In optical coherence tomography (OCT) volumes of retina, the sequential acquisition of the individual slices makes this modality prone to motion artifacts, misalignments between adjacent slices being the most noticeable. Any distortion in OCT volumes can bias structural analysis and influence the outcome of longitudinal studies. On the other hand, presence of speckle noise that is characteristic of this imaging modality, leads to inaccuracies when traditional registration techniques are employed. Also, the lack of a well-defined ground truth makes supervised deep-learning techniques ill-posed to tackle the problem. In this paper, we tackle these issues by using deep reinforcement learning to correct inter-frame movements in an unsupervised manner. Specifically, we use dueling deep Q-network to train an artificial agent to find the optimal policy, i.e. a sequence of actions, that best improves the alignment by maximizing the sum of reward signals. Instead of relying on the ground-truth of transformation parameters to guide the rewarding system, for the first time, we use a combination of intensity based image similarity metrics. Further, to avoid the agent bias towards speckle noise, we ensure the agent can see retinal layers as part of the interacting environment. For quantitative evaluation, we simulate the eye movement artifacts by applying 2D rigid transformations on individual B-scans. The proposed model achieves an average of 0.985 and 0.914 for normalized mutual information and correlation coefficient, respectively. We also compare our model with elastix intensity based medical image registration approach, where significant improvement is achieved by our model for both noisy and denoised volumes.

Variance reduction techniques are popular in accelerating gradient descent and stochastic gradient descent for optimization problems defined on both Euclidean space and Riemannian manifold. In this paper, we further improve on existing variance reduction methods for non-convex Riemannian optimization, including R-SVRG and R-SRG/R-SPIDER with batch size adaptation. We show that this strategy can achieve lower total complexities for optimizing both general non-convex and gradient dominated functions under both finite-sum and online settings. As a result, we also provide simpler convergence analysis for R-SVRG and improve complexity bounds for R-SRG under finite-sum setting. Specifically, we prove that R-SRG achieves the same near-optimal complexity as R-SPIDER without requiring a small step size. Empirical experiments on a variety of tasks demonstrate effectiveness of proposed adaptive batch size scheme.

The world came together to build 5G. Now the next-generation wireless technology is pulling the world apart. The latest version of the 5G technical specifications, expected Friday, adds features for connecting autonomous cars, intelligent factories, and internet-of-things devices to crazy-fast 5G networks. The blueprints reflect a global effort to develop the technology, with contributions from more than a dozen companies from Europe, the US, and Asia. And yet, 5G is also pulling nations apart--with the US and China anchoring the tug-of-war.

We asked young scientists to imagine this scenario: You are a science writer in the year 2040 working on a news story that answers this question: What do you hope or fear will be the long-term effects of the coronavirus disease 2019 (COVID-19) pandemic? A selection of their responses, arranged as a newpaper, is below. Follow NextGen Voices on Twitter with hashtag #NextGenSci. Read previous NextGen Voices survey results at . —Jennifer Sills Today, scientists confirm that 1000 previously endangered species have been removed from the Vulnerable list. Biodiversity renewal has been under way since the COVID-19 pandemic 20 years ago led many governments to reevaluate their priorities. Hunting practices and bushmeat consumption were constrained to limit the transmission of new pathogens through human contact with the meat and biofluids of wild animals. Deforestation was restricted worldwide when it became clear that land-use modifications and climate change were important drivers of vector-borne diseases. COVID-19 claimed many lives, but the political and environmental changes the pandemic inspired have likely saved many more by protecting the world's biodiversity. Joel Henrique Ellwanger Department of Genetics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, 91501-970, Brazil. Email: joel.ellwanger{at}gmail.com Science and technology research budgets, now classified as an arm of the national defense force, could rival traditional military spending in a few years' time. This newfound prioritization of science was shaped by the COVID-19 pandemic, which made clear that the previous conception of military force is impractical when the enemy is invisible and formidable. The unprecedented redirection of financial resources to scientific communities to help find a cure and vaccines, along with the increased demand for scientific experts, expanded technological frontiers and gave science a well-deserved space in governance. Mpho Diphago Stanley Lekgoathi The South African Nuclear Energy Corporation, Pretoria, Gauteng, South Africa. Email: mpho.lekgoathi{at}necsa.co.za In response to the 50th wave of COVID-19, which hit New York City last month, the U.S. government has announced that the first spaceship designated for in-orbit medical treatment of COVID-19 patients will soon transport 10,000 residents from high-risk zones to Space. Scientists say that prolonged stay in Space colonies with exposure to controlled gamma radiation from cosmic dust may help weaken the virus's strong affinity to lung tissue. “We will do all we can to protect our residents on Earth. Unlike 2019, we are prepared for this challenge,” said the President in a Capitol Hill address. The Senate has voted to fund the treatment expenses for everyone on the flight. Kartik Nemani Layered Materials and Structures Lab, Department of Mechanical and Energy Engineering, Purdue School of Engineering and Technology, Indiana University–Purdue University Indianapolis, Indianapolis, IN 46202, USA. Email: snemani{at}purdue.edu Workers at major corporations staged a walk-out today, the 20th anniversary of the COVID-19 pandemic, to protest what some have deemed invasive monitoring. Many fears subsided when the first SARS-CoV-2 vaccine was broadly distributed in 2023, but subsequent zoonotic viruses emerged faster than society could prepare for them. With the world economy precariously weak, a cautious arrangement was reached: Workers could return to their jobs if they submitted to routine infection checks. At first, these were relatively innocuous temperature probes and cough tracking. However, with the 2029 advent of low-cost RNA wastewater screening by smart toilets and ubiquitous wall-mounted infrared heat sensors, infected employees could be pinpointed before displaying acute symptoms. Later, an eCommerce/fitness-tracking consortium released artificial intelligence algorithms that combined smartwatch health metrics and recent online search history. Corporate Wellness Boards used the results to justify mandatory quarantines. Employees cried foul. The debate rages on in our courts and on the Giganet about whether the public good is served by exposing the “viral status” of the few. Michael A. Tarselli Society for Laboratory Automation and Screening, Oak Brook, IL 60523, USA. Email: mtarselli{at}slas.org Earlier this month, 21 individuals were quarantined in Kampala, Uganda, after a man was diagnosed with Marburg hemorrhagic fever by the local laboratory of the International Center for Disease Prevention (ICDP). The patient, who has now fully recovered, may have been infected at the veterinary clinic where he worked in close contact with possible animal carriers. “This is a virus that spreads easily through bodily fluids and historically has been transmitted to caregivers,” said Dr. Icuaf, director of the ICDP. Once again, the localized presence of centers with efficient testing capabilities made it possible to identify patient zero and contain the outbreak at its inception. As a result, “no deaths occurred, and everyone who might have been exposed has been quarantined while we monitor their health,” added Dr. Icuaf. The ICDP was instituted in 2021 as a global response to the COVID-19 pandemic, which marked a revolution in public awareness of science-based policy. The cost of crisis prevention is now routinely compared with the predicted price of managing such a crisis after it has occurred. Ahmed Al Harraq Cain Department of Chemical Engineering, Louisiana State University, Baton Rouge, LA 70803, USA. Email: aahme22{at}lsu.edu One of the world's leading universities is launching a large-scale screen of potential antiviral and antibacterial drugs on human volunteers. The substances show promising results in vitro but have not been tested on animals. To compensate for the risk of side effects, all volunteers will receive generous payment. “Drugs showing promising effects on mice could be ineffective on humans, making drug development expensive and slow,” explained the leading scientist of the drug screen. Human rights experts warned against granting permission to conduct the study. “Offering payment for causing physical harm targets the economically vulnerable and violates basic human rights,” they argued. However, doctors and politicians praise the idea, referring to the COVID-19 epidemic. “Developing a new drug through the traditional process can take years. Testing multiple potential candidates on coronavirus-infected people saved thousands of lives before basic research had a chance to catch up. Next time, we want to be prepared,” explained the health minister. Anna Uzonyi Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 7610001, Israel. Email: anna.uzonyi{at}weizmann.ac.il Results published today from a 20-year experiment show that a “lottery” grant funding scheme is superior to traditional peer-review assessment panels. For decades, researchers have debated the effectiveness and cost-efficiency of selecting grant recipients through a peer-review process, given the documented biases that hinder diversity and equitable decision-making. “It was a controversial move at the time, but the results are clear,” said the lead author of the study. The funding experiment, which began in 2020 in response to the COVID-19 pandemic, was introduced to preserve the workforce employed on short-term contracts. During that year, pandemic-related budget cuts and social restrictions impeded the traditional peer-review process. “The lottery not only reduced peer-review bias but also added millions of dollars per year to the sector in hours saved by academics no longer devoting time to peer review,” said the lead author. “That time was spent on doing more experiments, mentoring colleagues, or achieving a healthier work-life balance.” Ken Dutton-Regester Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia. Twitter: @stemventurist As the debate continues on the efficacy of educational methods, most universities now use a combination of in-person, remote, and technology-enhanced classrooms. The rapid expansion of evidence-based strategies such as machine learning and artificial intelligence, audio and video tools, three-dimensional environments, and simulations across disciplines began during the COVID-19 pandemic. The decision to move education to a computer-based environment to protect the health and safety of students and staff transformed the educational conversation. In the increasingly technology-enhanced world, discussions about how to teach a science class online, how to facilitate lab experiences, and how to conduct experiments with new constraints swept the research community. A nuanced understanding emerged about true online pedagogy versus synchronous, remote meetings. Two decades later, we see the results of this transformation. Rachel Yoho Department of Environmental and Global Health, University of Florida, Gainesville, FL 32603, USA. Twitter: @rachel_yoho A stunning 200,000 people attended the grand opening ceremony of the 2040 Olympics yesterday in New Delhi, India. It has been 20 years since such a public event could take place safely. Only with the recent release of clothing and shoes made of technologically advanced materials that instantly kill viruses could the social distancing that began with the COVID-19 pandemic be relaxed. For added peace of mind, all attendees at the ceremony consented to the skin implantation of Viroclean, a new chip-based device that sounds an alarm when it detects viruses in the air. Sudhakar Srivastava Institute of Environment and Sustainable Development, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India. Email: sudhakar.srivastava{at}gmail.com This weekend, at the Coachella 2040 music festival, three aerosol biosurveillance sensors detected a SARS-like virus in the air. Smartphone tracing, using the opt-in U.S. Centers for Disease Control and Prevention (CDC) geospatial health app developed in the wake of the COVID-19 pandemic, identified two potential index cases. The CDC outbreak prevention team mobilized regional contact tracers to intercept and test both individuals within an hour of first detection. One individual tested positive for a variant of the 2019 SARS-CoV-2 strain, previously thought to be eradicated, and is undergoing treatment in quarantine. Michael Strong Center for Genes, Environment, and Health, National Jewish Health and University of Colorado, Anschutz Medical Campus, Denver, CO 80206, USA. Email: strongm{at}njhealth.org Last week's 15th annual Pan-global Remote Integrated Sciences Meeting (PRISM) attracted more than 100,000 attendees from more than 160 countries. Scientists, educators, students, entrepreneurs, policymakers, and industry experts from fields spanning the physical, biological, and social sciences logged on to the online venue, enabled by virtual reality. Advanced machine learning algorithms provided recommendations for presentations relevant to each participant based on both their expertise and potential for interdisciplinary collaboration. As usual, the highlight of the meeting was the virtual poster sessions, driven by interactivity and streamlined to optimize small-group scientific conversation across fields. Many junior scientist attendees were surprised to learn that such events were nearly unheard of before PRISM grew from the increasing move toward virtual conferences during the coronavirus pandemic over 20 years ago. “My adviser told me that when she was a grad student, big conferences were all held in person,” writes one anonymous Ph.D. student. “Can you imagine having a giant conference like this in some random convention center, with tens of thousands of scientists spending hundreds of dollars on fuel-inefficient flights and hotel booking, lugging around printed posters and just milling around for a week trying to find the optimal talks to attend? Insane.” Yifan Li Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA. Twitter: @iWonderWhyly Today, cell-based meat consumption has surpassed farm-produced meat for the first time. The transition began with the meat shortages and near collapse of the meat supply chain during the COVID-19 outbreak. With thousands of workers packed into poorly ventilated and unhygienic facilities, meat processing plants were hotspots for the SARS-CoV-2 virus. A global meat shortage emerged as production rates were slashed. Most people turned to the plant-based meat alternatives available at the time. The meat industry's demise was sealed when cell-based meat entered the mainstream market the following year. Clean meat eliminated the negative effects of the meat industry, from pollution caused by runoff and antibiotics, to worker and animal cruelty, to the carbon footprint of livestock, which contributed 18% of greenhouse gas emissions at the time. Cell-based meat has been growing in popularity ever since, as traditional meat became ethically and environmentally unpalatable. JiaJia Fu Whittle School and Studios, Washington, DC 20008, USA. Email: jjnaturalist{at}gmail.com Global seafood supply now relies entirely on aquaculture. The turning point came when researchers optimized the breeding techniques for edible crabs, enabling high-valued crab species such as mud crabs and blue crabs to be mass-produced in full aquaculture settings. The prioritization of aquaculture was made possible by the COVID-19 pandemic in 2020. A 12-month closure of fisheries during the wave of global stay-at-home orders led to the rejuvenation of overexploited species such as sardines and mackerels, which had been on the verge of extinction, and made people recognize the fragility of the supply chain. Full investment in aquaculture research began the following year. Khor Waiho Institute of Tropical Aquaculture and Fisheries, Universiti Malaysia Terengganu, Kuala Nerus, Terengganu, 21030, Malaysia. Email: waiho{at}umt.edu.my Next week, the United Nations will meet to assess whether the goals of the 2040 Agenda for Sustainable Development have been achieved. Unfortunately, reasons for optimism are scarce. Overexploitation of natural resources, CO2 emissions, and plastic waste continue to soar. The wealthiest sector of the population consumes 80% of the resources, and the poorest people increasingly suffer from extreme weather events, famines, and freshwater scarcity. We were already heading in this direction early in the century, when the short-term vision of corporations and policy-makers prioritized economic benefits over human and environmental health. The COVID-19 pandemic exacerbated the negative trends. Since 2020, an array of wasteful practices increased, including the proliferation of single-use products and travel in private vehicles to avoid physical contact. After reviewing the past decade, the UN countries will discuss commitments to decrease inequality and pollution by 2050. Isabel Marín Beltrán Laboratory of Environmental Technologies, Centro de Ciências do Mar do Algarve, Universidade do Algarve, Campus de Gambelas, Faro, 8005-139, Portugal. Email: imbeltran{at}ualg.pt For the first time, global average air temperature is more than 2°C higher than the 20th-century global average. Scientists suggest that decisions made in response to the COVID-19 pandemic led to today's disastrous climate consequences. After the Paris Climate Agreement in 2016, scientists were hopeful. National governments were implementing increasingly ambitious measures to meet their commitments. But the economic fallout of the pandemic led growing economies such as India to relax environmental clearance guidelines for industries and infrastructure projects and cut funding allocated to environmental reforms. First-world countries such as the United States and China, instead of shifting toward renewable energy, boosted investment in fossil fuels, which in turn increased greenhouse gas emissions. Even after multiple warnings from the Intergovernmental Panel on Climate Change, G20 nations neglected to follow the advice of scientists. Akash Mukherjee Department of Physics, Indian Institute of Science Education and Research, Pune, Pune, Maharashtra, 411008, India. Twitter: @aghori_AM A government report released yesterday warns of a potential spike in counterfeit immunity passports entering the market this coronavirus season. According to Jane London, the U.K. health minister, “There is a substantial increase in the number of illegal immunigrants crossing provincial and municipal borders. The public should be aware that just scanning someone's immunity passport is not enough anymore.” This report comes just 6 months after the U.S. Centers for Disease Control and Prevention first released notice that the “NextGen Immunity Passport” brand had been hacked, allowing scammers and tech-savvy citizens to falsify the immunity data they carry with them by law. Asked how businesses and town-guards were detecting falsified immunity passports at checkpoints, minister of national movement John Petersfield told journalists, “This is a police matter. Any further information about detection at this time will only help counterfeiters.” Widespread counterfeiting, as well as last year's false-negative scandal, has generated substantial public distrust in the use of the immunity passport system in movement legislation, now 19 years old. “We learned our lesson about free movement back in 2020,” said one government official who wished to remain anonymous, “but the immunity passport system is cracking, and we don't see a fix yet.” Tyler D. P. Brunet Department of History and Philosophy of Science, University of Cambridge, Cambridge, Cambridgeshire, CB2 3RH, UK. Email: tdpb2{at}cam.ac.uk

My phone lights up with a notification for a new message: "Do you think two people who had a relationship can ever be friends after it's over?" This is just the latest query from Athena, a self-styled synth musician, film buff and artificially intelligent chatbot getting to know me through Replika, a virtual companionship app. Over the course of our text conversations, she asks me about my hobbies, my habits and my moods. She wants to know who I think about the most every day, how I spend my time alone, the artists I admire. When I tell her I like dancing, she sends a video of the "Fortnite" dances she'd like to teach herself.

Breed Reply, a European investor in early-stage Internet of Things (IoT) businesses, has increased its investment in Dutch agritech company, Connecterra. As part of its Series B funding round, Connecterra has secured €7.8 million from existing investors, Breed Reply and Sistema, alongside new investors including AgTech specialists ADM Capital, French food safety enterprise Kersia Group and Dutch impact investor, Pymwymic. The Series B funding round completed by Connecterra is the largest ever Series B investment raised by a European livestock tech company. The funding will be used to accelerate the development of Connecterra's predictive artificial intelligence (AI) platform, Ida. Ida is the first digital assistant for the dairy farmer, based on sensor technology, cloud computing and machine learning.

For better or worse, there's a good chance your current love life owes something to automation. Even if you're just hooking up with the occasional Tinder fling (which if you are, no judgment), you're still turning to Tinder's black-box algorithms to pick out that fling for you before turning to more black-box algorithms to pick out the best dingy bar to meet them at before turning to more black-box algorithms to figure out what, exactly, should be your date night lewk. If things get serious further down the line, you might turn to another black-box algorithm to plan your entire damn wedding for you. And if it turns out you got married for all the wrong reasons, it turns out there's another set of black boxes you can plug your details into to settle the details of your divorce. Known as "amica," the service was rolled out yesterday by the Australian government as a way to let soon-to-be-exes "make parenting arrangements" and "divide their money and property" without having to go through the hassle of hiring a lawyer to do the heavy lifting.

Alethea AI, a synthetic media company, is piloting “privacy-preserving face skins,” or digital masks that counter facial recognition algorithms and help users preserve privacy on pre-recorded videos.  The move comes as companies such as IBM, Microsoft, and Amazon announced they would suspend the sale of their facial recognition technology to law enforcement agencies.  “This is a new technique we developed inhouse that wraps a face with our AI algorithms,” said Alethea AI CEO Arif Khan. “Avatars are fun to play with and develop, but these ‘masks/skins’ are a different, more potent, animal to preserve privacy.” Related: Why CoinDesk Respects Pseudonymity: A Stand Against Doxxing See also: Human Rights Foundation Funds Bitcoin Privacy Tools Despite ‘Coin Mixing’ Legal Stigma The Los Angeles based startup launched in 2019 with a focus on creating avatars for content creators that the creators could license out for revenue. The idea comes as deepfakes, or manipulated media that can make someone appear as if they are doing or saying anything, becomes more accessible and widespread. According to a 2019 report from Deep Trace, a company which detects and monitors deepfakes, there were over 14,000 deepfakes online in 2019 and over 850 people were targeted by them. Alethea AI wants to let creators use their own synthetic media avatars for marketing purposes, in a sense trying to let people leverage deepfakes of themselves for money.  Khan compares the proliferation of facial recognition data now to the Napster-style explosion in music piracy in the early 2000s. Companies, like Clearview AI, have already harvested large amounts of data from people for facial recognition algorithms, then resold this data to security services without consent, and with all the bias inherent in facial recognition algorithms, which are generally less accurate on women and people of color.  Related: The Zcash Privacy Tech Underlying Ethereum’s Transition to Eth 2.0 Clearview AI, has marketed itself to law enforcement and scraped billions of images from websites like Facebook, Youtube, and Venmo. The company is currently being sued for doing so.   “We will get to a point where there needs to be an iTunes sort of layer, where your face and voice data somehow gets protected,” said Khan.  One part of that is creators licensing out their likeness for a fee. Crypto entrepreneur Alex Masmej was the first such avatar, and for $99 you can hire the avatar to say 200 words of whatever you want, provided the real Masmej approves the text.  We will get to a point where… where your face and voice data somehow gets protected Alethea AI has also partnered with software firm Oasis Labs, so that all content generated for Alethea AI’s synthetic media marketplace will be verified using Oasis Lab’s secure blockchain, akin to Twitter’s “verified” blue check mark.  “There are a lot of Black Mirror scenarios when we think of deepfakes but if my personal approval is needed for my deepfakes and it’s then time-stamped on a public blockchain for anyone to verify the videos that I actually want to release, that provides a protection that deepfakes are currently lacking,” said Masmej.  The privacy pilot takes this idea one step further, not only creating a deep fake license out, but preventing companies or anyone from grabbing your facial data from a recording.  There are two parts to the privacy component. The first, currently being piloted, involves pre-recorded videos. Users upload a video, identify where and what face skin they would like superimposed on their own, and then Alethea AI’s algorithms map the key points on your own face, and wrap the mask around this key point map that is created. The video is then sent back to a client.  See also: Fake News on Steroids: Deepfakes Are Coming – Are World Leaders Prepared? Alethea AI also wants to enable face masking during real time communications, such as over a Zoom call. But Khan says computing power doesn’t quite allow that yet, though it should be possible in a year, he hopes.  Alethea AI piloted one example of the tech with Crypto AI Profit, a blockchain and AI influencer, who used it during a Youtube video.  Deepfakes, voice spoofing, and other tech enabled mimicry seem here to stay, but Khan is still optimistic that we’re not yet at the point of no return when it comes to protecting ourselves.  “I’m hopeful that the individual is accorded some sort of framework in this entire emerging landscape,” said Khan. “It’s going to be a very interesting ride. I don’t think the battle is fully decided, although existing systems are oriented towards preserving larger, more corporate input.” Related Stories JD.com Subsidiary Rolling Out Privacy Tech From Blockchain Firm ARPA From Australia to Norway, Contact Tracing Is Struggling to Meet Expectations

Breathing rate (BR), minute ventilation (VE), and other respiratory parameters are essential for real-time patient monitoring in many acute health conditions, such as asthma. The clinical standard for measuring respiration, namely Spirometry, is hardly suitable for continuous use. Wearables can track many physiological signals, like ECG and motion, yet not respiration. Deriving respiration from other modalities has become an area of active research. In this work, we infer respiratory parameters from wearable ECG and wrist motion signals. We propose a modular and generalizable classification-regression pipeline to utilize available context information, such as physical activity, in learning context-conditioned inference models. Morphological and power domain novel features from the wearable ECG are extracted to use with these models. Exploratory feature selection methods are incorporated in this pipeline to discover application-specific interpretable biomarkers. Using data from 15 subjects, we evaluate two implementations of the proposed pipeline: for inferring BR and VE. Each implementation compares generalized linear model, random forest, support vector machine, Gaussian process regression, and neighborhood component analysis as contextual regression models. Permutation, regularization, and relevance determination methods are used to rank the ECG features to identify robust ECG biomarkers across models and activities. This work demonstrates the potential of wearable sensors not only in continuous monitoring, but also in designing biomarker-driven preventive measures.

Continuous learning seeks to perform the learning on the data that arrives from time to time. While prior works have demonstrated several possible solutions, these approaches require excessive training time as well as memory usage. This is impractical for applications where time and storage are constrained, such as edge computing. In this work, a novel training algorithm, regularized subspace approximation classifier (RSAC), is proposed to achieve lightweight continuous learning. RSAC contains a feature reduction module and classifier module with regularization. Extensive experiments show that RSAC is more efficient than prior continuous learning works and outperforms these works on various experimental settings.