The thesis explores the role machine learning methods play in creating intuitive computational models of neural processing. Combined with interpretability techniques, machine learning could replace human modeler and shift the focus of human effort to extracting the knowledge from the ready-made models and articulating that knowledge into intuitive descroptions of reality. This perspective makes the case in favor of the larger role that exploratory and data-driven approach to computational neuroscience could play while coexisting alongside the traditional hypothesis-driven approach. We exemplify the proposed approach in the context of the knowledge representation taxonomy with three research projects that employ interpretability techniques on top of machine learning methods at three different levels of neural organization. The first study (Chapter 3) explores feature importance analysis of a random forest decoder trained on intracerebral recordings from 100 human subjects to identify spectrotemporal signatures that characterize local neural activity during the task of visual categorization. The second study (Chapter 4) employs representation similarity analysis to compare the neural responses of the areas along the ventral stream with the activations of the layers of a deep convolutional neural network. The third study (Chapter 5) proposes a method that allows test subjects to visually explore the state representation of their neural signal in real time. This is achieved by using a topology-preserving dimensionality reduction technique that allows to transform the neural data from the multidimensional representation used by the computer into a two-dimensional representation a human can grasp. The approach, the taxonomy, and the examples, present a strong case for the applicability of machine learning methods to automatic knowledge discovery in neuroscience.

Contrastive representation learning has shown to be an effective way of learning representations from unlabeled data. However, much progress has been made in vision domains relying on data augmentations carefully designed using domain knowledge. In this work, we propose i-Mix, a simple yet effective regularization strategy for improving contrastive representation learning in both vision and non-vision domains. We cast contrastive learning as training a non-parametric classifier by assigning a unique virtual class to each data in a batch. Then, data instances are mixed in both the input and virtual label spaces, providing more augmented data during training. In experiments, we demonstrate that i-Mix consistently improves the quality of self-supervised representations across domains, resulting in significant performance gains on downstream tasks. Furthermore, we confirm its regularization effect via extensive ablation studies across model and dataset sizes.

Multimodal neural machine translation (NMT) has become an increasingly important area of research over the years because additional modalities, such as image data, can provide more context to textual data. Furthermore, the viability of training multimodal NMT models without a large parallel corpus continues to be investigated due to low availability of parallel sentences with images, particularly for English-Japanese data. However, this void can be filled with comparable sentences that contain bilingual terms and parallel phrases, which are naturally created through media such as social network posts and e-commerce product descriptions. In this paper, we propose a new multimodal English-Japanese corpus with comparable sentences that are compiled from existing image captioning datasets. In addition, we supplement our comparable sentences with a smaller parallel corpus for validation and test purposes. To test the performance of this comparable sentence translation scenario, we train several baseline NMT models with our comparable corpus and evaluate their English-Japanese translation performance. Due to low translation scores in our baseline experiments, we believe that current multimodal NMT models are not designed to effectively utilize comparable sentence data. Despite this, we hope for our corpus to be used to further research into multimodal NMT with comparable sentences.

About a quarter of people haven't ruled out the idea of dating a robot, according to a new survey, and the Dutch are the most accepting of the idea of artificial amour. Researchers from the University of Twente used data from the EU-backed SIENNA project that studies ethics and opinions surrounding cutting edge technology. They surveyed 11,000 people and found 27 per cent either supported the idea of dating a robot or hadn't completely ruled it out, and 72 per cent were completely opposed to the idea of a digital dalliance. In the Netherlands support for someone having a robotic boyfriend or girlfriend went up to 53 per cent, the highest of the 11 countries involved in the survey. The multinational telephone survey by the Dutch research team also found that people were uncomfortable with robots that look and behave like humans. About a quarter of people haven't ruled out the idea of dating a robot, according to a new survey, and the Dutch are the most accepting of the idea of artificial amour We are getting used to interacting with intelligent machines, from robot vacuum cleaners, smart speakers that can control our lights and AI assistants in our phones.

How do humans learn to acquire a powerful, flexible and robust representation of objects? While much of this process remains unknown, it is clear that humans do not require millions of object labels. Excitingly, recent algorithmic advancements in self-supervised learning now enable convolutional neural networks (CNNs) to learn useful visual object representations without supervised labels, too. In the light of this recent breakthrough, we here compare self-supervised networks to supervised models and human behaviour. We tested models on 15 generalisation datasets for which large-scale human behavioural data is available (130K highly controlled psychophysical trials). Surprisingly, current self-supervised CNNs share four key characteristics of their supervised counterparts: (1.) relatively poor noise robustness (with the notable exception of SimCLR), (2.) non-human category-level error patterns, (3.) non-human image-level error patterns (yet high similarity to supervised model errors) and (4.) a bias towards texture. Taken together, these results suggest that the strategies learned through today's supervised and self-supervised training objectives end up being surprisingly similar, but distant from human-like behaviour. That being said, we are clearly just at the beginning of what could be called a self-supervised revolution of machine vision, and we are hopeful that future self-supervised models behave differently from supervised ones, and---perhaps---more similar to robust human object recognition.

We consider the theory of regression on a manifold using reproducing kernel Hilbert space methods. Manifold models arise in a wide variety of modern machine learning problems, and our goal is to help understand the effectiveness of various implicit and explicit dimensionality-reduction methods that exploit manifold structure. Our first key contribution is to establish a novel nonasymptotic version of the Weyl law from differential geometry. From this we are able to show that certain spaces of smooth functions on a manifold are effectively finite-dimensional, with a complexity that scales according to the manifold dimension rather than any ambient data dimension. Finally, we show that given (potentially noisy) function values taken uniformly at random over a manifold, a kernel regression estimator (derived from the spectral decomposition of the manifold) yields minimax-optimal error bounds that are controlled by the effective dimension.

We prove a new upper bound on the generalization gap of classifiers that are obtained by first using self-supervision to learn a representation $r$ of the training data, and then fitting a simple (e.g., linear) classifier $g$ to the labels. Specifically, we show that (under the assumptions described below) the generalization gap of such classifiers tends to zero if $\mathsf{C}(g) \ll n$, where $\mathsf{C}(g)$ is an appropriately-defined measure of the simple classifier $g$'s complexity, and $n$ is the number of training samples. We stress that our bound is independent of the complexity of the representation $r$. We do not make any structural or conditional-independence assumptions on the representation-learning task, which can use the same training dataset that is later used for classification. Rather, we assume that the training procedure satisfies certain natural noise-robustness (adding small amount of label noise causes small degradation in performance) and rationality (getting the wrong label is not better than getting no label at all) conditions that widely hold across many standard architectures. We show that our bound is non-vacuous for many popular representation-learning based classifiers on CIFAR-10 and ImageNet, including SimCLR, AMDIM and MoCo.

Computing the discrepancy between time series of variable sizes is notoriously challenging. While dynamic time warping (DTW) is popularly used for this purpose, it is not differentiable everywhere and is known to lead to bad local optima when used as a "loss". Soft-DTW addresses these issues, but it is not a positive definite divergence: due to the bias introduced by entropic regularization, it can be negative and it is not minimized when the time series are equal. We propose in this paper a new divergence, dubbed soft-DTW divergence, which aims to correct these issues. We study its properties; in particular, under conditions on the ground cost, we show that it is non-negative and minimized when the time series are equal. We also propose a new "sharp" variant by further removing entropic bias. We showcase our divergences on time series averaging and demonstrate significant accuracy improvements compared to both DTW and soft-DTW on 84 time series classification datasets.

To design and construct hardware for general intelligence, we must consider principles of both neuroscience and very-large-scale integration. For large neural systems capable of general intelligence, the attributes of photonics for communication and electronics for computation are complementary and interdependent. Using light for communication enables high fan-out as well as low-latency signaling across large systems with no traffic-dependent bottlenecks. For computation, the inherent nonlinearities, high speed, and low power consumption of Josephson circuits are conducive to complex neural functions. Operation at 4\,K enables the use of single-photon detectors and silicon light sources, two features that lead to efficiency and economical scalability. Here I sketch a concept for optoelectronic hardware, beginning with synaptic circuits, continuing through wafer-scale integration, and extending to systems interconnected with fiber-optic white matter, potentially at the scale of the human brain and beyond.

Despite the many attempts and approaches for anomaly detection explored over the years, the automatic detection of rare events in data communication networks remains a complex problem. In this paper we introduce Net-GAN, a novel approach to network anomaly detection in time-series, using recurrent neural networks (RNNs) and generative adversarial networks (GAN). Different from the state of the art, which traditionally focuses on univariate measurements, Net-GAN detects anomalies in multivariate time-series, exploiting temporal dependencies through RNNs. Net-GAN discovers the underlying distribution of the baseline, multivariate data, without making any assumptions on its nature, offering a powerful approach to detect anomalies in complex, difficult to model network monitoring data. We further exploit the concepts behind generative models to conceive Net-VAE, a complementary approach to Net-GAN for network anomaly detection, based on variational auto-encoders (VAE). We evaluate Net-GAN and Net-VAE in different monitoring scenarios, including anomaly detection in IoT sensor data, and intrusion detection in network measurements. Generative models represent a promising approach for network anomaly detection, especially when considering the complexity and ever-growing number of time-series to monitor in operational networks.