Since the explosion in popularity of ChatGPT, large language models (LLMs) have continued to impact our everyday lives. Equipped with external tools that are designed for a specific purpose (e.g., for flight booking or an alarm clock), LLM agents exercise an increasing capability to assist humans in their daily work. Although LLM agents have shown a promising blueprint as daily assistants, there is a limited understanding of how they can provide daily assistance based on planning and sequential decision making capabilities. We draw inspiration from recent work that has highlighted the value of 'LLM-modulo' setups in conjunction with humans-in-the-loop for planning tasks. We conducted an empirical study (N = 248) of LLM agents as daily assistants in six commonly occurring tasks with different levels of risk typically associated with them (e.g., flight ticket booking and credit card payments). To ensure user agency and control over the LLM agent, we adopted LLM agents in a plan-then-execute manner, wherein the agents conducted step-wise planning and step-by-step execution in a simulation environment. We analyzed how user involvement at each stage affects their trust and collaborative team performance. Our findings demonstrate that LLM agents can be a double-edged sword -- (1) they can work well when a high-quality plan and necessary user involvement in execution are available, and (2) users can easily mistrust the LLM agents with plans that seem plausible. We synthesized key insights for using LLM agents as daily assistants to calibrate user trust and achieve better overall task outcomes. Our work has important implications for the future design of daily assistants and human-AI collaboration with LLM agents.

Achieving consensus in group decision-making often involves overcoming significant challenges, particularly in reconciling diverse perspectives and mitigating biases that hinder agreement. Traditional methods relying on human facilitators are often constrained by scalability and efficiency, especially in large-scale, fast-paced discussions. To address these challenges, this study proposes a novel framework employing large language models (LLMs) as automated facilitators within a custom-built multi-user chat system. Leveraging cosine similarity as a core metric, this approach evaluates the ability of three state-of-the-art LLMs- ChatGPT 4.0, Mistral Large 2, and AI21 Jamba Instruct- to synthesize consensus proposals that align with participants' viewpoints. Unlike conventional techniques, the system integrates adaptive facilitation strategies, including clarifying misunderstandings, summarizing discussions, and proposing compromises, enabling the LLMs to iteratively refine consensus proposals based on user feedback. Experimental results demonstrate the superiority of ChatGPT 4.0, which achieves higher alignment with participant opinions, requiring fewer iterations to reach consensus compared to its counterparts. Moreover, analysis reveals the nuanced performance of the models across various sustainability-focused discussion topics, such as climate action, quality education, good health and well-being, and access to clean water and sanitation. These findings highlight the transformative potential of LLM-driven facilitation for improving collective decision-making processes and underscore the importance of advancing evaluation metrics and cross-cultural adaptability in future research.

Technical standards, or simply standards, are established documented guidelines and rules that facilitate the interoperability, quality, and accuracy of systems and processes. In recent years, we have witnessed an emerging paradigm shift where the adoption of generative AI (GenAI) models has increased tremendously, spreading implementation interests across standard-driven industries, including engineering, legal, healthcare, and education. In this paper, we assess the criticality levels of different standards across domains and sectors and complement them by grading the current compliance capabilities of state-of-the-art GenAI models. To support the discussion, we outline possible challenges and opportunities with integrating GenAI for standard compliance tasks while also providing actionable recommendations for entities involved with developing and using standards. Overall, we argue that aligning GenAI with standards through computational methods can help strengthen regulatory and operational compliance. We anticipate this area of research will play a central role in the management, oversight, and trustworthiness of larger, more powerful GenAI-based systems in the near future.

Recent technological advances have introduced new high-throughput methods for studying host-virus interactions, but testing synergistic interactions between host gene pairs during infection remains relatively slow and labor intensive. Identification of multiple gene knockdowns that effectively inhibit viral replication requires a search over the combinatorial space of all possible target gene pairs and is infeasible via brute-force experiments. Although active learning methods for sequential experimental design have shown promise, existing approaches have generally been restricted to single-gene knockdowns or small-scale double knockdown datasets. In this study, we present an integrated Deep Active Learning (DeepAL) framework that incorporates information from a biological knowledge graph (SPOKE, the Scalable Precision Medicine Open Knowledge Engine) to efficiently search the configuration space of a large dataset of all pairwise knockdowns of 356 human genes in HIV infection. Through graph representation learning, the framework is able to generate task-specific representations of genes while also balancing the exploration-exploitation trade-off to pinpoint highly effective double-knockdown pairs. We additionally present an ensemble method for uncertainty quantification and an interpretation of the gene pairs selected by our algorithm via pathway analysis. To our knowledge, this is the first work to show promising results on double-gene knockdown experimental data of appreciable scale (356 by 356 matrix).

While Transformers have become the dominant architecture for visual generation, linear attention models, such as the state-space models (SSM), are increasingly recognized for their efficiency in processing long visual sequences. However, the essential efficiency of these models comes from formulating a limited recurrent state, enforcing causality among tokens that are prone to inconsistent modeling of N-dimensional visual data, leaving questions on their capacity to generate long non-causal sequences. In this paper, we explore the boundary of SSM on image and video generation by building the largest-scale diffusion SSM-Transformer hybrid model to date (5B parameters) based on the sub-quadratic bi-directional Hydra and self-attention, and generate up to 2K images and 360p 8 seconds (16 FPS) videos. Our results demonstrate that the model can produce faithful results aligned with complex text prompts and temporal consistent videos with high dynamics, suggesting the great potential of using SSMs for visual generation tasks.

In neuroscience, identifying distinct patterns linked to neurological disorders, such as Alzheimer's and Autism, is critical for early diagnosis and effective intervention. Graph Neural Networks (GNNs) have shown promising in analyzing brain networks, but there are two major challenges in using GNNs: (1) distribution shifts in multi-site brain network data, leading to poor Out-of-Distribution (OOD) generalization, and (2) limited interpretability in identifying key brain regions critical to neurological disorders. To bridge these gaps, we introduce BrainOOD, a novel framework tailored for brain networks that enhances GNNs' OOD generalization and interpretability. BrainOOD framework consists of a feature selector and a structure extractor, which incorporates various auxiliary losses including an improved Graph Information Bottleneck (GIB) objective to recover causal subgraphs. By aligning structure selection across brain networks and filtering noisy features, BrainOOD offers reliable interpretations of critical brain regions. Our approach outperforms 16 existing methods and improves generalization to OOD subjects by up to 8.5%. Case studies highlight the scientific validity of the patterns extracted, which aligns with the findings in known neuroscience literature. We also propose the first OOD brain network benchmark, which provides a foundation for future research in this field. In neuroscience, a major goal is to identify distinct patterns linked to neurological disorders, such as Alzheimer's and Autism, by examining brain data of both healthy individuals and patients with these disorders (Poldrack et al., 2009). Among the neuroimaging techniques, resting-state functional magnetic resonance imaging (fMRI) is widely used to capture the functional connectivity between different brain regions (Worsley et al., 2002). These connections provide insights into how different brain regions co-activate or show correlated activities, offering a framework to study neurological systems through graphbased methods (Kawahara et al., 2017; Lanciano et al., 2020; Wang et al., 2023; Xu et al., 2024c). The most prevalent brain network analysis model is based on Graph Neural Networks (GNNs), which have recently shown promising results (Li et al., 2019; 2021; Xu et al., 2024a).

Music is a deeply personal experience and our aim is to enhance this with a fullyautomated pipeline for personalized music video generation. Our work allows listeners to not just be consumers but co-creators in the music video generation process by creating personalized, consistent and context-driven visuals based on lyrics, rhythm and emotion in the music. The pipeline combines multimodal translation and generation techniques and utilizes low-rank adaptation on listeners' images to create immersive music videos that reflect both the music and the individual. To ensure the ethical use of users' identity, we also introduce CHARCHA, a facial identity verification protocol that protects people against unauthorized use of their face while at the same time collecting authorized images from users for personalizing their videos. This paper thus provides a secure and innovative framework for creating deeply personalized music videos. Figure 1: Image stills and lyrics from generated music videos for Rick Astley's "Never Gonna Give You Up," with character reference from CHARCHA. The videos use Queratogray Sketch[1], Western Animation Diffusion[2], and Realistic Vision V5.1[3] checkpoint models .

This study addresses the growing concern of information asymmetry in consumer contracts, exacerbated by the proliferation of online services with complex Terms of Service that are rarely even read. Even though research on automatic analysis methods is conducted, the problem is aggravated by the general focus on English-language Machine Learning approaches and on major jurisdictions, such as the European Union. We introduce a new methodology and a substantial dataset addressing this gap. We propose a novel annotation scheme with four categories and a total of 20 classes, and apply it on 50 online Terms of Service used in Chile. Our evaluation of transformer-based models highlights how factors like language- and/or domain-specific pre-training, few-shot sample size, and model architecture affect the detection and classification of potentially abusive clauses. Results show a large variability in performance for the different tasks and models, with the highest macro-F1 scores for the detection task ranging from 79% to 89% and micro-F1 scores up to 96%, while macro-F1 scores for the classification task range from 60% to 70% and micro-F1 scores from 64% to 80%. Notably, this is the first Spanish-language multi-label classification dataset for legal clauses, applying Chilean law and offering a comprehensive evaluation of Spanish-language models in the legal domain. Our work lays the ground for future research in method development for rarely considered legal analysis and potentially leads to practical applications to support consumers in Chile and Latin America as a whole.

This study develops a transfer learning model for the automated classification of two species of fruit flies, Anastrepha fraterculus and Ceratitis capitata, in a controlled laboratory environment. The research addresses the need to optimize identification and classification, which are currently performed manually by experts, being affected by human factors and facing time challenges. The methodological process of this study includes the capture of high-quality images using a mobile phone camera and a stereo microscope, followed by segmentation to reduce size and focus on relevant morphological areas. The images were carefully labeled and preprocessed to ensure the quality and consistency of the dataset used to train the pre-trained convolutional neural network models VGG16, VGG19, and Inception-v3. The results were evaluated using the F1-score, achieving 82% for VGG16 and VGG19, while Inception-v3 reached an F1-score of 93%. Inception-v3's reliability was verified through model testing in uncontrolled environments, with positive results, complemented by the Grad-CAM technique, demonstrating its ability to capture essential morphological features. These findings indicate that Inception-v3 is an effective and replicable approach for classifying Anastrepha fraterculus and Ceratitis capitata, with potential for implementation in automated monitoring systems.

Reinforcement Learning from Human Feedback (RLHF) has achieved considerable success in aligning large language models (LLMs) by modeling human preferences with a learnable reward model and employing a reinforcement learning algorithm to maximize the reward model's scores. However, these reward models are susceptible to exploitation through various superficial confounding factors, with length bias emerging as a particularly significant concern. Moreover, while the pronounced impact of length bias on preference modeling suggests that LLMs possess an inherent sensitivity to length perception, our preliminary investigations reveal that fine-tuned LLMs consistently struggle to adhere to explicit length instructions. To address these two limitations, we propose a novel framework wherein the reward model explicitly differentiates between human semantic preferences and response length requirements. Specifically, we introduce a Response-conditioned Bradley-Terry (Rc-BT) model that enhances the reward model's capability in length bias mitigating and length instruction following, through training on our augmented dataset. Furthermore, we propose the Rc-DPO algorithm to leverage the Rc-BT model for direct policy optimization (DPO) of LLMs, simultaneously mitigating length bias and promoting adherence to length instructions. Extensive evaluations demonstrate that our approach substantially improves both preference modeling and length instruction compliance, with its effectiveness validated across various foundational models and preference datasets.