Functional magnetic resonance imaging (fMRI) is a commonly used technique to measure neural activation. Its application has been particularly important in identifying underlying neurodegenerative conditions such as Parkinson's, Alzheimer's, and Autism. Recent analysis of fMRI data models the brain as a graph and extracts features by graph neural networks (GNNs). However, the unique characteristics of fMRI data require a special design of GNN. Tailoring GNN to generate effective and domain-explainable features remains challenging. In this paper, we propose a contrastive dual-attention block and a differentiable graph pooling method called ContrastPool to better utilize GNN for brain networks, meeting fMRI-specific requirements. We apply our method to 5 resting-state fMRI brain network datasets of 3 diseases and demonstrate its superiority over state-of-the-art baselines. Our case study confirms that the patterns extracted by our method match the domain knowledge in neuroscience literature, and disclose direct and interesting insights. Our contributions underscore the potential of ContrastPool for advancing the understanding of brain networks and neurodegenerative conditions.

Prior knowledge and symbolic rules in machine learning are often expressed in the form of label constraints, especially in structured prediction problems. In this work, we compare two common strategies for encoding label constraints in a machine learning pipeline, regularization with constraints and constrained inference, by quantifying their impact on model performance. For regularization, we show that it narrows the generalization gap by precluding models that are inconsistent with the constraints. However, its preference for small violations introduces a bias toward a suboptimal model. For constrained inference, we show that it reduces the population risk by correcting a model's violation, and hence turns the violation into an advantage. Given these differences, we further explore the use of two approaches together and propose conditions for constrained inference to compensate for the bias introduced by regularization, aiming to improve both the model complexity and optimal risk.

Deep learning systems have been proposed to improve the objectivity and efficiency of Ki- 67 PI scoring. The challenge is that while very accurate, deep learning techniques suffer from reduced performance when applied to out-of-domain data. This is a critical challenge for clinical translation, as models are typically trained using data available to the vendor, which is not from the target domain. To address this challenge, this study proposes a domain adaptation pipeline that employs an unsupervised framework to generate silver standard (pseudo) labels in the target domain, which is used to augment the gold standard (GS) source domain data. Five training regimes were tested on two validated Ki-67 scoring architectures (UV-Net and piNET), (1) SS Only: trained on target silver standard (SS) labels, (2) GS Only: trained on source GS labels, (3) Mixed: trained on target SS and source GS labels, (4) GS+SS: trained on source GS labels and fine-tuned on target SS labels, and our proposed method (5) SS+GS: trained on source SS labels and fine-tuned on source GS labels. The SS+GS method yielded significantly (p < 0.05) higher PI accuracy (95.9%) and more consistent results compared to the GS Only model on target data. Analysis of t-SNE plots showed features learned by the SS+GS models are more aligned for source and target data, resulting in improved generalization. The proposed pipeline provides an efficient method for learning the target distribution without manual annotations, which are time-consuming and costly to generate for medical images. This framework can be applied to any target site as a per-laboratory calibration method, for widescale deployment.

Abstraction-based techniques are an attractive approach for synthesizing correct-by-construction controllers to satisfy high-level temporal requirements. A main bottleneck for successful application of these techniques is the memory requirement, both during controller synthesis and in controller deployment. We propose memory-efficient methods for mitigating the high memory demands of the abstraction-based techniques using neural network representations. To perform synthesis for reach-avoid specifications, we propose an on-the-fly algorithm that relies on compressed neural network representations of the forward and backward dynamics of the system. In contrast to usual applications of neural representations, our technique maintains soundness of the end-to-end process. To ensure this, we correct the output of the trained neural network such that the corrected output representations are sound with respect to the finite abstraction. For deployment, we provide a novel training algorithm to find a neural network representation of the synthesized controller and experimentally show that the controller can be correctly represented as a combination of a neural network and a look-up table that requires a substantially smaller memory. We demonstrate experimentally that our approach significantly reduces the memory requirements of abstraction-based methods. For the selected benchmarks, our approach reduces the memory requirements respectively for the synthesis and deployment by a factor of $1.31\times 10^5$ and $7.13\times 10^3$ on average, and up to $7.54\times 10^5$ and $3.18\times 10^4$. Although this reduction is at the cost of increased off-line computations to train the neural networks, all the steps of our approach are parallelizable and can be implemented on machines with higher number of processing units to reduce the required computational time.

In this paper, we aim at establishing an approximation theory and a learning theory of distribution regression via a fully connected neural network (FNN). In contrast to the classical regression methods, the input variables of distribution regression are probability measures. Then we often need to perform a second-stage sampling process to approximate the actual information of the distribution. On the other hand, the classical neural network structure requires the input variable to be a vector. When the input samples are probability distributions, the traditional deep neural network method cannot be directly used and the difficulty arises for distribution regression. A well-defined neural network structure for distribution inputs is intensively desirable. There is no mathematical model and theoretical analysis on neural network realization of distribution regression. To overcome technical difficulties and address this issue, we establish a novel fully connected neural network framework to realize an approximation theory of functionals defined on the space of Borel probability measures. Furthermore, based on the established functional approximation results, in the hypothesis space induced by the novel FNN structure with distribution inputs, almost optimal learning rates for the proposed distribution regression model up to logarithmic terms are derived via a novel two-stage error decomposition technique.

Graph neural network (GNN) has gained increasing popularity in recent years owing to its capability and flexibility in modeling complex graph structure data. Among all graph learning methods, hypergraph learning is a technique for exploring the implicit higher-order correlations when training the embedding space of the graph. In this paper, we propose a hypergraph learning framework named LFH that is capable of dynamic hyperedge construction and attentive embedding update utilizing the heterogeneity attributes of the graph. Specifically, in our framework, the high-quality features are first generated by the pairwise fusion strategy that utilizes explicit graph structure information when generating initial node embedding. Afterwards, a hypergraph is constructed through the dynamic grouping of implicit hyperedges, followed by the type-specific hypergraph learning process. To evaluate the effectiveness of our proposed framework, we conduct comprehensive experiments on several popular datasets with eleven state-of-the-art models on both node classification and link prediction tasks, which fall into categories of homogeneous pairwise graph learning, heterogeneous pairwise graph learning, and hypergraph learning. The experiment results demonstrate a significant performance gain (average 12.5% in node classification and 13.3% in link prediction) compared with recent state-of-the-art methods.

With the increasing influence of social media platforms, it has become crucial to develop automated systems capable of detecting instances of sexism and other disrespectful and hateful behaviors to promote a more inclusive and respectful online environment. Nevertheless, these tasks are considerably challenging considering different hate categories and the author's intentions, especially under the learning with disagreements regime. This paper describes AI-UPV team's participation in the EXIST (sEXism Identification in Social neTworks) Lab at CLEF 2023 [1, 2]. The proposed approach aims at addressing the task of sexism identification and characterization under the learning with disagreements paradigm by training directly from the data with disagreements, without using any aggregated label. Yet, performances considering both soft and hard evaluations are reported. The proposed system uses large language models (i.e., mBERT and XLM-RoBERTa) and ensemble strategies for sexism identification and classification in English and Spanish. In particular, our system is articulated in three different pipelines. The ensemble approach outperformed the individual large language models obtaining the best performances both adopting a soft and a hard label evaluation. This work describes the participation in all the three EXIST tasks, considering a soft evaluation, it obtained fourth place in Task 2 at EXIST and first place in Task 3, with the highest ICM-Soft of 2.32 and a normalized ICM-Soft of 0.79.

This paper proposes a novelty approach to mitigate the negative transfer problem. In the field of machine learning, the common strategy is to apply the Single-Task Learning approach in order to train a supervised model to solve a specific task. Training a robust model requires a lot of data and a significant amount of computational resources, making this solution unfeasible in cases where data are unavailable or expensive to gather. Therefore another solution, based on the sharing of information between tasks, has been developed: Multi-Task Learning (MTL). Despite the recent developments regarding MTL, the problem of negative transfer has still to be solved. Negative transfer is a phenomenon that occurs when noisy information is shared between tasks, resulting in a drop in performance. This paper proposes a new approach to mitigate the negative transfer problem based on the task awareness concept. The proposed approach results in diminishing the negative transfer together with an improvement of performance over classic MTL solution. Moreover, the proposed approach has been implemented in two unified architectures to detect Sexism, Hate Speech, and Toxic Language in text comments. The proposed architectures set a new state-of-the-art both in EXIST-2021 and HatEval-2019 benchmarks.

The widespread usage of latent language representations via pre-trained language models (LMs) suggests that they are a promising source of structured knowledge. However, existing methods focus only on a single object per subject-relation pair, even though often multiple objects are correct. To overcome this limitation, we analyze these representations for their potential to yield materialized multi-object relational knowledge. We formulate the problem as a rank-then-select task. For ranking candidate objects, we evaluate existing prompting techniques and propose new ones incorporating domain knowledge. Among the selection methods, we find that choosing objects with a likelihood above a learned relation-specific threshold gives a 49.5% F1 score. Our results highlight the difficulty of employing LMs for the multi-valued slot-filling task and pave the way for further research on extracting relational knowledge from latent language representations.

Federated learning methods enable model training across distributed data sources without data leaving their original locations and have gained increasing interest in various fields. However, existing approaches are limited, excluding many structured probabilistic models. We present a general and elegant solution based on structured variational inference, widely used in Bayesian machine learning, adapted for the federated setting. Additionally, we provide a communication-efficient variant analogous to the canonical FedAvg algorithm. The proposed algorithms' effectiveness is demonstrated, and their performance is compared with hierarchical Bayesian neural networks and topic models.