Or maybe you're wondering why we should even care about trains and how they operate--what is this, the 1800s?--so let's back up a bit. If you think America is solely dependent on trucks to move freight, you might be suffering from tunnel vision: Trains account for a third of the ton-miles--that is, a ton of weight carried a mile--that freight travels in the U.S. every year. That's almost as much as is carried by trucks. The U.S. has the most extensive rail network of any country on earth by miles of track--yes, even bigger than China's--and it's currently facing some of the same snarls and congestion as seemingly every other part of the country's supply chains, on account of unprecedented activity at ports and record demand at some rail hubs. Trains might seem like a mature technology with little room for improvement or expansion, since adding new rail lines is prohibitively expensive, as battles over the cost of the expansion of Amtrak service have shown.

Now the threat is artificial intelligence. Or is it really a hope? Only three years ago, computer scientist Kai-Fu Lee published "AI Superpowers," a bestselling guide to the subject. But three years is a long time. In "AI 2041: Ten Visions for Our Future," Mr. Lee has teamed up with sci-fi writer Chen Qiufan to tell us what's going to happen next.

As a promising tool to navigate in the vast chemical space, artificial intelligence (AI) is leveraged for drug design. From the year 2017 to 2021, the number of applications of several recent AI models (i.e. graph neural network (GNN), recurrent neural network (RNN), variation autoencoder (VAE), generative adversarial network (GAN), flow and reinforcement learning (RL)) in drug design increases significantly. Many relevant literature reviews exist. However, none of them provides an in-depth summary of many applications of the recent AI models in drug design. To complement the existing literature, this survey includes the theoretical development of the previously mentioned AI models and detailed summaries of 42 recent applications of AI in drug design. Concretely, 13 of them leverage GNN for molecular property prediction and 29 of them use RL and/or deep generative models for molecule generation and optimization. In most cases, the focus of the summary is the models, their variants, and modifications for specific tasks in drug design. Moreover, 60 additional applications of AI in molecule generation and optimization are briefly summarized in a table. Finally, this survey provides a holistic discussion of the abundant applications so that the tasks, potential solutions, and challenges in AI-based drug design become evident.

Safe interaction between vehicles requires the ability to choose actions that reveal the preferences of the other vehicles. Since exploratory actions often do not directly contribute to their objective, an interactive vehicle must also able to identify when it is appropriate to perform them. In this work we demonstrate how Active Learning methods can be used to incentivise an autonomous vehicle (AV) to choose actions that reveal information about the altruistic inclinations of another vehicle. We identify a property, Information Sufficiency, that a reward function should have in order to keep exploration from unnecessarily interfering with the pursuit of an objective. We empirically demonstrate that reward functions that do not have Information Sufficiency are prone to inadequate exploration, which can result in sub-optimal behaviour. We propose a reward definition that has Information Sufficiency, and show that it facilitates an AV choosing exploratory actions to estimate altruistic tendency, whilst also compensating for the possibility of conflicting beliefs between vehicles.

Abdominal ultrasound imaging has been widely used to assist in the diagnosis and treatment of various abdominal organs. In order to shorten the examination time and reduce the cognitive burden on the sonographers, we present a classification method that combines the deep learning techniques and k-Nearest-Neighbor (k-NN) classification to automatically recognize various abdominal organs in the ultrasound images in real time. Fine-tuned deep neural networks are used in combination with PCA dimension reduction to extract high-level features from raw ultrasound images, and a k-NN classifier is employed to predict the abdominal organ in the image. We demonstrate the effectiveness of our method in the task of ultrasound image classification to automatically recognize six abdominal organs. A comprehensive comparison of different configurations is conducted to study the influence of different feature extractors and classifiers on the classification accuracy. Both quantitative and qualitative results show that with minimal training effort, our method can "lazily" recognize the abdominal organs in the ultrasound images in real time with an accuracy of 96.67%. Our implementation code is publicly available at: https://github.com/LeeKeyu/abdominal_ultrasound_classification.

We target open-world feature extrapolation problem where the feature space of input data goes through expansion and a model trained on partially observed features needs to handle new features in test data without further retraining. The problem is of much significance for dealing with features incrementally collected from different fields. To this end, we propose a new learning paradigm with graph representation and learning. Our framework contains two modules: 1) a backbone network (e.g., feedforward neural nets) as a lower model takes features as input and outputs predicted labels; 2) a graph neural network as an upper model learns to extrapolate embeddings for new features via message passing over a feature-data graph built from observed data. Based on our framework, we design two training strategies, a self-supervised approach and an inductive learning approach, to endow the model with extrapolation ability and alleviate feature-level over-fitting. We also provide theoretical analysis on the generalization error on test data with new features, which dissects the impact of training features and algorithms on generalization performance. Our experiments over several classification datasets and large-scale advertisement click prediction datasets demonstrate that our model can produce effective embeddings for unseen features and significantly outperforms baseline methods that adopt KNN and local aggregation.

In recent years, researchers attempt to utilize online social information to alleviate data sparsity for collaborative filtering, based on the rationale that social networks offers the insights to understand the behavioral patterns. However, due to the overlook of inter-dependent knowledge across items (e.g., categories of products), existing social recommender systems are insufficient to distill the heterogeneous collaborative signals from both user and item sides. In this work, we propose a Self-Supervised Metagraph Infor-max Network (SMIN) which investigates the potential of jointly incorporating social- and knowledge-aware relational structures into the user preference representation for recommendation. To model relation heterogeneity, we design a metapath-guided heterogeneous graph neural network to aggregate feature embeddings from different types of meta-relations across users and items, em-powering SMIN to maintain dedicated representations for multi-faceted user- and item-wise dependencies. Additionally, to inject high-order collaborative signals, we generalize the mutual information learning paradigm under the self-supervised graph-based collaborative filtering. This endows the expressive modeling of user-item interactive patterns, by exploring global-level collaborative relations and underlying isomorphic transformation property of graph topology. Experimental results on several real-world datasets demonstrate the effectiveness of our SMIN model over various state-of-the-art recommendation methods. We release our source code at https://github.com/SocialRecsys/SMIN.

Sensory and emotional experiences such as pain and empathy are relevant to mental and physical health. The current drive for automated pain recognition is motivated by a growing number of healthcare requirements and demands for social interaction make it increasingly essential. Despite being a trending area, they have not been explored in great detail. Over the past decades, behavioral science and neuroscience have uncovered mechanisms that explain the manifestations of pain. Recently, also artificial intelligence research has allowed empathic machine learning methods to be approachable. Generally, the purpose of this paper is to review the current developments for computational pain recognition and artificial empathy implementation. Our discussion covers the following topics: How can AI recognize pain from unimodality and multimodality? Is it necessary for AI to be empathic? How can we create an AI agent with proactive and reactive empathy? This article explores the challenges and opportunities of real-world multimodal pain recognition from a psychological, neuroscientific, and artificial intelligence perspective. Finally, we identify possible future implementations of artificial empathy and analyze how humans might benefit from an AI agent equipped with empathy.

A fundamental question in the field of Learning and Games is Nash convergence of online learning dynamics: if the players in a repeated game employ some online learning algorithms to adjust strategies, will their strategies converge to the Nash equilibrium of the game? Although the answer to this question is "no" in general (see Related Works for details), positive results do exist for some special cases of online learning algorithms and games: for example, no-regret learning algorithms provably converge to Nash equilibria in zero-sum games, 2 2 games, and routing games (see e.g., Fudenberg and Levine, 1998; Cesa-Bianchi and Lugosi, 2006; Nisan et al., 2007). In this work, we analyze Nash convergence of online learning dynamics in repeated auctions, where bidders learn to bid using online learning algorithms. Although auctions are of both theoretical and practical importance, little is known about their Nash convergence properties, even for the perhaps simplest and most popular auction, the single-item first-price sealed-bid auction (or first price auction for short). One of the obstacles to the theoretical analysis of Nash convergence in the first price auction is the lack of explicit characterization of its Nash equilibrium.

We present a literature survey on non-interactive computational story generation. The article starts with the presentation of requirements for creative systems, three types of models of creativity (computational, socio-cultural, and individual), and models of human creative writing. Then it reviews each class of story generation approach depending on the used technology: story-schemas, analogy, rules, planning, evolutionary algorithms, implicit knowledge learning, and explicit knowledge learning. Before the concluding section, the article analyses the contributions of the reviewed work to improve the quality of the generated stories. This analysis addresses the description of the story characters, the use of narrative knowledge including about character believability, and the possible lack of more comprehensive or more detailed knowledge or creativity models. Finally, the article presents concluding remarks in the form of suggestions of research topics that might have a significant impact on the advancement of the state of the art on autonomous non-interactive story generation systems. The article concludes that the autonomous generation and adoption of the main idea to be conveyed and the autonomous design of the creativity ensuring criteria are possibly two of most important topics for future research.