The sidewalk outside Majed Zeidan's grocery store in San Francisco's Mission District has stayed filled with flowers, candles, memorials and pictures since his cat was crushed under a Waymo in late October. A month later, a Waymo reportedly crushed a dog. Amid the pictures of the cat, a visitor had placed a poster that said, "save the cat, kill the car". That's when Zeidan knew Kit Kat, his bodega cat, had become the face of the simmering discontent over San Francisco's growing number of self-driving cars. Residents became increasingly comfortable riding one, costumed Halloween parade goers clambered on its rooftops and danced, and pedestrians occasionally banged its bonnet to get it to give way to them.

A therapy that would once have been considered a feat of science fiction has reversed aggressive and incurable blood cancers in some patients, doctors report. The treatment involves precisely editing the DNA in white blood cells to transform them into a cancer-fighting living drug. The first girl to be treated, whose story we reported in 2022, is still free of the disease and now plans to become a cancer scientist. Now eight more children and two adults with T-cell acute lymphoblastic leukaemia have been treated, with almost two thirds (64%) of patients in remission. T-cells are supposed to be the body's guardians - seeking out and destroying threats - but in this form of leukaemia, they grow out of control.

Activewear brand Sweaty Betty has become involved in a new dispute over advertising slogans, which a period underwear company claims were copied. Kelly Newton said Sweaty Betty's use of two taglines that were very similar to her firm Nixi Body's seemed a little off, and while she could not get them trademarked she felt Sweaty Betty was taking from other female founders. Sweaty Betty said the No ifs. Ms Newton said she was speaking out after seeing personal trainer Georgina Cox reveal Sweaty Betty had offered her a settlement over a disputed slogan . Ms Newton, who co-founded Nixi Body in 2019, said the company has advertised its leak-proof period underwear with the lines Keeping you moving through menstruation, motherhood and menopause and No leaks.

Environment Conservation Ocean Underwater robot survives voyage to'never-accessed region of the planet' An Argo float delivered unprecedented data after eight months beneath Antarctic ice. Breakthroughs, discoveries, and DIY tips sent every weekday. Thanks to an underwater survey robot, oceanographers are getting the first-ever readings collected from underneath East Antarctic's vast ice shelves . But for a moment, it wasn't clear when(or if) the bright yellow float would return to the ocean's surface after it dove underneath the ice. "We got lucky," Steve Rintoul, an oceanographer with Australia's Commonwealth Scientific and Industrial Research Organization (CSIRO), said in a statement .

What is in the 28-point US plan for Ukraine? 'Ukraine is running out of men, money and time' Can the US get all sides to end the war? Why is Europe opposing Trump's peace plan? Firefighters evacuated residents and their pets from a nine-storey apartment building in Ukraine's Sumy region after a Russian drone strike. The strikes come as Ukrainian President Volodymyr Zelenskyy met with leaders of the UK, France and Germany in London to discuss the US peace plan.

Two armed men have stolen eight engravings by French artist Matisse and at least another five by Brazilian painter Cândido Portinari from a library in São Paulo. Brazilian officials say the thieves held up a security guard and an elderly couple who were visiting the library before making off with the artworks on foot. They reportedly entered the library by the main entrance at 10:00 (13:00 GMT) on Sunday, and left by the same route, heading towards the nearest metro station. The heist comes less than two months after the art world was rocked by a brazen break-in at the Louvre museum in Paris, where thieves made off with priceless jewels. The engravings stolen from Biblioteca Mário de Andrade on Sunday formed part of a joint exhibition with the São Paulo Museum of Modern Art.

What are the implications of Trump's Somali'garbage' comments? What happens if the US attacks Venezuela? Does'America First' make the US weaker? What we know about the DC pipe bomb suspect Brian Cole Jr. Trump to sign'one-rule' executive order on AI to bypass US state approvals United States President Donald Trump has said he will sign an executive order creating "one rulebook" for artificial intelligence (AI) development. The announcement on Monday via Trump's Truth Social account represented the US president's latest effort to remove AI barriers, a priority of his administration that has raised concerns related to oversight of the transformative technology.

A new strain of mpox, previously called monkeypox, has been detected in a person in England, say UK health officials. The virus is a mix of two major types of the mpox virus, and was found in someone who recently returned from travelling in Asia. Officials say they are still assessing the significance of the new strain. The UK Health Security Agency (UKHSA) says it is normal for viruses to evolve. Getting vaccinated remains the best way to protect against severe disease - although an mpox infection is mild for many.

Japan is facing a dementia crisis - can technology help? Last year, more than 18,000 older people living with dementia left their homes and wandered off in Japan. Almost 500 were later found dead. Police say such cases have doubled since 2012. Elderly people aged 65 and over now make up nearly 30% of Japan's population - the second-highest proportion in the world after Monaco, according to the World Bank.

As artificial intelligence and machine learning tools become more accessible, and scientists face new obstacles to data collection (e.g., rising costs, declining survey response rates), researchers increasingly use predictions from pre-trained algorithms as substitutes for missing or unobserved data. Though appealing for financial and logistical reasons, using standard tools for inference can misrepresent the association between independent variables and the outcome of interest when the true, unobserved outcome is replaced by a predicted value. In this paper, we characterize the statistical challenges inherent to drawing inference with predicted data (IPD) and show that high predictive accuracy does not guarantee valid downstream inference. We show that all such failures reduce to statistical notions of (i) bias, when predictions systematically shift the estimand or distort relationships among variables, and (ii) variance, when uncertainty from the prediction model and the intrinsic variability of the true data are ignored. We then review recent methods for conducting IPD and discuss how this framework is deeply rooted in classical statistical theory. We then comment on some open questions and interesting avenues for future work in this area, and end with some comments on how to use predicted data in scientific studies that is both transparent and statistically principled.