We study contextual online pricing with biased offline data. For the scalar price elasticity case, we identify the instance-dependent quantity $δ^2$ that measures how far the offline data lies from the (unknown) online optimum. We show that the time length $T$, bias bound $V$, size $N$ and dispersion $λ_{\min}(\hatΣ)$ of the offline data, and $δ^2$ jointly determine the statistical complexity. An Optimism-in-the-Face-of-Uncertainty (OFU) policy achieves a minimax-optimal, instance-dependent regret bound $\tilde{\mathcal{O}}\big(d\sqrt{T} \wedge (V^2T + \frac{dT}{λ_{\min}(\hatΣ) + (N \wedge T) δ^2})\big)$. For general price elasticity, we establish a worst-case, minimax-optimal rate $\tilde{\mathcal{O}}\big(d\sqrt{T} \wedge (V^2T + \frac{dT }{λ_{\min}(\hatΣ)})\big)$ and provide a generalized OFU algorithm that attains it. When the bias bound $V$ is unknown, we design a robust variant that always guarantees sub-linear regret and strictly improves on purely online methods whenever the exact bias is small. These results deliver the first tight regret guarantees for contextual pricing in the presence of biased offline data. Our techniques also transfer verbatim to stochastic linear bandits with biased offline data, yielding analogous bounds.

Ultrasound (US) is a widely used medical imaging modality due to its real-time capabilities, non-invasive nature, and cost-effectiveness. Robotic ultrasound can further enhance its utility by reducing operator dependence and improving access to complex anatomical regions. For this, while deep reinforcement learning (DRL) and imitation learning (IL) have shown potential for autonomous navigation, their use in complex surgical tasks such as anatomy reconstruction and surgical guidance remains limited -- largely due to the lack of realistic and efficient simulation environments tailored to these tasks. We introduce SonoGym, a scalable simulation platform for complex robotic ultrasound tasks that enables parallel simulation across tens to hundreds of environments. Our framework supports realistic and real-time simulation of US data from CT-derived 3D models of the anatomy through both a physics-based and a generative modeling approach. Sonogym enables the training of DRL and recent IL agents (vision transformers and diffusion policies) for relevant tasks in robotic orthopedic surgery by integrating common robotic platforms and orthopedic end effectors. We further incorporate submodular DRL -- a recent method that handles history-dependent rewards -- for anatomy reconstruction and safe reinforcement learning for surgery. Our results demonstrate successful policy learning across a range of scenarios, while also highlighting the limitations of current methods in clinically relevant environments. We believe our simulation can facilitate research in robot learning approaches for such challenging robotic surgery applications. Dataset, codes, and videos are publicly available at https://sonogym.github.io/.

Fetal abdominal malformations are serious congenital anomalies that require accurate diagnosis to guide pregnancy management and reduce mortality. Although AI has demonstrated significant potential in medical diagnosis, its application to prenatal abdominal anomalies remains limited. Most existing studies focus on image-level classification and rely on standard plane localization, placing less emphasis on case-level diagnosis. In this paper, we develop a case-level multiple instance learning (MIL)-based method, free of standard plane localization, for classifying fetal abdominal anomalies in prenatal ultrasound. Our contribution is three-fold. First, we adopt a mixture-of-attention-experts module (MoAE) to weight different attention heads for various planes. Secondly, we propose a medical-knowledge-driven feature selection module (MFS) to align image features with medical knowledge, performing self-supervised image token selection at the case-level. Finally, we propose a prompt-based prototype learning (PPL) to enhance the MFS. Extensively validated on a large prenatal abdominal ultrasound dataset containing 2,419 cases, with a total of 24,748 images and 6 categories, our proposed method outperforms the state-of-the-art competitors. Codes are available at:https://github.com/LL-AC/AAcls.

Modern vehicles are increasingly connected, and in this context, automotive Ethernet is one of the technologies that promise to provide the necessary infrastructure for intra-vehicle communication. However, these systems are subject to attacks that can compromise safety, including flow injection attacks. Deep Learning-based Intrusion Detection Systems (IDS) are often designed to combat this problem, but they require expensive hardware to run in real time. In this work, we propose to evaluate and apply fast neural network inference techniques like Distilling and Prunning for deploying IDS models on low-cost platforms in real time. The results show that these techniques can achieve intrusion detection times of up to 727 μs using a Raspberry Pi 4, with AUCROC values of 0.9890.

Large language models (LLMs) can simulate clinical reasoning based on natural language prompts, but their utility in ophthalmology is largely unexplored. This study evaluated GPT-4's ability to interpret structured textual descriptions of retinal fundus photographs and simulate clinical decisions for diabetic retinopathy (DR) and glaucoma screening, including the impact of adding real or synthetic clinical metadata. We conducted a retrospective diagnostic validation study using 300 annotated fundus images. GPT-4 received structured prompts describing each image, with or without patient metadata. The model was tasked with assigning an ICDR severity score, recommending DR referral, and estimating the cup-to-disc ratio for glaucoma referral. Performance was evaluated using accuracy, macro and weighted F1 scores, and Cohen's kappa. McNemar's test and change rate analysis were used to assess the influence of metadata. GPT-4 showed moderate performance for ICDR classification (accuracy 67.5%, macro F1 0.33, weighted F1 0.67, kappa 0.25), driven mainly by correct identification of normal cases. Performance improved in the binary DR referral task (accuracy 82.3%, F1 0.54, kappa 0.44). For glaucoma referral, performance was poor across all settings (accuracy ~78%, F1 <0.04, kappa <0.03). Metadata inclusion did not significantly affect outcomes (McNemar p > 0.05), and predictions remained consistent across conditions. GPT-4 can simulate basic ophthalmic decision-making from structured prompts but lacks precision for complex tasks. While not suitable for clinical use, LLMs may assist in education, documentation, or image annotation workflows in ophthalmology.

Foundation models are at the forefront of AI research, appealing for their ability to learn from vast datasets and cater to diverse tasks. Yet, their significant computational demands raise issues of environmental impact and the risk of centralized control in their development. We put forward a vision towards decentralized and sustainable foundation model training that leverages the collective compute of sparingly used connected edge AI devices. We present the rationale behind our vision, particularly in support of its sustainability benefit. We further outline a set of challenges that need to be addressed to turn this vision into reality.

There is justifiable interest in leveraging conversational AI (CAI) for health across the majority world, but to be effective, CAI must respond appropriately within cultur ally and linguistically diverse context s . Therefore, we need ways to address the fact that current LLMs exclude many lived experience s globally . Various advances are underway which focus on top - down approaches and increas ing training data . In this paper, we aim to complement these with a bottom - up locally - grounded approach based on qualitative data collected during participatory workshops in Latin America. Our goal is to construct a rich and human - centred understanding o f: a) potential areas of cultural misalignment in digital health; b) regional perspectives on chatbots for health and c) strategies for creating culturally - appropriate CAI; with a focus on the understudied Latin American context . Our findings show that academic boundaries on notions of cultur e lose meaning at the ground level and technologies will need to engage with a broad er framework; one that encapsulates the way economics, politics, geogr aphy and local logistics are entangled in cultural experience. To this end, we introduce a framework for ' Pluriversal Conversational AI for H ealth ' which allows for the possibility that more relationality and tolerance, rather than just more data, may be called for .

Extremile regression, as a least squares analog of quantile regression, is potentially useful tool for modeling and understanding the extreme tails of a distribution. However, existing extremile regression methods, as nonparametric approaches, may face challenges in high-dimensional settings due to data sparsity, computational inefficiency, and the risk of overfitting. While linear regression serves as the foundation for many other statistical and machine learning models due to its simplicity, interpretability, and relatively easy implementation, particularly in high-dimensional settings, this paper introduces a novel definition of linear extremile regression along with an accompanying estimation methodology. The regression coefficient estimators of this method achieve $\sqrt{n}$-consistency, which nonparametric extremile regression may not provide. In particular, while semi-supervised learning can leverage unlabeled data to make more accurate predictions and avoid overfitting to small labeled datasets in high-dimensional spaces, we propose a semi-supervised learning approach to enhance estimation efficiency, even when the specified linear extremile regression model may be misspecified. Both simulation studies and real data analyses demonstrate the finite-sample performance of our proposed methods.

AI-engineered paint could reduce the sweltering urban heat island effect in cities and cut air-conditioning bills, scientists have claimed, as machine learning accelerates the creation of new materials for everything from electric motors to carbon capture. Materials experts have used artificial intelligence to formulate new coatings that can keep buildings between 5C and 20C cooler than normal paint after exposure to midday sun. They could also be applied to cars, trains, electrical equipment and other objects that will require more cooling in a world that is heating up. Using machine learning, researchers at universities in the US, China, Singapore and Sweden designed new paint formulas tuned to best reflect the sun's rays and emit heat, according to a peer-reviewed study published in the science journal Nature. It is the latest example of AI being used to leapfrog traditional trial-and-error approaches to scientific advances.

We introduce HyperCLOVA X THINK, the first reasoning-focused large language model in the HyperCLOVA X family, pre-trained on roughly $6$ trillion high-quality Korean, and English tokens, augmented with targeted synthetic Korean data. It was implemented as a compute-memory-balanced Peri-LN Transformer scaled with $μ$P, pre-trained through a three-stage curriculum that expands the context window to $128$K tokens, and post-trained via supervised fine-tuning with Reinforcement Learning from Verifiable Rewards supports both detailed rationale and concise-answer modes. It delivers competitive performance against similarly sized models on Korea-focused benchmarks such as KMMLU, CSAT, KoBALT-700, HAERAE-1.0, and KoBigBench, while preserving robust bilingual consistency and translation quality. In addition, a vision-augmented variant matches or exceeds GPT-4.1 on the KCSAT STEM benchmark, all of which are achieved with substantially lower training compute than existing models of similar sizes. We also present a pruning and distillation technique that will soon be applied to HyperCLOVA X THINK for an open-source and business-friendly foundation model. Altogether, these capabilities position HyperCLOVA X THINK as a robust foundation for Korean AI innovation and a valuable resource for the global research community.