the generated samples.

Developing electrophysiological recordings of brain neuronal activity and their analysis provide a basis for exploring the structure of brain function and nervous system investigation. The recorded signals are typically a combination of spikes and noise. High amounts of background noise and possibility of electric signaling recording from several neurons adjacent to the recording site have led scientists to develop neuronal signal processing tools such as spike sorting to facilitate brain data analysis. Spike sorting plays a pivotal role in understanding the electrophysiological activity of neuronal networks. This process prepares recorded data for interpretations of neurons interactions and understanding the overall structure of brain functions. Spike sorting consists of three steps: spike detection, feature extraction, and spike clustering. There are several methods to implement each of spike sorting steps. This paper provides a systematic comparison of various spike sorting sub-techniques applied to real extracellularly recorded data from a rat brain basolateral amygdala. An efficient sorted data resulted from careful choice of spike sorting sub-methods leads to better interpretation of the brain structures connectivity under different conditions, which is a very sensitive concept in diagnosis and treatment of neurological disorders. Here, spike detection is performed by appropriate choice of threshold level via three different approaches. Feature extraction is done through PCA and Kernel PCA methods, which Kernel PCA outperforms. We have applied four different algorithms for spike clustering including K-means, Fuzzy C-means, Bayesian and Fuzzy maximum likelihood estimation. As one requirement of most clustering algorithms, optimal number of clusters is achieved through validity indices for each method. Finally, the sorting results are evaluated using inter-spike interval histograms.

Finding a code to unravel the population of neural responses that leads to a distinct animal behavior has been a long-standing question in the field of neuroscience. With the recent advances in machine learning, it is shown that the hierarchically Deep Neural Networks (DNNs) perform optimally in decoding unique features out of complex datasets. In this study, we utilize the power of a DNN to explore the computational principles in the mammalian brain by exploiting the Neuropixel data from Allen Brain Institute. We decode the neural responses from mouse visual cortex to predict the presented stimuli to the animal for natural (bear, trees, cheetah, etc.) and artificial (drifted gratings, orientated bars, etc.) classes. Our results indicate that neurons in mouse visual cortex encode the features of natural and artificial objects in a distinct manner, and such neural code is consistent across animals. We investigate this by applying transfer learning to train a DNN on the neural responses of a single animal and test its generalized performance across multiple animals. Within a single animal, DNN is able to decode the neural responses with as much as 100% classification accuracy. Across animals, this accuracy is reduced to 91%. This study demonstrates the potential of utilizing the DNN models as a computational framework to understand the neural coding principles in the mammalian brain.

Two types of zeroth-order stochastic algorithms have recently been designed for nonconvex optimization respectively based on the first-order techniques SVRG and SARAH/SPIDER. This paper addresses several important issues that are still open in these methods. First, all existing SVRG-type zeroth-order algorithms suffer from worse function query complexities than either zeroth-order gradient descent (ZO-GD) or stochastic gradient descent (ZO-SGD). In this paper, we propose a new algorithm ZO-SVRG-Coord-Rand and develop a new analysis for an existing ZO-SVRG-Coord algorithm proposed in Liu et al. 2018b, and show that both ZO-SVRG-Coord-Rand and ZO-SVRG-Coord (under our new analysis) outperform other exiting SVRG-type zeroth-order methods as well as ZO-GD and ZO-SGD. Second, the existing SPIDER-type algorithm SPIDER-SZO (Fang et al. 2018) has superior theoretical performance, but suffers from the generation of a large number of Gaussian random variables as well as a $\sqrt{\epsilon}$-level stepsize in practice. In this paper, we develop a new algorithm ZO-SPIDER-Coord, which is free from Gaussian variable generation and allows a large constant stepsize while maintaining the same convergence rate and query complexity, and we further show that ZO-SPIDER-Coord automatically achieves a linear convergence rate as the iterate enters into a local PL region without restart and algorithmic modification.

State-of-art deep neural networks (DNN) are vulnerable to attacks by adversarial examples: a carefully designed small perturbation to the input, that is imperceptible to human, can mislead DNN. To understand the root cause of adversarial examples, we quantify the probability of adversarial example existence for linear classifiers. Previous mathematical definition of adversarial examples only involves the overall perturbation amount, and we propose a more practical relevant definition of strong adversarial examples that separately limits the perturbation along the signal direction also. We show that linear classifiers can be made robust to strong adversarial examples attack in cases where no adversarial robust linear classifiers exist under the previous definition. The quantitative formulas are confirmed by numerical experiments using a linear support vector machine (SVM) classifier. The results suggest that designing general strong-adversarial-robust learning systems is feasible but only through incorporating human knowledge of the underlying classification problem.