Protein sequence design, determined by amino acid sequences, are essential to protein engineering problems in drug discovery. Prior approaches have resorted to evolutionary strategies or Monte-Carlo methods for protein design, but often fail to exploit the structure of the combinatorial search space, to generalize to unseen sequences. In the context of discrete black box optimization over large search spaces, learning a mutation policy to generate novel sequences with reinforcement learning is appealing. Recent advances in protein language models (PLMs) trained on large corpora of protein sequences offer a potential solution to this problem by scoring proteins according to their biological plausibility (such as the TM-score). In this work, we propose to use PLMs as a reward function to generate new sequences. Yet the PLM can be computationally expensive to query due to its large size. To this end, we propose an alternative paradigm where optimization can be performed on scores from a smaller proxy model that is periodically finetuned, jointly while learning the mutation policy. We perform extensive experiments on various sequence lengths to benchmark RL-based approaches, and provide comprehensive evaluations along biological plausibility and diversity of the protein. Our experimental results include favorable evaluations of the proposed sequences, along with high diversity scores, demonstrating that RL is a strong candidate for biological sequence design. Finally, we provide a modular open source implementation can be easily integrated in most RL training loops, with support for replacing the reward model with other PLMs, to spur further research in this domain. The code for all experiments is provided in the supplementary material.

The alarming decline in global biodiversity, driven by various factors, underscores the urgent need for large-scale wildlife monitoring. In response, scientists have turned to automated deep learning methods for data processing in wildlife monitoring. However, applying these advanced methods in real-world scenarios is challenging due to their complexity and the need for specialized knowledge, primarily because of technical challenges and interdisciplinary barriers. To address these challenges, we introduce Pytorch-Wildlife, an open-source deep learning platform built on PyTorch. It is designed for creating, modifying, and sharing powerful AI models. This platform emphasizes usability and accessibility, making it accessible to individuals with limited or no technical background. It also offers a modular codebase to simplify feature expansion and further development. Pytorch-Wildlife offers an intuitive, user-friendly interface, accessible through local installation or Hugging Face, for animal detection and classification in images and videos. As two real-world applications, Pytorch-Wildlife has been utilized to train animal classification models for species recognition in the Amazon Rainforest and for invasive opossum recognition in the Galapagos Islands. The Opossum model achieves 98% accuracy, and the Amazon model has 92% recognition accuracy for 36 animals in 90% of the data. As Pytorch-Wildlife evolves, we aim to integrate more conservation tasks, addressing various environmental challenges. Pytorch-Wildlife is available at https://github.com/microsoft/CameraTraps.

Large language models (LLMs) have brought a paradigm shift to the field of code generation, offering the potential to enhance the software development process. However, previous research mainly focuses on the accuracy of code generation, while coding style differences between LLMs and human developers remain under-explored. In this paper, we empirically analyze the differences in coding style between the code generated by mainstream Code LLMs and the code written by human developers, and summarize coding style inconsistency taxonomy. Specifically, we first summarize the types of coding style inconsistencies by manually analyzing a large number of generation results. We then compare the code generated by Code LLMs with the code written by human programmers in terms of readability, conciseness, and robustness. The results reveal that LLMs and developers have different coding styles. Additionally, we study the possible causes of these inconsistencies and provide some solutions to alleviate the problem.

This trend is particularly evident in the logistics sector, where companies are actively integrating EVs into their transportation fleets. At the heart of this transition is the electric vehicle routing problem (EVRP), an optimization problem central to the operations of these logistics companies, focusing on dealing with the complexities of deploying EVs instead of internal combustion engine vehicles. This article addresses a practical routing problem for EVs, named heterogeneous electric vehicle routing problem with time-window constraints (HEVRPTW). It considers both vehicle attributes, such as varying cargo and battery capacities [4] and customer preferences regarding delivery times [5]. These factors create a more realistic and applicable model for contemporary logistics challenges. HEVRPTW, recognized as an NP-hard optimization problem, seeks to determine a set of routes with minimal cost, total traveling time, or total traveling distance, for a fleet of Heterogeneous EVs to serve each geographically dispersed customer's demands within a specified time-window. Traditional methods, including exact and heuristics solvers, are conventionally employed to solve various vehicle routing problem (VRP) variants. Due to the NP-Hard nature of HEVRPTW, and VRPs in general, exact methods, such as branch-and-price [6] and branchand-price-and-cut [7], consume prohibitively long time for solving practical-size problems [8].

Graph structures are effectively capable of describing the complex relationship between the objects, i.e. nodes, through edges. Besides, Graph-based representation is an effective method for feature dimensionality reduction [4, 5]. GNNs, as powerful tools for representational learning on graph-structured data, have attracted increasing attention in recent years. GNNs are used for effective deep representational learning to perform graph analysis for tasks such as node classification, link prediction, and clustering in Euclidean and non-Euclidean domains [6]. Among the proposed methods for learning representations on graphs, GCNs proposed by Kipf et al. [7] proved to be a simple and effective GNN model. This model is able to learn hidden representations comprising both node features and local graph structure while scaling linearly relative to the number of edges in the given graph. Most classification algorithms, in GNNs, tend to minimize the average loss over all training examples which produces reasonable outcomes for class-balanced datasets.

Multilingual automatic lyrics transcription (ALT) is a challenging task due to the limited availability of labelled data and the challenges introduced by singing, compared to multilingual automatic speech recognition. Although some multilingual singing datasets have been released recently, English continues to dominate these collections. Multilingual ALT remains underexplored due to the scale of data and annotation quality. In this paper, we aim to create a multilingual ALT system with available datasets. Inspired by architectures that have been proven effective for English ALT, we adapt these techniques to the multilingual scenario by expanding the target vocabulary set. We then evaluate the performance of the multilingual model in comparison to its monolingual counterparts. Additionally, we explore various conditioning methods to incorporate language information into the model. We apply analysis by language and combine it with the language classification performance. Our findings reveal that the multilingual model performs consistently better than the monolingual models trained on the language subsets. Furthermore, we demonstrate that incorporating language information significantly enhances performance.

Federated learning offers a compelling solution to the challenges of networking and data privacy within aerial and space networks by utilizing vast private edge data and computing capabilities accessible through drones, balloons, and satellites. While current research has focused on optimizing the learning process, computing efficiency, and minimizing communication overhead, the issue of heterogeneity and class imbalance remains a significant barrier to rapid model convergence. In our study, we explore the influence of heterogeneity on class imbalance, which diminishes performance in ASN-based federated learning. We illustrate the correlation between heterogeneity and class imbalance within grouped data and show how constraints such as battery life exacerbate the class imbalance challenge. Our findings indicate that ASN-based FL faces heightened class imbalance issues even with similar levels of heterogeneity compared to other scenarios. Finally, we analyze the impact of varying degrees of heterogeneity on FL training and evaluate the efficacy of current state-of-the-art algorithms under these conditions. Our results reveal that the heterogeneity challenge is more pronounced in ASN-based federated learning and that prevailing algorithms often fail to effectively address high levels of heterogeneity.

Integration of speech into healthcare has intensified privacy concerns due to its potential as a non-invasive biomarker containing individual biometric information. In response, speaker anonymization aims to conceal personally identifiable information while retaining crucial linguistic content. However, the application of anonymization techniques to pathological speech, a critical area where privacy is especially vital, has not been extensively examined. This study investigates anonymization's impact on pathological speech across over 2,700 speakers from multiple German institutions, focusing on privacy, pathological utility, and demographic fairness. We explore both deep-learning-based and signal processing-based anonymization methods, and document substantial privacy improvements across disorders-evidenced by equal error rate increases up to 1933%, with minimal overall impact on utility. Specific disorders such as Dysarthria, Dysphonia, and Cleft Lip and Palate experienced minimal utility changes, while Dysglossia showed slight improvements. Our findings underscore that the impact of anonymization varies substantially across different disorders. This necessitates disorder-specific anonymization strategies to optimally balance privacy with diagnostic utility. Additionally, our fairness analysis revealed consistent anonymization effects across most of the demographics. This study demonstrates the effectiveness of anonymization in pathological speech for enhancing privacy, while also highlighting the importance of customized and disorder-specific approaches to account for inversion attacks.

Urban land use inference is a critically important task that aids in city planning and policy-making. Recently, the increased use of sensor and location technologies has facilitated the collection of multi-modal mobility data, offering valuable insights into daily activity patterns. Many studies have adopted advanced data-driven techniques to explore the potential of these multi-modal mobility data in land use inference. However, existing studies often process samples independently, ignoring the spatial correlations among neighbouring objects and heterogeneity among different services. Furthermore, the inherently low interpretability of complex deep learning methods poses a significant barrier in urban planning, where transparency and extrapolability are crucial for making long-term policy decisions. To overcome these challenges, we introduce an explainable framework for inferring land use that synergises heterogeneous graph neural networks (HGNs) with Explainable AI techniques, enhancing both accuracy and explainability. The empirical experiments demonstrate that the proposed HGNs significantly outperform baseline graph neural networks for all six land-use indicators, especially in terms of 'office' and 'sustenance'. As explanations, we consider feature attribution and counterfactual explanations. The analysis of feature attribution explanations shows that the symmetrical nature of the `residence' and 'work' categories predicted by the framework aligns well with the commuter's 'work' and 'recreation' activities in London. The analysis of the counterfactual explanations reveals that variations in node features and types are primarily responsible for the differences observed between the predicted land use distribution and the ideal mixed state. These analyses demonstrate that the proposed HGNs can suitably support urban stakeholders in their urban planning and policy-making.

The evolution of speech technology has been spurred by the rapid increase in dataset sizes. Traditional speech models generally depend on a large amount of labeled training data, which is scarce for low-resource languages. This paper presents GigaSpeech 2, a large-scale, multi-domain, multilingual speech recognition corpus. It is designed for low-resource languages and does not rely on paired speech and text data. GigaSpeech 2 comprises about 30,000 hours of automatically transcribed speech, including Thai, Indonesian, and Vietnamese, gathered from unlabeled YouTube videos. We also introduce an automated pipeline for data crawling, transcription, and label refinement. Specifically, this pipeline uses Whisper for initial transcription and TorchAudio for forced alignment, combined with multi-dimensional filtering for data quality assurance. A modified Noisy Student Training is developed to further refine flawed pseudo labels iteratively, thus enhancing model performance. Experimental results on our manually transcribed evaluation set and two public test sets from Common Voice and FLEURS confirm our corpus's high quality and broad applicability. Notably, ASR models trained on GigaSpeech 2 can reduce the word error rate for Thai, Indonesian, and Vietnamese on our challenging and realistic YouTube test set by 25% to 40% compared to the Whisper large-v3 model, with merely 10% model parameters. Furthermore, our ASR models trained on Gigaspeech 2 yield superior performance compared to commercial services. We believe that our newly introduced corpus and pipeline will open a new avenue for low-resource speech recognition and significantly facilitate research in this area.