In the realm of time series forecasting (TSF), it is imperative for models to adeptly discern and distill hidden patterns within historical time series data to forecast future states. Transformer-based models exhibit formidable efficacy in TSF, primarily attributed to their advantage in apprehending these patterns. However, the quadratic complexity of the Transformer leads to low computational efficiency and high costs, which somewhat hinders the deployment of the TSF model in real-world scenarios. Recently, Mamba, a selective state space model, has gained traction due to its ability to process dependencies in sequences while maintaining near-linear complexity. For TSF tasks, these characteristics enable Mamba to comprehend hidden patterns as the Transformer and reduce computational overhead compared to the Transformer. Therefore, we propose a Mamba-based model named Simple-Mamba (S-Mamba) for TSF. Specifically, we tokenize the time points of each variate autonomously via a linear layer. A bidirectional Mamba layer is utilized to extract inter-variate correlations and a Feed-Forward Network is set to learn temporal dependencies. Finally, the generation of forecast outcomes through a linear mapping layer. Experiments on thirteen public datasets prove that S-Mamba maintains low computational overhead and achieves leading performance. Furthermore, we conduct extensive experiments to explore Mamba's potential in TSF tasks. Our code is available at https://github.com/wzhwzhwzh0921/S-D-Mamba.

The introduction of genome engineering technology has transformed biomedical research, making it possible to make precise changes to genetic information. However, creating an efficient gene-editing system requires a deep understanding of CRISPR technology, and the complex experimental systems under investigation. While Large Language Models (LLMs) have shown promise in various tasks, they often lack specific knowledge and struggle to accurately solve biological design problems. In this work, we introduce CRISPR-GPT, an LLM agent augmented with domain knowledge and external tools to automate and enhance the design process of CRISPR-based gene-editing experiments. CRISPR-GPT leverages the reasoning ability of LLMs to facilitate the process of selecting CRISPR systems, designing guide RNAs, recommending cellular delivery methods, drafting protocols, and designing validation experiments to confirm editing outcomes. We showcase the potential of CRISPR-GPT for assisting non-expert researchers with gene-editing experiments from scratch and validate the agent's effectiveness in a real-world use case. Furthermore, we explore the ethical and regulatory considerations associated with automated gene-editing design, highlighting the need for responsible and transparent use of these tools. Our work aims to bridge the gap between beginner biological researchers and CRISPR genome engineering techniques, and demonstrate the potential of LLM agents in facilitating complex biological discovery tasks.

With the advent of large language models(LLMs) enhanced by the chain-of-thought(CoT) methodology, visual reasoning problem is usually decomposed into manageable sub-tasks and tackled sequentially with various external tools. However, such a paradigm faces the challenge of the potential "determining hallucinations" in decision-making due to insufficient visual information and the limitation of low-level perception tools that fail to provide abstract summaries necessary for comprehensive reasoning. We argue that converging visual context acquisition and logical reasoning is pivotal for tackling visual reasoning tasks. This paper delves into the realm of multimodal CoT to solve intricate visual reasoning tasks with multimodal large language models(MLLMs) and their cognitive capability. To this end, we propose an innovative multimodal CoT framework, termed Cantor, characterized by a perception-decision architecture. Cantor first acts as a decision generator and integrates visual inputs to analyze the image and problem, ensuring a closer alignment with the actual context. Furthermore, Cantor leverages the advanced cognitive functions of MLLMs to perform as multifaceted experts for deriving higher-level information, enhancing the CoT generation process. Our extensive experiments demonstrate the efficacy of the proposed framework, showing significant improvements in multimodal CoT performance across two complex visual reasoning datasets, without necessitating fine-tuning or ground-truth rationales. Project Page: https://ggg0919.github.io/cantor/ .

Despite the recent progress in long-context language models, it remains elusive how transformer-based models exhibit the capability to retrieve relevant information from arbitrary locations within the long context. This paper aims to address this question. Our systematic investigation across a wide spectrum of models reveals that a special type of attention heads are largely responsible for retrieving information, which we dub retrieval heads. We identify intriguing properties of retrieval heads:(1) universal: all the explored models with long-context capability have a set of retrieval heads; (2) sparse: only a small portion (less than 5\%) of the attention heads are retrieval. (3) intrinsic: retrieval heads already exist in models pretrained with short context. When extending the context length by continual pretraining, it is still the same set of heads that perform information retrieval. (4) dynamically activated: take Llama-2 7B for example, 12 retrieval heads always attend to the required information no matter how the context is changed. The rest of the retrieval heads are activated in different contexts. (5) causal: completely pruning retrieval heads leads to failure in retrieving relevant information and results in hallucination, while pruning random non-retrieval heads does not affect the model's retrieval ability. We further show that retrieval heads strongly influence chain-of-thought (CoT) reasoning, where the model needs to frequently refer back the question and previously-generated context. Conversely, tasks where the model directly generates the answer using its intrinsic knowledge are less impacted by masking out retrieval heads. These observations collectively explain which internal part of the model seeks information from the input tokens. We believe our insights will foster future research on reducing hallucination, improving reasoning, and compressing the KV cache.

The widespread deployment of wireless and mobile devices results in a proliferation of spatio-temporal data that is used in applications, e.g., traffic prediction, human mobility mining, and air quality prediction, where spatio-temporal prediction is often essential to enable safety, predictability, or reliability. Many recent proposals that target deep learning for spatio-temporal prediction suffer from so-called catastrophic forgetting, where previously learned knowledge is entirely forgotten when new data arrives. Such proposals may experience deteriorating prediction performance when applied in settings where data streams into the system. To enable spatio-temporal prediction on streaming data, we propose a unified replay-based continuous learning framework. The framework includes a replay buffer of previously learned samples that are fused with training data using a spatio-temporal mixup mechanism in order to preserve historical knowledge effectively, thus avoiding catastrophic forgetting. To enable holistic representation preservation, the framework also integrates a general spatio-temporal autoencoder with a carefully designed spatio-temporal simple siamese (STSimSiam) network that aims to ensure prediction accuracy and avoid holistic feature loss by means of mutual information maximization. The framework further encompasses five spatio-temporal data augmentation methods to enhance the performance of STSimSiam. Extensive experiments on real data offer insight into the effectiveness of the proposed framework.

Accurately forecasting traffic flows is critically important to many real applications including public safety and intelligent transportation systems. The challenges of this problem include both the dynamic mobility patterns of the people and the complex spatial-temporal correlations of the urban traffic data. Meanwhile, most existing models ignore the diverse impacts of the various traffic observations (e.g. vehicle speed and road occupancy) on the traffic flow prediction, and different traffic observations can be considered as different channels of input features. We argue that the analysis in multiple-channel traffic observations might help to better address this problem. In this paper, we study the novel problem of multi-channel traffic flow prediction, and propose a deep \underline{M}ulti-\underline{V}iew \underline{C}hannel-wise \underline{S}patio-\underline{T}emporal \underline{Net}work (MVC-STNet) model to effectively address it. Specifically, we first construct the localized and globalized spatial graph where the multi-view fusion module is used to effectively extract the local and global spatial dependencies. Then LSTM is used to learn the temporal correlations. To effectively model the different impacts of various traffic observations on traffic flow prediction, a channel-wise graph convolutional network is also designed. Extensive experiments are conducted over the PEMS04 and PEMS08 datasets. The results demonstrate that the proposed MVC-STNet outperforms state-of-the-art methods by a large margin.

Self-supervised learned (SSL) models such as Wav2vec and HuBERT yield state-of-the-art results on speech-related tasks. Given the effectiveness of such models, it is advantageous to use them in conventional ASR systems. While some approaches suggest incorporating these models as a trainable encoder or a learnable frontend, training such systems is extremely slow and requires a lot of computation cycles. In this work, we propose two simple approaches that use (1) framewise addition and (2) cross-attention mechanisms to efficiently incorporate the representations from the SSL model(s) into the ASR architecture, resulting in models that are comparable in size with standard encoder-decoder conformer systems while also avoiding the usage of SSL models during training. Our approach results in faster training and yields significant performance gains on the Librispeech and Tedlium datasets compared to baselines. We further provide detailed analysis and ablation studies that demonstrate the effectiveness of our approach.

Extracting structured event knowledge, including event triggers and corresponding arguments, from military texts is fundamental to many applications, such as intelligence analysis and decision assistance. However, event extraction in the military field faces the data scarcity problem, which impedes the research of event extraction models in this domain. To alleviate this problem, we propose CMNEE, a large-scale, document-level open-source Chinese Military News Event Extraction dataset. It contains 17,000 documents and 29,223 events, which are all manually annotated based on a pre-defined schema for the military domain including 8 event types and 11 argument role types. We designed a two-stage, multi-turns annotation strategy to ensure the quality of CMNEE and reproduced several state-of-the-art event extraction models with a systematic evaluation. The experimental results on CMNEE fall shorter than those on other domain datasets obviously, which demonstrates that event extraction for military domain poses unique challenges and requires further research efforts. Our code and data can be obtained from https://github.com/Mzzzhu/CMNEE.

A multimodal AI agent is characterized by its ability to process and learn from various types of data, including natural language, visual, and audio inputs, to inform its actions. Despite advancements in large language models that incorporate visual data, such as GPT-4V, effectively translating image-based data into actionable outcomes for AI agents continues to be challenging. In this paper, we introduce a multimodal model that incorporates the concept of functional token specifically designed for AI agent applications. To ensure compatibility with edge devices, our model is optimized to a compact size of less than 1B parameters. Like GPT-4, our model can process both English and Chinese. We demonstrate that this model is capable of operating efficiently on a wide range of edge devices, including as constrained as a Raspberry Pi.

Scientists claim they have had the first one-on-one conversation with a whale. The team from the SETI Institute and the University of California'spoke' with a 38-year-old humpback whale, named Twain, off the coast of Alaska. They used an underwater microphone to send out whale calls, 'whup/throp' sounds, and received 36 responses that seemed like Twain was actively engaged in a communicative exchange. AI-powered algorithms analyzed the replies, revealing Twain may have shared a greeting call with the team on a boat in the Pacific Ocean. While speaking to a different species has never been done in this manner, researchers are using the experience to hopefully one day converse with extraterrestrial life.