Artificial intelligence (AI) models are increasingly finding applications in the field of medicine. Concerns have been raised about the explainability of the decisions that are made by these AI models. In this article, we give a systematic analysis of explainable artificial intelligence (XAI), with a primary focus on models that are currently being used in the field of healthcare. The literature search is conducted following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) standards for relevant work published from 1 January 2012 to 02 February 2022. The review analyzes the prevailing trends in XAI and lays out the major directions in which research is headed. We investigate the why, how, and when of the uses of these XAI models and their implications. We present a comprehensive examination of XAI methodologies as well as an explanation of how a trustworthy AI can be derived from describing AI models for healthcare fields. The discussion of this work will contribute to the formalization of the XAI field.

We consider the well-studied problem of decomposing a vector time series signal into components with different characteristics, such as smooth, periodic, nonnegative, or sparse. We describe a simple and general framework in which the components are defined by loss functions (which include constraints), and the signal decomposition is carried out by minimizing the sum of losses of the components (subject to the constraints). When each loss function is the negative log-likelihood of a density for the signal component, this framework coincides with maximum a posteriori probability (MAP) estimation; but it also includes many other interesting cases. Summarizing and clarifying prior results, we give two distributed optimization methods for computing the decomposition, which find the optimal decomposition when the component class loss functions are convex, and are good heuristics when they are not. Both methods require only the masked proximal operator of each of the component loss functions, a generalization of the well-known proximal operator that handles missing entries in its argument. Both methods are distributed, i.e., handle each component separately. We derive tractable methods for evaluating the masked proximal operators of some loss functions that, to our knowledge, have not appeared in the literature.

The use of Augmented Reality (AR) for navigation purposes has shown beneficial in assisting physicians during the performance of surgical procedures. These applications commonly require knowing the pose of surgical tools and patients to provide visual information that surgeons can use during the task performance. Existing medical-grade tracking systems use infrared cameras placed inside the Operating Room (OR) to identify retro-reflective markers attached to objects of interest and compute their pose. Some commercially available AR Head-Mounted Displays (HMDs) use similar cameras for self-localization, hand tracking, and estimating the objects' depth. This work presents a framework that uses the built-in cameras of AR HMDs to enable accurate tracking of retro-reflective markers, such as those used in surgical procedures, without the need to integrate any additional components. This framework is also capable of simultaneously tracking multiple tools. Our results show that the tracking and detection of the markers can be achieved with an accuracy of 0.09 +- 0.06 mm on lateral translation, 0.42 +- 0.32 mm on longitudinal translation, and 0.80 +- 0.39 deg for rotations around the vertical axis. Furthermore, to showcase the relevance of the proposed framework, we evaluate the system's performance in the context of surgical procedures. This use case was designed to replicate the scenarios of k-wire insertions in orthopedic procedures. For evaluation, two surgeons and one biomedical researcher were provided with visual navigation, each performing 21 injections. Results from this use case provide comparable accuracy to those reported in the literature for AR-based navigation procedures.

Access to dermatological care is a major issue, with an estimated 3 billion people lacking access to care globally. Artificial intelligence (AI) may aid in triaging skin diseases. However, most AI models have not been rigorously assessed on images of diverse skin tones or uncommon diseases. To ascertain potential biases in algorithm performance in this context, we curated the Diverse Dermatology Images (DDI) dataset-the first publicly available, expertly curated, and pathologically confirmed image dataset with diverse skin tones. Using this dataset of 656 images, we show that state-of-the-art dermatology AI models perform substantially worse on DDI, with receiver operator curve area under the curve (ROC-AUC) dropping by 27-36 percent compared to the models' original test results. All the models performed worse on dark skin tones and uncommon diseases, which are represented in the DDI dataset. Additionally, we find that dermatologists, who typically provide visual labels for AI training and test datasets, also perform worse on images of dark skin tones and uncommon diseases compared to ground truth biopsy annotations. Finally, fine-tuning AI models on the well-characterized and diverse DDI images closed the performance gap between light and dark skin tones. Moreover, algorithms fine-tuned on diverse skin tones outperformed dermatologists on identifying malignancy on images of dark skin tones. Our findings identify important weaknesses and biases in dermatology AI that need to be addressed to ensure reliable application to diverse patients and diseases.

The program schedule will cover six days from July 26 until July 31. Presentations each day will start at 10:30 and end at 12:30 US Eastern Time. We will start on July 26 with a presentation on the IEEE Entrepreneur Program and an overview of the Entrepreneur Process and the resources that are available to support the aspiring Entrepreneur. Each following day will provide a Speaker that can give their experience in creating a IoT based Start Up. On the last day, July 31, we will have a spirited competition of Start Ups making their "Pitches".

Early detection of skin cancers like melanoma is crucial to ensure high chances of survival for patients. Clinical application of Deep Learning (DL)-based Decision Support Systems (DSS) for skin cancer screening has the potential to improve the quality of patient care. The majority of work in the medical AI community focuses on a diagnosis setting that is mainly relevant for autonomous operation. Practical decision support should, however, go beyond plain diagnosis and provide explanations. This paper provides an overview of works towards explainable, DL-based decision support in medical applications with the example of skin cancer diagnosis from clinical, dermoscopic and histopathologic images. Analysis reveals that comparably little attention is payed to the explanation of histopathologic skin images and that current work is dominated by visual relevance maps as well as dermoscopic feature identification. We conclude that future work should focus on meeting the stakeholder's cognitive concepts, providing exhaustive explanations that combine global and local approaches and leverage diverse modalities. Moreover, the possibility to intervene and guide models in case of misbehaviour is identified as a major step towards successful deployment of AI as DL-based DSS and beyond.

Explainable Artificial Intelligence (XAI) is an emerging research topic of machine learning aimed at unboxing how AI systems' black-box choices are made. This research field inspects the measures and models involved in decision-making and seeks solutions to explain them explicitly. Many of the machine learning algorithms can not manifest how and why a decision has been cast. This is particularly true of the most popular deep neural network approaches currently in use. Consequently, our confidence in AI systems can be hindered by the lack of explainability in these black-box models. The XAI becomes more and more crucial for deep learning powered applications, especially for medical and healthcare studies, although in general these deep neural networks can return an arresting dividend in performance. The insufficient explainability and transparency in most existing AI systems can be one of the major reasons that successful implementation and integration of AI tools into routine clinical practice are uncommon. In this study, we first surveyed the current progress of XAI and in particular its advances in healthcare applications. We then introduced our solutions for XAI leveraging multi-modal and multi-centre data fusion, and subsequently validated in two showcases following real clinical scenarios. Comprehensive quantitative and qualitative analyses can prove the efficacy of our proposed XAI solutions, from which we can envisage successful applications in a broader range of clinical questions.

Microsatellite instability (MSI) is associated with several tumor types and its status has become increasingly vital in guiding patient treatment decisions. However, in clinical practice, distinguishing MSI from its counterpart is challenging since the diagnosis of MSI requires additional genetic or immunohistochemical tests. In this study, interpretable pathological image analysis strategies are established to help medical experts to automatically identify MSI. The strategies only require ubiquitous Haematoxylin and eosin-stained whole-slide images and can achieve decent performance in the three cohorts collected from The Cancer Genome Atlas. The strategies provide interpretability in two aspects. On the one hand, the image-level interpretability is achieved by generating localization heat maps of important regions based on the deep learning network; on the other hand, the feature-level interpretability is attained through feature importance and pathological feature interaction analysis. More interestingly, both from the image-level and feature-level interpretability, color features and texture characteristics are shown to contribute the most to the MSI predictions. Therefore, the classification models under the proposed strategies can not only serve as an efficient tool for predicting the MSI status of patients, but also provide more insights to pathologists with clinical understanding.

The Noise Collector for sparse recovery in high dimensions Miguel Moscoso, Alexei Novikov †, George Papanicolaou ‡, Chrysoula Tsogka § August 14, 2019 Abstract The ability to detect sparse signals from noisy high-dimensional data is a top priority in modern science and engineering. A sparse solution of the linear system A ρ b 0 can be found efficiently with an null 1-norm minimization approach if the data is noiseless. Detection of the signal's support from data corrupted by noise is still a challenging problem, especially if the level of noise must be estimated. We propose a new efficient approach that does not require any parameter estimation. We introduce the Noise Collector (NC) matrix C and solve an augmented system A ρ C η b 0 e, where e is the noise. We show that the l 1-norm minimal solution of the augmented system has zero false discovery rate for any level of noise and with probability that tends to one as the dimension of b 0 increases to infinity. We also obtain exact support recovery if the noise is not too large, and develop a Fast Noise Collector Algorithm which makes the computational cost of solving the augmented system comparable to that of the original one. Finally, we demonstrate the effectiveness of the method in applications to passive array imaging. In the noiseless case, ρ can be found exactly by solving the optimization problem [9] ρ arg min ρ null ρnull null 1, subject to A ρ b, (2) provided the measurement matrix A R N K satisfies additional conditions, e.g., decoherence or restricted isometry properties [11, 4], and the solution vector ρ has a small number M of nonzero components or degrees of freedom.