We detail the accuracy and validity of AI in diagnostic and prognostic models and biofluid markers that provide insight into AMD pathogenesis and progression. This review was conducted in accordance with the Preferred Reporting Items for a Systematic Review and Meta-analysis guidelines. A comprehensive search was conducted across 5 electronic databases including Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, EMBASE, Medline, and Web of Science from inception to July 14, 2021. Studies pertaining to biofluid marker analysis using AI or bioinformatics in AMD were included. Identified studies were assessed for risk of bias and critically appraised using the Joanna Briggs Institute Critical Appraisal tools.

The Patent Act requires an "inventor" to be a natural person, the US Court of Appeals for the Federal Circuit said, rejecting computer scientist Stephen Thaler's bid for patents on two inventions he said his DABUS system created. Thaler said in an email Friday that DABUS, which stands for "Device for the Autonomous Bootstrapping of Unified Sentience," is "natural and sentient." His attorney Ryan Abbott of Brown Neri Smith & Khan said the decision "ignores the purpose of the Patent Act" and has "real negative social consequences." He said they plan to appeal. The US Patent and Trademark Office declined to comment on the decision.

Thaler had asked for patents on behalf of his AI system Court affirms ruling that patent'inventor' must be human being Court affirms ruling that patent'inventor' must be human being The Patent Act requires an "inventor" to be a natural person, the U.S. Court of Appeals for the Federal Circuit said, rejecting computer scientist Stephen Thaler's bid for patents on two inventions he said his DABUS system created. Thaler said in an email Friday that DABUS, which stands for "Device for the Autonomous Bootstrapping of Unified Sentience," is "natural and sentient." His attorney Ryan Abbott of Brown Neri Smith & Khan said the decision "ignores the purpose of the Patent Act" and has "real negative social consequences." He said they plan to appeal. The U.S. Patent and Trademark Office declined to comment on the decision.

We propose a new spectrum allocation strategy, aided by unsupervised learning, for multiuser terahertz communication systems. In this strategy, adaptive sub-band bandwidth is considered such that the spectrum of interest can be divided into sub-bands with unequal bandwidths. This strategy reduces the variation in molecular absorption loss among the users, leading to the improved data rate performance. We first formulate an optimization problem to determine the optimal sub-band bandwidth and transmit power, and then propose the unsupervised learning-based approach to obtaining the near-optimal solution to this problem. In the proposed approach, we first train a deep neural network (DNN) while utilizing a loss function that is inspired by the Lagrangian of the formulated problem. Then using the trained DNN, we approximate the near-optimal solutions. Numerical results demonstrate that comparing to existing approaches, our proposed unsupervised learning-based approach achieves a higher data rate, especially when the molecular absorption coefficient within the spectrum of interest varies in a highly non-linear manner.

This paper introduces a system that learns to sing new tunes by listening to examples. It extracts sequencing rules from input music and uses these rules to generate new tunes, which are sung by a vocal synthesiser. We developed a method to represent rules for musical composition as quantum circuits. We claim that such musical rules are quantum native: they are naturally encodable in the amplitudes of quantum states. To evaluate a rule to generate a subsequent event, the system builds the respective quantum circuit dynamically and measures it. After a brief discussion about the vocal synthesis methods that we have been experimenting with, the paper introduces our novel generative music method through a practical example. The paper shows some experiments and concludes with a discussion about harnessing the creative potential of the system.

Traffic signal control is a challenging real-world problem aiming to minimize overall travel time by coordinating vehicle movements at road intersections. Existing traffic signal control systems in use still rely heavily on oversimplified information and rule-based methods. Specifically, the periodicity of green/red light alternations can be considered as a prior for better planning of each agent in policy optimization. To better learn such adaptive and predictive priors, traditional RL-based methods can only return a fixed length from predefined action pool with only local agents. If there is no cooperation between these agents, some agents often make conflicts to other agents and thus decrease the whole throughput. This paper proposes a cooperative, multi-objective architecture with age-decaying weights to better estimate multiple reward terms for traffic signal control optimization, which termed COoperative Multi-Objective Multi-Agent Deep Deterministic Policy Gradient (COMMA-DDPG). Two types of agents running to maximize rewards of different goals - one for local traffic optimization at each intersection and the other for global traffic waiting time optimization. The global agent is used to guide the local agents as a means for aiding faster learning but not used in the inference phase. We also provide an analysis of solution existence together with convergence proof for the proposed RL optimization. Evaluation is performed using real-world traffic data collected using traffic cameras from an Asian country. Our method can effectively reduce the total delayed time by 60\%. Results demonstrate its superiority when compared to SoTA methods.

Graph Neural Networks (GNNs) are widely adopted in advanced AI systems due to their capability of representation learning on graph data. Even though GNN explanation is crucial to increase user trust in the systems, it is challenging due to the complexity of GNN execution. Lately, many works have been proposed to address some of the issues in GNN explanation. However, they lack generalization capability or suffer from computational burden when the size of graphs is enormous. To address these challenges, we propose a multi-level GNN explanation framework based on an observation that GNN is a multimodal learning process of multiple components in graph data. The complexity of the original problem is relaxed by breaking into multiple sub-parts represented as a hierarchical structure. The top-level explanation aims at specifying the contribution of each component to the model execution and predictions, while fine-grained levels focus on feature attribution and graph structure attribution analysis based on knowledge distillation. Student models are trained in standalone modes and are responsible for capturing different teacher behaviors, later used for particular component interpretation. Besides, we also aim for personalized explanations as the framework can generate different results based on user preferences. Finally, extensive experiments demonstrate the effectiveness and fidelity of our proposed approach.

Multi-types of behaviors (e.g., clicking, adding to cart, purchasing, etc.) widely exist in most real-world recommendation scenarios, which are beneficial to learn users' multi-faceted preferences. As dependencies are explicitly exhibited by the multiple types of behaviors, effectively modeling complex behavior dependencies is crucial for multi-behavior prediction. The state-of-the-art multi-behavior models learn behavior dependencies indistinguishably with all historical interactions as input. However, different behaviors may reflect different aspects of user preference, which means that some irrelevant interactions may play as noises to the target behavior to be predicted. To address the aforementioned limitations, we introduce multi-interest learning to the multi-behavior recommendation. More specifically, we propose a novel Coarse-to-fine Knowledge-enhanced Multi-interest Learning (CKML) framework to learn shared and behavior-specific interests for different behaviors. CKML introduces two advanced modules, namely Coarse-grained Interest Extracting (CIE) and Fine-grained Behavioral Correlation (FBC), which work jointly to capture fine-grained behavioral dependencies. CIE uses knowledge-aware information to extract initial representations of each interest. FBC incorporates a dynamic routing scheme to further assign each behavior among interests. Additionally, we use the self-attention mechanism to correlate different behavioral information at the interest level. Empirical results on three real-world datasets verify the effectiveness and efficiency of our model in exploiting multi-behavior data. Further experiments demonstrate the effectiveness of each module and the robustness and superiority of the shared and specific modelling paradigm for multi-behavior data.

Machine learning plays an increasingly important role in many areas of chemistry and materials science, e.g. to predict materials properties, to accelerate simulations, to design new materials, and to predict synthesis routes of new materials. Graph neural networks (GNNs) are one of the fastest growing classes of machine learning models. They are of particular relevance for chemistry and materials science, as they directly work on a graph or structural representation of molecules and materials and therefore have full access to all relevant information required to characterize materials. In this review article, we provide an overview of the basic principles of GNNs, widely used datasets, and state-of-the-art architectures, followed by a discussion of a wide range of recent applications of GNNs in chemistry and materials science, and concluding with a road-map for the further development and application of GNNs.

Bloom filters are widely used data structures that compactly represent sets of elements. Querying a Bloom filter reveals if an element is not included in the underlying set or is included with a certain error rate. This membership testing can be modeled as a binary classification problem and solved through deep learning models, leading to what is called learned Bloom filters. We have identified that the benefits of learned Bloom filters are apparent only when considering a vast amount of data, and even then, there is a possibility to further reduce their memory consumption. For that reason, we introduce a lossless input compression technique that improves the memory consumption of the learned model while preserving a comparable model accuracy. We evaluate our approach and show significant memory consumption improvements over learned Bloom filters.