As recommender systems have become more widespread and moved into areas with greater social impact, such as employment and housing, researchers have begun to seek ways to ensure fairness in the results that such systems produce. This work has primarily focused on developing recommendation approaches in which fairness metrics are jointly optimized along with recommendation accuracy. However, the previous work had largely ignored how individual preferences may limit the ability of an algorithm to produce fair recommendations. Furthermore, with few exceptions, researchers have only considered scenarios in which fairness is measured relative to a single sensitive feature or attribute (such as race or gender). In this paper, we present a re-ranking approach to fairness-aware recommendation that learns individual preferences across multiple fairness dimensions and uses them to enhance provider fairness in recommendation results. Specifically, we show that our opportunistic and metric-agnostic approach achieves a better trade-off between accuracy and fairness than prior re-ranking approaches and does so across multiple fairness dimensions.

The adaptive learning capabilities seen in biological neural networks are largely a product of the self-modifying behavior emerging from online plastic changes in synaptic connectivity. Current methods in Reinforcement Learning (RL) only adjust to new interactions after reflection over a specified time interval, preventing the emergence of online adaptivity. Recent work addressing this by endowing artificial neural networks with neuromodulated plasticity have been shown to improve performance on simple RL tasks trained using backpropagation, but have yet to scale up to larger problems. Here we study the problem of meta-learning in a challenging quadruped domain, where each leg of the quadruped has a chance of becoming unusable, requiring the agent to adapt by continuing locomotion with the remaining limbs. Results demonstrate that agents evolved using self-modifying plastic networks are more capable of adapting to complex meta-learning learning tasks, even outperforming the same network updated using gradient-based algorithms while taking less time to train.

Personalization is very powerful in improving the effectiveness of health interventions. Reinforcement learning (RL) algorithms are suitable for learning these tailored interventions from sequential data collected about individuals. However, learning can be very fragile. The time to learn intervention policies is limited as disengagement from the user can occur quickly. Also, in e-Health intervention timing can be crucial before the optimal window passes. We present an approach that learns tailored personalization policies for groups of users by combining RL and clustering. The benefits are two-fold: speeding up the learning to prevent disengagement while maintaining a high level of personalization. Our clustering approach utilizes dynamic time warping to compare user trajectories consisting of states and rewards. We apply online and batch RL to learn policies over clusters of individuals and introduce our self-developed and publicly available simulator for e-Health interventions to evaluate our approach. We compare our methods with an e-Health intervention benchmark. We demonstrate that batch learning outperforms online learning for our setting. Furthermore, our proposed clustering approach for RL finds near-optimal clusterings which lead to significantly better policies in terms of cumulative reward compared to learning a policy per individual or learning one non-personalized policy across all individuals. Our findings also indicate that the learned policies accurately learn to send interventions at the right moments and that the users workout more and at the right times of the day.

Locomotion is a prime example for adaptive behavior in animals and biological control principles have inspired control architectures for legged robots. While machine learning has been successfully applied to many tasks in recent years, Deep Reinforcement Learning approaches still appear to struggle when applied to real world robots in continuous control tasks and in particular do not appear as robust solutions that can handle uncertainties well. Therefore, there is a new interest in incorporating biological principles into such learning architectures. While inducing a hierarchical organization as found in motor control has shown already some success, we here propose a decentralized organization as found in insect motor control for coordination of different legs. A decentralized and distributed architecture is introduced on a simulated hexapod robot and the details of the controller are learned through Deep Reinforcement Learning. We first show that such a concurrent local structure is able to learn better walking behavior. Secondly, that the simpler organization is learned faster compared to holistic approaches.

Multi-hop knowledge based question answering (KBQA) is a complex task for natural language understanding. Many KBQA approaches have been proposed in recent years, and most of them are trained based on labeled reasoning path. This hinders the system's performance as many correct reasoning paths are not labeled as ground truth, and thus they cannot be learned. In this paper, we introduce an end-to-end KBQA system which can leverage multiple reasoning paths' information and only requires labeled answer as supervision. We conduct experiments on several benchmark datasets containing both single-hop simple questions as well as muti-hop complex questions, including WebQuestionSP (WQSP), ComplexWebQuestion-1.1 (CWQ), and PathQuestion-Large (PQL), and demonstrate strong performance.

Few-shot meta-learning has been recently reviving with expectations to mimic humanity's fast adaption to new concepts based on prior knowledge. In this short communication, we give a concise review on recent representative methods in few-shot meta-learning, which are categorized into four branches according to their technical characteristics. We conclude this review with some vital current challenges and future prospects in few-shot meta-learning.

Recent studies of cancer somatic mutation profiles seek to identify mutations for targeted therapy in personalized medicine. Analysis of profiles, however, is not trivial, as each profile is heterogeneous and there are multiple confounding factors that influence the cause-and-effect relationships between cancer genes such as cancer (sub)type, biological processes, total number of mutations, and non-linear mutation interactions. Moreover, cancer is biologically redundant, i.e., distinct mutations can result in the alteration of similar biological processes, so it is important to identify all possible combinatorial sets of mutations for effective patient treatment. To model this phenomena, we propose the correlated zero-inflated negative binomial process to infer the inherent structure of somatic mutation profiles through latent representations. This stochastic process takes into account different, yet correlated, co-occurring mutations using profile-specific negative binomial dispersion parameters that are mixed with a correlated beta-Bernoulli process and a probability parameter to model profile heterogeneity. These model parameters are inferred by iterative optimization via amortized and stochastic variational inference using the Pan Cancer dataset from The Cancer Genomic Archive (TCGA). By examining the the latent space, we identify biologically relevant correlations between somatic mutations.

There is a growing interest in applying deep learning (DL) to healthcare, driven by the availability of data with multiple feature channels in rich-data environments (e.g., intensive care units). However, in many other practical situations, we can only access data with much fewer feature channels in a poor-data environments (e.g., at home), which often results in predictive models with poor performance. How can we boost the performance of models learned from such poor-data environment by leveraging knowledge extracted from existing models trained using rich data in a related environment? To address this question, we develop a knowledge infusion framework named CHEER that can succinctly summarize such rich model into transferable representations, which can be incorporated into the poor model to improve its performance. The infused model is analyzed theoretically and evaluated empirically on several datasets. Our empirical results showed that CHEER outperformed baselines by 5.60% to 46.80% in terms of the macro-F1 score on multiple physiological datasets.

The pervasiveness of "Internet-of-Things" in our daily life has led to a recent surge in fog computing, encompassing a collaboration of cloud computing and edge intelligence. To that effect, deep learning has been a major driving force towards enabling such intelligent systems. However, growing model sizes in deep learning pose a significant challenge towards deployment in resource-constrained edge devices. Moreover, in a distributed intelligence environment, efficient workload distribution is necessary between edge and cloud systems. To address these challenges, we propose a conditionally deep hybrid neural network for enabling AI-based fog computing. The proposed network can be deployed in a distributed manner, consisting of quantized layers and early exits at the edge and full-precision layers on the cloud. During inference, if an early exit has high confidence in the classification results, it would allow samples to exit at the edge, and the deeper layers on the cloud are activated conditionally, which can lead to improved energy efficiency and inference latency. We perform an extensive design space exploration with the goal of minimizing energy consumption at the edge while achieving state-of-the-art classification accuracies on image classification tasks. We show that with binarized layers at the edge, the proposed conditional hybrid network can process 65% of inferences at the edge, leading to 5.5x computational energy reduction with minimal accuracy degradation on CIFAR-10 dataset. For the more complex dataset CIFAR-100, we observe that the proposed network with 4-bit quantization at the edge achieves 52% early classification at the edge with 4.8x energy reduction. The analysis gives us insights on designing efficient hybrid networks which achieve significantly higher energy efficiency than full-precision networks for edge-cloud based distributed intelligence systems.

There have been more than 850,000 confirmed cases and over 48,000 deaths from the human coronavirus disease 2019 (COVID-19) pandemic, caused by novel severe acute respiratory syndrome coronavirus (SARS-CoV-2), in the United States alone. However, there are currently no proven effective medications against COVID-19. Drug repurposing offers a promising way for the development of prevention and treatment strategies for COVID-19. This study reports an integrative, network-based deep learning methodology to identify repurposable drugs for COVID-19 (termed CoV-KGE). Specifically, we built a comprehensive knowledge graph that includes 15 million edges across 39 types of relationships connecting drugs, diseases, genes, pathways, and expressions, from a large scientific corpus of 24 million PubMed publications. Using Amazon AWS computing resources, we identified 41 repurposable drugs (including indomethacin, toremifene and niclosamide) whose therapeutic association with COVID-19 were validated by transcriptomic and proteomic data in SARS-CoV-2 infected human cells and data from ongoing clinical trials. While this study, by no means recommends specific drugs, it demonstrates a powerful deep learning methodology to prioritize existing drugs for further investigation, which holds the potential of accelerating therapeutic development for COVID-19.