Past efforts to map the Medline database have been limited to small subsets of the available data because of the exponentially increasing memory and processing demands of existing algorithms. We designed a novel algorithm for sparse matrix multiplication that allowed us to apply a self-organizing map to the entire Medline dataset, allowing for a more complete map of existing medical knowledge. The algorithm also increases the feasibility of refining the self-organizing map to account for changes in the dataset over time.

Genomic question answering often requires complex reasoning and integration across diverse biomedical sources. GeneGPT addressed this challenge by combining domain-specific APIs with OpenAI's code-davinci-002 large language model to enable natural language interaction with genomic databases. However, its reliance on a proprietary model limits scalability, increases operational costs, and raises concerns about data privacy and generalization. In this work, we revisit and reproduce GeneGPT in a pilot study using open source models, including Llama 3.1, Qwen2.5, and Qwen2.5 Coder, within a monolithic architecture; this allows us to identify the limitations of this approach. Building on this foundation, we then develop OpenBioLLM, a modular multi-agent framework that extends GeneGPT by introducing agent specialization for tool routing, query generation, and response validation. This enables coordinated reasoning and role-based task execution. OpenBioLLM matches or outperforms GeneGPT on over 90% of the benchmark tasks, achieving average scores of 0.849 on Gene-Turing and 0.830 on GeneHop, while using smaller open-source models without additional fine-tuning or tool-specific pretraining. OpenBioLLM's modular multi-agent design reduces latency by 40-50% across benchmark tasks, significantly improving efficiency without compromising model capability. The results of our comprehensive evaluation highlight the potential of open-source multi-agent systems for genomic question answering. Code and resources are available at https://github.com/ielab/OpenBioLLM.

The law draws a sharp distinction between objects and persons, and between two kinds of persons, the ''fictional'' kind (i.e. corporations), and the ''non-fictional'' kind (individual or ''natural'' persons). This paper will assess whether we maximize overall long-term legal coherence by (A) maintaining an object classification for all future AI systems, (B) creating fictional legal persons associated with suitably advanced, individuated AI systems (giving these fictional legal persons derogable rights and duties associated with certified groups of existing persons, potentially including free speech, contract rights, and standing to sue ''on behalf of'' the AI system), or (C) recognizing non-fictional legal personhood through legal identity for suitably advanced, individuated AI systems (recognizing them as entities meriting legal standing with non-derogable rights which for the human case include life, due process, habeas corpus, freedom from slavery, and freedom of conscience). We will clarify the meaning and implications of each option along the way, considering liability, copyright, family law, fundamental rights, civil rights, citizenship, and AI safety regulation. We will tentatively find that the non-fictional personhood approach may be best from a coherence perspective, for at least some advanced AI systems. An object approach may prove untenable for sufficiently humanoid advanced systems, though we suggest that it is adequate for currently existing systems as of 2025. While fictional personhood would resolve some coherence issues for future systems, it would create others and provide solutions that are neither durable nor fit for purpose. Finally, our review will suggest that ''hybrid'' approaches are likely to fail and lead to further incoherence: the choice between object, fictional person and non-fictional person is unavoidable.

We propose a novel and efficient search algorithm which finds initial centers that can be used subsequently for the local search algorithm.

Senior Pentagon officials have arrived in Ukraine to discuss efforts to end the war with Russia, the US military has said. The team, led by US Army Secretary Dan Driscoll, is expected to meet Ukrainian President Volodymyr Zelensky in Kyiv on Thursday when he returns from a trip to Turkey. Reports began surfacing on Wednesday that the US and Russia had prepared a new peace plan, containing major concessions from Ukraine. Neither Washington nor Moscow has officially confirmed the plan. Earlier in the day, at least 26 people were killed in a Russian missile and drone attack on Ukraine's western city of Ternopil, officials there said.

To benchmark a model's long-form factuality in open domains, we first use GPT -4 to generate LongFact, a prompt set comprising thousands of questions spanning 38 topics. We then propose that LLM agents can be used as automated evaluators for long-form factuality through a method which we call Search-Augmented Factuality Evaluator (SAFE).

However, training EBMs on data in discrete or mixed state spaces poses significant challenges due to the lack of robust and fast sampling methods. In this work, we propose to train discrete EBMs with Energy Discrepancy, a loss function which only requires the evaluation of the energy function at data points and their perturbed counterparts, thus eliminating the need for Markov chain Monte Carlo.

Disease grading is a crucial task in medical image analysis.

Though important, attribute modeling usually requires significant manual annotations and thus is labor-intensive.

Equal contribution; authors are listed in random order.