Research in machine learning for autism spectrum disorder (ASD) classification bears the promise to improve clinical diagnoses. However, recent studies in clinical imaging have shown the limited generalization of biomarkers across and beyond benchmark datasets. Despite increasing model complexity and sample size in neuroimaging, the classification performance of ASD remains far away from clinical application. This raises the question of how we can overcome these barriers to develop early biomarkers for ASD. One approach might be to rethink how we operationalize the theoretical basis of this disease in machine learning models. Here we introduced unsupervised graph representations that explicitly map the neural mechanisms of a core aspect of ASD, deficits in dyadic social interaction, as assessed by dual brain recordings, termed hyperscanning, and evaluated their predictive performance. The proposed method differs from existing approaches in that it is more suitable to capture social interaction deficits on a neural level and is applicable to young children and infants. First results from functional near-infrared spectroscopy data indicate potential predictive capacities of a task-agnostic, interpretable graph representation. This first effort to leverage interaction-related deficits on neural level to classify ASD may stimulate new approaches and methods to enhance existing models to achieve developmental ASD biomarkers in the future.

Clinical diagnosis of the eye is performed over multifarious data modalities including scalar clinical labels, vectorized biomarkers, two-dimensional fundus images, and three-dimensional Optical Coherence Tomography (OCT) scans. Clinical practitioners use all available data modalities for diagnosing and treating eye diseases like Diabetic Retinopathy (DR) or Diabetic Macular Edema (DME). Enabling usage of machine learning algorithms within the ophthalmic medical domain requires research into the relationships and interactions between all relevant data over a treatment period. Existing datasets are limited in that they neither provide data nor consider the explicit relationship modeling between the data modalities. In this paper, we introduce the Ophthalmic Labels for Investigating Visual Eye Semantics (OLIVES) dataset that addresses the above limitation. This is the first OCT and near-IR fundus dataset that includes clinical labels, biomarker labels, disease labels, and time-series patient treatment information from associated clinical trials. The dataset consists of 1268 near-IR fundus images each with at least 49 OCT scans, and 16 biomarkers, along with 4 clinical labels and a disease diagnosis of DR or DME. In total, there are 96 eyes' data averaged over a period of at least two years with each eye treated for an average of 66 weeks and 7 injections. We benchmark the utility of OLIVES dataset for ophthalmic data as well as provide benchmarks and concrete research directions for core and emerging machine learning paradigms within medical image analysis.

Taking advantage of the many recent advances in deep learning, text-to-image generative models currently have the merit of attracting the general public attention. Two of these models, DALL-E 2 and Imagen, have demonstrated that highly photorealistic images could be generated from a simple textual description of an image. Based on a novel approach for image generation called diffusion models, text-to-image models enable the production of many different types of high resolution images, where human imagination is the only limit. However, these models require exceptionally large amounts of computational resources to train, as well as handling huge datasets collected from the internet. In addition, neither the codebase nor the models have been released. It consequently prevents the AI community from experimenting with these cutting-edge models, making the reproduction of their results complicated, if not impossible. In this thesis, we aim to contribute by firstly reviewing the different approaches and techniques used by these models, and then by proposing our own implementation of a text-to-image model. Highly based on DALL-E 2, we introduce several slight modifications to tackle the high computational cost induced. We thus have the opportunity to experiment in order to understand what these models are capable of, especially in a low resource regime. In particular, we provide additional and analyses deeper than the ones performed by the authors of DALL-E 2, including ablation studies. Besides, diffusion models use so-called guidance methods to help the generating process. We introduce a new guidance method which can be used in conjunction with other guidance methods to improve image quality. Finally, the images generated by our model are of reasonably good quality, without having to sustain the significant training costs of state-of-the-art text-to-image models.

Coherence is one of the critical factors that determine the quality of writing. We propose writing relevance (WR) training method for neural encoder-decoder natural language generation (NLG) models which improves coherence of the continuation by leveraging negative examples. WR loss regresses the vector representation of the context and generated sentence toward positive continuation by contrasting it with the negatives. We compare our approach with Unlikelihood (UL) training in a text continuation task on commonsense natural language inference (NLI) corpora to show which method better models the coherence by avoiding unlikely continuations. The preference of our approach in human evaluation shows the efficacy of our method in improving coherence.

Large Language Models (LLMs) have in recent years demonstrated impressive prowess in natural language generation. A common practice to improve generation diversity is to sample multiple outputs from the model. However, there lacks a simple and robust way of selecting the best output from these stochastic samples. As a case study framed in the context of question generation, we propose two prompt-based approaches to selecting high-quality questions from a set of LLM-generated candidates. Our method works under the constraints of 1) a black-box (non-modifiable) question generation model and 2) lack of access to human-annotated references -- both of which are realistic limitations for real-world deployment of LLMs. With automatic as well as human evaluations, we empirically demonstrate that our approach can effectively select questions of higher qualities than greedy generation.

In lifelong learning, an agent learns throughout its entire life without resets, in a constantly changing environment, as we humans do. Consequently, lifelong learning comes with a plethora of research problems such as continual domain shifts, which result in non-stationary rewards and environment dynamics. These non-stationarities are difficult to detect and cope with due to their continuous nature. Therefore, exploration strategies and learning methods are required that are capable of tracking the steady domain shifts, and adapting to them. We propose Reactive Exploration to track and react to continual domain shifts in lifelong reinforcement learning, and to update the policy correspondingly. To this end, we conduct experiments in order to investigate different exploration strategies. We empirically show that representatives of the policy-gradient family are better suited for lifelong learning, as they adapt more quickly to distribution shifts than Q-learning. Thereby, policy-gradient methods profit the most from Reactive Exploration and show good results in lifelong learning with continual domain shifts. Our code is available at: https://github.com/ml-jku/reactive-exploration.

The Game Theory & Multi-Agent team at DeepMind studies several aspects of multi-agent learning ranging from computing approximations to fundamental concepts in game theory to simulating social dilemmas in rich spatial environments and training 3-d humanoids in difficult team coordination tasks. A signature aim of our group is to use the resources and expertise made available to us at DeepMind in deep reinforcement learning to explore multi-agent systems in complex environments and use these benchmarks to advance our understanding. Here, we summarise the recent work of our team and present a taxonomy that we feel highlights many important open challenges in multi-agent research.

What will it take for a car to be able to drive itself anywhere a human can? Ask autonomous vehicle experts this question and the answer invariably includes a discussion of geofencing. In the broadest sense, geofencing is simply a virtual boundary around a physical area. In the world of self-driving cars, it describes a crucial subset of the operational design domain -- the geographic region where the vehicle is functional. Reaching full Level 5 autonomy means removing the "fence" from geofenced autonomous cars. Experts say that will require artificial intelligence that can make abstractions, inferences, and become smarter as it is being used.

This entirely absorbing movie from Korean-American director Kogonada is adapted from a short story by Alexander Weinstein in his collection Children of the New World; it floats on a Zen updraft of wisdom and ideas. After Yang is an enigmatic sci-fi drama about a family of the future whose AI robot child (a "techno-sapien") bought by the parents to be a kindly big brother to their adopted Chinese daughter, goes wrong and cannot be fixed. There are touches of Philip K Dick and even Charlie Kaufman, and this is also a pregnant meditation on grief, loss, memory and consciousness. Colin Farrell and Jodie Turner-Smith play Jake and Kyra, who have an adopted daughter Mika (Malea Emma Tjandrawidjaja) – and also AI bot Yang (Justin H Min), a happy, calm, friendly and very lovable figure of Chinese appearance, programmed with Chinese memories and Chinese knowledge, whom the family has grown to love. When Yang goes into an unexplained coma, it is deeply upsetting: a bereavement-shock far beyond the malfunction of some gadget.

Originally published on Towards AI the World's Leading AI and Technology News and Media Company. If you are building an AI-related product or service, we invite you to consider becoming an AI sponsor. At Towards AI, we help scale AI and technology startups. Let us help you unleash your technology to the masses. One of the major components of the economy is the insurance industry, it protects against the financial risks that are present at all stages of people's lives and businesses.