While diffusion models excel at conditional generating high-quality images, prior works in discrete diffusion models were not evaluated on conditional long-text generation. In this work, we address the limitations of prior discrete diffusion models for conditional long-text generation, particularly in long sequence-to-sequence tasks such as abstractive summarization. Despite fast decoding speeds compared to autoregressive methods, previous diffusion models failed on the abstractive summarization task due to the incompatibility between the backbone architectures and the random noising process. To overcome these challenges, we introduce a novel semantic-aware noising process that enables Transformer backbones to handle long sequences effectively. Additionally, we propose CrossMamba, an adaptation of the Mamba model to the encoder-decoder paradigm, which integrates seamlessly with the random absorbing noising process. Our approaches achieve state-of-the-art performance on three benchmark summarization datasets: Gigaword, CNN/DailyMail, and Arxiv, outperforming existing discrete diffusion models on ROUGE metrics as well as possessing much faster speed in inference compared to autoregressive models.

Clinical trials are fundamental in developing new drugs, medical devices, and treatments. However, they are often time-consuming and have low success rates. Although there have been initial attempts to create large language models (LLMs) for clinical trial design and patient-trial matching, these models remain task-specific and not adaptable to diverse clinical trial tasks. To address this challenge, we propose a clinical trial foundation model named Panacea, designed to handle multiple tasks, including trial search, trial summarization, trial design, and patient-trial matching. We also assemble a large-scale dataset, named TrialAlign, of 793,279 trial documents and 1,113,207 trial-related scientific papers, to infuse clinical knowledge into the model by pre-training. We further curate TrialInstruct, which has 200,866 of instruction data for fine-tuning. These resources enable Panacea to be widely applicable for a range of clinical trial tasks based on user requirements. We evaluated Panacea on a new benchmark, named TrialPanorama, which covers eight clinical trial tasks. Our method performed the best on seven of the eight tasks compared to six cutting-edge generic or medicine-specific LLMs. Specifically, Panacea showed great potential to collaborate with human experts in crafting the design of eligibility criteria, study arms, and outcome measures, in multi-round conversations. In addition, Panacea achieved 14.42% improvement in patient-trial matching, 41.78% to 52.02% improvement in trial search, and consistently ranked at the top for five aspects of trial summarization. Our approach demonstrates the effectiveness of Panacea in clinical trials and establishes a comprehensive resource, including training data, model, and benchmark, for developing clinical trial foundation models, paving the path for AI-based clinical trial development.

Foundation models, enhanced by self-supervised learning (SSL) techniques, represent a cutting-edge frontier in biomedical signal analysis, particularly for electrocardiograms (ECGs), crucial for cardiac health monitoring and diagnosis. This study conducts a comprehensive analysis of foundation models for ECGs by employing and refining innovative SSL methodologies - namely, generative and contrastive learning - on a vast dataset of over 1.1 million ECG samples. By customizing these methods to align with the intricate characteristics of ECG signals, our research has successfully developed foundation models that significantly elevate the precision and reliability of cardiac diagnostics. These models are adept at representing the complex, subtle nuances of ECG data, thus markedly enhancing diagnostic capabilities. The results underscore the substantial potential of SSL-enhanced foundation models in clinical settings and pave the way for extensive future investigations into their scalable applications across a broader spectrum of medical diagnostics. This work sets a benchmark in the ECG field, demonstrating the profound impact of tailored, data-driven model training on the efficacy and accuracy of medical diagnostics.

Patients often face difficulties in understanding their hospitalizations, while healthcare workers have limited resources to provide explanations. In this work, we investigate the potential of large language models to generate patient summaries based on doctors' notes and study the effect of training data on the faithfulness and quality of the generated summaries. To this end, we release (i) a rigorous labeling protocol for errors in medical texts and (ii) a publicly available dataset of annotated hallucinations in 100 doctor-written and 100 generated summaries. We show that fine-tuning on hallucination-free data effectively reduces hallucinations from 2.60 to 1.55 per summary for Llama 2, while preserving relevant information. We observe a similar effect on GPT-4 (0.70 to 0.40), when the few-shot examples are hallucination-free. We also conduct a qualitative evaluation using hallucination-free and improved training data. We find that common quantitative metrics do not correlate well with faithfulness and quality. Finally, we test GPT-4 for automatic hallucination detection, which clearly outperforms common baselines.

The current paradigm of evaluating Large Language Models (LLMs) through static benchmarks comes with significant limitations, such as vulnerability to data contamination and a lack of adaptability to the evolving capabilities of LLMs. Therefore, evaluation methods that can adapt and generate evaluation data with controlled complexity are urgently needed. In this work, we introduce Dynamic Evaluation of LLMs via Adaptive Reasoning Graph Evolvement (DARG) to dynamically extend current benchmarks with controlled complexity and diversity. Specifically, we first extract the reasoning graphs of data points in current benchmarks and then perturb the reasoning graphs to generate novel testing data. Such newly generated test samples can have different levels of complexity while maintaining linguistic diversity similar to the original benchmarks. We further use a code-augmented LLM to ensure the label correctness of newly generated data. We apply our DARG framework to diverse reasoning tasks in four domains with 15 state-of-the-art LLMs. Experimental results show that almost all LLMs experience a performance decrease with increased complexity and certain LLMs exhibit significant drops. Additionally, we find that LLMs exhibit more biases when being evaluated via the data generated by DARG with higher complexity levels. These observations provide useful insights into how to dynamically and adaptively evaluate LLMs. The code is available at https://github.com/SALT-NLP/DARG.

This study examines transformer-based models and their effectiveness in named entity recognition tasks. The study investigates data representation strategies, including single, merged, and context, which respectively use one sentence, multiple sentences, and sentences joined with attention to context per vector. Analysis shows that training models with a single strategy may lead to poor performance on different data representations. To address this limitation, the study proposes a combined training procedure that utilizes all three strategies to improve model stability and adaptability. The results of this approach are presented and discussed for four languages (English, Polish, Czech, and German) across various datasets, demonstrating the effectiveness of the combined strategy.

The conventional training approaches often face challenges in balancing the breadth of multi-task learning (MTL) with the depth of single-task learning (STL). To address this issue, we introduce the Multi-Task to Single-Task (MT2ST) framework, a groundbreaking approach that can combine the generalizability of MTL with the precision of STL. Our work include two strategies: 'Diminish' and 'Switch'. 'Diminish' Strategy will gradually reduce the influence of auxiliary tasks, while the 'Switch' strategy involves a shift from multi-tasking to single-tasking at a specific timepoint at the training process. In this paper, we propose the Multi-Task to Single-Task (MT2ST) framework, a novel approach that significantly enhances the efficiency and accuracy of word embedding training while concurrently addressing prevalent issues such as overfitting. Our empirical studies demonstrate that MT2ST can reduce training time by 67\% when contrasted with single-task learning approaches, and by 13\% compared to traditional multi-task learning methods. These findings underscore MT2ST's potential to be a powerful tools for word embedding training acceleration.

Automatic Speech Recognition (ASR) for adults' speeches has made significant progress by employing deep neural network (DNN) models recently, but improvement in children's speech is still unsatisfactory due to children's speech's distinct characteristics. DNN models pre-trained on adult data often struggle in generalizing children's speeches with fine tuning because of the lack of high-quality aligned children's speeches. When generating datasets, human annotations are not scalable, and existing forced-alignment tools are not usable as they make impractical assumptions about the quality of the input transcriptions. To address these challenges, we propose a new forced-alignment tool, FASA, as a flexible and automatic speech aligner to extract high-quality aligned children's speech data from many of the existing noisy children's speech data. We demonstrate its usage on the CHILDES dataset and show that FASA can improve data quality by 13.6$\times$ over human annotations.

Dialogue systems have been used as conversation partners in English learning, but few have studied whether these systems improve learning outcomes. Student passion and perseverance, or grit, has been associated with language learning success. Recent work establishes that as students perceive their English teachers to be more supportive, their grit improves. Hypothesizing that the same pattern applies to English-teaching chatbots, we create EDEN, a robust open-domain chatbot for spoken conversation practice that provides empathetic feedback. To construct EDEN, we first train a specialized spoken utterance grammar correction model and a high-quality social chit-chat conversation model. We then conduct a preliminary user study with a variety of strategies for empathetic feedback. Our experiment suggests that using adaptive empathetic feedback leads to higher perceived affective support, which, in turn, predicts increased student grit.

In Explainable AI, rule extraction translates model knowledge into logical rules, such as IF-THEN statements, crucial for understanding patterns learned by black-box models. This could significantly aid in fields like disease diagnosis, disease progression estimation, or drug discovery. However, such application domains often contain imbalanced data, with the class of interest underrepresented. Existing methods inevitably compromise the performance of rules for the minor class to maximise the overall performance. As the first attempt in this field, we propose a model-agnostic approach for extracting rules from specific subgroups of data, featuring automatic rule generation for numerical features. This method enhances the regional explainability of machine learning models and offers wider applicability compared to existing methods. We additionally introduce a new method for selecting features to compose rules, reducing computational costs in high-dimensional spaces. Experiments across various datasets and models demonstrate the effectiveness of our methods.