Fostered by novel analytical techniques, digitalization and automation, modern bioprocess development provides high amounts of heterogeneous experimental data, containing valuable process information. In this context, data-driven methods like machine learning (ML) approaches have a high potential to rationally explore large design spaces while exploiting experimental facilities most efficiently. The aim of this review is to demonstrate how ML methods have been applied so far in bioprocess development, especially in strain engineering and selection, bioprocess optimization, scale-up, monitoring and control of bioprocesses. For each topic, we will highlight successful application cases, current challenges and point out domains that can potentially benefit from technology transfer and further progress in the field of ML.

The COVID-19 crisis has emphasized the need for scientific methods such as machine learning to speed up the discovery of solutions to the pandemic. Harnessing machine learning techniques requires quality data, skilled personnel and advanced compute infrastructure. In Africa, however, machine learning competencies and compute infrastructures are limited. This paper demonstrates a cross-border collaborative capacity building approach to the application of machine learning techniques in discovering answers to COVID-19 questions.

Cloud removal is an essential task in remote sensing data analysis. As the image sensors are distant from the earth ground, it is likely that part of the area of interests is covered by cloud. Moreover, the atmosphere in between creates a constant haze layer upon the acquired images. To recover the ground image, we propose to use scattering model for temporal sequence of images of any scene in the framework of low rank and sparse models. We further develop its variant, which is much faster and yet more accurate. To measure the performance of different methods {\em objectively}, we develop a semi-realistic simulation method to produce cloud cover so that various methods can be quantitatively analysed, which enables detailed study of many aspects of cloud removal algorithms, including verifying the effectiveness of proposed models in comparison with the state-of-the-arts, including deep learning models, and addressing the long standing problem of the determination of regularisation parameters. The latter is companioned with theoretic analysis on the range of the sparsity regularisation parameter and verified numerically.

Machine learning based traffic forecasting models leverage sophisticated spatiotemporal auto-correlations to provide accurate predictions of city-wide traffic states. However, existing methods assume a reliable and unbiased forecasting environment, which is not always available in the wild. In this work, we investigate the vulnerability of spatiotemporal traffic forecasting models and propose a practical adversarial spatiotemporal attack framework. Specifically, instead of simultaneously attacking all geo-distributed data sources, an iterative gradient-guided node saliency method is proposed to identify the time-dependent set of victim nodes. Furthermore, we devise a spatiotemporal gradient descent based scheme to generate real-valued adversarial traffic states under a perturbation constraint. Meanwhile, we theoretically demonstrate the worst performance bound of adversarial traffic forecasting attacks. Extensive experiments on two real-world datasets show that the proposed two-step framework achieves up to $67.8\%$ performance degradation on various advanced spatiotemporal forecasting models. Remarkably, we also show that adversarial training with our proposed attacks can significantly improve the robustness of spatiotemporal traffic forecasting models. Our code is available in \url{https://github.com/luckyfan-cs/ASTFA}.

Most previous studies of document-level event extraction mainly focus on building argument chains in an autoregressive way, which achieves a certain success but is inefficient in both training and inference. In contrast to the previous studies, we propose a fast and lightweight model named as PTPCG. In our model, we design a novel strategy for event argument combination together with a non-autoregressive decoding algorithm via pruned complete graphs, which are constructed under the guidance of the automatically selected pseudo triggers. Compared to the previous systems, our system achieves competitive results with 19.8\% of parameters and much lower resource consumption, taking only 3.8\% GPU hours for training and up to 8.5 times faster for inference. Besides, our model shows superior compatibility for the datasets with (or without) triggers and the pseudo triggers can be the supplements for annotated triggers to make further improvements. Codes are available at https://github.com/Spico197/DocEE .

Knowledge graph question answering (KGQA) based on information retrieval aims to answer a question by retrieving answer from a large-scale knowledge graph. Most existing methods first roughly retrieve the knowledge subgraphs (KSG) that may contain candidate answer, and then search for the exact answer in the KSG. However, the KSG may contain thousands of candidate nodes since the knowledge graph involved in querying is often of large scale, thus decreasing the performance of answer selection. To tackle this problem, we first propose to partition the retrieved KSG to several smaller sub-KSGs via a new subgraph partition algorithm and then present a graph-augmented learning to rank model to select the top-ranked sub-KSGs from them. Our proposed model combines a novel subgraph matching networks to capture global interactions in both question and subgraphs, and an Enhanced Bilateral Multi-Perspective Matching model is proposed to capture local interactions. Finally, we apply an answer selection model on the full KSG and the top-ranked sub-KSGs respectively to validate the effectiveness of our proposed graph-augmented learning to rank method. The experimental results on multiple benchmark datasets have demonstrated the effectiveness of our approach.

Federated Learning (FL) has recently become an effective approach for cyberattack detection systems, especially in Internet-of-Things (IoT) networks. By distributing the learning process across IoT gateways, FL can improve learning efficiency, reduce communication overheads and enhance privacy for cyberattack detection systems. Challenges in implementation of FL in such systems include unavailability of labeled data and dissimilarity of data features in different IoT networks. In this paper, we propose a novel collaborative learning framework that leverages Transfer Learning (TL) to overcome these challenges. Particularly, we develop a novel collaborative learning approach that enables a target network with unlabeled data to effectively and quickly learn knowledge from a source network that possesses abundant labeled data. It is important that the state-of-the-art studies require the participated datasets of networks to have the same features, thus limiting the efficiency, flexibility as well as scalability of intrusion detection systems. However, our proposed framework can address these problems by exchanging the learning knowledge among various deep learning models, even when their datasets have different features. Extensive experiments on recent real-world cybersecurity datasets show that the proposed framework can improve more than 40% as compared to the state-of-the-art deep learning based approaches.

Humans can generate reasonable answers to novel queries (Schulz, 2012): if I asked you what kind of food you want to eat for lunch, you would respond with a food, not a time. The thought that one would respond "After 4pm" to "What would you like to eat" is either a joke or a mistake, and seriously entertaining it as a lunch option would likely never happen in the first place. While understanding how people come up with new ideas, thoughts, explanations, and hypotheses that obey the basic constraints of a novel search space is of central importance to cognitive science, there is no agreed-on formal model for this kind of reasoning. We propose that a core component of any such reasoning system is a type theory: a formal imposition of structure on the kinds of computations an agent can perform, and how they're performed. We motivate this proposal with three empirical observations: adaptive constraints on learning and inference (i.e. generating reasonable hypotheses), how people draw distinctions between improbability and impossibility, and people's ability to reason about things at varying levels of abstraction.

An intelligent control strategy is proposed to eliminate the actuator saturation problem that exists in the trajectory tracking process of unmanned underwater vehicles (UUV). The control strategy consists of two parts: for the kinematic modeling part, a fuzzy logic-refined backstepping control is developed to achieve control velocities within acceptable ranges and errors of small fluctuations; on the basis of the velocities deducted by the improved kinematic control, the sliding mode control (SMC) is introduced in the dynamic modeling to obtain corresponding torques and forces that should be applied to the vehicle body. With the control velocities computed by the kinematic model and applied forces derived by the dynamic model, the robustness and accuracy of the UUV trajectory without actuator saturation can be achieved.

Arrival/Travel times for public transit exhibit variability on account of factors like seasonality, dwell times at bus stops, traffic signals, travel demand fluctuation etc. The developing world in particular is plagued by additional factors like lack of lane discipline, excess vehicles, diverse modes of transport and so on. This renders the bus arrival time prediction (BATP) to be a challenging problem especially in the developing world. A novel data-driven model based on recurrent neural networks (RNNs) is proposed for BATP (in real-time) in the current work. The model intelligently incorporates both spatial and temporal correlations in a unique (non-linear) fashion distinct from existing approaches. In particular, we propose a Gated Recurrent Unit (GRU) based Encoder-Decoder(ED) OR Seq2Seq RNN model (originally introduced for language translation) for BATP. The geometry of the dynamic real time BATP problem enables a nice fit with the Encoder-Decoder based RNN structure. We feed relevant additional synchronized inputs (from previous trips) at each step of the decoder (a feature classically unexplored in machine translation applications). Further motivated from accurately modelling congestion influences on travel time prediction, we additionally propose to use a bidirectional layer at the decoder (something unexplored in other time-series based ED application contexts). The effectiveness of the proposed algorithms is demonstrated on real field data collected from challenging traffic conditions. Our experiments indicate that the proposed method outperforms diverse existing state-of-art data-driven approaches proposed for the same problem.