Prevalent in biological applications (e.g., human phenotype measurements), multimodal datasets can provide valuable insights into the underlying biological mechanisms. However, current machine learning models designed to analyze such datasets still lack interpretability and theoretical guarantees, which are essential to biological applications. Recent advances in causal representation learning have shown promise in uncovering the interpretable latent causal variables with formal theoretical certificates. Unfortunately, existing works for multimodal distributions either rely on restrictive parametric assumptions or provide rather coarse identification results, limiting their applicability to biological research which favors a detailed understanding of the mechanisms. In this work, we aim to develop flexible identification conditions for multimodal data and principled methods to facilitate the understanding of biological datasets. Theoretically, we consider a flexible nonparametric latent distribution (c.f., parametric assumptions in prior work) permitting causal relationships across potentially different modalities. We establish identifiability guarantees for each latent component, extending the subspace identification results from prior work. Our key theoretical ingredient is the structural sparsity of the causal connections among distinct modalities, which, as we will discuss, is natural for a large collection of biological systems. Empirically, we propose a practical framework to instantiate our theoretical insights. We demonstrate the effectiveness of our approach through extensive experiments on both numerical and synthetic datasets. Results on a real-world human phenotype dataset are consistent with established medical research, validating our theoretical and methodological framework.

Contextual ASR or hotword customization holds substantial practical value. Despite the impressive performance of current end-to-end (E2E) automatic speech recognition (ASR) systems, they often face challenges in accurately recognizing rare words. Typical E2E contextual ASR models commonly feature complex architectures and decoding mechanisms, limited in performance and susceptible to interference from distractor words. With large language model (LLM)-based ASR models emerging as the new mainstream, we propose a CTC-Assisted LLM-Based Contextual ASR model with an efficient filtering algorithm. By using coarse CTC decoding results to filter potential relevant hotwords and incorporating them into LLM prompt input, our model attains WER/B-WER of 1.27%/3.67% and 2.72%/8.02% on the Librispeech test-clean and test-other sets targeting on recognizing rare long-tail words, demonstrating significant improvements compared to the baseline LLM-based ASR model, and substantially surpassing other related work. More remarkably, with the help of the large language model and proposed filtering algorithm, our contextual ASR model still performs well with 2000 biasing words.

Knowledge graph completion (KGC) is a task of inferring missing triples based on existing Knowledge Graphs (KGs). Both structural and semantic information are vital for successful KGC. However, existing methods only use either the structural knowledge from the KG embeddings or the semantic information from pre-trained language models (PLMs), leading to suboptimal model performance. Moreover, since PLMs are not trained on KGs, directly using PLMs to encode triples may be inappropriate. To overcome these limitations, we propose a novel framework called Bridge, which jointly encodes structural and semantic information of KGs. Specifically, we strategically encode entities and relations separately by PLMs to better utilize the semantic knowledge of PLMs and enable structured representation learning via a structural learning principle. Furthermore, to bridge the gap between KGs and PLMs, we employ a self-supervised representation learning method called BYOL to fine-tune PLMs with two different views of a triple. Unlike BYOL, which uses augmentation methods to create two semantically similar views of the same image, potentially altering the semantic information. We strategically separate the triple into two parts to create different views, thus avoiding semantic alteration. Experiments demonstrate that Bridge outperforms the SOTA models on three benchmark datasets.

Objectives: Our research adopts computational techniques to analyze disease outbreaks weekly over a large geographic area while maintaining local-level analysis by incorporating relevant high-spatial resolution cultural and environmental datasets. The abundance of data about disease outbreaks gives scientists an excellent opportunity to uncover patterns in disease spread and make future predictions. However, data over a sizeable geographic area quickly outpace human cognition. Our study area covers a significant portion of the African continent (about 17,885,000 km2). The data size makes computational analysis vital to assist human decision-makers. Methods: We first applied global and local spatial autocorrelation for malaria, cholera, meningitis, and yellow fever case counts. We then used machine learning to predict the weekly presence of these diseases in the second-level administrative district. Lastly, we used machine learning feature importance methods on the variables that affect spread. Results: Our spatial autocorrelation results show that geographic nearness is critical but varies in effect and space. Moreover, we identified many interesting hot and cold spots and spatial outliers. The machine learning model infers a binary class of cases or none with the best F1 score of 0.96 for malaria. Machine learning feature importance uncovered critical cultural and environmental factors affecting outbreaks and variations between diseases. Conclusions: Our study shows that data analytics and machine learning are vital to understanding and monitoring disease outbreaks locally across vast areas. The speed at which these methods produce insights can be critical during epidemics and emergencies.

To effectively manage and utilize knowledge graphs, it is crucial to have metrics that can assess the quality of knowledge graphs from various perspectives. While there have been studies on knowledge graph quality metrics, there has been a lack of research on metrics that measure how richly ontologies, which form the backbone of knowledge graphs, are defined or the impact of richly defined ontologies. In this study, we propose a new metric called Class Granularity, which measures how well a knowledge graph is structured in terms of how finely classes with unique characteristics are defined. Furthermore, this research presents potential impact of Class Granularity in knowledge graph's on downstream tasks. In particular, we explore its influence on graph embedding and provide experimental results. Additionally, this research goes beyond traditional Linked Open Data comparison studies, which mainly focus on factors like scale and class distribution, by using Class Granularity to compare four different LOD sources.

Fine-tuning large language models (LLMs) is essential for enhancing their performance on specific tasks but is often resource-intensive due to redundant or uninformative data. To address this inefficiency, we introduce DELIFT (Data Efficient Language model Instruction Fine-Tuning), a novel algorithm that systematically optimizes data selection across the three key stages of fine-tuning: (1) instruction tuning, (2) task-specific fine-tuning (e.g., reasoning, question-answering), and (3) continual fine-tuning (e.g., incorporating new data versions). Unlike existing methods that focus on single-stage optimization or rely on computationally intensive gradient calculations, DELIFT operates efficiently across all stages. Central to our approach is a pairwise utility metric that quantifies how beneficial a data sample is for improving the model's responses to other samples, effectively measuring the informational value relative to the model's current capabilities. By leveraging different submodular functions applied to this metric, DELIFT selects diverse and optimal subsets that are useful across all stages of fine-tuning. Experiments across various tasks and model scales demonstrate that DELIFT can reduce the fine-tuning data size by up to 70% without compromising performance, offering significant computational savings and outperforming existing methods in both efficiency and efficacy. Fine-tuning large language models (LLMs) is pivotal for adapting these powerful architectures (Devlin et al., 2019; Brown et al., 2020a; Touvron et al., 2023) to specialized tasks such as intricate reasoning, precise question-answering, and the seamless integration of new information (Ouyang et al., 2022). This transformation--from a general-purpose model to a task-specific agent--heavily relies on the quality and nature of the data employed during fine-tuning, which critically determines the model's subsequent performance (Wei et al., 2022; Zhou et al., 2023; Hoffmann et al., 2024). The effectiveness of fine-tuning hinges on the quality, diversity, and relevance of the selected data (Gururangan et al., 2020; Wei et al., 2022; Zhou et al., 2023). High-quality data ensures accurate learning, diverse data enhances generalization, and relevant data aligns the model's capabilities with specific application needs. However, optimizing data selection across different fine-tuning phases remains a significant challenge, leading to our central research question: How can we create a unified framework for efficient data selection across all fine-tuning stages of LLMs, while optimizing performance and maximizing data efficiency? To address this challenge, we present DELIFT (Data Efficient Language model Instruction Fine-Tuning), a novel, unified, and computationally efficient algorithm engineered to optimize data selection across all stages of the fine-tuning process.

A crash between two double-decker buses close to a city centre has left 13 people needing hospital treatment. Two Bee Network buses crashed on Rochdale Road off Livesey Street, Manchester, but no-one was seriously injured, Greater Manchester Police (GMP) said. Images show debris strewn across the highway as one of the vehicles appeared to have hit the back of the other. A GMP spokesman said the road remained shut while emergency services were at the scene.PatKarneyAn air ambulance was seen at the site of the crash on Rochdale Road Police were called to the incident at about 08:30 GMT. Manchester councillor Pat Karney, who was at the site, posted on X to say there had been "unbelievable damage" to the front of the bus.

This systematic review explores the theoretical foundations, evolution, applications, and future potential of Kolmogorov-Arnold Networks (KAN), a neural network model inspired by the Kolmogorov-Arnold representation theorem. KANs distinguish themselves from traditional neural networks by using learnable, spline-parameterized functions instead of fixed activation functions, allowing for flexible and interpretable representations of high-dimensional functions. This review details KAN's architectural strengths, including adaptive edge-based activation functions that improve parameter efficiency and scalability in applications such as time series forecasting, computational biomedicine, and graph learning. Key advancements, including Temporal-KAN, FastKAN, and Partial Differential Equation (PDE) KAN, illustrate KAN's growing applicability in dynamic environments, enhancing interpretability, computational efficiency, and adaptability for complex function approximation tasks. Additionally, this paper discusses KAN's integration with other architectures, such as convolutional, recurrent, and transformer-based models, showcasing its versatility in complementing established neural networks for tasks requiring hybrid approaches. Despite its strengths, KAN faces computational challenges in high-dimensional and noisy data settings, motivating ongoing research into optimization strategies, regularization techniques, and hybrid models. This paper highlights KAN's role in modern neural architectures and outlines future directions to improve its computational efficiency, interpretability, and scalability in data-intensive applications.

Large Language Models (LLMs) often encounter conflicts between their learned, internal (parametric knowledge, PK) and external knowledge provided during inference (contextual knowledge, CK). Understanding how LLMs models prioritize one knowledge source over the other remains a challenge. In this paper, we propose a novel probing framework to explore the mechanisms governing the selection between PK and CK in LLMs. Using controlled prompts designed to contradict the model's PK, we demonstrate that specific model activations are indicative of the knowledge source employed. We evaluate this framework on various LLMs of different sizes and demonstrate that mid-layer activations, particularly those related to relations in the input, are crucial in predicting knowledge source selection, paving the way for more reliable models capable of handling knowledge conflicts effectively.

Causal inference and model interpretability are gaining increasing attention, particularly in the biomedical domain. Despite recent advance, decorrelating features in nonlinear environments with human-interpretable representations remains underexplored. In this study, we introduce a novel method called causal rule generation with target trial emulation framework (CRTRE), which applies randomize trial design principles to estimate the causal effect of association rules. We then incorporate such association rules for the downstream applications such as prediction of disease onsets. Extensive experiments on six healthcare datasets, including synthetic data, real-world disease collections, and MIMIC-III/IV, demonstrate the model's superior performance. Specifically, our method achieved a $\beta$ error of 0.907, outperforming DWR (1.024) and SVM (1.141). On real-world datasets, our model achieved accuracies of 0.789, 0.920, and 0.300 for Esophageal Cancer, Heart Disease, and Cauda Equina Syndrome prediction task, respectively, consistently surpassing baseline models. On the ICD code prediction tasks, it achieved AUC Macro scores of 92.8 on MIMIC-III and 96.7 on MIMIC-IV, outperforming the state-of-the-art models KEPT and MSMN. Expert evaluations further validate the model's effectiveness, causality, and interpretability.