Molecular data from tumor profiles is high dimensional. Tumor profiles can be characterized by tens of thousands of gene expression features. Due to the size of the gene expression feature set machine learning methods are exposed to noisy variables and complexity. Tumor types present heterogeneity and can be subdivided in tumor subtypes. In many cases tumor data does not include tumor subtype labeling thus unsupervised learning methods are necessary for tumor subtype discovery. This work aims to learn meaningful and low dimensional representations of tumor samples and find tumor subtype clusters while keeping biological signatures without using tumor labels. The proposed method named Latent Kernel Feature Selection (LKFS) is an unsupervised approach for gene selection in tumor gene expression profiles. By using Autoencoders a low dimensional and denoised latent space is learned as a target representation to guide a Multiple Kernel Learning model that selects a subset of genes. By using the selected genes a clustering method is used to group samples. In order to evaluate the performance of the proposed unsupervised feature selection method the obtained features and clusters are analyzed by clinical significance. The proposed method has been applied on three tumor datasets which are Brain, Renal and Lung, each one composed by two tumor subtypes. When compared with benchmark unsupervised feature selection methods the results obtained by the proposed method reveal lower redundancy in the selected features and a better clustering performance.

To be an international trade or development hub, the WHO should take seriously this opportunity. We should not treat other countries as an obstacle to globalisation. A globalisation that requires the development of high-quality, effective and sustainable healthcare would also need to address the real needs of the non-human animals. It must be seen in that the current outbreak in Wuhan's Zhuhai Province in China is one of the most complex challenges to social control of the animal population in Wuhan, the number of infected animals at the time are estimated to be about 200,000, and the number of non-human animals is estimated to be about 400,000. All these numbers are based on the assumption that the animal rights of non-human animals are not strictly based on the rights and behaviour of non-human animals but only on the rights and behaviour of them.

Deterministic Policy Gradient (DPG) removes a level of randomness from standard randomized-action Policy Gradient (PG), and demonstrates substantial empirical success for tackling complex dynamic problems involving Markov decision processes. At the same time, though, DPG loses its ability to learn in a model-free (i.e., actor-only) fashion, frequently necessitating the use of critics in order to obtain consistent estimates of the associated policy-reward gradient. In this work, we introduce Zeroth-order Deterministic Policy Gradient (ZDPG), which approximates policy-reward gradients via two-point stochastic evaluations of the $Q$-function, constructed by properly designed low-dimensional action-space perturbations. Exploiting the idea of random horizon rollouts for obtaining unbiased estimates of the $Q$-function, ZDPG lifts the dependence on critics and restores true model-free policy learning, while enjoying built-in and provable algorithmic stability. Additionally, we present new finite sample complexity bounds for ZDPG, which improve upon existing results by up to two orders of magnitude. Our findings are supported by several numerical experiments, which showcase the effectiveness of ZDPG in a practical setting, and its advantages over both PG and Baseline PG.

ModiHost is a new platform for hotels that uses artificial intelligence to offer a better hotel management system, centered around personalization of the guest experience. In turn they aim to drive increased spending and brand loyalty. They say they've cracked the code that many hotels haven't, offering a solution for remembering guest preferences and anticipating their needs that most hotels wouldn't be able to employ on their own. As the company says it in its whitepaper: "Hotel management is a complex and convoluted industry. It is also a highly inefficient one. The need to operate multiple systems, integrate different booking systems, and process reservations via mediums ranging from email to fax, have made hotel management hopelessly complicated."

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In this work, we propose a novel approach for reinforcement learning driven by evolutionary computation. Our algorithm, dubbed as Evolutionary-Driven Reinforcement Learning (evo-RL), embeds the reinforcement learning algorithm in an evolutionary cycle, where we distinctly differentiate between purely evolvable (instinctive) behaviour versus purely learnable behaviour. Furthermore, we propose that this distinction is decided by the evolutionary process, thus allowing evo-RL to be adaptive to different environments. In addition, evo-RL facilitates learning on environments with rewardless states, which makes it more suited for real-world problems with incomplete information. To show that evo-RL leads to state-of-the-art performance, we present the performance of different state-of-the-art reinforcement learning algorithms when operating within evo-RL and compare it with the case when these same algorithms are executed independently. Results show that reinforcement learning algorithms embedded within our evo-RL approach significantly outperform the stand-alone versions of the same RL algorithms on OpenAI Gym control problems with rewardless states constrained by the same computational budget.

The Clustered Traveling Salesman Problem (CTSP) is a variant of the popular Traveling Salesman Problem (TSP) arising from a number of real-life applications. In this work, we explore an uncharted solution approach that solves the CTSP by transforming it to the well-studied TSP. For this purpose, we first investigate a technique to convert a CTSP instance to a TSP and then apply popular TSP solvers (including exact and heuristic solvers) to solve the resulting TSP instance. We want to answer the following questions: How do state-of-the-art TSP solvers perform on clustered instances converted from the CTSP? Do state-of-the-art TSP solvers compete well with the best performing methods specifically designed for the CTSP? For this purpose, we present intensive computational experiments on various CTSP benchmark instances to draw conclusions.

The increasing rise in machine learning and deep learning applications is requiring ever more computational resources to successfully meet the growing demands of an always-connected, automated world. Neuromorphic technologies based on Spiking Neural Network algorithms hold the promise to implement advanced artificial intelligence using a fraction of the computations and power requirements by modeling the functioning, and spiking, of the human brain. With the proliferation of tools and platforms aiding data scientists and machine learning engineers to develop the latest innovations in artificial and deep neural networks, a transition to a new paradigm will require building from the current well-established foundations. This paper explains the theoretical workings of neuromorphic technologies based on spikes, and overviews the state-of-art in hardware processors, software platforms and neuromorphic sensing devices. A progression path is paved for current machine learning specialists to update their skillset, as well as classification or predictive models from the current generation of deep neural networks to SNNs. This can be achieved by leveraging existing, specialized hardware in the form of SpiNNaker and the Nengo migration toolkit. First-hand, experimental results of converting a VGG-16 neural network to an SNN are shared. A forward gaze into industrial, medical and commercial applications that can readily benefit from SNNs wraps up this investigation into the neuromorphic computing future.

Deep learning's recent history has been one of achievement: from triumphing over humans in the game of Go to world-leading performance in image recognition, voice recognition, translation, and other tasks. But this progress has come with a voracious appetite for computing power. This article reports on the computational demands of Deep Learning applications in five prominent application areas and shows that progress in all five is strongly reliant on increases in computing power. Extrapolating forward this reliance reveals that progress along current lines is rapidly becoming economically, technically, and environmentally unsustainable. Thus, continued progress in these applications will require dramatically more computationally-efficient methods, which will either have to come from changes to deep learning or from moving to other machine learning methods.

Many of the world's most important fisheries are experiencing increases in illegal fishing, undermining efforts to sustainably conserve and manage fish stocks. A major challenge to ending illegal, unreported, and unregulated (IUU) fishing is improving our ability to identify whether a vessel is fishing illegally and where illegal fishing is likely to occur in the ocean. However, monitoring the oceans is costly, time-consuming, and logistically challenging for maritime authorities to patrol. To address this problem, we use vessel tracking data and machine learning to predict illegal fishing on the Patagonian Shelf, one of the world's most productive regions for fisheries. Specifically, we focus on Chinese fishing vessels, which have consistently fished illegally in this region. We combine vessel location data with oceanographic seascapes -- classes of oceanic areas based on oceanographic variables -- as well as other remotely sensed oceanographic variables to train a series of machine learning models of varying levels of complexity. These models are able to predict whether a Chinese vessel is operating illegally with 69-96% confidence, depending on the year and predictor variables used. These results offer a promising step towards preempting illegal activities, rather than reacting to them forensically.