We explore conditions for when the gradient of a deep declarative node can be approximated by ignoring constraint terms and still result in a descent direction for the global loss function. This has important practical application when training deep learning models since the approximation is often computationally much more efficient than the true gradient calculation. We provide theoretical analysis for problems with linear equality constraints and normalization constraints, and show examples where the approximation works well in practice as well as some cautionary tales for when it fails.

Drug repurposing (or repositioning) is the process of finding new therapeutic uses for drugs already approved by drug regulatory authorities (e.g., the Food and Drug Administration (FDA) and Therapeutic Goods Administration (TGA)) for other diseases. This involves analyzing the interactions between different biological entities, such as drug targets (genes/proteins and biological pathways) and drug properties, to discover novel drug-target or drug-disease relations. Artificial intelligence methods such as machine learning and deep learning have successfully analyzed complex heterogeneous data in the biomedical domain and have also been used for drug repurposing. This study presents a novel unsupervised machine learning framework that utilizes a graph-based autoencoder for multi-feature type clustering on heterogeneous drug data. The dataset consists of 438 drugs, of which 224 are under clinical trials for COVID-19 (category A). The rest are systematically filtered to ensure the safety and efficacy of the treatment (category B). The framework solely relies on reported drug data, including its pharmacological properties, chemical/physical properties, interaction with the host, and efficacy in different publicly available COVID-19 assays. Our machine-learning framework reveals three clusters of interest and provides recommendations featuring the top 15 drugs for COVID-19 drug repurposing, which were shortlisted based on the predicted clusters that were dominated by category A drugs. The anti-COVID efficacy of the drugs should be verified by experimental studies. Our framework can be extended to support other datasets and drug repurposing studies, given open-source code and data availability.

Model inversion attacks involve reconstructing the training data of a target model, which raises serious privacy concerns for machine learning models. However, these attacks, especially learning-based methods, are likely to suffer from low attack accuracy, i.e., low classification accuracy of these reconstructed data by machine learning classifiers. Recent studies showed an alternative strategy of model inversion attacks, GAN-based optimization, can improve the attack accuracy effectively. However, these series of GAN-based attacks reconstruct only class-representative training data for a class, whereas learning-based attacks can reconstruct diverse data for different training data in each class. Hence, in this paper, we propose a new training paradigm for a learning-based model inversion attack that can achieve higher attack accuracy in a black-box setting. First, we regularize the training process of the attack model with an added semantic loss function and, second, we inject adversarial examples into the training data to increase the diversity of the class-related parts (i.e., the essential features for classification tasks) in training data. This scheme guides the attack model to pay more attention to the class-related parts of the original data during the data reconstruction process. The experimental results show that our method greatly boosts the performance of existing learning-based model inversion attacks. Even when no extra queries to the target model are allowed, the approach can still improve the attack accuracy of reconstructed data. This new attack shows that the severity of the threat from learning-based model inversion adversaries is underestimated and more robust defenses are required.

The COVID-19 Infodemic had an unprecedented impact on health behaviors and outcomes at a global scale. While many studies have focused on a qualitative and quantitative understanding of misinformation, including sentiment analysis, there is a gap in understanding the emotion-carriers of misinformation and their differences across geographies. In this study, we characterized emotion carriers and their impact on vaccination rates in India and the United States. A manually labelled dataset was created from 2.3 million tweets and collated with three publicly available datasets (CoAID, AntiVax, CMU) to train deep learning models for misinformation classification. Misinformation labelled tweets were further analyzed for behavioral aspects by leveraging Plutchik Transformers to determine the emotion for each tweet. Time series analysis was conducted to study the impact of misinformation on spatial and temporal characteristics. Further, categorical classification was performed using transformer models to assign categories for the misinformation tweets. Word2Vec+BiLSTM was the best model for misinformation classification, with an F1-score of 0.92. The US had the highest proportion of misinformation tweets (58.02%), followed by the UK (10.38%) and India (7.33%). Disgust, anticipation, and anger were associated with an increased prevalence of misinformation tweets. Disgust was the predominant emotion associated with misinformation tweets in the US, while anticipation was the predominant emotion in India. For India, the misinformation rate exhibited a lead relationship with vaccination, while in the US it lagged behind vaccination. Our study deciphered that emotions acted as differential carriers of misinformation across geography and time. These carriers can be monitored to develop strategic interventions for countering misinformation, leading to improved public health.

As numerous biomedical research articles are published regularly, adding knowledge to the accumulated literature on different diseases, such as cancer, neurodegenerative diseases, and hereditary diseases. One of the leading causes of global mortality disease is cancer due to various reasons such as lifestyle habits, radiation exposure, viral infections, and tobacco consumption [1] [2]. These reasons ultimately make some genetic change in a cell of tissue which causes it to become cancerous. Due to the top priority given to cancer research compared to other human diseases, enormous articles were published [3] [4] in a short period [5]. It can serve as a relevant source for cancer knowledge discovery in different fields of diagnostics, application of drugs, genetic association, prevention, and treatment. An automate downloading of articles and extraction of related entities will advance the progression of the research faster. Natural Language Processing (NLP) helps in communicating computers with humans in their language and converts the unstructured data into structured data to improve the accuracy of text mining. NLP function guides to understanding the human query language to discover knowledge from literature without much manual effort [6]. Named Entity Recognition (NER) and text classification is used mainly for text mining [7].

A self-explaining rationalization model is generally constructed by a cooperative game where a generator selects the most human-intelligible pieces from the input text as rationales, followed by a predictor that makes predictions based on the selected rationales. However, such a cooperative game may incur the degeneration problem where the predictor overfits to the uninformative pieces generated by a not yet well-trained generator and in turn, leads the generator to converge to a sub-optimal model that tends to select senseless pieces. In this paper, we theoretically bridge degeneration with the predictor's Lipschitz continuity. Then, we empirically propose a simple but effective method named DR, which can naturally and flexibly restrain the Lipschitz constant of the predictor, to address the problem of degeneration. The main idea of DR is to decouple the generator and predictor to allocate them with asymmetric learning rates. A series of experiments conducted on two widely used benchmarks have verified the effectiveness of the proposed method. Codes: \href{https://github.com/jugechengzi/Rationalization-DR}{https://github.com/jugechengzi/Rationalization-DR}.

In-context learning has shown great success in i.i.d semantic parsing splits, where the training and test sets are drawn from the same distribution. In this setup, models are typically prompted with demonstrations that are similar to the input utterance. However, in the setup of compositional generalization, where models are tested on outputs with structures that are absent from the training set, selecting similar demonstrations is insufficient, as often no example will be similar enough to the input. In this work, we propose a method to select diverse demonstrations that aims to collectively cover all of the structures required in the output program, in order to encourage the model to generalize to new structures from these demonstrations. We empirically show that combining diverse demonstrations with in-context learning substantially improves performance across three compositional generalization semantic parsing datasets in the pure in-context learning setup and when combined with finetuning.

Recent work in Dialogue Act (DA) classification approaches the task as a sequence labeling problem, using neural network models coupled with a Conditional Random Field (CRF) as the last layer. CRF models the conditional probability of the target DA label sequence given the input utterance sequence. However, the task involves another important input sequence, that of speakers, which is ignored by previous work. To address this limitation, this paper proposes a simple modification of the CRF layer that takes speaker-change into account. Experiments on the SwDA corpus show that our modified CRF layer outperforms the original one, with very wide margins for some DA labels. Further, visualizations demonstrate that our CRF layer can learn meaningful, sophisticated transition patterns between DA label pairs conditioned on speaker-change in an end-to-end way. Code is publicly available.

Increasing productivity in manufacturing has been an elusive goal despite significant advances in factory automation technology and robotics. There are four main challenges currently facing manufacturers: low production efficiency; product defects and inconsistent quality; unforeseen machine maintenance; and high energy use and waste costs. The fourth industrial revolution--also referred to as Industry 4.0--sets out critical technological directions for addressing these grand challenges via data-driven digital manufacturing (DM) solutions incorporating novel computing technology that combines AI/machine learning (ML) and digital twins (DTs)4 for digitally representing complex physical industrial machine, products, and people in production. While digital manufacturing powered by digital twins and dependency/constraint-aware ML is still in early stages, it has shown its potential in improving manufacturing productivity by 20%-30%. Although the Industry 4.0 vision and directions are supported by major manufacturing companies and technology providers (for example, Siemens, Bosch, and IBM), its technology baseline is not mature enough to address related computing needs.

We describe a significant emerging trend away from the techno-solutionist approach to problems that seeks to create and understand a new paradigm: a productive interplay between algorithms and people.