Clinical trials are indispensable for medical research and the development of new treatments. However, clinical trials often involve thousands of participants and can span several years to complete, with a high probability of failure during the process. Recently, there has been a burgeoning interest in virtual clinical trials, which simulate real-world scenarios and hold the potential to significantly enhance patient safety, expedite development, reduce costs, and contribute to the broader scientific knowledge in healthcare. Existing research often focuses on leveraging electronic health records (EHRs) to support clinical trial outcome prediction. Yet, trained with limited clinical trial outcome data, existing approaches frequently struggle to perform accurate predictions. Some research has attempted to generate EHRs to augment model development but has fallen short in personalizing the generation for individual patient profiles. Recently, the emergence of large language models has illuminated new possibilities, as their embedded comprehensive clinical knowledge has proven beneficial in addressing medical issues. In this paper, we propose a large language model-based digital twin creation approach, called TWIN-GPT. TWIN-GPT can establish cross-dataset associations of medical information given limited data, generating unique personalized digital twins for different patients, thereby preserving individual patient characteristics. Comprehensive experiments show that using digital twins created by TWIN-GPT can boost the clinical trial outcome prediction, exceeding various previous prediction approaches.

Current studies on human locomotion focus mainly on solid ground walking conditions. In this paper, we present a biomechanic comparison of human walking locomotion on solid ground and sand. A novel dataset containing 3-dimensional motion and biomechanical data from 20 able-bodied adults for locomotion on solid ground and sand is collected. We present the data collection methods and report the sensor data along with the kinematic and kinetic profiles of joint biomechanics. A comprehensive analysis of human gait and joint stiffness profiles is presented. The kinematic and kinetic analysis reveals that human walking locomotion on sand shows different ground reaction forces and joint torque profiles, compared with those patterns from walking on solid ground. These gait differences reflect that humans adopt motion control strategies for yielding terrain conditions such as sand. The dataset also provides a source of locomotion data for researchers to study human activity recognition and assistive devices for walking on different terrains.

Detecting Type 2 Diabetes (T2D) and Prediabetes (PD) is a real challenge for medicine due to the absence of pathogenic symptoms and the lack of known associated risk factors. Even though some proposals for machine learning models enable the identification of people at risk, the nature of the condition makes it so that a model suitable for one population may not necessarily be suitable for another. In this article, the development and assessment of predictive models to identify people at risk for T2D and PD specifically in Argentina are discussed. First, the database was thoroughly preprocessed and three specific datasets were generated considering a compromise between the number of records and the amount of available variables. After applying 5 different classification models, the results obtained show that a very good performance was observed for two datasets with some of these models. In particular, RF, DT, and ANN demonstrated great classification power, with good values for the metrics under consideration. Given the lack of this type of tool in Argentina, this work represents the first step towards the development of more sophisticated models.

Many recent language models (LMs) are capable of in-context learning (ICL), manifested in the LMs' ability to perform a new task solely from natural-language instruction. Previous work curating in-context learners assumes that ICL emerges from a vast over-parametrization or the scale of multi-task training. However, recent theoretical work attributes the ICL ability to concept-dependent training data and creates functional in-context learners even in small-scale, synthetic settings. In this work, we practically explore this newly identified axis of ICL quality. We propose Concept-aware Training (CoAT), a framework for constructing training scenarios that make it beneficial for the LM to learn to utilize the analogical reasoning concepts from demonstrations. We find that by using CoAT, pre-trained transformers can learn to better utilise new latent concepts from demonstrations and that such ability makes ICL more robust to the functional deficiencies of the previous models. Finally, we show that concept-aware in-context learning is more effective for a majority of new tasks when compared to traditional instruction tuning, resulting in a performance comparable to the previous in-context learners using magnitudes of more training data.

The development of Crud-Induced Power Shift (CIPS) is an operational challenge in Pressurized Water Reactors that is due to the development of crud on the fuel rod cladding. The available predictive tools developed previously, usually based on fundamental physics, are computationally expensive and have shown differing degrees of accuracy. This work proposes a completely top-down approach to predict CIPS instances on an assembly level with reactor-specific calibration built-in. Built using artificial neural networks, this work uses a three-dimensional convolutional approach to leverage the image-like layout of the input data. As a classifier, the convolutional neural network model predicts whether a given assembly will experience CIPS as well as the time of occurrence during a given cycle. This surrogate model is both trained and tested using a combination of calculated core model parameters and measured plant data from Unit 1 of the Catawba Nuclear Station. After the evaluation of its performance using various metrics, Monte Carlo dropout is employed for extensive uncertainty quantification of the model predictions. The results indicate that this methodology could be a viable approach in predicting CIPS with an assembly-level resolution across both clean and afflicted cycles, while using limited computational resources.

Cardiac magnetic resonance imaging (MRI) has emerged as a clinically gold-standard technique for diagnosing cardiac diseases, thanks to its ability to provide diverse information with multiple modalities and anatomical views. Accelerated cardiac MRI is highly expected to achieve time-efficient and patient-friendly imaging, and then advanced image reconstruction approaches are required to recover high-quality, clinically interpretable images from undersampled measurements. However, the lack of publicly available cardiac MRI k-space dataset in terms of both quantity and diversity has severely hindered substantial technological progress, particularly for data-driven artificial intelligence. Here, we provide a standardized, diverse, and high-quality CMRxRecon2024 dataset to facilitate the technical development, fair evaluation, and clinical transfer of cardiac MRI reconstruction approaches, towards promoting the universal frameworks that enable fast and robust reconstructions across different cardiac MRI protocols in clinical practice. To the best of our knowledge, the CMRxRecon2024 dataset is the largest and most diverse publicly available cardiac k-space dataset. It is acquired from 330 healthy volunteers, covering commonly used modalities, anatomical views, and acquisition trajectories in clinical cardiac MRI workflows. Besides, an open platform with tutorials, benchmarks, and data processing tools is provided to facilitate data usage, advanced method development, and fair performance evaluation.

The rapid advancement of Artificial Intelligence (AI) has led to its integration into various areas, especially with Large Language Models (LLMs) significantly enhancing capabilities in Artificial Intelligence Generated Content (AIGC). However, the complexity of AI systems has also exposed their vulnerabilities, necessitating robust methods for failure analysis (FA) and fault injection (FI) to ensure resilience and reliability. Despite the importance of these techniques, there lacks a comprehensive review of FA and FI methodologies in AI systems. This study fills this gap by presenting a detailed survey of existing FA and FI approaches across six layers of AI systems. We systematically analyze 160 papers and repositories to answer three research questions including (1) what are the prevalent failures in AI systems, (2) what types of faults can current FI tools simulate, (3) what gaps exist between the simulated faults and real-world failures. Our findings reveal a taxonomy of AI system failures, assess the capabilities of existing FI tools, and highlight discrepancies between real-world and simulated failures. Moreover, this survey contributes to the field by providing a framework for fault diagnosis, evaluating the state-of-the-art in FI, and identifying areas for improvement in FI techniques to enhance the resilience of AI systems.

Machine learning (ML) technologies have become substantial in practically all aspects of our society, and data quality (DQ) is critical for the performance, fairness, robustness, safety, and scalability of ML models. With the large and complex data in data-centric AI, traditional methods like exploratory data analysis (EDA) and cross-validation (CV) face challenges, highlighting the importance of mastering DQ tools. In this survey, we review 17 DQ evaluation and improvement tools in the last 5 years. By introducing the DQ dimensions, metrics, and main functions embedded in these tools, we compare their strengths and limitations and propose a roadmap for developing open-source DQ tools for ML. Based on the discussions on the challenges and emerging trends, we further highlight the potential applications of large language models (LLMs) and generative AI in DQ evaluation and improvement for ML. We believe this comprehensive survey can enhance understanding of DQ in ML and could drive progress in data-centric AI. A complete list of the literature investigated in this survey is available on GitHub at: https://github.com/haihua0913/awesome-dq4ml.

Synthetic data generation has gained significant attention recently for its utility in training large vision and language models. However, the application of synthetic data to the training of multimodal context-augmented generation systems has been relatively unexplored. This gap in existing work is important because existing vision and language models (VLMs) are not trained specifically for context-augmented generation. Resources for adapting such models are therefore crucial for enabling their use in retrieval-augmented generation (RAG) settings, where a retriever is used to gather relevant information that is then subsequently provided to a generative model via context augmentation. To address this challenging problem, we generate SK-VQA: a large synthetic multimodal dataset containing over 2 million question-answer pairs which require external knowledge to determine the final answer. Our dataset is both larger and significantly more diverse than existing resources of its kind, possessing over 11x more unique questions and containing images from a greater variety of sources than previously-proposed datasets. Through extensive experiments, we demonstrate that our synthetic dataset can not only serve as a challenging benchmark, but is also highly effective for adapting existing generative multimodal models for context-augmented generation.

Large-scale endeavors like RT-1 and widespread community efforts such as Open-X-Embodiment have contributed to growing the scale of robot demonstration data. However, there is still an opportunity to improve the quality, quantity, and diversity of robot demonstration data. Although vision-language models have been shown to automatically generate demonstration data, their utility has been limited to environments with privileged state information, they require hand-designed skills, and are limited to interactions with few object instances. We propose Manipulate-Anything, a scalable automated generation method for real-world robotic manipulation. Unlike prior work, our method can operate in real-world environments without any privileged state information, hand-designed skills, and can manipulate any static object. We evaluate our method using two setups. First, Manipulate-Anything successfully generates trajectories for all 5 real-world and 12 simulation tasks, significantly outperforming existing methods like VoxPoser. Second, Manipulate-Anything's demonstrations can train more robust behavior cloning policies than training with human demonstrations, or from data generated by VoxPoser and Code-As-Policies. We believe Manipulate-Anything can be the scalable method for both generating data for robotics and solving novel tasks in a zero-shot setting.