The model was pretrained on two of the largest neuroimaging datasets to date, encompassing 64,594 T1-weighted structural MRI 3D volumes (~14 million images) and 70,933 functional MRI (fMRI) time series. BrainHarmonix is grounded in two foundational neuroscience principles: structure complements function - structural and functional modalities offer distinct yet synergistic insights into brain organization; function follows structure brain functional dynamics are shaped by cortical morphology. The modular pretraining process involves single-modality training with geometric pre-alignment followed by modality fusion through shared brain hub tokens. Notably, our dynamics encoder uniquely handles fMRI time series with heterogeneous repetition times (TRs), addressing a major limitation in existing models. BrainHarmonix is also the first to deeply compress high-dimensional neuroimaging signals into unified, continuous 1D tokens, forming a compact latent space of the human brain. BrainHarmonix achieves strong generalization across diverse downstream tasks, including neurodevelopmental and neurodegenerative disorder classification and cognition prediction - consistently outperforming previous approaches. Our models - pretrained on 8 H100 GPUs - aim to catalyze a new era of AI-driven neuroscience powered by large-scale multimodal neuroimaging.

World models aim to capture the dynamics of the environment, enabling agents to predict and plan for future states. In most scenarios of interest, the dynamics are highly centered on interactions among objects within the environment. This motivates the development of world models that operate on object-centric rather than monolithic representations, with the goal of more effectively capturing environment dynamics and enhancing compositional generalization. However, the development of object-centric world models has largely been explored in environments with limited visual complexity (such as basic geometries). It remains underexplored whether such models can be effective in more challenging settings. In this paper, we fill this gap by introducing Dyn-O, an enhanced structured world model built upon object-centric representations. Compared to prior work in object-centric representations, Dyn-O improves in both learning representations and modeling dynamics. On the challenging Procgen games, we demonstrate that our method can learn objectcentric world models directly from pixel observations, outperforming DreamerV3 in rollout prediction accuracy. Furthermore, by decoupling object-centric features into dynamic-agnostic and dynamic-aware components, we enable finer-grained manipulation of these features and generate more diverse imagined trajectories.

In this work, we explore the trade-offs of explicit structural priors, particularly group-equivariance. We address this through theoretical analysis and a comprehensive empirical study focusing on point clouds. To enable controlled and fair comparisons, we introduce Rapidash, a unified group convolutional architecture that allows for different variants of equivariant and non-equivariant models. Our results suggest that more constrained equivariant models outperform less constrained alternatives when aligned with the geometry of the task, and increasing representation capacity does not fully eliminate performance gaps. We see improved performance of models with equivariance and symmetry-breaking through tasks like segmentation, regression, and generation across diverse datasets. Explicit symmetry breaking via geometric reference frames consistently improves performance, while breaking equivariance through geometric input features can be helpful when aligned with task geometry. Our results provide task-specific performance trends that offer a more nuanced way for model selection.

We introduce learning to condition (L2C), a scalable, data-driven framework for accelerating Most Probable Explanation (MPE) inference in Probabilistic Graphical Models (PGMs), a fundamentally intractable problem. L2C trains a neural network to score variable-value assignments based on their utility for conditioning, given observed evidence. To facilitate supervised learning, we develop a scalable data generation pipeline that extracts training signals from the search traces of existing MPE solvers. The trained network serves as a heuristic that integrates with search algorithms, acting as a conditioning strategy prior to exact inference or as a branching and node selection policy within branch-and-bound solvers.

Detecting structural change in dynamic network data has wide-ranging applications. Existing approaches typically divide the data into time bins, extract network features within each bin, and then compare these features over time. This introduces an inherent tradeoff between temporal resolution and statistical stability of the extracted features. Despite this tradeoff, reminiscent of time-frequency tradeoffs in signal processing, most methods rely on a fixed temporal resolution. Choosing an appropriate resolution parameter is typically difficult, and can be especially problematic in domains like cybersecurity, where anomalous behavior may emerge at multiple time scales.

Human intelligence effortlessly interprets visual scenes along a rich spectrum of semantic dimensions. However, existing approaches to language-grounded visual concept learning are limited to a few predefined primitive axes, such as color and shape, and are typically explored in synthetic datasets. In this work, we propose a scalable framework that adaptively identifies image-related concept axes and grounds visual concepts along these axes in real-world scenes. Leveraging a pretrained vision-language model and our universal prompting strategy, our framework identifies a diverse image-related axes without any prior knowledge. Our universal concept encoder adaptively binds visual features to the discovered axes without introducing additional model parameters for each concept. To ground visual concepts along the discovered axes, we optimize a compositional anchoring objective, which ensures that each axis can be independently manipulated without affecting others. We demonstrate the effectiveness of our framework on subsets of ImageNet, CelebA-HQ, and AFHQ, showcasing superior editing capabilities across diverse real-world concepts that are too varied to be manually predefined. Our method also exhibits strong compositional generalization, outperforming existing visual concept learning and text-based editing methods.

The integration of image and event streams offers a promising approach for achieving robust visual object tracking in complex environments. However, current fusion methods achieve high performance at the cost of significant computational overhead and struggle to efficiently extract the sparse, asynchronous information from event streams, failing to leverage the energy-efficient advantages of event-driven spiking paradigms. To address this challenge, we propose the first fully Spiking FrameEvent Tracking framework called SpikeFET. This network achieves synergistic integration of convolutional local feature extraction and Transformer-based global modeling within the spiking paradigm, effectively fusing frame and event data. To overcome the degradation of translation invariance caused by convolutional padding, we introduce a Random Patchwork Module (RPM) that eliminates positional bias through randomized spatial reorganization and learnable type encoding while preserving residual structures. Furthermore, we propose a Spatial-Temporal Regularization (STR) strategy that overcomes similarity metric degradation from asymmetric features by enforcing spatio-temporal consistency among temporal template features in latent space. Extensive experiments across multiple benchmarks demonstrate that the proposed framework achieves superior tracking accuracy over existing methods while significantly reducing power consumption, attaining an optimal balance between performance and efficiency.

Physics-Informed Machine Learning (PIML) has successfully integrated mechanistic understanding into machine learning, particularly in domains governed by well-known physical laws. This success has motivated efforts to apply PIML to biology, a field rich in dynamical systems but shaped by different constraints. Biological modeling, however, presents unique challenges: multi-faceted and uncertain prior knowledge, heterogeneous and noisy data, partial observability, and complex, high-dimensional networks. In this position paper, we argue that these challenges should not be seen as obstacles to PIML, but as catalysts for its evolution. We propose Biology-Informed Machine Learning (BIML): a principled extension of PIML that retains its structural grounding while adapting to the practical realities of biology. Rather than replacing PIML, BIML retools its methods to operate under softer, probabilistic forms of prior knowledge. We outline four foundational pillars as a roadmap for this transition: uncertainty quantification, contextualization, constrained latent structure inference, and scalability. Foundation Models and Large Language Models will be key enablers, bridging human expertise with computational modeling. We conclude with concrete recommendations to build the BIML ecosystem and channel PIML-inspired innovation toward challenges of high scientific and societal relevance.

We present STARFlow, a scalable generative model based on normalizing flows that achieves strong performance on high-resolution image synthesis. STARFlow's main building block is Transformer Autoregressive Flow (TARFlow), which combines normalizing flows with Autoregressive Transformer architectures and has recently achieved impressive results in image modeling. In this work, we first establish the theoretical universality of TARFlow for modeling continuous distributions. Building on this foundation, we introduce a set of architectural and algorithmic innovations that significantly enhance the scalability: (1) a deep-shallow design where a deep Transformer block captures most of the model's capacity, followed by a few shallow Transformer blocks that are computationally cheap yet contribute non-negligibly, (2) learning in the latent space of pretrained autoencoders, which proves far more effective than modeling pixels directly, and (3) a novel guidance algorithm that substantially improves sample quality. Crucially, our model remains a single, end-to-end normalizing flow, allowing exact maximum likelihood training in continuous space without discretization. STARFlow achieves competitive results in both class-and text-conditional image generation, with sample quality approaching that of state-of-the-art diffusion models. To our knowledge, this is the first successful demonstration of normalizing flows at this scale and resolution.

Distributional discrepancy between training and test data can lead models to make inaccurate predictions when encountering out-of-distribution (OOD) samples in real-world applications. Although existing graph OOD detection methods leverage data-centric techniques to extract effective representations, their performance remains compromised by structural redundancy that induces semantic shifts. To address this dilemma, we propose RedOUT, an unsupervised framework that integrates structural entropy into test-time OOD detection for graph classification. Concretely, we introduce the Redundancy-aware Graph Information Bottleneck (ReGIB) and decompose the objective into essential information and irrelevant redundancy. By minimizing structural entropy, the decoupled redundancy is reduced, and theoretically grounded upper and lower bounds are proposed for optimization. Extensive experiments on real-world datasets demonstrate the superior performance of RedOUT on OOD detection. Specifically, our method achieves an average improvement of 6.7%, significantly surpassing the best competitor by 17.3% on the ClinTox/LIPO dataset pair.