Predicting protein function from sequence is a central challenge in computational biology. While existing methods rely heavily on structured ontologies or similaritybased techniques, they often lack the flexibility to express structure-free functional descriptions and novel biological functions. In this work, we introduce Prot2TextV2, a novel multimodal sequence-to-text model that generates free-form natural language descriptions of protein function directly from amino acid sequences. Our method combines a protein language model as a sequence encoder (ESM-3B) and a decoder-only language model (LLaMA-3.1-8B-Instruct)

Learning effective multi-modal 3D representations of objects is essential for numerous applications, such as augmented reality and robotics. Existing methods often rely on task-specific embeddings that are tailored either for semantic understanding or geometric reconstruction. As a result, these embeddings typically cannot be decoded into explicit geometry and simultaneously reused across tasks. In this paper, we propose Object-X, a versatile multi-modal object representation framework capable of encoding rich object embeddings (e.g., images, point cloud, text) and decoding them back into detailed geometric and visual reconstructions. Object-X operates by geometrically grounding the captured modalities in a 3D voxel grid and learning an unstructured embedding fusing the information from the voxels with the object attributes. The learned embedding enables 3D Gaussian Splatting-based object reconstruction, while also supporting a range of downstream tasks, including scene alignment, single-image 3D object reconstruction, and localization. Evaluations on two challenging real-world datasets demonstrate that Object-X achieves high-fidelity novel-view synthesis comparable to standard 3DGaussian Splatting, while significantly improving geometric accuracy. Moreover, Object-X achieves competitive performance with specialized methods in scene alignment and localization. Critically, our object-centric descriptors require 3-4 orders of magnitude less storage compared to traditional imageor point cloud-based approaches, establishing Object-X as a scalable and highly practical solution for multi-modal 3D scene representation.

Science Archaeology America's Time Capsule includes fabric from the Wright Brother's plane, whale bone, poker chips, and more The time capsule will remain sealed in Philadelphia for 250 years. More information Adding us as a Preferred Source in Google by using this link indicates that you would like to see more of our content in Google News results. The state of Ohio included fabric from the Wright Brothers' 1903 flight at Kitty Hawk, North Carolina. Breakthroughs, discoveries, and DIY tips sent six days a week. By signing up, you confirm you are 16+, will receive newsletters and promotional content and agree to our Terms of Use and acknowledge the data practices in our Privacy Policy .

Online structured prediction is a task of sequentially predicting outputs with complex structures based on inputs and past observations, encompassing online classification. Recent studies showed that in the full-information setting, we can achieve finite bounds on the surrogate regret, i.e., the extra target loss relative to the best possible surrogate loss. In practice, however, full-information feedback is often unrealistic as it requires immediate access to the whole structure of complex outputs. Motivated by this, we propose algorithms that work with less demanding feedback, bandit and delayed feedback. For bandit feedback, by using a standard inverseweighted gradient estimator, we achieve a surrogate regret bound of O( KT) for the time horizon T and the size of the output set K. However, K can be extremely large when outputs are highly complex, resulting in an undesirable bound. To address this issue, we propose another algorithm that achieves a surrogate regret bound of O(T2/3), which is independent of K. This is achieved with a carefully designed pseudo-inverse matrix estimator. Furthermore, we numerically compare the performance of these algorithms, as well as existing ones. Regarding delayed feedback, we provide algorithms and regret analyses that cover various scenarios, including full-information and bandit feedback, as well as fixed and variable delays.

The problem of optimally covering a given compact subset of RN with a preassigned number n of Euclidean metric balls has a long-standing history and it is well-recognized to be computationally hard. This article establishes a numerically viable algorithm for obtaining optimal covers of compact sets via two key contributions. The first is a foundational result establishing Lipschitz continuity of the marginal function of a certain parametric non-convex maximization problem in the optimal covering problem, and it provides the substrate for numerical gradient algorithms to be employed in this context. The second is an adaptation of a stochastically smoothed numerical gradient-based (zeroth-order) algorithm for a non-convex minimization problem, that, equipped with randomized restarts, spurs global convergence to an optimal cover. Several numerical experiments with complicated nonconvex compact sets demonstrate the excellent performance of our techniques.

After pre-training, large language models are aligned with human preferences based on pairwise comparisons. State-of-the-art alignment methods (such as PPO-based RLHF and DPO) are built on the assumption of aligning with a single preference model, despite being deployed in settings where users have diverse preferences. As a result, it is not even clear that these alignment methods produce models that satisfy users on average -- a minimal requirement for pluralistic alignment. Drawing on social choice theory and modeling users' comparisons through individual BradleyTerry (BT) models, we introduce an alignment method's distortion: the worst-case ratio between the optimal achievable average utility, and the average utility of the learned policy. The notion of distortion helps draw sharp distinctions between alignment methods: Nash Learning from Human Feedback achieves the minimax optimal distortion of (12+o(1)) β (for the BT temperature β), robustly across utility distributions, distributions of comparison pairs, and permissible KL divergences from the reference policy. RLHF and DPO, by contrast, suffer (1 o(1)) β distortion already without a KL constraint, and eΩ(β) or even unbounded distortion in the full setting, depending on how comparison pairs are sampled.

Planning under opponent uncertainty is a fundamental challenge in multi-agent environments, where an agent must act while inferring the hidden policies of its opponents. Existing type-based methods rely on manually defined behavior classes and struggle to scale, while model-free approaches are sample-inefficient and lack a principled way to incorporate uncertainty into planning. We propose Quantized Opponent Models (QOM), which learn a compact catalog of opponent types via a quantized autoencoder and maintain a Bayesian belief over these types online. This posterior supports both a belief-weighted meta-policy and a Monte-Carlo planning algorithm that directly integrates uncertainty, enabling real-time belief updates and focused exploration. Experiments show that QOM achieves superior performance with lower search cost, offering a tractable and effective solution for belief-aware planning.

Typically, a modern reinforcement learning (RL) agent solves a task by updating its neural network parameters to adapt its policy to the task. Recently, it has been observed that some RL agents can solve a wide range of new out-of-distribution tasks without parameter updates after pretraining on some task distribution. When evaluated in a new task, instead of making parameter updates, the pretrained agent conditions its policy on additional input called the context, e.g., the agent's interaction history in the new task. The agent's performance increases as the information in the context increases, with the agent's parameters fixed. This phenomenon is typically called in-context RL (ICRL). The pretrained parameters of the agent network enable the remarkable ICRL phenomenon.

Visual personalization is essential in user-facing AI systems such as smart homes and healthcare, where aligning model behavior with user-centric concepts is critical. However, recent large Vision-Language Models (VLMs), despite their broad applicability, remain underexplored in their ability to adapt to individual users. In this paper, we introduce MMPB, the first extensive benchmark for evaluating VLMs on personalization. MMPB comprises 10k image-query pairs and includes 111 personalizable concepts across four categories: humans, animals, objects, and characters, with the human category enriched with preference-grounded queries.

Sperm whales communicate in short sequences of clicks known as codas. We present WhAM (Whale Acoustics Model), the first transformer-based model capable of generating synthetic sperm whale codas from any audio prompt. WhAM is built by finetuning VampNet, a masked acoustic token model pretrained on musical audio, using 10k coda recordings collected over the past two decades. Through iterative masked token prediction, WhAM generates high-fidelity synthetic codas that preserve key acoustic features of the source recordings. We evaluate WhAM's synthetic codas using Fréchet Audio Distance and through perceptual studies with expert marine biologists. On downstream classification tasks including rhythm, social unit, and vowel classification, WhAM's learned representations achieve strong performance, despite being trained for generation rather than classification.