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Toward an AI Reasoning-Enabled System for Patient-Clinical Trial Matching

arXiv.org Artificial Intelligence

Screening patients for clinical trial eligibility remains a manual, time - consuming, and resource-intensive process. W e present a secure, scalable proof-of - concept system for Artificial Intelligence ( AI)- augmented patient - trial matching that addresses key implementation challenges: integrating heterogeneous electronic health record (EHR) data, facilitating expert review, and maintaining rigorous security standards. Leveraging open-source, reasoning-enabled large language models (LLMs), the system moves beyond binary classification to generate structured eligibility assessments with interpretable reasoning chains that support human-in - the - loop review. This decision support tool represents eligibility as a dynamic state rather than a fixed determination, identifying matches whe n available and offering actionable recommendations that could render a patient eligible in the future . The system aims to reduce coordinator burden, intelligently broaden the set of trials considered for each patient and guarantee comprehensive auditability of all AI - generated outputs. Introduction Applications of artificial intelligence (AI) in healthcare are increasingly focused on improving administrative efficiency and optimizing clinical workflows . Identifying relevant trials and screening them for a particular patient is traditionally manual, time - consuming, and heavily reliant on clinical expertise.


FRIEDA: Benchmarking Multi-Step Cartographic Reasoning in Vision-Language Models

arXiv.org Artificial Intelligence

Cartographic reasoning is the skill of interpreting geographic relationships by aligning legends, map scales, compass directions, map texts, and geometries across one or more map images. Although essential as a concrete cognitive capability and for critical tasks such as disaster response and urban planning, it remains largely unevaluated. Building on progress in chart and infographic understanding, recent large vision language model studies on map visual question-answering often treat maps as a special case of charts. In contrast, map VQA demands comprehension of layered symbology (e.g., symbols, geometries, and text labels) as well as spatial relations tied to orientation and distance that often span multiple maps and are not captured by chart-style evaluations. To address this gap, we introduce FRIEDA, a benchmark for testing complex open-ended cartographic reasoning in LVLMs. FRIEDA sources real map images from documents and reports in various domains and geographical areas. Following classifications in Geographic Information System (GIS) literature, FRIEDA targets all three categories of spatial relations: topological (border, equal, intersect, within), metric (distance), and directional (orientation). All questions require multi-step inference, and many require cross-map grounding and reasoning. We evaluate eleven state-of-the-art LVLMs under two settings: (1) the direct setting, where we provide the maps relevant to the question, and (2) the contextual setting, where the model may have to identify the maps relevant to the question before reasoning. Even the strongest models, Gemini-2.5-Pro and GPT-5-Think, achieve only 38.20% and 37.20% accuracy, respectively, far below human performance of 84.87%. These results reveal a persistent gap in multi-step cartographic reasoning, positioning FRIEDA as a rigorous benchmark to drive progress on spatial intelligence in LVLMs.


Benchmarking Offline Multi-Objective Reinforcement Learning in Critical Care

arXiv.org Artificial Intelligence

In critical care settings such as the Intensive Care Unit, clinicians face the complex challenge of balancing conflicting objectives, primarily maximizing patient survival while minimizing resource utilization (e.g., length of stay). Single-objective Reinforcement Learning approaches typically address this by optimizing a fixed scalarized reward function, resulting in rigid policies that fail to adapt to varying clinical priorities. Multi-objective Reinforcement Learning (MORL) offers a solution by learning a set of optimal policies along the Pareto Frontier, allowing for dynamic preference selection at test time. However, applying MORL in healthcare necessitates strict offline learning from historical data. In this paper, we benchmark three offline MORL algorithms, Conditioned Conservative Pareto Q-Learning (CPQL), Adaptive CPQL, and a modified Pareto Efficient Decision Agent (PEDA) Decision Transformer (PEDA DT), against three scalarized single-objective baselines (BC, CQL, and DDQN) on the MIMIC-IV dataset. Using Off-Policy Evaluation (OPE) metrics, we demonstrate that PEDA DT algorithm offers superior flexibility compared to static scalarized baselines. Notably, our results extend previous findings on single-objective Decision Transformers in healthcare, confirming that sequence modeling architectures remain robust and effective when scaled to multi-objective conditioned generation. These findings suggest that offline MORL is a promising framework for enabling personalized, adjustable decision-making in critical care without the need for retraining.


DIJIT: A Robotic Head for an Active Observer

arXiv.org Artificial Intelligence

We present DIJIT, a novel binocular robotic head expressly designed for mobile agents that behave as active observers. DIJIT's unique breadth of functionality enables active vision research and the study of human-like eye and head-neck motions, their interrelationships, and how each contributes to visual ability. DIJIT is also being used to explore the differences between how human vision employs eye/head movements to solve visual tasks and current computer vision methods. DIJIT's design features nine mechanical degrees of freedom, while the cameras and lenses provide an additional four optical degrees of freedom. The ranges and speeds of the mechanical design are comparable to human performance. Our design includes the ranges of motion required for convergent stereo, namely, vergence, version, and cyclotorsion. The exploration of the utility of these to both human and machine vision is ongoing. Here, we present the design of DIJIT and evaluate aspects of its performance. We present a new method for saccadic camera movements. In this method, a direct relationship between camera orientation and motor values is developed. The resulting saccadic camera movements are close to human movements in terms of their accuracy.


A Comparative Study of EMG- and IMU-based Gesture Recognition at the Wrist and Forearm

arXiv.org Artificial Intelligence

Gestures are an integral part of our daily interactions with the environment. Hand gesture recognition (HGR) is the process of interpreting human intent through various input modalities, such as visual data (images and videos) and bio-signals. Bio-signals are widely used in HGR due to their ability to be captured non-invasively via sensors placed on the arm. Among these, surface electromyography (sEMG), which measures the electrical activity of muscles, is the most extensively studied modality. However, less-explored alternatives such as inertial measurement units (IMUs) can provide complementary information on subtle muscle movements, which makes them valuable for gesture recognition. In this study, we investigate the potential of using IMU signals from different muscle groups to capture user intent. Our results demonstrate that IMU signals contain sufficient information to serve as the sole input sensor for static gesture recognition. Moreover, we compare different muscle groups and check the quality of pattern recognition on individual muscle groups. We further found that tendon-induced micro-movement captured by IMUs is a major contributor to static gesture recognition. We believe that leveraging muscle micro-movement information can enhance the usability of prosthetic arms for amputees. This approach also offers new possibilities for hand gesture recognition in fields such as robotics, teleoperation, sign language interpretation, and beyond.


SkipKV: Selective Skipping of KV Generation and Storage for Efficient Inference with Large Reasoning Models

arXiv.org Artificial Intelligence

Large reasoning models (LRMs) often cost significant key-value (KV) cache overhead, due to their linear growth with the verbose chain-of-thought (CoT) reasoning process. This costs both memory and throughput bottleneck limiting their efficient deployment. Towards reducing KV cache size during inference, we first investigate the effectiveness of existing KV cache eviction methods for CoT reasoning. Interestingly, we find that due to unstable token-wise scoring and the reduced effective KV budget caused by padding tokens, state-of-the-art (SoTA) eviction methods fail to maintain accuracy in the multi-batch setting. Additionally, these methods often generate longer sequences than the original model, as semantic-unaware token-wise eviction leads to repeated revalidation during reasoning. To address these issues, we present \textbf{SkipKV}, a \textbf{\textit{training-free}} KV compression method for selective \textit{eviction} and \textit{generation} operating at a coarse-grained sentence-level sequence removal for efficient CoT reasoning. In specific, it introduces a \textit{sentence-scoring metric} to identify and remove highly similar sentences while maintaining semantic coherence. To suppress redundant generation, SkipKV dynamically adjusts a steering vector to update the hidden activation states during inference enforcing the LRM to generate concise response. Extensive evaluations on multiple reasoning benchmarks demonstrate the effectiveness of SkipKV in maintaining up to $\mathbf{26.7}\%$ improved accuracy compared to the alternatives, at a similar compression budget. Additionally, compared to SoTA, SkipKV yields up to $\mathbf{1.6}\times$ fewer generation length while improving throughput up to $\mathbf{1.7}\times$.


Bridging the Clinical Expertise Gap: Development of a Web-Based Platform for Accessible Time Series Forecasting and Analysis

arXiv.org Artificial Intelligence

Time series forecasting has applications across domains and industries, especially in healthcare, but the technical expertise required to analyze data, build models, and interpret results can be a barrier to using these techniques. This article presents a web platform that makes the process of analyzing and plotting data, training forecasting models, and interpreting and viewing results accessible to researchers and clinicians. Users can upload data and generate plots to showcase their variables and the relationships between them. The platform supports multiple forecasting models and training techniques which are highly customizable according to the user's needs. Additionally, recommendations and explanations can be generated from a large language model that can help the user choose appropriate parameters for their data and understand the results for each model. The goal is to integrate this platform into learning health systems for continuous data collection and inference from clinical pipelines.


A Gray Literature Study on Fairness Requirements in AI-enabled Software Engineering

arXiv.org Artificial Intelligence

Today, with the growing obsession with applying Artificial Intelligence (AI), particularly Machine Learning (ML), to software across various contexts, much of the focus has been on the effectiveness of AI models, often measured through common metrics such as F1- score, while fairness receives relatively little attention. This paper presents a review of existing gray literature, examining fairness requirements in AI context, with a focus on how they are defined across various application domains, managed throughout the Software Development Life Cycle (SDLC), and the causes, as well as the corresponding consequences of their violation by AI models. Our gray literature investigation shows various definitions of fairness requirements in AI systems, commonly emphasizing non-discrimination and equal treatment across different demographic and social attributes. Fairness requirement management practices vary across the SDLC, particularly in model training and bias mitigation, fairness monitoring and evaluation, and data handling practices. Fairness requirement violations are frequently linked, but not limited, to data representation bias, algorithmic and model design bias, human judgment, and evaluation and transparency gaps. The corresponding consequences include harm in a broad sense, encompassing specific professional and societal impacts as key examples, stereotype reinforcement, data and privacy risks, and loss of trust and legitimacy in AI-supported decisions. These findings emphasize the need for consistent frameworks and practices to integrate fairness into AI software, paying as much attention to fairness as to effectiveness.


CIP-Net: Continual Interpretable Prototype-based Network

arXiv.org Artificial Intelligence

Continual learning constrains models to learn new tasks over time without forgetting what they have already learned. A key challenge in this setting is catastrophic forgetting, where learning new information causes the model to lose its performance on previous tasks. Recently, explainable AI has been proposed as a promising way to better understand and reduce forgetting. In particular, self-explainable models are useful because they generate explanations during prediction, which can help preserve knowledge. However, most existing explainable approaches use post-hoc explanations or require additional memory for each new task, resulting in limited scalability. In this work, we introduce CIP-Net, an exemplar-free self-explainable prototype-based model designed for continual learning. CIP-Net avoids storing past examples and maintains a simple architecture, while still providing useful explanations and strong performance. We demonstrate that CIP-Net achieves state-of-the-art performances compared to previous exemplar-free and self-explainable methods in both task-and class-incremental settings, while bearing significantly lower memory-related overhead. This makes it a practical and interpretable solution for continual learning.


VLD: Visual Language Goal Distance for Reinforcement Learning Navigation

arXiv.org Artificial Intelligence

Training end-to-end policies from image data to directly predict navigation actions for robotic systems has proven inherently difficult. Existing approaches often suffer from either the sim-to-real gap during policy transfer or a limited amount of training data with action labels. To address this problem, we introduce Vision-Language Distance (VLD) learning, a scalable framework for goal-conditioned navigation that decouples perception learning from policy learning. Instead of relying on raw sensory inputs during policy training, we first train a self-supervised distance-to-goal predictor on internet-scale video data. This predictor generalizes across both image- and text-based goals, providing a distance signal that can be minimized by a reinforcement learning (RL) policy. The RL policy can be trained entirely in simulation using privileged geometric distance signals, with injected noise to mimic the uncertainty of the trained distance predictor. At deployment, the policy consumes VLD predictions, inheriting semantic goal information-"where to go"-from large-scale visual training while retaining the robust low-level navigation behaviors learned in simulation. We propose using ordinal consistency to assess distance functions directly and demonstrate that VLD outperforms prior temporal distance approaches, such as ViNT and VIP. Experiments show that our decoupled design achieves competitive navigation performance in simulation while supporting flexible goal modalities, providing an alternative and, most importantly, scalable path toward reliable, multimodal navigation policies.