The task of dimensionality reduction and visualization of high-dimensional datasets remains a challenging problem since long. Modern high-throughput technologies produce newer high-dimensional datasets having multiple views with relatively new data types. Visualization of these datasets require proper methodology that can uncover hidden patterns in the data without affecting the local and global structures within the data. To this end, however, very few such methodology exist, which can realise this task. In this work, we have introduced a novel unsupervised deep neural network model, called NeuroDAVIS, for data visualization. NeuroDAVIS is capable of extracting important features from the data, without assuming any data distribution, and visualize effectively in lower dimension. It has been shown theoritically that neighbourhood relationship of the data in high dimension remains preserved in lower dimension. The performance of NeuroDAVIS has been evaluated on a wide variety of synthetic and real high-dimensional datasets including numeric, textual, image and biological data. NeuroDAVIS has been highly competitive against both t-Distributed Stochastic Neighbor Embedding (t-SNE) and Uniform Manifold Approximation and Projection (UMAP) with respect to visualization quality, and preservation of data size, shape, and both local and global structure. It has outperformed Fast interpolation-based t-SNE (Fit-SNE), a variant of t-SNE, for most of the high-dimensional datasets as well. For the biological datasets, besides t-SNE, UMAP and Fit-SNE, NeuroDAVIS has also performed well compared to other state-of-the-art algorithms, like Potential of Heat-diffusion for Affinity-based Trajectory Embedding (PHATE) and the siamese neural network-based method, called IVIS. Downstream classification and clustering analyses have also revealed favourable results for NeuroDAVIS-generated embeddings.

Generative AI – including large language models such as GPT-4, and image generators such as DALL-E, Midjourney, and Stable Diffusion – is advancing in a "storm of hype and fright", as some commentators have observed. Recent advances in artificial intelligence have yielded warnings that the rapidly developing technology may result in "ever more powerful digital minds that no one – not even their creators – can understand, predict, or reliably control". That's according to an open letter signed by more than 1,000 AI experts, researchers and backers, which calls for an immediate pause on the creation of "giant" AIs for six months so that safety protocols can be developed to mitigate their dangers. But what is the technology currently capable of doing? Midjourney creates images from text descriptions.

For instance, according to the Centers for Medicare & Medicaid Services, in December 2021, it was reported that the total national health expenditure in the U.S. increased to USD 4.1 trillion in 2020, which was a growth of 9.7% as compared to the previous year. Thus, a significant number of insurance providers are relying on the service providers to negotiate the drug price with retail pharmacy units and lower the price of the listed drugs in the insurance coverage. Furthermore, increasing initiatives, such as extending mail order delivery services and strengthening distribution network in remote areas, were responsible for the growing adoption of these services. Hence, these initiatives by the major players coupled with increasing demand for specialty drugs boosted the pharmacy benefit management market growth during the COVID-19 pandemic. Request a Free sample to learn more about this report.

Artificial intelligence in some shape or form has been a part of everyday life for years, but the meteoric rise of ChatGPT and the resulting aggressive development pace of conversational and generative AI models is, for the first time ever, putting the underlying technology into the hands of the general public. Even though current large language models are primarily able to guess the best-fitting next word in a sentence based on the corpus of content they were fed, CEOs, researchers and AI experts are now urging the industry to pump the brakes on training and developing models more capable than OpenAI's GPT-4. The company's latest large language model is currently available in a limited capacity for ChatGPT Plus subscribers and will soon be integrated into Microsoft productivity and security products. According to an open letter signed by influential figures like Elon Musk and Stability AI CEO Emad Mostaque, « powerful AI systems should be developed only once we are confident that their effects will be positive and their risks will be manageable. The Musk Foundation is a primary donor to the organization.

Despite the recent remarkable improvements in scene text recognition (STR), the majority of the studies focused mainly on the English language, which only includes few number of characters. However, STR models show a large performance degradation on languages with a numerous number of characters (e.g., Chinese and Korean), especially on characters that rarely appear due to the long-tailed distribution of characters in such languages. To address such an issue, we conducted an empirical analysis using synthetic datasets with different character-level distributions (e.g., balanced and long-tailed distributions). While increasing a substantial number of tail classes without considering the context helps the model to correctly recognize characters individually, training with such a synthetic dataset interferes the model with learning the contextual information (i.e., relation among characters), which is also important for predicting the whole word. Based on this motivation, we propose a novel Context-Aware and Free Experts Network (CAFE-Net) using two experts: 1) context-aware expert learns the contextual representation trained with a long-tailed dataset composed of common words used in everyday life and 2) context-free expert focuses on correctly predicting individual characters by utilizing a dataset with a balanced number of characters. By training two experts to focus on learning contextual and visual representations, respectively, we propose a novel confidence ensemble method to compensate the limitation of each expert. Through the experiments, we demonstrate that CAFE-Net improves the STR performance on languages containing numerous number of characters. Moreover, we show that CAFE-Net is easily applicable to various STR models.

This paper provides a comprehensive tutorial for Bayesian practitioners in pharmacometrics using Pumas workflows. We start by giving a brief motivation of Bayesian inference for pharmacometrics highlighting limitations in existing software that Pumas addresses. We then follow by a description of all the steps of a standard Bayesian workflow for pharmacometrics using code snippets and examples. This includes: model definition, prior selection, sampling from the posterior, prior and posterior simulations and predictions, counter-factual simulations and predictions, convergence diagnostics, visual predictive checks, and finally model comparison with cross-validation. Finally, the background and intuition behind many advanced concepts in Bayesian statistics are explained in simple language. This includes many important ideas and precautions that users need to keep in mind when performing Bayesian analysis. Many of the algorithms, codes, and ideas presented in this paper are highly applicable to clinical research and statistical learning at large but we chose to focus our discussions on pharmacometrics in this paper to have a narrower scope in mind and given the nature of Pumas as a software primarily for pharmacometricians.

Neural networks are a powerful class of non-linear functions. However, their black-box nature makes it difficult to explain their behaviour and certify their safety. Abstraction techniques address this challenge by transforming the neural network into a simpler, over-approximated function. Unfortunately, existing abstraction techniques are slack, which limits their applicability to small local regions of the input domain. In this paper, we propose Global Interval Neural Network Abstractions with Center-Exact Reconstruction (GINNACER). Our novel abstraction technique produces sound over-approximation bounds over the whole input domain while guaranteeing exact reconstructions for any given local input. Our experiments show that GINNACER is several orders of magnitude tighter than state-of-the-art global abstraction techniques, while being competitive with local ones.

Average-K classification is an alternative to top-K classification in which the number of labels returned varies with the ambiguity of the input image but must average to K over all the samples. A simple method to solve this task is to threshold the softmax output of a model trained with the cross-entropy loss. This approach is theoretically proven to be asymptotically consistent, but it is not guaranteed to be optimal for a finite set of samples. In this paper, we propose a new loss function based on a multi-label classification head in addition to the classical softmax. This second head is trained using pseudo-labels generated by thresholding the softmax head while guaranteeing that K classes are returned on average. We show that this approach allows the model to better capture ambiguities between classes and, as a result, to return more consistent sets of possible classes. Experiments on two datasets from the literature demonstrate that our approach outperforms the softmax baseline, as well as several other loss functions more generally designed for weakly supervised multi-label classification. The gains are larger the higher the uncertainty, especially for classes with few samples.

Sound correspondence patterns form the basis of cognate detection and phonological reconstruction in historical language comparison. Methods for the automatic inference of correspondence patterns from phonetically aligned cognate sets have been proposed, but their application to multilingual wordlists requires extremely well annotated datasets. Since annotation is tedious and time consuming, it would be desirable to find ways to improve aligned cognate data automatically. Taking inspiration from trimming techniques in evolutionary biology, which improve alignments by excluding problematic sites, we propose a workflow that trims phonetic alignments in comparative linguistics prior to the inference of correspondence patterns. Testing these techniques on a large standardized collection of ten datasets with expert annotations from different language families, we find that the best trimming technique substantially improves the overall consistency of the alignments. The results show a clear increase in the proportion of frequent correspondence patterns and words exhibiting regular cognate relations.

This paper studies the problem of designing an optimal sequence of interventions in a causal graphical model to minimize cumulative regret with respect to the best intervention in hindsight. This is, naturally, posed as a causal bandit problem. The focus is on causal bandits for linear structural equation models (SEMs) and soft interventions. It is assumed that the graph's structure is known and has $N$ nodes. Two linear mechanisms, one soft intervention and one observational, are assumed for each node, giving rise to $2^N$ possible interventions. Majority of the existing causal bandit algorithms assume that at least the interventional distributions of the reward node's parents are fully specified. However, there are $2^N$ such distributions (one corresponding to each intervention), acquiring which becomes prohibitive even in moderate-sized graphs. This paper dispenses with the assumption of knowing these distributions or their marginals. Two algorithms are proposed for the frequentist (UCB-based) and Bayesian (Thompson Sampling-based) settings. The key idea of these algorithms is to avoid directly estimating the $2^N$ reward distributions and instead estimate the parameters that fully specify the SEMs (linear in $N$) and use them to compute the rewards. In both algorithms, under boundedness assumptions on noise and the parameter space, the cumulative regrets scale as $\tilde{\cal O} (d^{L+\frac{1}{2}} \sqrt{NT})$, where $d$ is the graph's maximum degree, and $L$ is the length of its longest causal path. Additionally, a minimax lower of $\Omega(d^{\frac{L}{2}-2}\sqrt{T})$ is presented, which suggests that the achievable and lower bounds conform in their scaling behavior with respect to the horizon $T$ and graph parameters $d$ and $L$.