Estimating heterogeneous treatment effects (HTEs) of continuous-valued interventions on survival, that is, time-to-event (TTE) outcomes, is crucial in various fields, notably in clinical decision-making and in driving the advancement of nextgeneration clinical trials. However, while HTE estimation for continuous-valued (i.e., dosage-dependent) interventions and for TTE outcomes have been separately explored, their combined application remains largely overlooked in the machine learning literature. We propose DoseSurv, a varying-coefficient network designed to estimate HTEs for different dosage-dependent and non-dosage treatment options from TTE data. DoseSurv uses radial basis functions to model continuity in doseresponse relationships and learns balanced representations to address covariate shifts arising in HTE estimation from observational TTE data.

Casey Harrell has had a set of electrodes embedded in his brain for almost three years. Harrell, who has amyotrophic lateral sclerosis (ALS) and is paralyzed, first used his brain-computer interface (BCI) to "speak" sentences with the help of a research team in 2023. Since then, Harrell has clocked thousands of hours of use. He can use the device largely independently, once he's been "plugged in" with the help of a carer. His team has added new features to it, and Harrell also uses it to surf the web and perform his job.

Predicting future neural activity is a core challenge in modeling brain dynamics, with applications ranging from scientific investigation to closed-loop neurotechnology. While recent models of population activity emphasize interpretability and behavioral decoding, neural forecasting--particularly across multi-session, spontaneous calcium recordings--remains underexplored. We introduce POCO, a unified forecasting model that combines a lightweight univariate forecaster with a population-level encoder to capture both neuron-specific and brain-wide dynamics in calcium imaging recordings. Trained across five calcium imaging datasets spanning zebrafish, mice, and C. elegans, POCO achieves state-of-the-art accuracy at cellular resolution in spontaneous behaviors.

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Former Olympian seen in handcuffs as Trump threatens'years in jail' and more arrests after vandals SABOTAGE Reflecting Pool with'corrosive and destructive chemicals' Angelina Jolie's son Pax, 22, surfaces in LA after bombshell revelation about his relationship to Brad Pitt Keir Starmer'will announce as early as Monday that he is quitting as Prime Minister' after spending weekend locked in tense talks about his future with his wife Victoria at Chequers Mortifying truth about Clavicular's'botched' nose job: Infertile influencer's'trans' admission to friends... as insider reveals what's said behind closed doors - and twisted secrets that'll leave fans floored Giorgia Meloni rips'senseless' attacks from Trump as Italian Prime Minister refuses to back down amid G7 feud Inside America's new fattest town: Burgers are the size of your head, gyms lie empty and custom mobility scooters carry 800lb loads... as we investigate why Ozempic just DOESN'T work Call me cynical, but the real reason Gruesome Twosome Harry and Meghan are returning to the UK is just so obvious... and highly humiliating: MAUREEN CALLAHAN Stingy fast food giant named America's favorite restaurant AGAIN... and experts think they know why I lost 50lb without jabs using this easy but overlooked method. But I still felt dowdy - until I discovered these expert anti-ageing fashion and beauty tips. No one can see the real reason Jelly Roll divorced Bunnie XO. Blake Lively runs errands in frumpy outfit after reconciling with ex-BFF Taylor Swift... miles away from reported'bachelorette party' Embattled Alexi Lalas makes controversial World Cup declaration amid tension with Fox colleagues: 'Makes you look like a weak poser' Scientists propose radical new theory of consciousness - and claim it doesn't depend on flesh and blood Candace Owens hits out at nasty rumors claiming she was DEAD... as fellow MAGA influencer claims her account was hacked Grace Kelly's lookalike granddaughter, 27, wows in bikini snaps...as she packs on the PDA during beach getaway TV star mom, 46, who appeared on'quitting everything to change your life' show died in fire at luxury Caribbean beach resort that sent 1,700 tourists running for their lives The four mistakes that led to bungee tragedy on Skeleton Bridge: FRED KELLY saw the scene for himself, now he retraces the prelude to disaster. So was it really an accident?

Models of hybrid dynamical systems are widely used to answer questions about the causes and effects of dynamic events in time. Unfortunately, existing causal reasoning formalisms lack support for queries involving the dynamically triggered, discontinuous interventions that characterize hybrid dynamical systems. This mismatch can lead to ad-hoc and error-prone causal analysis workflows in practice. To bridge the gap between the needs of hybrid systems users and current causal inference capabilities, we develop a rigorous counterfactual semantics by formalizing interventions as transformations to the constraints of hybrid systems. Unlike interventions in a typical structural causal model, however, interventions in hybrid systems can easily render the model ill-posed. Thus, we identify mild conditions under which our interventions maintain solution existence, uniqueness, and measurability by making explicit connections to established hybrid systems theory. To illustrate the utility of our framework, we formalize a number of canonical causal estimands and explore a case study on the probabilities of causation with applications to fishery management. Our work simultaneously expands the modeling possibilities available to causal inference practitioners and begins to unlock decades of causality research for users of hybrid systems.

Game-theoretic algorithms are commonly benchmarked on recreational games, classical constructs from economic theory such as congestion and dispersion games, or entirely random game instances. While the past two decades have seen the rise of security games - grounded in real-world scenarios like patrolling and infrastructure protection - their practical evaluation has been hindered by limited access to the datasets used to generate them. In particular, although the structural components of these games (e.g., patrol paths derived from maps) can be replicated, the critical data defining target values - central to utility modeling - remain inaccessible. In this paper, we introduce a flexible framework that leverages open-access datasets to generate realistic matrix and security game instances. These include animal movement data for modeling anti-poaching scenarios and demographic and infrastructure data for infrastructure protection. Our framework allows users to customize utility functions and game parameters, while also offering a suite of preconfigured instances. We provide theoretical results highlighting the degeneracy and limitations of benchmarking on random games, and empirically compare our generated games against random baselines across a variety of standard algorithms for computing Nash and Stackelberg equilibria, including linear programming, incremental strategy generation, and self-play with no-regret learners.

Time Series Forecasting has made significant progress with the help of Patching technique, which partitions time series into multiple patches to effectively retain contextual semantic information into a representation space beneficial for modeling long-term dependencies. However, conventional patching partitions a time series into adjacent patches, which causes a fixed representation space, thus resulting in insufficiently expressful representations. In this paper, we pioneer the exploration of constructing a selective representation space to flexibly include the most informative patches for forecasting. Specifically, we propose the Selective Representation Space (SRS) module, which utilizes the learnable Selective Patching and Dynamic Reassembly techniques to adaptively select and shuffle the patches from the contextual time series, aiming at fully exploiting the information of contextual time series to enhance the forecasting performance of patch-based models. To demonstrate the effectiveness of SRS module, we propose a simple yet effective SRSNet consisting of SRS and an MLP head, which achieves state-of-the-art performance on real-world datasets from multiple domains. Furthermore, as a novel plug-and-play module, SRS can also enhance the performance of existing patch-based models.

The integration of evolutionary algorithms (EAs) with reinforcement learning (RL) has shown superior performance compared to standalone methods. However, previous research focuses on exploration in policy parameter space, while overlooking the reward function search. To bridge this gap, we propose LaRes, a novel hybrid framework that achieves efficient policy learning through reward function search. LaRes leverages large language models (LLMs) to generate the reward function population, guiding RL in policy learning. The reward functions are evaluated by the policy performance and improved through LLMs.

Dozens of students walked out of their Stanford University graduation ceremony as Google CEO Sundar Pichai took the stage to deliver a keynote address. Video filmed by the BBC shows the students protesting against the company's controversial work with the US government. A group named Stanford Students for Justice in Palestine encouraged the walkout. This follows other recent campus protests against tech leaders, but those have largely focused on artificial intelligence and concerns about jobs. Pichai largely sidestepped the issue of AI in his remarks, though he appeared to make light of the expected protests.