We describe the results of applying causal discovery methods on the data from a multi-site clinical trial, on the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT). The trial was inconclusive, with no clear benefits consistently shown for the whole cohort. However, there were questions regarding the reliability of the diagnosis and treatment protocol for a geographic subgroup of the cohort. With the inclusion of medical context in the form of domain knowledge, causal discovery is used to demonstrate regional discrepancies and to frame the regional transportability of the results. Furthermore, we show that, globally and especially for some subgroups, the treatment has significant causal effects, thus offering a more refined view of the trial results.

A longstanding mystery about how salt dissolves in water has finally been solved, thanks to machine learning. Understanding the complete process of how sodium chloride, or salt, dissolves in water is important for a range of scientific disciplines, from accurate climate models to making batteries.

Some humans would say a football match is impossible to predict with any great certainty, but Kashef, our Artificial Intelligence (AI) predictor, would disagree. Kashef has been playing with historical data and performance to predict the results of each game all the way to the final. No surprise that Kashef is backing Lionel Messi and his team to beat the Green Falcons in today's first fixture. Kashef is siding with the Danish Dynamite on this one. However, Tunisia still stands an almost 50 percent chance of picking up at least a point.

CTG a leading provider of digital IT solutions and services that drive clients' productivity and profitability in North America and Western Europe,announced Rénald Wauthier, Senior Vice President of Europe, is immediately stepping down from his position. The Company has appointed Bob Daelman, the current Vice President of Belgium and the United Kingdom and Managing Director of Belgium, as his successor. Data to Power BI: 3 Ways to Export ServiceNow Data to Power BI Under Mr. Wauthier's leadership, CTG Europe achieved many notable accomplishments, including: "After a distinguished 27-year career with the Company, Rénald leaves CTG Europe in a strong position for continued growth. It has been my distinct pleasure to work closely with him throughout his career at CTG," said Filip Gydé, CTG President and CEO. "On behalf of the entire organization, I extend our sincere thanks to Rénald for his many years of valuable contributions and wish him the very best in his future endeavors."

Heart failure is typically diagnosed with a global function assessment, such as ejection fraction. However, these metrics have low discriminate power, failing to distinguish different types of this disease. Quantifying local deformations in the form of cardiac strain can provide helpful information, but it remains a challenge. In this work, we introduce WarpPINN, a physics-informed neural network to perform image registration to obtain local metrics of the heart deformation. We apply this method to cine magnetic resonance images to estimate the motion during the cardiac cycle. We inform our neural network of near-incompressibility of cardiac tissue by penalizing the jacobian of the deformation field. The loss function has two components: an intensity-based similarity term between the reference and the warped template images, and a regularizer that represents the hyperelastic behavior of the tissue. The architecture of the neural network allows us to easily compute the strain via automatic differentiation to assess cardiac activity. We use Fourier feature mappings to overcome the spectral bias of neural networks, allowing us to capture discontinuities in the strain field. We test our algorithm on a synthetic example and on a cine-MRI benchmark of 15 healthy volunteers. We outperform current methodologies both landmark tracking and strain estimation. We expect that WarpPINN will enable more precise diagnostics of heart failure based on local deformation information. Source code is available at https://github.com/fsahli/WarpPINN.

The SARS-CoV-2 coronavirus is the cause of the COVID-19 disease in humans. Like many coronaviruses, it can adapt to different hosts and evolve into different lineages. It is well-known that the major SARS-CoV-2 lineages are characterized by mutations that happen predominantly in the spike protein. Understanding the spike protein structure and how it can be perturbed is vital for understanding and determining if a lineage is of concern. These are crucial to identifying and controlling current outbreaks and preventing future pandemics. Machine learning (ML) methods are a viable solution to this effort, given the volume of available sequencing data, much of which is unaligned or even unassembled. However, such ML methods require fixed-length numerical feature vectors in Euclidean space to be applicable. Similarly, euclidean space is not considered the best choice when working with the classification and clustering tasks for biological sequences. For this purpose, we design a method that converts the protein (spike) sequences into the sequence similarity network (SSN). We can then use SSN as an input for the classical algorithms from the graph mining domain for the typical tasks such as classification and clustering to understand the data. We show that the proposed alignment-free method is able to outperform the current SOTA method in terms of clustering results. Similarly, we are able to achieve higher classification accuracy using well-known Node2Vec-based embedding compared to other baseline embedding approaches.

Recent advances in text classification and knowledge capture in language models have relied on availability of large-scale text datasets. However, language models are trained on static snapshots of knowledge and are limited when that knowledge evolves. This is especially critical for misinformation detection, where new types of misinformation continuously appear, replacing old campaigns. We propose time-aware misinformation datasets to capture time-critical phenomena. In this paper, we first present evidence of evolving misinformation and show that incorporating even simple time-awareness significantly improves classifier accuracy. Second, we present COVID-TAD, a large-scale COVID-19 misinformation da-taset spanning 25 months. It is the first large-scale misinformation dataset that contains multiple snapshots of a datastream and is orders of magnitude bigger than related misinformation datasets. We describe the collection and labeling pro-cess, as well as preliminary experiments.

This paper addresses the problem of enabling inter-machine Ultra-Reliable Low-Latency Communication (URLLC) in future 6G Industrial Internet of Things (IIoT) networks. As far as the Radio Access Network (RAN) is concerned, centralized pre-configured resource allocation requires scheduling grants to be disseminated to the User Equipments (UEs) before uplink transmissions, which is not efficient for URLLC, especially in case of flexible/unpredictable traffic. To alleviate this burden, we study a distributed, user-centric scheme based on machine learning in which UEs autonomously select their uplink radio resources without the need to wait for scheduling grants or preconfiguration of connections. Using simulation, we demonstrate that a Multi-Armed Bandit (MAB) approach represents a desirable solution to allocate resources with URLLC in mind in an IIoT environment, in case of both periodic and aperiodic traffic, even considering highly populated networks and aggressive traffic.

How do author perceptions match up to the outcomes of the peer-review process and perceptions of others? In a top-tier computer science conference (NeurIPS 2021) with more than 23,000 submitting authors and 9,000 submitted papers, we survey the authors on three questions: (i) their predicted probability of acceptance for each of their papers, (ii) their perceived ranking of their own papers based on scientific contribution, and (iii) the change in their perception about their own papers after seeing the reviews. The salient results are: (1) Authors have roughly a three-fold overestimate of the acceptance probability of their papers: The median prediction is 70% for an approximately 25% acceptance rate. (2) Female authors exhibit a marginally higher (statistically significant) miscalibration than male authors; predictions of authors invited to serve as meta-reviewers or reviewers are similarly calibrated, but better than authors who were not invited to review. (3) Authors' relative ranking of scientific contribution of two submissions they made generally agree (93%) with their predicted acceptance probabilities, but there is a notable 7% responses where authors think their better paper will face a worse outcome. (4) The author-provided rankings disagreed with the peer-review decisions about a third of the time; when co-authors ranked their jointly authored papers, co-authors disagreed at a similar rate -- about a third of the time. (5) At least 30% of respondents of both accepted and rejected papers said that their perception of their own paper improved after the review process. The stakeholders in peer review should take these findings into account in setting their expectations from peer review.

Self-supervised learning (SSL) has proven vital in speech and audio-related applications. The paradigm trains a general model on unlabeled data that can later be used to solve specific downstream tasks. This type of model is costly to train as it requires manipulating long input sequences that can only be handled by powerful centralised servers. Surprisingly, despite many attempts to increase training efficiency through model compression, the effects of truncating input sequence lengths to reduce computation have not been studied. In this paper, we provide the first empirical study of SSL pre-training for different specified sequence lengths and link this to various downstream tasks. We find that training on short sequences can dramatically reduce resource costs while retaining a satisfactory performance for all tasks. This simple one-line change would promote the migration of SSL training from data centres to user-end edge devices for more realistic and personalised applications.