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EOCSA: Predicting Prognosis of Epithelial Ovarian Cancer with Whole Slide Histopathological Images

arXiv.org Artificial Intelligence

Ovarian cancer is one of the most serious cancers that threaten women around the world. Epithelial ovarian cancer (EOC), as the most commonly seen subtype of ovarian cancer, has rather high mortality rate and poor prognosis among various gynecological cancers. Survival analysis outcome is able to provide treatment advices to doctors. In recent years, with the development of medical imaging technology, survival prediction approaches based on pathological images have been proposed. In this study, we designed a deep framework named EOCSA which analyzes the prognosis of EOC patients based on pathological whole slide images (WSIs). Specifically, we first randomly extracted patches from WSIs and grouped them into multiple clusters. Next, we developed a survival prediction model, named DeepConvAttentionSurv (DCAS), which was able to extract patch-level features, removed less discriminative clusters and predicted the EOC survival precisely. Particularly, channel attention, spatial attention, and neuron attention mechanisms were used to improve the performance of feature extraction. Then patient-level features were generated from our weight calculation method and the survival time was finally estimated using LASSO-Cox model. The proposed EOCSA is efficient and effective in predicting prognosis of EOC and the DCAS ensures more informative and discriminative features can be extracted. As far as we know, our work is the first to analyze the survival of EOC based on WSIs and deep neural network technologies. The experimental results demonstrate that our proposed framework has achieved state-of-the-art performance of 0.980 C-index. The implementation of the approach can be found at https://github.com/RanSuLab/EOCprognosis.


Augmenting Operations Research with Auto-Formulation of Optimization Models from Problem Descriptions

arXiv.org Artificial Intelligence

We describe an augmented intelligence system for simplifying and enhancing the modeling experience for operations research. Using this system, the user receives a suggested formulation of an optimization problem based on its description. To facilitate this process, we build an intuitive user interface system that enables the users to validate and edit the suggestions. We investigate controlled generation techniques to obtain an automatic suggestion of formulation. Then, we evaluate their effectiveness with a newly created dataset of linear programming problems drawn from various application domains.


Detecting Backdoors in Deep Text Classifiers

arXiv.org Artificial Intelligence

Deep neural networks are vulnerable to adversarial attacks, such as backdoor attacks in which a malicious adversary compromises a model during training such that specific behaviour can be triggered at test time by attaching a specific word or phrase to an input. This paper considers the problem of diagnosing whether a model has been compromised and if so, identifying the backdoor trigger. We present the first robust defence mechanism that generalizes to several backdoor attacks against text classification models, without prior knowledge of the attack type, nor does our method require access to any (potentially compromised) training resources. Our experiments show that our technique is highly accurate at defending against state-of-the-art backdoor attacks, including data poisoning and weight poisoning, across a range of text classification tasks and model architectures. Our code will be made publicly available upon acceptance.


Extracting or Guessing? Improving Faithfulness of Event Temporal Relation Extraction

arXiv.org Artificial Intelligence

In this paper, we seek to improve the faithfulness of TempRel extraction models from two perspectives. The first perspective is to extract genuinely based on contextual description. To achieve this, we propose to conduct counterfactual analysis to attenuate the effects of two significant types of training biases: the event trigger bias and the frequent label bias. We also add tense information into event representations to explicitly place an emphasis on the contextual description. The second perspective is to provide proper uncertainty estimation and abstain from extraction when no relation is described in the text. By parameterization of Dirichlet Prior over the model-predicted categorical distribution, we improve the model estimates of the correctness likelihood and make TempRel predictions more selective. We also employ temperature scaling to recalibrate the model confidence measure after bias mitigation. Through experimental analysis on MATRES, MATRES-DS, and TDDiscourse, we demonstrate that our model extracts TempRel and timelines more faithfully compared to SOTA methods, especially under distribution shifts.


Bellman Residual Orthogonalization for Offline Reinforcement Learning

arXiv.org Artificial Intelligence

Markov decision processes (MDP) provide a general framework for optimal decision-making in sequential settings (e.g., [Put94, Ber95a, Ber95b]). Reinforcement learning refers to a general class of procedures for estimating near-optimal policies based on data from an unknown MDP (e.g., [BT96, SB18]). Different classes of problems can be distinguished depending on our access to the data-generating mechanism. Many modern applications of RL involve learning based on a pre-collected or offline dataset. Moreover, the state-action spaces are often sufficiently complex that it becomes necessary to implement function approximation. In this paper, we focus on model-free offline reinforcement learning (RL) with function approximation, where prior knowledge about the MDP is encoded via the value function. In this setting, we focus on two fundamental problems: (1) offline policy evaluation--namely, the task of accurately predicting the value of a target policy; and (2) offline policy optimization, which is the task of finding a high-performance policy. There are various broad classes of approaches to off-policy evaluation, including importance sampling [Pre00, TB16, JL16, LLTZ18], as well as regression-based methods [LP03, MS08, CJ19]. 1


Observability Analysis of Graph SLAM-Based Joint Calibration of Multiple Microphone Arrays and Sound Source Localization

arXiv.org Artificial Intelligence

Multiple microphone arrays have many applications in robot audition, including sound source localization, audio scene perception and analysis, etc. However, accurate calibration of multiple microphone arrays remains a challenge because there are many unknown parameters to be identified, including the Euler angles, geometry, asynchronous factors between the microphone arrays. This paper is concerned with joint calibration of multiple microphone arrays and sound source localization using graph simultaneous localization and mapping (SLAM). By using a Fisher information matrix (FIM) approach, we focus on the observability analysis of the graph SLAM framework for the above-mentioned calibration problem. We thoroughly investigate the identifiability of the unknown parameters, including the Euler angles, geometry, asynchronous effects between the microphone arrays, and the sound source locations. We establish necessary/sufficient conditions under which the FIM and the Jacobian matrix have full column rank, which implies the identifiability of the unknown parameters. These conditions are closely related to the variation in the motion of the sound source and the configuration of microphone arrays, and have intuitive and physical interpretations. We also discover several scenarios where the unknown parameters are not uniquely identifiable. All theoretical findings are demonstrated using simulation data.


Entity Disambiguation with Entity Definitions

arXiv.org Artificial Intelligence

Local models have recently attained astounding performances in Entity Disambiguation (ED), with generative and extractive formulations being the most promising research directions. However, previous works limited their studies to using, as the textual representation of each candidate, only its Wikipedia title. Although certainly effective, this strategy presents a few critical issues, especially when titles are not sufficiently informative or distinguishable from one another. In this paper, we address this limitation and investigate to what extent more expressive textual representations can mitigate it. We thoroughly evaluate our approach against standard benchmarks in ED and find extractive formulations to be particularly well-suited to these representations: we report a new state of the art on 2 out of 6 benchmarks we consider and strongly improve the generalization capability over unseen patterns. We release our code, data and model checkpoints at https://github.com/SapienzaNLP/extend.


C-Mixup: Improving Generalization in Regression

arXiv.org Artificial Intelligence

Improving the generalization of deep networks is an important open challenge, particularly in domains without plentiful data. The mixup algorithm improves generalization by linearly interpolating a pair of examples and their corresponding labels. These interpolated examples augment the original training set. Mixup has shown promising results in various classification tasks, but systematic analysis of mixup in regression remains underexplored. Using mixup directly on regression labels can result in arbitrarily incorrect labels. In this paper, we propose a simple yet powerful algorithm, C-Mixup, to improve generalization on regression tasks. In contrast with vanilla mixup, which picks training examples for mixing with uniform probability, C-Mixup adjusts the sampling probability based on the similarity of the labels. Our theoretical analysis confirms that C-Mixup with label similarity obtains a smaller mean square error in supervised regression and meta-regression than vanilla mixup and using feature similarity. Another benefit of C-Mixup is that it can improve out-of-distribution robustness, where the test distribution is different from the training distribution. By selectively interpolating examples with similar labels, it mitigates the effects of domain-associated information and yields domain-invariant representations. We evaluate C-Mixup on eleven datasets, ranging from tabular to video data. Compared to the best prior approach, C-Mixup achieves 6.56%, 4.76%, 5.82% improvements in in-distribution generalization, task generalization, and out-of-distribution robustness, respectively. Code is released at https://github.com/huaxiuyao/C-Mixup.


Multilingual CheckList: Generation and Evaluation

arXiv.org Artificial Intelligence

Multilingual evaluation benchmarks usually contain limited high-resource languages and do not test models for specific linguistic capabilities. CheckList is a template-based evaluation approach that tests models for specific capabilities. The CheckList template creation process requires native speakers, posing a challenge in scaling to hundreds of languages. In this work, we explore multiple approaches to generate Multilingual CheckLists. We device an algorithm - Template Extraction Algorithm (TEA) for automatically extracting target language CheckList templates from machine translated instances of a source language templates. We compare the TEA CheckLists with CheckLists created with different levels of human intervention. We further introduce metrics along the dimensions of cost, diversity, utility, and correctness to compare the CheckLists. We thoroughly analyze different approaches to creating CheckLists in Hindi. Furthermore, we experiment with 9 more different languages. We find that TEA followed by human verification is ideal for scaling Checklist-based evaluation to multiple languages while TEA gives a good estimates of model performance.


CHAE: Fine-Grained Controllable Story Generation with Characters, Actions and Emotions

arXiv.org Artificial Intelligence

Story generation has emerged as an interesting yet challenging NLP task in recent years. Some existing studies aim at generating fluent and coherent stories from keywords and outlines; while others attempt to control the global features of the story, such as emotion, style and topic. However, these works focus on coarse-grained control on the story, neglecting control on the details of the story, which is also crucial for the task. To fill the gap, this paper proposes a model for fine-grained control on the story, which allows the generation of customized stories with characters, corresponding actions and emotions arbitrarily assigned. Extensive experimental results on both automatic and human manual evaluations show the superiority of our method. It has strong controllability to generate stories according to the fine-grained personalized guidance, unveiling the effectiveness of our methodology. Our code is available at https://github.com/victorup/CHAE.