The efficient treatment for a patient with her/his clinical and other characteristics [1, 2] can be regarded as an important goal of the real personalized medicine. The goal can be achieved by means of the machine learning methods due to the increasing amount of available electronic health records which are a basis for developing accurate models. To estimate the treatment effect, patients are divided into two groups called treatment and control, and then patients from the different groups are compared. One of the popular measures of the efficient treatment used in machine learning models is the average treatment effect (ATE) [3], which is estimated on the basis of observed data about patients as the mean difference between outcomes of patients from the treatment and control groups. Due to the difference between the patients characteristics and the difference between their responses to a particular treatment, the treatment effect is measured by the conditional average treatment effects (CATE) or the heterogeneous treatment effect (HTE) defined as ATE conditional on a patient feature vector [4, 5, 6, 7]. Two main problems can be pointed out when CATE is estimated. The first one is that the control group is usually larger than the treatment group. As a result, we meet the problem of a small training dataset, which does not allow us to apply directly many efficient machine learning methods.

Synchron, a brain-computer interface startup, reportedly implanted its first device in a US patient earlier this month -- overtaking Elon Musk's Neuralink for the third time. The startup implanted a 1.5-inch device into the brain of an ALS patient at Mount Sinai West medical center in New York on July 6, Bloomberg first reported. A spokesperson from Synchron did not immediately respond to a request for comment. The purpose of the device is to allow the patient to communicate -- even after they have lost the ability to move -- by using their thoughts to send emails and texts. Bloomberg reported that Synchron has already implanted the device in four patients in Australia who have been able to use the brain implant to send messages on WhatsApp and shop online.

On July 13, Boston's Merlin Labs announced that it would be working with the US Air Force to add autonomy to the C-130J Super Hercules cargo transport plane. Merlin's technology is a kind of advanced auto-copilot, designed to take over the responsibilities of one crew member in flight while being supervised by a human pilot. If the technology delivers as promised, it will allow planes that normally fly with two human pilots to operate with just one, and could even allow single-seater planes to fly fully autonomously. The same day that Merlin announced its partnership with the Air Force, it also announced a second round of $105 million in funding, which combined with a first round means the company has $130 million of runway to develop its technologies. This funding, says Merlin Labs CEO Matthew George, will help the company continue to develop "the world's most capable, safest and flexible pilot, that will eventually enable very large aircraft to fly with reduced crew and small aircraft to fly totally uncrewed."

This paper presents a multifunctional interdisciplinary framework that makes four scientific contributions towards the development of personalized ambient assisted living, with a specific focus to address the different and dynamic needs of the diverse aging population in the future of smart living environments. First, it presents a probabilistic reasoning-based mathematical approach to model all possible forms of user interactions for any activity arising from the user diversity of multiple users in such environments. Second, it presents a system that uses this approach with a machine learning method to model individual user profiles and user-specific user interactions for detecting the dynamic indoor location of each specific user. Third, to address the need to develop highly accurate indoor localization systems for increased trust, reliance, and seamless user acceptance, the framework introduces a novel methodology where two boosting approaches Gradient Boosting and the AdaBoost algorithm are integrated and used on a decision tree-based learning model to perform indoor localization. Fourth, the framework introduces two novel functionalities to provide semantic context to indoor localization in terms of detecting each user's floor-specific location as well as tracking whether a specific user was located inside or outside a given spatial region in a multi-floor-based indoor setting. These novel functionalities of the proposed framework were tested on a dataset of localization-related Big Data collected from 18 different users who navigated in 3 buildings consisting of 5 floors and 254 indoor spatial regions. The results show that this approach of indoor localization for personalized AAL that models each specific user always achieves higher accuracy as compared to the traditional approach of modeling an average user.

It was shown that adversarial examples improve object recognition. But what about their opposite side, easy examples? Easy examples are samples that the machine learning model classifies correctly with high confidence. In our paper, we are making the first step toward exploring the potential benefits of using easy examples in the training procedure of neural networks. We propose to use an auxiliary batch normalization for easy examples for the standard and robust accuracy improvement.

The classical $\textit{Procrustes}$ problem is to find a rigid motion (orthogonal transformation and translation) that best aligns two given point-sets in the least-squares sense. The $\textit{Robust Procrustes}$ problem is an important variant, in which a power-1 objective is used instead of least squares to improve robustness to outliers. While the optimal solution of the least-squares problem can be easily computed in closed form, dating back to Sch\"onemann (1966), no such solution is known for the power-1 problem. In this paper we propose a novel convex relaxation for the Robust Procrustes problem. Our relaxation enjoys several theoretical and practical advantages: Theoretically, we prove that our method provides a $\sqrt{2}$-factor approximation to the Robust Procrustes problem, and that, under appropriate assumptions, it exactly recovers the true rigid motion from point correspondences contaminated by outliers. In practice, we find in numerical experiments on both synthetic and real robust Procrustes problems, that our method performs similarly to the standard Iteratively Reweighted Least Squares (IRLS). However the convexity of our algorithm allows incorporating additional convex penalties, which are not readily amenable to IRLS. This turns out to be a substantial advantage, leading to improved results in high-dimensional problems, including non-rigid shape alignment and semi-supervised interlingual word translation.

Data-Efficient GANs (DE-GANs), which aim to learn generative models with a limited amount of training data, encounter several challenges for generating high-quality samples. Since data augmentation strategies have largely alleviated the training instability, how to further improve the generative performance of DE-GANs becomes a hotspot. Recently, contrastive learning has shown the great potential of increasing the synthesis quality of DE-GANs, yet related principles are not well explored. In this paper, we revisit and compare different contrastive learning strategies in DE-GANs, and identify (i) the current bottleneck of generative performance is the discontinuity of latent space; (ii) compared to other contrastive learning strategies, Instance-perturbation works towards latent space continuity, which brings the major improvement to DE-GANs. Based on these observations, we propose FakeCLR, which only applies contrastive learning on perturbed fake samples, and devises three related training techniques: Noise-related Latent Augmentation, Diversity-aware Queue, and Forgetting Factor of Queue. Our experimental results manifest the new state of the arts on both few-shot generation and limited-data generation. On multiple datasets, FakeCLR acquires more than 15% FID improvement compared to existing DE-GANs. Code is available at https://github.com/iceli1007/FakeCLR.

In this work we show how large language models (LLMs) can learn statistical dependencies between otherwise unconditionally independent variables due to dataset selection bias. To demonstrate the effect, we developed a masked gender task that can be applied to BERT-family models to reveal spurious correlations between predicted gender pronouns and a variety of seemingly gender-neutral variables like date and location, on pre-trained (unmodified) BERT and RoBERTa large models. Finally, we provide an online demo, inviting readers to experiment further.

Pretrained language models (PTLMs) are typically learned over a large, static corpus and further fine-tuned for various downstream tasks. However, when deployed in the real world, a PTLM-based model must deal with data distributions that deviate from what the PTLM was initially trained on. In this paper, we study a lifelong language model pretraining challenge where a PTLM is continually updated so as to adapt to emerging data. Over a domain-incremental research paper stream and a chronologically-ordered tweet stream, we incrementally pretrain a PTLM with different continual learning algorithms, and keep track of the downstream task performance (after fine-tuning). We evaluate PTLM's ability to adapt to new corpora while retaining learned knowledge in earlier corpora. Our experiments show distillation-based approaches to be most effective in retaining downstream performance in earlier domains. The algorithms also improve knowledge transfer, allowing models to achieve better downstream performance over the latest data, and improve temporal generalization when distribution gaps exist between training and evaluation because of time. We believe our problem formulation, methods, and analysis will inspire future studies towards continual pretraining of language models.

In this paper, we take the advantage of previous pre-trained models (PTMs) and propose a novel Chinese Pre-trained Unbalanced Transformer (CPT). Different from previous Chinese PTMs, CPT is designed to utilize the shared knowledge between natural language understanding (NLU) and natural language generation (NLG) to boost the performance. CPT consists of three parts: a shared encoder, an understanding decoder, and a generation decoder. Two specific decoders with a shared encoder are pre-trained with masked language modeling (MLM) and denoising auto-encoding (DAE) tasks, respectively. With the partially shared architecture and multi-task pre-training, CPT can (1) learn specific knowledge of both NLU or NLG tasks with two decoders and (2) be fine-tuned flexibly that fully exploits the potential of the model. Moreover, the unbalanced Transformer saves the computational and storage cost, which makes CPT competitive and greatly accelerates the inference of text generation. Experimental results on a wide range of Chinese NLU and NLG tasks show the effectiveness of CPT.